HK1024694A1 - Pro-drugs and counterparts of camptothecin, their application as medicines - Google Patents

Pro-drugs and counterparts of camptothecin, their application as medicines

Info

Publication number
HK1024694A1
HK1024694A1 HK00104033A HK00104033A HK1024694A1 HK 1024694 A1 HK1024694 A1 HK 1024694A1 HK 00104033 A HK00104033 A HK 00104033A HK 00104033 A HK00104033 A HK 00104033A HK 1024694 A1 HK1024694 A1 HK 1024694A1
Authority
HK
Hong Kong
Prior art keywords
camptothecin
counterparts
medicines
pro
drugs
Prior art date
Application number
HK00104033A
Other languages
English (en)
Inventor
Dennis Bigg
Olivier Lavergne
Jerry Harnett
Alain Rolland
Anne-Marie Liberatore
Christoph Lanco
Original Assignee
S C R A S Soc De Conseils De R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9615775A external-priority patent/FR2757515B1/fr
Application filed by S C R A S Soc De Conseils De R filed Critical S C R A S Soc De Conseils De R
Publication of HK1024694A1 publication Critical patent/HK1024694A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK00104033A 1996-12-20 2000-07-04 Pro-drugs and counterparts of camptothecin, their application as medicines HK1024694A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9615775A FR2757515B1 (fr) 1996-12-20 1996-12-20 Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR9615945 1996-12-24
PCT/FR1997/002217 WO1998028304A1 (fr) 1996-12-20 1997-12-05 Formes prodrogues et analogues de la camptothecine, leur application comme medicaments

Publications (1)

Publication Number Publication Date
HK1024694A1 true HK1024694A1 (en) 2000-10-20

Family

ID=26233188

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00104033A HK1024694A1 (en) 1996-12-20 2000-07-04 Pro-drugs and counterparts of camptothecin, their application as medicines

Country Status (24)

Country Link
EP (1) EP0946566B1 (ja)
JP (1) JP3576174B2 (ja)
KR (1) KR100516873B1 (ja)
CN (1) CN1090634C (ja)
AR (1) AR005849A1 (ja)
AT (1) ATE253582T1 (ja)
AU (1) AU734512B2 (ja)
BR (1) BR9713977B1 (ja)
CA (1) CA2275345C (ja)
CZ (1) CZ299794B6 (ja)
DE (1) DE69726007T2 (ja)
DK (1) DK0946566T3 (ja)
ES (1) ES2206760T3 (ja)
HK (1) HK1024694A1 (ja)
HU (1) HUP0001385A3 (ja)
IL (2) IL129892A0 (ja)
MY (1) MY122042A (ja)
NO (1) NO324973B1 (ja)
NZ (1) NZ335938A (ja)
PL (1) PL188109B1 (ja)
PT (1) PT946566E (ja)
TW (1) TW410224B (ja)
UA (1) UA57757C2 (ja)
WO (1) WO1998028304A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
DE69932649T2 (de) * 1998-09-02 2007-08-09 Pharmagenesis, Inc., Palo Alto Triptolid-Prodrugs mit hoher Wasserlöslichkeit
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
AU2003243380A1 (en) 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
EP1694684B1 (en) * 2003-12-17 2011-08-03 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives
CN1964979B (zh) * 2004-04-09 2011-07-27 中外制药株式会社 新颖的水溶性前药
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
FR2892417B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN100465175C (zh) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-位取代高喜树碱类化合物及作为药物的用途
CN100441580C (zh) * 2006-07-14 2008-12-10 中山大学 喹啉二酮衍生物及其在制备抗菌药物中的应用
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN117164601A (zh) * 2022-06-02 2023-12-05 华东师范大学 一种高喜树碱类小分子及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
RU2164515C2 (ru) * 1995-06-21 2001-03-27 Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (СКРАС) Соединения камптотецина, способы их получения, промежуточные соединения и терапевтические композиции

