NO983509L - Taksanderivater med en pyridylsubstituert C13-sidekjede, fremstilling derav og anvendelse derav som antitumormidler - Google Patents

Taksanderivater med en pyridylsubstituert C13-sidekjede, fremstilling derav og anvendelse derav som antitumormidler

Info

Publication number
NO983509L
NO983509L NO983509A NO983509A NO983509L NO 983509 L NO983509 L NO 983509L NO 983509 A NO983509 A NO 983509A NO 983509 A NO983509 A NO 983509A NO 983509 L NO983509 L NO 983509L
Authority
NO
Norway
Prior art keywords
microtubules
pct
taxol
depolymerisation
mitosis
Prior art date
Application number
NO983509A
Other languages
English (en)
Other versions
NO983509D0 (no
Inventor
Ulrich Klar
Guenter Neef
Hermann Graf
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO983509D0 publication Critical patent/NO983509D0/no
Publication of NO983509L publication Critical patent/NO983509L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO983509A 1996-01-31 1998-07-30 Taksanderivater med en pyridylsubstituert C13-sidekjede, fremstilling derav og anvendelse derav som antitumormidler NO983509L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19605024A DE19605024A1 (de) 1996-01-31 1996-01-31 Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
PCT/EP1997/000440 WO1997028156A1 (en) 1996-01-31 1997-01-31 Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents

Publications (2)

Publication Number Publication Date
NO983509D0 NO983509D0 (no) 1998-07-30
NO983509L true NO983509L (no) 1998-07-30

Family

ID=7785142

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983509A NO983509L (no) 1996-01-31 1998-07-30 Taksanderivater med en pyridylsubstituert C13-sidekjede, fremstilling derav og anvendelse derav som antitumormidler

Country Status (26)

Country Link
US (1) US6162920A (no)
EP (1) EP0896577B1 (no)
JP (1) JP2001505527A (no)
KR (1) KR19990082151A (no)
CN (1) CN1073108C (no)
AT (1) ATE233757T1 (no)
AU (1) AU714313B2 (no)
BR (1) BR9708295A (no)
CA (1) CA2244746A1 (no)
CZ (1) CZ292504B6 (no)
DE (2) DE19605024A1 (no)
DK (1) DK0896577T3 (no)
ES (1) ES2192261T3 (no)
HK (1) HK1018778A1 (no)
HU (1) HUP9901027A3 (no)
IL (1) IL124951A (no)
NO (1) NO983509L (no)
PL (1) PL186796B1 (no)
PT (1) PT896577E (no)
RU (1) RU2163599C2 (no)
SK (1) SK101198A3 (no)
TR (1) TR199801415T2 (no)
TW (1) TW444015B (no)
UA (1) UA49007C2 (no)
WO (1) WO1997028156A1 (no)
ZA (1) ZA97847B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311591T3 (es) 2001-03-07 2009-02-16 Daiichi Sankyo Company, Limited Proceso para producir un derivado de 2-azetidinona.
EP1605866B1 (en) 2003-03-03 2016-07-06 Syntach AG Electrical conduction block implant device
CN1296391C (zh) * 2004-03-04 2007-01-24 中国人民解放军第二军医大学 氟代羧烷基环糊精醚类化合物及其制备方法和应用
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
CA2821167C (en) 2004-05-03 2016-06-28 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
TWI724018B (zh) 2015-08-20 2021-04-11 英商益普生生物製藥有限公司 用於癌症治療之組合療法
EP3337478B1 (en) 2015-08-21 2020-08-12 Ipsen Biopharm Ltd. Drug combination comprising liposomal irinotecan, oxaliplatin, 5-fluorouracil and leucovorin for treating metastatic pancreatic cancer
SG10201912568PA (en) 2015-10-16 2020-02-27 Ipsen Biopharm Ltd Stabilizing camptothecin pharmaceutical compositions
MX2019004783A (es) 2016-11-02 2019-08-12 Ipsen Biopharm Ltd Tratamiento de cancer gastrico usando terapias de combinacion que comprenden irinotecan liposomico oxaliplatino, 5-fluoruracilo (y leucovorina).

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
IL109049A (en) * 1993-03-22 2006-12-31 Univ Florida State Texans have a side chain that is converted into pyridyl and pharmaceutical preparations that contain them
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
FR2715307B1 (fr) * 1994-01-25 1996-04-05 Commissariat Energie Atomique Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation.
ES2123996T3 (es) * 1994-06-28 1999-01-16 Upjohn Co Analogos de 7-etertaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
DE19605024A1 (de) 1997-08-07
HK1018778A1 (en) 2000-01-07
HUP9901027A2 (hu) 2001-05-28
PL328055A1 (en) 1999-01-04
NO983509D0 (no) 1998-07-30
AU714313B2 (en) 1999-12-23
PL186796B1 (pl) 2004-02-27
HUP9901027A3 (en) 2001-08-28
US6162920A (en) 2000-12-19
IL124951A (en) 2003-12-10
ATE233757T1 (de) 2003-03-15
CN1210535A (zh) 1999-03-10
SK101198A3 (en) 1998-12-02
TW444015B (en) 2001-07-01
ES2192261T3 (es) 2003-10-01
EP0896577A1 (en) 1999-02-17
DE69719502T2 (de) 2004-02-19
RU2163599C2 (ru) 2001-02-27
ZA97847B (en) 1997-08-04
CZ292504B6 (cs) 2003-10-15
DK0896577T3 (da) 2003-05-19
JP2001505527A (ja) 2001-04-24
TR199801415T2 (xx) 1998-10-21
AU1598497A (en) 1997-08-22
DE69719502D1 (de) 2003-04-10
WO1997028156A1 (en) 1997-08-07
KR19990082151A (ko) 1999-11-15
UA49007C2 (uk) 2002-09-16
CA2244746A1 (en) 1997-08-07
EP0896577B1 (en) 2003-03-05
PT896577E (pt) 2003-06-30
CN1073108C (zh) 2001-10-17
IL124951A0 (en) 1999-01-26
CZ242698A3 (cs) 1999-07-14
BR9708295A (pt) 1999-08-03

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