HK1017033A1 - Azolyl piperazinyl phenyl oxazolidinone antimicrobials - Google Patents

Azolyl piperazinyl phenyl oxazolidinone antimicrobials

Info

Publication number
HK1017033A1
HK1017033A1 HK99102256A HK99102256A HK1017033A1 HK 1017033 A1 HK1017033 A1 HK 1017033A1 HK 99102256 A HK99102256 A HK 99102256A HK 99102256 A HK99102256 A HK 99102256A HK 1017033 A1 HK1017033 A1 HK 1017033A1
Authority
HK
Hong Kong
Prior art keywords
carbon
nitrogen
image
azolyl
piperazinyl phenyl
Prior art date
Application number
HK99102256A
Other languages
English (en)
Inventor
Robert C Gadwood
Michael R Barbachyn
Dana S Toops
Herman W Smith
Valerie A Vaillancourt
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of HK1017033A1 publication Critical patent/HK1017033A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK99102256A 1996-02-26 1999-05-24 Azolyl piperazinyl phenyl oxazolidinone antimicrobials HK1017033A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1231696P 1996-02-26 1996-02-26
PCT/US1997/001970 WO1997030981A1 (en) 1996-02-26 1997-02-18 Azolyl piperazinyl phenyl oxazolidinone antimicrobials

Publications (1)

Publication Number Publication Date
HK1017033A1 true HK1017033A1 (en) 1999-11-12

Family

ID=21754387

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99102256A HK1017033A1 (en) 1996-02-26 1999-05-24 Azolyl piperazinyl phenyl oxazolidinone antimicrobials

Country Status (19)

Country Link
US (1) US5736545A (pt)
EP (1) EP0883611B1 (pt)
JP (1) JP2000505084A (pt)
KR (1) KR19990087238A (pt)
CN (1) CN1082952C (pt)
AT (1) ATE221521T1 (pt)
AU (1) AU703831B2 (pt)
DE (1) DE69714418T2 (pt)
DK (1) DK0883611T3 (pt)
ES (1) ES2180945T3 (pt)
HK (1) HK1017033A1 (pt)
ID (1) ID18467A (pt)
MY (1) MY116093A (pt)
NZ (1) NZ331011A (pt)
PE (1) PE55898A1 (pt)
PT (1) PT883611E (pt)
TW (1) TW442460B (pt)
WO (1) WO1997030981A1 (pt)
ZA (1) ZA971287B (pt)

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GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
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AU729745B2 (en) * 1997-07-11 2001-02-08 Pharmacia & Upjohn Company Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
BR9907183A (pt) * 1998-01-23 2003-06-10 Versicor Inc Colet neas combinatórias de oxazolidinona, composições e processos de preparação
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CA2333332A1 (en) 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
US6689372B1 (en) * 1998-08-04 2004-02-10 Ciba Specialty Chemicals Corporation Microbicidal active substances
JP2002535680A (ja) 1999-01-27 2002-10-22 ファルマシア・アンド・アップジョン・カンパニー 延長因子ｐ活性モジュレーターのアッセイ方法
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
PE20010851A1 (es) * 1999-12-14 2001-08-17 Upjohn Co Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2002006278A1 (en) * 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
ATE304536T1 (de) * 2001-04-17 2005-09-15 Merck & Co Inc Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate
EP1409464A4 (en) * 2001-07-16 2005-11-02 Ranbaxy Lab Ltd OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS
CN1662240A (zh) * 2002-05-15 2005-08-31 兰贝克赛实验室有限公司 苯基噁唑烷酮衍生物
EP1542696A4 (en) * 2002-07-29 2006-08-02 Ranbaxy Lab Ltd OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIAL AGENTS
US7094900B2 (en) 2002-08-12 2006-08-22 Pharmacia & Upjohn Company Llc N-Aryl-2-oxazolidinones and their derivatives
AU2002339721A1 (en) * 2002-09-20 2004-04-08 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
DE60309504T2 (de) 2002-11-21 2007-05-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5-carbosäureamid-derivate und verwandte verbindungen als antibakterielle mittel
AU2004256084B2 (en) * 2003-07-02 2007-10-18 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
BRPI0411688A (pt) * 2003-07-02 2006-12-26 Merck & Co Inc antibióticos de oxazolidinona substituìda de grupo de ciclopropil e seus derivados
WO2005005422A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
WO2005051933A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
WO2005082899A1 (en) * 2004-01-28 2005-09-09 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
BRPI0510394A (pt) * 2004-05-24 2007-11-13 Amgen Inc inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
WO2006035283A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006043121A1 (en) * 2004-10-20 2006-04-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006051408A1 (en) * 2004-11-11 2006-05-18 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
CN100406455C (zh) * 2006-02-20 2008-07-30 中国科学院上海药物研究所 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途
JO2642B1 (en) * 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
KR20100016498A (ko) * 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 피리딘 유도체
JP5431306B2 (ja) * 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのチア（ジア）ゾール
PT2148873E (pt) * 2007-04-23 2012-11-20 Janssen Pharmaceutica Nv Derivados da 4-alcoxipiridazina antagonistas de dissociação rápida do recetor da dopamina 2
CA2712613C (en) * 2008-03-26 2017-02-28 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
RU2502734C2 (ru) * 2008-07-03 2013-12-27 Янссен Фармацевтика Нв Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора
HUE033768T2 (en) * 2008-07-31 2017-12-28 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted pyridines as rapidly dissociating dopamine-2 receptor antagonists
WO2011152442A1 (ja) * 2010-06-03 2011-12-08 塩野義製薬株式会社 2－クロロ－6－フルオロベンゾオキサゾールの製造方法
CN102079730B (zh) * 2010-09-06 2013-10-16 贵州大学 一类含2,5-取代杂环基砜类衍生物及其合成方法和应用
CN103450173B (zh) * 2013-09-07 2015-06-03 吉首大学 吡咯酮-苯基-噁唑烷酮型化合物及其制法和用途
CN103709119B (zh) * 2013-12-04 2015-05-20 上海应用技术学院 一种制备5-氨基噻唑-4-甲酰胺的方法
CN104202835A (zh) * 2014-09-03 2014-12-10 苏州微站通信科技有限公司 Ue进入静默期时让基站及时释放时频资源的方法
EP3789383B9 (en) 2018-04-27 2024-02-28 Osaka University Inhibitors of the trpc3 or trpc6 channel

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US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4977173A (en) * 1987-10-21 1990-12-11 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
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SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
KR100312903B1 (ko) * 1993-11-22 2002-02-28 로렌스 티. 마이젠헬더 치환된-하이드록시아세틸피페라진페닐옥사졸리디논의에스테르

Also Published As

Publication number Publication date
PT883611E (pt) 2002-12-31
AU1954797A (en) 1997-09-10
NZ331011A (en) 2000-04-28
ES2180945T3 (es) 2003-02-16
DE69714418T2 (de) 2003-01-16
EP0883611A1 (en) 1998-12-16
EP0883611B1 (en) 2002-07-31
AU703831B2 (en) 1999-04-01
KR19990087238A (ko) 1999-12-15
DK0883611T3 (da) 2002-12-02
TW442460B (en) 2001-06-23
CN1206410A (zh) 1999-01-27
ZA971287B (en) 1998-08-14
ATE221521T1 (de) 2002-08-15
WO1997030981A1 (en) 1997-08-28
US5736545A (en) 1998-04-07
JP2000505084A (ja) 2000-04-25
CN1082952C (zh) 2002-04-17
MY116093A (en) 2003-11-28
DE69714418D1 (de) 2002-09-05
ID18467A (id) 1998-04-09
PE55898A1 (es) 1998-09-16

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060218