IL124951A - Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the same - Google Patents
Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- IL124951A IL124951A IL12495197A IL12495197A IL124951A IL 124951 A IL124951 A IL 124951A IL 12495197 A IL12495197 A IL 12495197A IL 12495197 A IL12495197 A IL 12495197A IL 124951 A IL124951 A IL 124951A
- Authority
- IL
- Israel
- Prior art keywords
- microtubules
- pct
- taxol
- depolymerisation
- mitosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605024A DE19605024A1 (de) | 1996-01-31 | 1996-01-31 | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| PCT/EP1997/000440 WO1997028156A1 (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, their preparation and their use as anti-tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124951A0 IL124951A0 (en) | 1999-01-26 |
| IL124951A true IL124951A (en) | 2003-12-10 |
Family
ID=7785142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12495197A IL124951A (en) | 1996-01-31 | 1997-01-31 | Taxane derivatives having a pyridyl substituted c13 side chain, a process for their preparation and pharmaceutical compositions containing the same |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6162920A (de) |
| EP (1) | EP0896577B1 (de) |
| JP (1) | JP2001505527A (de) |
| KR (1) | KR19990082151A (de) |
| CN (1) | CN1073108C (de) |
| AT (1) | ATE233757T1 (de) |
| AU (1) | AU714313B2 (de) |
| BR (1) | BR9708295A (de) |
| CA (1) | CA2244746A1 (de) |
| CZ (1) | CZ292504B6 (de) |
| DE (2) | DE19605024A1 (de) |
| DK (1) | DK0896577T3 (de) |
| ES (1) | ES2192261T3 (de) |
| HK (1) | HK1018778A1 (de) |
| HU (1) | HUP9901027A3 (de) |
| IL (1) | IL124951A (de) |
| NO (1) | NO983509L (de) |
| PL (1) | PL186796B1 (de) |
| PT (1) | PT896577E (de) |
| RU (1) | RU2163599C2 (de) |
| SK (1) | SK101198A3 (de) |
| TR (1) | TR199801415T2 (de) |
| TW (1) | TW444015B (de) |
| UA (1) | UA49007C2 (de) |
| WO (1) | WO1997028156A1 (de) |
| ZA (1) | ZA97847B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2311591T3 (es) | 2001-03-07 | 2009-02-16 | Daiichi Sankyo Company, Limited | Proceso para producir un derivado de 2-azetidinona. |
| EP1605866B1 (de) | 2003-03-03 | 2016-07-06 | Syntach AG | Implantatvorrichtung für elektrischen leitungsblock |
| CN1296391C (zh) * | 2004-03-04 | 2007-01-24 | 中国人民解放军第二军医大学 | 氟代羧烷基环糊精醚类化合物及其制备方法和应用 |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| CA2821167C (en) | 2004-05-03 | 2016-06-28 | Merrimack Pharmaceuticals, Inc. | Drug delivery liposomes containing anionic polyols or anionic sugars |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| TWI724018B (zh) | 2015-08-20 | 2021-04-11 | 英商益普生生物製藥有限公司 | 用於癌症治療之組合療法 |
| EP3337478B1 (de) | 2015-08-21 | 2020-08-12 | Ipsen Biopharm Ltd. | Arzneimittelkombination enthaltend liposomales irinotecan, oxaliplatin, 5-fluorouracil und leucovorin zur behandlung von metastasierendem pankreaskrebs |
| SG10201912568PA (en) | 2015-10-16 | 2020-02-27 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| MX2019004783A (es) | 2016-11-02 | 2019-08-12 | Ipsen Biopharm Ltd | Tratamiento de cancer gastrico usando terapias de combinacion que comprenden irinotecan liposomico oxaliplatino, 5-fluoruracilo (y leucovorina). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| IL109049A (en) * | 1993-03-22 | 2006-12-31 | Univ Florida State | Texans have a side chain that is converted into pyridyl and pharmaceutical preparations that contain them |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| FR2715307B1 (fr) * | 1994-01-25 | 1996-04-05 | Commissariat Energie Atomique | Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation. |
| ES2123996T3 (es) * | 1994-06-28 | 1999-01-16 | Upjohn Co | Analogos de 7-etertaxol, uso antineoplasico y composiciones farmaceuticas que los contienen. |
-
1996
- 1996-01-31 DE DE19605024A patent/DE19605024A1/de not_active Withdrawn
-
1997
- 1997-01-31 PL PL97328055A patent/PL186796B1/pl not_active IP Right Cessation
- 1997-01-31 RU RU98116122/04A patent/RU2163599C2/ru not_active IP Right Cessation
- 1997-01-31 DK DK97902286T patent/DK0896577T3/da active
- 1997-01-31 JP JP52730897A patent/JP2001505527A/ja active Pending
- 1997-01-31 HU HU9901027A patent/HUP9901027A3/hu unknown
- 1997-01-31 CA CA002244746A patent/CA2244746A1/en not_active Abandoned
- 1997-01-31 EP EP97902286A patent/EP0896577B1/de not_active Expired - Lifetime
- 1997-01-31 SK SK1011-98A patent/SK101198A3/sk unknown
- 1997-01-31 WO PCT/EP1997/000440 patent/WO1997028156A1/en not_active Application Discontinuation
- 1997-01-31 AU AU15984/97A patent/AU714313B2/en not_active Ceased
- 1997-01-31 CN CN97192006A patent/CN1073108C/zh not_active Expired - Fee Related
- 1997-01-31 CZ CZ19982426A patent/CZ292504B6/cs not_active IP Right Cessation
- 1997-01-31 US US09/117,506 patent/US6162920A/en not_active Expired - Fee Related
- 1997-01-31 ZA ZA9700847A patent/ZA97847B/xx unknown
- 1997-01-31 DE DE69719502T patent/DE69719502T2/de not_active Expired - Lifetime
- 1997-01-31 TW TW086101169A patent/TW444015B/zh active
- 1997-01-31 UA UA98084638A patent/UA49007C2/uk unknown
- 1997-01-31 KR KR1019980705874A patent/KR19990082151A/ko not_active Application Discontinuation
- 1997-01-31 BR BR9708295A patent/BR9708295A/pt not_active Application Discontinuation
- 1997-01-31 AT AT97902286T patent/ATE233757T1/de not_active IP Right Cessation
- 1997-01-31 TR TR1998/01415T patent/TR199801415T2/xx unknown
- 1997-01-31 PT PT97902286T patent/PT896577E/pt unknown
- 1997-01-31 IL IL12495197A patent/IL124951A/xx not_active IP Right Cessation
- 1997-01-31 ES ES97902286T patent/ES2192261T3/es not_active Expired - Lifetime
-
1998
- 1998-07-30 NO NO983509A patent/NO983509L/no unknown
-
1999
- 1999-09-02 HK HK99103795A patent/HK1018778A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |