HK1011363A1 - Tricyclc diazepines vasopressin and oxytocin antagonists - Google Patents
Tricyclc diazepines vasopressin and oxytocin antagonistsInfo
- Publication number
- HK1011363A1 HK1011363A1 HK98112375A HK98112375A HK1011363A1 HK 1011363 A1 HK1011363 A1 HK 1011363A1 HK 98112375 A HK98112375 A HK 98112375A HK 98112375 A HK98112375 A HK 98112375A HK 1011363 A1 HK1011363 A1 HK 1011363A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- opt
- substd
- satd
- membered aromatic
- tricyclc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10000493A | 1993-07-29 | 1993-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1011363A1 true HK1011363A1 (en) | 1999-07-09 |
Family
ID=22277643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98112375A HK1011363A1 (en) | 1993-07-29 | 1998-11-27 | Tricyclc diazepines vasopressin and oxytocin antagonists |
Country Status (29)
Country | Link |
---|---|
US (2) | US5516774A (ja) |
EP (1) | EP0636625B1 (ja) |
JP (1) | JP3782475B2 (ja) |
KR (1) | KR100347479B1 (ja) |
CN (2) | CN1039908C (ja) |
AT (1) | ATE176234T1 (ja) |
AU (1) | AU683660B2 (ja) |
BR (1) | BR1100563A (ja) |
CA (1) | CA2128956C (ja) |
CZ (1) | CZ291322B6 (ja) |
DE (1) | DE69416211T2 (ja) |
DK (1) | DK0636625T3 (ja) |
EC (1) | ECSP941137A (ja) |
ES (1) | ES2129090T3 (ja) |
FI (3) | FI110944B (ja) |
GR (1) | GR3030069T3 (ja) |
HK (1) | HK1011363A1 (ja) |
HU (1) | HU220707B1 (ja) |
IL (1) | IL110435A (ja) |
LV (1) | LV12497B (ja) |
NO (1) | NO301827B1 (ja) |
NZ (1) | NZ264115A (ja) |
PE (1) | PE17895A1 (ja) |
PH (1) | PH31469A (ja) |
PL (1) | PL178563B1 (ja) |
RU (1) | RU2126006C1 (ja) |
SG (1) | SG47522A1 (ja) |
SK (1) | SK280836B6 (ja) |
ZA (1) | ZA945603B (ja) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5889001A (en) * | 1993-07-29 | 1999-03-30 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5733905A (en) * | 1993-07-29 | 1998-03-31 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5968930A (en) * | 1993-07-29 | 1999-10-19 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5521173A (en) * | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
US5753648A (en) * | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
AR002459A1 (es) * | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
US5536718A (en) * | 1995-01-17 | 1996-07-16 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5880122A (en) * | 1996-11-01 | 1999-03-09 | American Home Products Corporation | 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines |
AU737689B2 (en) * | 1996-11-01 | 2001-08-30 | Wyeth | 3-carboxamide derivatives of 5H-pyrrolo(2,1-c)(1,4)- benzodiazepines |
AUPO395396A0 (en) * | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
US6511974B1 (en) | 1997-07-30 | 2003-01-28 | Wyeth | Tricyclic vasopressin agonists |
PT1000062E (pt) * | 1997-07-30 | 2004-12-31 | Wyeth Corp | Agonistas triciclicos de vasopressina |
AR018818A1 (es) * | 1998-04-03 | 2001-12-12 | Yamano Masaki | Una composicion farmaceutica para la terapia de un edema. |
US6090803A (en) * | 1998-07-24 | 2000-07-18 | American Home Products Corporation | Tricyclic vasopressin agonists |
US7138393B2 (en) * | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
ATE249465T1 (de) * | 1999-01-19 | 2003-09-15 | Ortho Mcneil Pharm Inc | Tricyclische benzodiazepine als vasopressin antagonisten |
US6235900B1 (en) | 1999-02-04 | 2001-05-22 | American Home Products Corporation | Tricyclic pyridine N-oxides vasopressin agonists |
US6344451B1 (en) | 1999-02-04 | 2002-02-05 | American Home Products | Pyrrolobenzodiazepine carboxyamide vasopressin agonists |
US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
US6620807B1 (en) | 1999-02-04 | 2003-09-16 | Wyeth | Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists |
ATE229528T1 (de) * | 1999-02-04 | 2002-12-15 | Wyeth Corp | Pyrrolobenzodiazepine carboxamide vasopressin agonisten |
US6352718B1 (en) | 1999-09-27 | 2002-03-05 | American Cyanamid Company | Vasopressin antagonist formulation and process |
