HK1018688A1 - Use of rapamycin derivatives in vasculopqthies and xenotransplantation - Google Patents

Use of rapamycin derivatives in vasculopqthies and xenotransplantation

Info

Publication number
HK1018688A1
HK1018688A1 HK99103744A HK99103744A HK1018688A1 HK 1018688 A1 HK1018688 A1 HK 1018688A1 HK 99103744 A HK99103744 A HK 99103744A HK 99103744 A HK99103744 A HK 99103744A HK 1018688 A1 HK1018688 A1 HK 1018688A1
Authority
HK
Hong Kong
Prior art keywords
vasculopqthies
xenotransplantation
rapamycin derivatives
rapamycin
deoxyspergualine
Prior art date
Application number
HK99103744A
Other languages
English (en)
Inventor
Walter Schuler
Hendrik Schuurman
Gisbert Weckbecker
Hans-Guenther Zerwes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10791127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1018688(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1018688A1 publication Critical patent/HK1018688A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
HK99103744A 1996-03-27 1999-08-31 Use of rapamycin derivatives in vasculopqthies and xenotransplantation HK1018688A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606452.2A GB9606452D0 (en) 1996-03-27 1996-03-27 Organic compounds
PCT/EP1997/001548 WO1997035575A1 (en) 1996-03-27 1997-03-26 Use of rapamycin derivatives in vasculopathies and xenotransplantation

Publications (1)

Publication Number Publication Date
HK1018688A1 true HK1018688A1 (en) 1999-12-30

Family

ID=10791127

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99103744A HK1018688A1 (en) 1996-03-27 1999-08-31 Use of rapamycin derivatives in vasculopqthies and xenotransplantation

Country Status (30)

Country Link
US (5) US6384046B1 (es)
EP (3) EP1149581A3 (es)
JP (2) JP2000507226A (es)
KR (2) KR20070083654A (es)
CN (1) CN1124135C (es)
AT (1) ATE224194T1 (es)
AU (1) AU716514B2 (es)
BR (1) BR9708358A (es)
CA (1) CA2247275C (es)
CY (1) CY2404B1 (es)
CZ (1) CZ292483B6 (es)
DE (1) DE69715611T2 (es)
DK (2) DK0893996T3 (es)
ES (2) ES2184078T3 (es)
GB (1) GB9606452D0 (es)
HK (1) HK1018688A1 (es)
HU (1) HU226422B1 (es)
ID (1) ID17195A (es)
IL (1) IL125812A (es)
MY (1) MY117798A (es)
NO (1) NO316667B1 (es)
NZ (1) NZ331463A (es)
PL (1) PL187732B1 (es)
PT (2) PT893996E (es)
RU (1) RU2214247C2 (es)
SI (1) SI2008657T1 (es)
SK (1) SK284343B6 (es)
TR (1) TR199801919T2 (es)
WO (1) WO1997035575A1 (es)
ZA (1) ZA972719B (es)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
JP3942641B2 (ja) 1996-07-30 2007-07-11 ノバルティス アクチエンゲゼルシャフト サイクロスポリンａおよび４０―ｏ―（２―ヒドロキシエチル）―ラパマイシンを含む移植拒絶、自己免疫疾患または炎症性状態の処置用医薬組成物
US6890546B2 (en) 1998-09-24 2005-05-10 Abbott Laboratories Medical devices containing rapamycin analogs
EP1181034B1 (en) 1999-05-10 2010-07-21 Paolo Brenner Combinations of immunosuppressive agents for the treatment or prevention of graft rejections
US20070032853A1 (en) † 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US20070055367A1 (en) * 2000-03-15 2007-03-08 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
ATE362382T1 (de) 2000-03-15 2007-06-15 Orbusneich Medical Inc Beschichtung welche ein anhaften von endothelzellen stimuliert
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US8460367B2 (en) * 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
US20020013335A1 (en) * 2000-06-16 2002-01-31 American Home Products Corporation Method of treating cardiovascular disease
EP1709974A3 (en) * 2000-06-16 2006-12-06 Wyeth Method of treating cardiovascular disease using rapamycin
CA2424029C (en) 2000-09-29 2008-01-29 Cordis Corporation Coated medical devices
LT3143995T (lt) * 2001-02-19 2019-01-25 Novartis Ag Rapamicino darinys, skirtas plaučių vėžio gydymui
US8741378B1 (en) 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US7682387B2 (en) * 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20040024450A1 (en) * 2002-04-24 2004-02-05 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
KR20050010827A (ko) * 2002-05-20 2005-01-28 오르버스 메디칼 테크놀로지즈 인코포레이티드 약물 용리 이식성 의료 장치
US8109987B2 (en) 2003-04-14 2012-02-07 Tryton Medical, Inc. Method of treating a lumenal bifurcation
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
US7220755B2 (en) 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
WO2005107817A2 (en) * 2004-04-30 2005-11-17 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US8709469B2 (en) 2004-06-30 2014-04-29 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
WO2006069038A1 (en) * 2004-12-20 2006-06-29 Ariad Gene Therapeutics, Inc. Therapeutic materials and methods
CA2629714A1 (en) 2005-11-14 2007-05-24 Ariad Gene Therapeutics, Inc. Administration of an mtor inhibitor to treat patients with cancer
EP1948079A1 (en) * 2005-11-17 2008-07-30 Access Plus Co., Ltd. A tube for connecting marteriovenous and interposition for medical operation
US20070173923A1 (en) * 2006-01-20 2007-07-26 Savage Douglas R Drug reservoir stent
EP2702993B1 (en) 2006-09-13 2017-12-06 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US8067055B2 (en) * 2006-10-20 2011-11-29 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method of use
US20080097591A1 (en) 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US20080103584A1 (en) * 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
KR100930167B1 (ko) * 2007-09-19 2009-12-07 삼성전기주식회사 초광각 광학계
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
JP5693228B2 (ja) 2007-11-14 2015-04-01 バイオセンサーズ インターナショナル グループ、リミテッド 自動被覆装置および方法
US8921642B2 (en) * 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
CN102231969A (zh) * 2008-10-03 2011-11-02 万能医药公司 大环内酯化合物及其使用方法
US8366763B2 (en) 2009-07-02 2013-02-05 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
US8685433B2 (en) 2010-03-31 2014-04-01 Abbott Cardiovascular Systems Inc. Absorbable coating for implantable device
UA104738C2 (ru) 2011-05-18 2014-03-11 Олег Миколайович Лазаренко Композиция для повышения биосовместимости имплантатов и клеток для трансплантации с организмом реципиента и способ ее приготовления
CN102268015B (zh) * 2011-08-30 2013-08-28 成都摩尔生物医药有限公司 一种依维莫司的合成方法
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
KR101723265B1 (ko) 2013-08-16 2017-04-04 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
CN110101485B (zh) 2013-09-24 2021-07-06 吉纳生命科学公司 用于细胞植入物的气体处理的系统
WO2015054280A1 (en) 2013-10-08 2015-04-16 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
AU2015217349A1 (en) 2014-02-11 2016-09-08 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
US10307371B2 (en) 2014-02-11 2019-06-04 AI Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
CA2944075C (en) 2014-04-04 2022-06-28 Lam Therapeutics, Inc. An inhalable rapamycin formulation for treating age-related conditions
AU2015330905B2 (en) 2014-10-07 2021-02-25 AI Therapeutics, Inc. An inhalable rapamycin formulation for the treatment of pulmonary hypertension
MA40910A (fr) 2014-11-07 2017-09-12 Civitas Therapeutics Inc Poudres de rapamycine pour administration pulmonaire
WO2016130645A1 (en) 2015-02-10 2016-08-18 Lam Therapeutics, Inc. Rapamycin for the treatment of lymphangioleiomyomatosis
WO2018031789A1 (en) 2016-08-10 2018-02-15 The Board Of Regents Of The University Of Texas System Topical rapamycin therapy
CN109715224B (zh) 2016-09-19 2022-02-22 百多力股份公司 无聚合物的药物洗脱血管支架
MX2019005676A (es) 2016-11-15 2019-09-10 Giner Life Sciences Inc Dispositivo percutáneo de difusión de gases adecuado para su uso con un implante subcutáneo.
EP3558408B1 (en) 2016-12-22 2024-04-17 Biotronik AG Intratumoral drug delivery materials and methods for treating breast cancer
WO2018204867A1 (en) 2017-05-04 2018-11-08 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
AR112834A1 (es) 2017-09-26 2019-12-18 Novartis Ag Derivados de rapamicina
AU2020226527A1 (en) 2019-02-20 2021-10-14 AI Therapeutics, Inc. Topical rapamycin formulations and their use in treating facial angiofibromas and other skin disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
US5516781A (en) * 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
CA2086642C (en) * 1992-01-09 2004-06-15 Randall E. Morris Method of treating hyperproliferative vascular disease
AU670937B2 (en) * 1992-04-28 1996-08-08 Wyeth Method of treating hyperproliferative vascular disease
US5747034A (en) * 1992-07-09 1998-05-05 Chiron Corporation Methods and materials for the induction of T cell anergy
US5283257A (en) * 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds
SG64372A1 (en) * 1993-12-17 1999-04-27 Novartis Ag Rapamycin derivatives
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US6265427B1 (en) * 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
WO1996041807A1 (en) * 1995-06-09 1996-12-27 Novartis Ag Rapamycin derivatives
GB9606452D0 (en) * 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
ES2184078T3 (es) 2003-04-01
EP0893996B1 (en) 2002-09-18
PL187732B1 (pl) 2004-09-30
CA2247275A1 (en) 1997-10-02
US20120177690A1 (en) 2012-07-12
GB9606452D0 (en) 1996-06-05
SI2008657T1 (sl) 2013-07-31
WO1997035575A1 (en) 1997-10-02
NO316667B1 (no) 2004-03-29
NO984340L (no) 1998-09-18
SK284343B6 (sk) 2005-02-04
JP2000507226A (ja) 2000-06-13
IL125812A (en) 2001-12-23
DK2008657T3 (da) 2013-07-22
PL328659A1 (en) 1999-02-15
ZA972719B (en) 1998-09-28
IL125812A0 (en) 1999-04-11
EP2008657A2 (en) 2008-12-31
MY117798A (en) 2004-08-30
ATE224194T1 (de) 2002-10-15
US20020127248A1 (en) 2002-09-12
CY2404B1 (en) 2004-09-10
CZ307098A3 (cs) 1999-01-13
JP5124431B2 (ja) 2013-01-23
NO984340D0 (no) 1998-09-18
TR199801919T2 (xx) 1999-02-22
ID17195A (id) 1997-12-11
HUP0001267A3 (en) 2002-01-28
ES2421455T3 (es) 2013-09-02
BR9708358A (pt) 1999-08-03
DE69715611T2 (de) 2003-05-22
CZ292483B6 (cs) 2003-09-17
PT893996E (pt) 2002-12-31
US20140187574A1 (en) 2014-07-03
US20100152105A1 (en) 2010-06-17
KR20050038656A (ko) 2005-04-27
JP2009102349A (ja) 2009-05-14
NZ331463A (en) 2001-10-26
EP1149581A2 (en) 2001-10-31
CN1124135C (zh) 2003-10-15
RU2214247C2 (ru) 2003-10-20
DE69715611D1 (de) 2002-10-24
PT2008657E (pt) 2013-07-12
DK0893996T3 (da) 2002-12-09
US6384046B1 (en) 2002-05-07
AU2291897A (en) 1997-10-17
SK132798A3 (en) 1999-03-12
EP0893996A1 (en) 1999-02-03
EP1149581A3 (en) 2003-12-03
AU716514B2 (en) 2000-02-24
CN1214631A (zh) 1999-04-21
EP2008657A3 (en) 2009-02-04
HUP0001267A2 (hu) 2000-11-28
KR20070083654A (ko) 2007-08-24
HU226422B1 (en) 2008-12-29
EP2008657B1 (en) 2013-04-24
KR100836971B1 (ko) 2008-06-10
CA2247275C (en) 2011-10-11

