DE69719502D1 - TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL - Google Patents

TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL

Info

Publication number
DE69719502D1
DE69719502D1 DE69719502T DE69719502T DE69719502D1 DE 69719502 D1 DE69719502 D1 DE 69719502D1 DE 69719502 T DE69719502 T DE 69719502T DE 69719502 T DE69719502 T DE 69719502T DE 69719502 D1 DE69719502 D1 DE 69719502D1
Authority
DE
Germany
Prior art keywords
microtubules
pct
taxol
depolymerisation
mitosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69719502T
Other languages
English (en)
Other versions
DE69719502T2 (de
Inventor
Ulrich Klar
Guenter Neef
Hermann Graf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE69719502T priority Critical patent/DE69719502T2/de
Application granted granted Critical
Publication of DE69719502D1 publication Critical patent/DE69719502D1/de
Publication of DE69719502T2 publication Critical patent/DE69719502T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69719502T 1996-01-31 1997-01-31 TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL Expired - Lifetime DE69719502T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69719502T DE69719502T2 (de) 1996-01-31 1997-01-31 TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19605024A DE19605024A1 (de) 1996-01-31 1996-01-31 Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE19605024 1996-01-31
PCT/EP1997/000440 WO1997028156A1 (en) 1996-01-31 1997-01-31 Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents
DE69719502T DE69719502T2 (de) 1996-01-31 1997-01-31 TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL

Publications (2)

Publication Number Publication Date
DE69719502D1 true DE69719502D1 (de) 2003-04-10
DE69719502T2 DE69719502T2 (de) 2004-02-19

Family

ID=7785142

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19605024A Withdrawn DE19605024A1 (de) 1996-01-31 1996-01-31 Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE69719502T Expired - Lifetime DE69719502T2 (de) 1996-01-31 1997-01-31 TAXAN-DERIVATE MIT EINER PXRIDYL-SUBSTITUIERTEN C-13 SEItENKETTE UND DEREN VERWENDUNG ALS ANTITUMOR-MITTEL

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19605024A Withdrawn DE19605024A1 (de) 1996-01-31 1996-01-31 Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung

Country Status (26)

Country Link
US (1) US6162920A (de)
EP (1) EP0896577B1 (de)
JP (1) JP2001505527A (de)
KR (1) KR19990082151A (de)
CN (1) CN1073108C (de)
AT (1) ATE233757T1 (de)
AU (1) AU714313B2 (de)
BR (1) BR9708295A (de)
CA (1) CA2244746A1 (de)
CZ (1) CZ292504B6 (de)
DE (2) DE19605024A1 (de)
DK (1) DK0896577T3 (de)
ES (1) ES2192261T3 (de)
HK (1) HK1018778A1 (de)
HU (1) HUP9901027A3 (de)
IL (1) IL124951A (de)
NO (1) NO983509L (de)
PL (1) PL186796B1 (de)
PT (1) PT896577E (de)
RU (1) RU2163599C2 (de)
SK (1) SK101198A3 (de)
TR (1) TR199801415T2 (de)
TW (1) TW444015B (de)
UA (1) UA49007C2 (de)
WO (1) WO1997028156A1 (de)
ZA (1) ZA97847B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2311591T3 (es) 2001-03-07 2009-02-16 Daiichi Sankyo Company, Limited Proceso para producir un derivado de 2-azetidinona.
EP1605866B1 (de) 2003-03-03 2016-07-06 Syntach AG Implantatvorrichtung für elektrischen leitungsblock
CN1296391C (zh) * 2004-03-04 2007-01-24 中国人民解放军第二军医大学 氟代羧烷基环糊精醚类化合物及其制备方法和应用
US8658203B2 (en) 2004-05-03 2014-02-25 Merrimack Pharmaceuticals, Inc. Liposomes useful for drug delivery to the brain
CA2821167C (en) 2004-05-03 2016-06-28 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
TWI724018B (zh) 2015-08-20 2021-04-11 英商益普生生物製藥有限公司 用於癌症治療之組合療法
EP3337478B1 (de) 2015-08-21 2020-08-12 Ipsen Biopharm Ltd. Arzneimittelkombination enthaltend liposomales irinotecan, oxaliplatin, 5-fluorouracil und leucovorin zur behandlung von metastasierendem pankreaskrebs
SG10201912568PA (en) 2015-10-16 2020-02-27 Ipsen Biopharm Ltd Stabilizing camptothecin pharmaceutical compositions
MX2019004783A (es) 2016-11-02 2019-08-12 Ipsen Biopharm Ltd Tratamiento de cancer gastrico usando terapias de combinacion que comprenden irinotecan liposomico oxaliplatino, 5-fluoruracilo (y leucovorina).

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227400A (en) * 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
IL109049A (en) * 1993-03-22 2006-12-31 Univ Florida State Texans have a side chain that is converted into pyridyl and pharmaceutical preparations that contain them
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
FR2715307B1 (fr) * 1994-01-25 1996-04-05 Commissariat Energie Atomique Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation.
ES2123996T3 (es) * 1994-06-28 1999-01-16 Upjohn Co Analogos de 7-etertaxol, uso antineoplasico y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
DE19605024A1 (de) 1997-08-07
HK1018778A1 (en) 2000-01-07
HUP9901027A2 (hu) 2001-05-28
PL328055A1 (en) 1999-01-04
NO983509D0 (no) 1998-07-30
AU714313B2 (en) 1999-12-23
PL186796B1 (pl) 2004-02-27
HUP9901027A3 (en) 2001-08-28
US6162920A (en) 2000-12-19
IL124951A (en) 2003-12-10
ATE233757T1 (de) 2003-03-15
CN1210535A (zh) 1999-03-10
SK101198A3 (en) 1998-12-02
NO983509L (no) 1998-07-30
TW444015B (en) 2001-07-01
ES2192261T3 (es) 2003-10-01
EP0896577A1 (de) 1999-02-17
DE69719502T2 (de) 2004-02-19
RU2163599C2 (ru) 2001-02-27
ZA97847B (en) 1997-08-04
CZ292504B6 (cs) 2003-10-15
DK0896577T3 (da) 2003-05-19
JP2001505527A (ja) 2001-04-24
TR199801415T2 (xx) 1998-10-21
AU1598497A (en) 1997-08-22
WO1997028156A1 (en) 1997-08-07
KR19990082151A (ko) 1999-11-15
UA49007C2 (uk) 2002-09-16
CA2244746A1 (en) 1997-08-07
EP0896577B1 (de) 2003-03-05
PT896577E (pt) 2003-06-30
CN1073108C (zh) 2001-10-17
IL124951A0 (en) 1999-01-26
CZ242698A3 (cs) 1999-07-14
BR9708295A (pt) 1999-08-03

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8364 No opposition during term of opposition
8330 Complete renunciation