ES2192261T3 - Derivados de taxanos que poseen una cadena lateral de c13 sustituida con piridilo y su utilizacion como agentes anti tumores. - Google Patents
Derivados de taxanos que poseen una cadena lateral de c13 sustituida con piridilo y su utilizacion como agentes anti tumores.Info
- Publication number
- ES2192261T3 ES2192261T3 ES97902286T ES97902286T ES2192261T3 ES 2192261 T3 ES2192261 T3 ES 2192261T3 ES 97902286 T ES97902286 T ES 97902286T ES 97902286 T ES97902286 T ES 97902286T ES 2192261 T3 ES2192261 T3 ES 2192261T3
- Authority
- ES
- Spain
- Prior art keywords
- replaced
- taxanos
- piridilo
- tumors
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- -1 HYDROXYL GROUPS Chemical group 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 108090000704 Tubulin Proteins 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
SE DESCRIBEN TAXANOS CON LA FORMULA GENERAL (I), EN DONDE SK PODRIA SER (I),R 1 PODRIA SER HIDROGENO O C 1 - C10 ACILO. R 2 PODRIA SER AL - OH O BE - OH, R S UP,3 PODRIA SER C 1 - C 10 ALQUILO, X - FENIL SUSTITUIDO, C 1 - C 10 ALCOXI, X PODRIA SER HIDROGENO, HA LOGENO, - N 3 O - CN , Y GRUPOS DE HIDROXILO LIBRES EN (I) PODRA SER FUNCIONALMENTE MODIFICADAS DESPUES POR ETERIFICACION O ESTERIFICACION, Y TAMBIEN LOS CLATRATOS AL - , BE Y GA-CICLODEXTRINA DE LOS MISMOS, Y TAMBIEN COMPUESTOS DE LA FORMULA GENERAL (I) ENCAPSULADOS CON LIPOSOMAS. LOS COMPUESTOS DE LA FORMULA (I) SEGUN LA INVENCION, COMPARANDOSE CON EL TAXOL, TIENEN UN PERFIL DE ACTIVIDAD VENTAJOSAMENTE MODIFICADO. ADEMAS DE UNA ESTABILIZACION MEJORADA DE MICROTUBULOS, LOS COMPUESTOS DE LA FORMULA (I) DEMUESTRA UNA INFLUENCIA ADICIONAL SOBRE LA POLIMERIZACION DE LA TUBULINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605024A DE19605024A1 (de) | 1996-01-31 | 1996-01-31 | Neue selektive Taxane, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2192261T3 true ES2192261T3 (es) | 2003-10-01 |
Family
ID=7785142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97902286T Expired - Lifetime ES2192261T3 (es) | 1996-01-31 | 1997-01-31 | Derivados de taxanos que poseen una cadena lateral de c13 sustituida con piridilo y su utilizacion como agentes anti tumores. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6162920A (es) |
| EP (1) | EP0896577B1 (es) |
| JP (1) | JP2001505527A (es) |
| KR (1) | KR19990082151A (es) |
| CN (1) | CN1073108C (es) |
| AT (1) | ATE233757T1 (es) |
| AU (1) | AU714313B2 (es) |
| BR (1) | BR9708295A (es) |
| CA (1) | CA2244746A1 (es) |
| CZ (1) | CZ292504B6 (es) |
| DE (2) | DE19605024A1 (es) |
| DK (1) | DK0896577T3 (es) |
| ES (1) | ES2192261T3 (es) |
| HK (1) | HK1018778A1 (es) |
| HU (1) | HUP9901027A3 (es) |
| IL (1) | IL124951A (es) |
| NO (1) | NO983509L (es) |
| PL (1) | PL186796B1 (es) |
| PT (1) | PT896577E (es) |
| RU (1) | RU2163599C2 (es) |
| SK (1) | SK101198A3 (es) |
| TR (1) | TR199801415T2 (es) |
| TW (1) | TW444015B (es) |
| UA (1) | UA49007C2 (es) |
| WO (1) | WO1997028156A1 (es) |
| ZA (1) | ZA97847B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50212728D1 (de) | 2001-03-07 | 2008-10-16 | Daiichi Sankyo Co Ltd | Verfahren zur herstellung von 2-azetidinonderivaten |
| US20040220655A1 (en) | 2003-03-03 | 2004-11-04 | Sinus Rhythm Technologies, Inc. | Electrical conduction block implant device |
| CN1296391C (zh) * | 2004-03-04 | 2007-01-24 | 中国人民解放军第二军医大学 | 氟代羧烷基环糊精醚类化合物及其制备方法和应用 |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| WO2005107712A1 (en) | 2004-05-03 | 2005-11-17 | Hermes Biosciences, Inc. | Liposomes useful for drug delivery |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| JP7042739B2 (ja) | 2015-08-20 | 2022-03-28 | イプセン バイオファーム リミティド | 癌処置のためのリポソーム型イリノテカン及びｐａｒｐ阻害薬を使用する併用療法 |
| TW202243677A (zh) | 2015-08-21 | 2022-11-16 | 英商益普生生物製藥有限公司 | 使用包含微脂伊立替康(irinotecan)及奧沙利鉑(oxaliplatin)之組合療法治療轉移性胰臟癌的方法 |
| MA42991A (fr) | 2015-10-16 | 2018-08-22 | Ipsen Biopharm Ltd | Stabilisation de compositions pharmaceutiques de camptothécine |
| MX2019004783A (es) | 2016-11-02 | 2019-08-12 | Ipsen Biopharm Ltd | Tratamiento de cancer gastrico usando terapias de combinacion que comprenden irinotecan liposomico oxaliplatino, 5-fluoruracilo (y leucovorina). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| JPH08508471A (ja) * | 1993-03-22 | 1996-09-10 | フロリダ・ステート・ユニバーシティー | ピリジル置換側鎖を有するタキサン |
| US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| FR2715307B1 (fr) * | 1994-01-25 | 1996-04-05 | Commissariat Energie Atomique | Procédé de solubilisation dans un milieu aqueux d'agents antitumoraux de la famille du taxol, et cyclodextrines ramifiées utilisables pour cette solubilisation. |
| NZ288802A (en) * | 1994-06-28 | 1998-05-27 | Upjohn Co | Ether taxol derivatives, preparation and pharmaceutical compositions thereof |
-
1996
- 1996-01-31 DE DE19605024A patent/DE19605024A1/de not_active Withdrawn
-
1997
- 1997-01-31 BR BR9708295A patent/BR9708295A/pt not_active Application Discontinuation
- 1997-01-31 PT PT97902286T patent/PT896577E/pt unknown
- 1997-01-31 DK DK97902286T patent/DK0896577T3/da active
- 1997-01-31 AT AT97902286T patent/ATE233757T1/de not_active IP Right Cessation
- 1997-01-31 HU HU9901027A patent/HUP9901027A3/hu unknown
- 1997-01-31 TW TW086101169A patent/TW444015B/zh active
- 1997-01-31 KR KR1019980705874A patent/KR19990082151A/ko not_active Application Discontinuation
- 1997-01-31 ES ES97902286T patent/ES2192261T3/es not_active Expired - Lifetime
- 1997-01-31 SK SK1011-98A patent/SK101198A3/sk unknown
- 1997-01-31 IL IL12495197A patent/IL124951A/xx not_active IP Right Cessation
- 1997-01-31 PL PL97328055A patent/PL186796B1/pl not_active IP Right Cessation
- 1997-01-31 JP JP52730897A patent/JP2001505527A/ja active Pending
- 1997-01-31 CA CA002244746A patent/CA2244746A1/en not_active Abandoned
- 1997-01-31 EP EP97902286A patent/EP0896577B1/en not_active Expired - Lifetime
- 1997-01-31 UA UA98084638A patent/UA49007C2/uk unknown
- 1997-01-31 RU RU98116122/04A patent/RU2163599C2/ru not_active IP Right Cessation
- 1997-01-31 AU AU15984/97A patent/AU714313B2/en not_active Ceased
- 1997-01-31 ZA ZA9700847A patent/ZA97847B/xx unknown
- 1997-01-31 CN CN97192006A patent/CN1073108C/zh not_active Expired - Fee Related
- 1997-01-31 TR TR1998/01415T patent/TR199801415T2/xx unknown
- 1997-01-31 WO PCT/EP1997/000440 patent/WO1997028156A1/en not_active Application Discontinuation
- 1997-01-31 CZ CZ19982426A patent/CZ292504B6/cs not_active IP Right Cessation
- 1997-01-31 US US09/117,506 patent/US6162920A/en not_active Expired - Fee Related
- 1997-01-31 DE DE69719502T patent/DE69719502T2/de not_active Expired - Lifetime
-
1998
- 1998-07-30 NO NO983509A patent/NO983509L/no unknown
-
1999
- 1999-09-02 HK HK99103795A patent/HK1018778A1/xx not_active IP Right Cessation
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