KR950703945A - 탁산 유도체를 함유하는 항종양 조성물(antitumour compositions containing taxane derivatives) - Google Patents

탁산 유도체를 함유하는 항종양 조성물(antitumour compositions containing taxane derivatives)

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KR950703945A
KR950703945A KR1019950701848A KR19950701848A KR950703945A KR 950703945 A KR950703945 A KR 950703945A KR 1019950701848 A KR1019950701848 A KR 1019950701848A KR 19950701848 A KR19950701848 A KR 19950701848A KR 950703945 A KR950703945 A KR 950703945A
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combination
combination according
derivatives
taxotere
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크리스틴 비세리 마리
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자끄 필라드
로오느-푸우랜크 로레르 소시에테 아노님
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C12Y305/01001—Asparaginase (3.5.1.1)

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Abstract

신생 질병의 치료에 치료적으로 유용한 하나 이상의 물질과 조합된 탁솔 또는 탁소테르 또는 이의 유사체로 구성된 항 종양 조합물.

Description

탁산 유도체를 함유하는 항종양 조성물(ANTITUMOUR COMPOSITIONS CONTAINING TAXANE DERIVATIVES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 치료적으로 신생 질병의 치료에 유용한 하나 이상의 물질과 탁솔, 탁소테르 및 상기 유도체의 조합물.
  2. 알킬화제, 대사길항질, 스핀들 독, 에피도필로톡신, 항생물질, 효소, 토포이소머라제 저해제, 프로카르 바진, 미톡산트론 또는 백금 배위 복합체로부터 선택되는 다양한 화합물, 생물학적 반응 변형제 또는 성장 인자 저해제와 탁소테르의 조합물.
  3. 제2항에 있어서, 알킬화제를 시클로포스파미드, 이포스파미드, 멜팔란, 헥사메틸멜라민, 티오테파 또는 디카르바진으로부터 선택하는 것을 륵징으로 하는 조합물.
  4. 제2항에 있어서, 대가 길항질을 5-플루오로우라실, 시타라반, 및 메토트렉세이트, 이다트렉세이트 및 트리메트렉세이트로부터 선택되는 폴산 유사체로부터 선택하는 것을 특징으로 하는 조합물.
  5. 제2항에 있어서, 스핀들 독을 빈카 알칼로이드, 상기의 합성 또는 반-합성 유사체, 또는 에스트라머스틴 또는 탁소이드로부터 선택하는 것을 특징으로 하는 조합물.
  6. 제2항에 있어서, 에피도필로톡신을 에토포시드 및 테니포시드로부터 선택하는 것을 특징으로 하는 조합물.
  7. 제2항에 있어서, 항생물질을 다우노루비신, 독소루비신, 블레오마이신 및 미토마이신으로부터 선택하는 것을 특징으로 하는 조합물.
  8. 제2항에 있어서, 효소가 L-아스파라기나제인 것을 특징으로 하는 조합물.
  9. 제2항에 있어서, 토포이소머라제 저해제를 캄프토테신, 및 CPT-11및 토포테칸으로부터 선택되는 상기 유도체 및 피리도벤조인돌 유도체로부터 선택하는 것을 특징으로 하는 조합물.
  10. 제2항에 있어서, 다양한 화합물을 프로카르바진, 미톡산트론 및 시스플라틴 및 카르보플라틴으로부터 선택된 백금 배위 복합체로부터 선택하는 것을 특징으로 하는 조합물.
  11. 제2항에 있어서, 생물학적 반응 조절제 및 성장 인자 저해제를 인터페론 및 인터루킨으로부터 선택하는 것을 특징으로 하는 조합물.
  12. 제1내지 11항 중 한 항에 있어서, 상기가 부가로 조혈형의 성장인자를 함유하는 것을 특징으로 하는 조합물.
  13. 제1내지 12항 중 한 항에 있어서, 상기가 10-90 중량%의 탁솔, 탁소테르 또는 이의 유사체를 함유하는 것을 특징으로 하는 조합물.
  14. 항암 치료로 동시에, 따로따로 또는 일정 시간의 간격을 두고 사용하기 위한 조합된 제조물로서, 탁소테르 또는 상기 유사체 및 제1내지 12항 중 한 항에 정의된 바와 같은, 신생 질병의 치료에 치료적으로 유용한 하나 이상의 물질을 함유하는 생성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950701848A 1992-11-10 1993-11-08 탁산유도체를함유하는항종양조성물 KR100334051B1 (ko)

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Application Number Priority Date Filing Date Title
FR92/13525 1992-11-10
FR92/138525 1992-11-10
FR9213525A FR2697752B1 (fr) 1992-11-10 1992-11-10 Compositions antitumorales contenant des dérivés du taxane.
PCT/FR1993/001096 WO1994010995A1 (fr) 1992-11-10 1993-11-08 Compositions antitumorales contenant des derives du taxane

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KR100334051B1 KR100334051B1 (ko) 2002-09-04

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KR1019950701848A KR100334051B1 (ko) 1992-11-10 1993-11-08 탁산유도체를함유하는항종양조성물

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