Similar Documents

Publication Publication Date Title
HK1018688A1 (en) Use of rapamycin derivatives in vasculopqthies and xenotransplantation
EA200000848A1 (ru) Способ селективного снижения числа или активности макрофагов (варианты), способ лечения или профилактики заболевания субъекта (варианты), способ диагностики заболевания у субъекта
TW249198B (en) Stents for autologous tissue heart valve
IL140137A0 (en) Receptor bodies specifically binding tie-2 ligands
CY2332B1 (en) Use of rapamycin in the manufacture of a medicament for preventing and heating hyperproliferactive vascular diseases, eventually in combination with mycophenolic acid.
ES2184800T3 (es) Uso de agentes anti-vegf en el tratamiento de la endometriosis.
DE69112007D1 (de) Ferritischer, hitzebeständiger Gussstahl und Verfahren zu seiner Herstellung.
PT939809E (pt) Ligandos do receptor de tie-2 (ligando 3 de tie e ligando 4 de tie) e suas utilizacoes
DE69522564T2 (de) Alkalibeständiges proteinadsorbens
ZA951293B (en) 4-amino derivatives of 5-substituted mycophenolic acid
DE69014582D1 (de) Polyamid-Ester, Verfahren zu ihrer Herstellung und Zwischenverbindungen dafür.
RU2000124058A (ru) Способ лечения миопии
IT1241270B (it) Procedimento per realizzare vaschette di contenimento per cuscini, particolarmente cuscini di sedili per autoveicoli.
Chun et al. Acute Pandysautonomic Neuropathy 2 Cases
Pioli Reactivation failure in infants: A processing analysis.
White DNA testing exposes whale trade.
RU96118013A (ru) Способ реконструкции молочной железы
IT9053024U1 (it) Sedile per tazza di w. c. dotato di dispositivo di riscaldamento, di as pirazione e filtrazione
UA36539A (uk) Спосіб проведення тренувань, що засновані на переміщеннях пацієнта, та комплекс засобів для його здійснення

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20170325