ATE267804T1 - Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen - Google Patents

Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen

Info

Publication number
ATE267804T1
ATE267804T1 AT99935342T AT99935342T ATE267804T1 AT E267804 T1 ATE267804 T1 AT E267804T1 AT 99935342 T AT99935342 T AT 99935342T AT 99935342 T AT99935342 T AT 99935342T AT E267804 T1 ATE267804 T1 AT E267804T1
Authority
AT
Austria
Prior art keywords
hydroxyphenyl
inflammation
alpha
nitrones
treatment
Prior art date
Application number
AT99935342T
Other languages
English (en)
Inventor
L David Waterbury
John M Carney
Allan L Wilcox
Original Assignee
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Application granted granted Critical
Publication of ATE267804T1 publication Critical patent/ATE267804T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99935342T 1998-07-17 1999-07-16 Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen ATE267804T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9323798P 1998-07-17 1998-07-17
PCT/US1999/014150 WO2000003977A1 (en) 1998-07-17 1999-07-16 Alpha-(2-hydroxyphenyl) nitrone compounds, pharmaceutical compositions containing the same and their use for treating inflammation

Publications (1)

Publication Number Publication Date
ATE267804T1 true ATE267804T1 (de) 2004-06-15

Family

ID=22237881

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935342T ATE267804T1 (de) 1998-07-17 1999-07-16 Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen

Country Status (9)

Country Link
US (1) US6197826B1 (de)
EP (1) EP1098873B1 (de)
JP (1) JP2002520386A (de)
AT (1) ATE267804T1 (de)
AU (1) AU750599B2 (de)
CA (1) CA2337850A1 (de)
DE (1) DE69917643T2 (de)
NZ (1) NZ509530A (de)
WO (1) WO2000003977A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
US7115666B2 (en) * 2002-10-15 2006-10-03 Renovis, Inc. Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20050215646A1 (en) * 2004-03-09 2005-09-29 Renovis, Inc. Methods for treating multiple sclerosis and pharmaceutical compositions therefor
US20060138083A1 (en) * 2004-10-26 2006-06-29 Declan Ryan Patterning and alteration of molecules

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917700A (en) 1974-01-30 1975-11-04 Goodyear Tire & Rubber Nitrone compounds
US4128664A (en) 1977-05-16 1978-12-05 Riker Laboratories, Inc. Substituted benzamides as anti-inflammatory agents
US4153722A (en) 1977-10-06 1979-05-08 William H. Rorer, Inc. Method of treatment
GB2137619A (en) 1983-03-30 1984-10-10 Gerald Scott Nitrone compounds and stabilised rubber compositions containing them
EP0496796B1 (de) 1989-10-17 1994-08-31 Oklahoma Medical Research Foundation Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten
EP0590072B1 (de) 1991-06-18 2001-12-05 Oklahoma Medical Research Foundation Radikalfänger ("spin traps") zur behandlung von mit oxidation von lipiden und proteinen verbundenen erkrankungen
US5292746A (en) 1991-09-12 1994-03-08 Merrell Dow Pharmaceuticals Inc. Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5288896A (en) 1992-01-15 1994-02-22 Warner-Lambert Company 3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their derivatives, pharmaceutical compositions, and methods of use therefor
US5455272A (en) 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
US5972977A (en) 1996-04-23 1999-10-26 Centaur Pharmaceuticals, Inc. Ophthalmic pharmaceutical compositions comprising a nitrone compound and methods for treating ocular inflammation using such compositions
EP1021430A1 (de) 1996-07-19 2000-07-26 Centaur Pharmaceuticals, Inc. Furan-nitronverbindungen
US5994396A (en) 1997-08-18 1999-11-30 Centaur Pharmaceuticals, Inc. Furansulfonic acid derivatives and pharmaceutical compositions containing the same
MA26553A1 (fr) 1997-10-17 2004-12-20 Centaur Pharmaceuticals Inc Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la
JP2002509147A (ja) 1998-01-16 2002-03-26 センター ファーマシューティカルズ， インコーポレイテッド チオフェンニトロン化合物
NZ505757A (en) 1998-01-16 2002-09-27 Centaur Pharmaceuticals Inc Thioether furan nitrone compounds and pharmaceuticals thereof; useful for the treatment or prophylaxis of neurodegenerative, autoimmune and inflammatory conditions

Also Published As

Publication number Publication date
EP1098873B1 (de) 2004-05-26
CA2337850A1 (en) 2000-01-27
AU750599B2 (en) 2002-07-25
EP1098873A1 (de) 2001-05-16
WO2000003977A1 (en) 2000-01-27
DE69917643D1 (de) 2004-07-01
US6197826B1 (en) 2001-03-06
DE69917643T2 (de) 2004-10-07
JP2002520386A (ja) 2002-07-09
AU5083899A (en) 2000-02-07
NZ509530A (en) 2003-09-26

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties