HK1018778A1 - Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents - Google Patents
Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agentsInfo
- Publication number
- HK1018778A1 HK1018778A1 HK99103795A HK99103795A HK1018778A1 HK 1018778 A1 HK1018778 A1 HK 1018778A1 HK 99103795 A HK99103795 A HK 99103795A HK 99103795 A HK99103795 A HK 99103795A HK 1018778 A1 HK1018778 A1 HK 1018778A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- microtubules
- pct
- taxol
- depolymerisation
- mitosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605024A DE19605024A1 (de) | 1996-01-31 | 1996-01-31 | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| PCT/EP1997/000440 WO1997028156A1 (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1018778A1 true HK1018778A1 (en) | 2000-01-07 |
Family
ID=7785142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK99103795A HK1018778A1 (en) | 1996-01-31 | 1999-09-02 | Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6162920A (es) |
| EP (1) | EP0896577B1 (es) |
| JP (1) | JP2001505527A (es) |
| KR (1) | KR19990082151A (es) |
| CN (1) | CN1073108C (es) |
| AT (1) | ATE233757T1 (es) |
| AU (1) | AU714313B2 (es) |
| BR (1) | BR9708295A (es) |
| CA (1) | CA2244746A1 (es) |
| CZ (1) | CZ292504B6 (es) |
| DE (2) | DE19605024A1 (es) |
| DK (1) | DK0896577T3 (es) |
| ES (1) | ES2192261T3 (es) |
| HK (1) | HK1018778A1 (es) |
| HU (1) | HUP9901027A3 (es) |
| IL (1) | IL124951A (es) |
| NO (1) | NO983509L (es) |
| PL (1) | PL186796B1 (es) |
| PT (1) | PT896577E (es) |
| RU (1) | RU2163599C2 (es) |
| SK (1) | SK101198A3 (es) |
| TR (1) | TR199801415T2 (es) |
| TW (1) | TW444015B (es) |
| UA (1) | UA49007C2 (es) |
| WO (1) | WO1997028156A1 (es) |
| ZA (1) | ZA97847B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1266148C (zh) | 2001-03-07 | 2006-07-26 | 第一制药株式会社 | 制备2－吖丁啶酮衍生物的方法 |
| WO2004078065A2 (en) | 2003-03-03 | 2004-09-16 | Sinus Rhythm Technologies, Inc. | Electrical conduction block implant device |
| CN1296391C (zh) * | 2004-03-04 | 2007-01-24 | 中国人民解放军第二军医大学 | 氟代羧烷基环糊精醚类化合物及其制备方法和应用 |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| KR101462819B1 (ko) * | 2004-05-03 | 2014-11-21 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| CA2992789A1 (en) | 2015-08-20 | 2017-02-23 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| KR102714060B1 (ko) | 2015-08-21 | 2024-10-08 | 입센 바이오팜 리미티드 | 리포솜 이리노테칸 및 옥살리플라틴을 포함하는 병용 치료를 이용하여 전이성 췌장암을 치료하는 방법 |
| MA42991A (fr) | 2015-10-16 | 2018-08-22 | Ipsen Biopharm Ltd | Stabilisation de compositions pharmaceutiques de camptothécine |
| MX2019004783A (es) | 2016-11-02 | 2019-08-12 | Ipsen Biopharm Ltd | Tratamiento de cancer gastrico usando terapias de combinacion que comprenden irinotecan liposomico oxaliplatino, 5-fluoruracilo (y leucovorina). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| WO1994021252A1 (en) * | 1993-03-22 | 1994-09-29 | Florida State University | Taxanes having a pyridyl substituted side-chain |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| FR2715307B1 (fr) * | 1994-01-25 | 1996-04-05 | Commissariat Energie Atomique | Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation. |
| MX9700026A (es) * | 1994-06-28 | 1997-04-30 | Upjohn Co | Analogos de 7-eter-taxol, su uso antineoplastico y composiciones farmaceuticas que los contienen. |
-
1996
- 1996-01-31 DE DE19605024A patent/DE19605024A1/de not_active Withdrawn
-
1997
- 1997-01-31 DK DK97902286T patent/DK0896577T3/da active
- 1997-01-31 ZA ZA9700847A patent/ZA97847B/xx unknown
- 1997-01-31 TR TR1998/01415T patent/TR199801415T2/xx unknown
- 1997-01-31 CA CA002244746A patent/CA2244746A1/en not_active Abandoned
- 1997-01-31 WO PCT/EP1997/000440 patent/WO1997028156A1/en not_active Application Discontinuation
- 1997-01-31 RU RU98116122/04A patent/RU2163599C2/ru not_active IP Right Cessation
- 1997-01-31 UA UA98084638A patent/UA49007C2/uk unknown
- 1997-01-31 TW TW086101169A patent/TW444015B/zh active
- 1997-01-31 PT PT97902286T patent/PT896577E/pt unknown
- 1997-01-31 PL PL97328055A patent/PL186796B1/pl not_active IP Right Cessation
- 1997-01-31 EP EP97902286A patent/EP0896577B1/en not_active Expired - Lifetime
- 1997-01-31 US US09/117,506 patent/US6162920A/en not_active Expired - Fee Related
- 1997-01-31 AT AT97902286T patent/ATE233757T1/de not_active IP Right Cessation
- 1997-01-31 DE DE69719502T patent/DE69719502T2/de not_active Expired - Lifetime
- 1997-01-31 IL IL12495197A patent/IL124951A/xx not_active IP Right Cessation
- 1997-01-31 AU AU15984/97A patent/AU714313B2/en not_active Ceased
- 1997-01-31 ES ES97902286T patent/ES2192261T3/es not_active Expired - Lifetime
- 1997-01-31 HU HU9901027A patent/HUP9901027A3/hu unknown
- 1997-01-31 KR KR1019980705874A patent/KR19990082151A/ko not_active Application Discontinuation
- 1997-01-31 BR BR9708295A patent/BR9708295A/pt not_active Application Discontinuation
- 1997-01-31 CN CN97192006A patent/CN1073108C/zh not_active Expired - Fee Related
- 1997-01-31 CZ CZ19982426A patent/CZ292504B6/cs not_active IP Right Cessation
- 1997-01-31 SK SK1011-98A patent/SK101198A3/sk unknown
- 1997-01-31 JP JP52730897A patent/JP2001505527A/ja active Pending
-
1998
- 1998-07-30 NO NO983509A patent/NO983509L/no unknown
-
1999
- 1999-09-02 HK HK99103795A patent/HK1018778A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20060131 |