Also Published As

Publication number Publication date
EP0946566B1 (fr) 2003-11-05
AR005849A1 (es) 1999-07-21
WO1998028304A1 (fr) 1998-07-02
ES2206760T3 (es) 2004-05-16
DE69726007T2 (de) 2004-06-03
AU5326498A (en) 1998-07-17
CA2275345A1 (fr) 1998-07-02
IL129892A (en) 2007-09-20
NZ335938A (en) 2000-04-28
CN1090634C (zh) 2002-09-11
NO324973B1 (no) 2008-01-14
PL334092A1 (en) 2000-01-31
DK0946566T3 (da) 2004-03-15
MY122042A (en) 2006-03-31
NO992997L (no) 1999-08-18
JP2001506270A (ja) 2001-05-15
PT946566E (pt) 2004-03-31
BR9713977A (pt) 2000-04-11
TW410224B (en) 2000-11-01
UA57757C2 (uk) 2003-07-15
AU734512B2 (en) 2001-06-14
JP3576174B2 (ja) 2004-10-13
ATE253582T1 (de) 2003-11-15
HUP0001385A3 (en) 2002-12-28
BR9713977B1 (pt) 2010-06-29
IL129892A0 (en) 2000-02-29
CZ209299A3 (cs) 1999-09-15
DE69726007D1 (de) 2003-12-11
CZ299794B6 (cs) 2008-11-26
HUP0001385A2 (hu) 2000-10-28
CA2275345C (fr) 2010-01-26
KR100516873B1 (ko) 2005-09-26
KR20000062260A (ko) 2000-10-25
NO992997D0 (no) 1999-06-18
EP0946566A1 (fr) 1999-10-06
CN1241192A (zh) 2000-01-12
PL188109B1 (pl) 2004-12-31

Similar Documents

Publication Publication Date Title
HK1024694A1 (en) Pro-drugs and counterparts of camptothecin, their application as medicines
EG24144A (en) Disubstituted bicyclic heterocycles their preparation and their use as medicaments
GB9721069D0 (en) Polymeric derivatives of camptothecin
CZ161599A3 (cs) N-substituované 2-kyanopyrrolidiny, způsob jejich přípravy a jejich použití jako léčiv
ZA989505B (en) Substituted isoquinoline-3-carboxamides their preparation and their use as pharmaceuticals
AP9901556A0 (en) Sulpponamide derivatives process for their preparation and their use as medicaments
HK1015765A1 (en) Dithiolan derivatives, their preparation and their therapeutic effect
LT2000004A (en) Derivatives of acyl-piperazinil-pyrimidins, preparation thereof and application as medicaments
PL328608A1 (en) Novel derivatives of erythromycin, method of obtaining them and their therapeutic application as drugs
EP0943327A4 (en) DRUG
PL343512A1 (en) Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
PL319758A1 (en) Bicyclic tetrahydropyrasole pyridines and their application as medicines
HUP9900563A3 (en) Chinoline-2-(1h)-ones, their production, pharmaceutical compositions and use
HU9700955D0 (en) Substituted 2-naphtoylguanidine derivatives, their production, their use and pharmaceutical compositions containing them
HRP980502B1 (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments
HUP9902311A3 (en) New triazolopurines, method of preparing them and their use as drugs
ZA9711168B (en) New therapeutic application of pyrrole derivatives.
HK1024695A1 (en) Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them
HUP9600665A3 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
PL329213A1 (en) Novel derivatives of diarylmethylidene furane, method of obtaining them and their therapeutic application
CY2590B2 (en) Preparation of 1-butyl-4-piperidinylmethylamine
HUP0001245A3 (en) Novel erythromycin derivatives, method of preparation and application as medicines
PL331153A1 (en) Novel derivatives of erythromycin, method of obtaining them and their applications as drugs
HU9700954D0 (en) Substituted 1-naphtoylguanidine derivatives, their production, their use and pharmaceutical compositions containing them
HUP9700437A3 (en) Guanidino-derivatives of substituted thienyl-alkenyl-carboxylic-acids, their production, and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111205