US6437006B1 (en) | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
AR025780A1 (es) * | 1999-09-27 | 2002-12-11 | American Home Prod | Formulacion de antagonista de vasopresina y su proceso |
US6420358B1 (en) | 1999-09-27 | 2002-07-16 | American Cyanamid Company | Vasopressin antagonist and diuretic combination |
GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
KR20020089493A (ko) * | 2000-04-28 | 2002-11-29 | 상꾜 가부시키가이샤 | PPARγ모듈레이터 |
GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
US7326700B2 (en) * | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7064120B2 (en) * | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
US7202239B2 (en) * | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
US6977254B2 (en) * | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
JP2004530668A (ja) * | 2001-04-12 | 2004-10-07 | ワイス | バソプレッシンアゴニストとしてのn−ビフェニルカルボニル−およびn−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン |
US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
MXPA03009159A (es) * | 2001-04-12 | 2004-02-12 | Wyeth Corp | Ciclohexilfenilos agonistas de vasopresina. |
WO2003035602A1 (fr) * | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
US7414052B2 (en) * | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) * | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
GB0412874D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
EP1632494A1 (en) * | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
EP2113178A1 (en) | 2008-04-30 | 2009-11-04 | Philip Morris Products S.A. | An electrically heated smoking system having a liquid storage portion |
US8420633B2 (en) * | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) * | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
EP2587919B1 (en) * | 2010-07-01 | 2017-12-13 | Azevan Pharmaceuticals, Inc. | Methods for treating post traumatic stress disorder |
US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
BR112013022757A2 (pt) | 2011-03-09 | 2021-01-05 | Chong Corporation | Sistema de entrega de medicamento |
US9399110B2 (en) | 2011-03-09 | 2016-07-26 | Chong Corporation | Medicant delivery system |
US8903228B2 (en) | 2011-03-09 | 2014-12-02 | Chong Corporation | Vapor delivery devices and methods |
US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
CN103763954B (zh) | 2011-09-06 | 2017-06-20 | 英美烟草(投资)有限公司 | 加热可点燃抽吸材料 |
BR112013032558B1 (pt) | 2011-09-06 | 2021-01-12 | British American Tobacco (Investments) Limited | aparelho para aquecer material fumável |
CN103288829A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法 |
GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
CN104379561B (zh) * | 2012-06-22 | 2016-12-21 | 住友化学株式会社 | 酰胺化合物及其有害生物防除用途 |
EP2765128A1 (en) * | 2013-02-07 | 2014-08-13 | Almirall, S.A. | Substituted benzamides with activity towards EP4 receptors |
CN104059070B (zh) * | 2013-09-17 | 2016-02-10 | 天津药物研究院有限公司 | 利希普坦晶型ⅰ及其制备方法和用途 |
CN103755707B (zh) * | 2013-09-17 | 2015-11-18 | 天津药物研究院 | 利希普坦晶型ⅱ及其制备方法和用途 |
CN103694240B (zh) * | 2013-09-18 | 2015-11-18 | 天津药物研究院 | 利希普坦的溶剂合物及其制备方法和用途 |
DK3157928T3 (da) | 2014-06-20 | 2019-05-20 | Constellation Pharmaceuticals Inc | Krystallinske former af 2-((4s)-6-(4-chlorphenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamid |
CN104140429B (zh) * | 2014-07-25 | 2015-11-18 | 天津药物研究院 | 利希普坦晶型ⅴ及其制备方法和用途 |
CN104710429B (zh) * | 2015-02-04 | 2017-02-22 | 浙江大学 | 手性螺环磷酸催化合成光学活性喹喔啉衍生物的方法 |
US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
CA3065910A1 (en) * | 2017-06-09 | 2018-12-13 | Palladio Biosciences, Inc. | Formulations of lixivaptan for the treatment of polycystic disease |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3860600A (en) * | 1972-07-10 | 1975-01-14 | Sterling Drug Inc | Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines |
EP0382185B1 (en) * | 1989-02-10 | 1994-06-15 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
TW199153B (ja) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
TW198715B (ja) * | 1991-04-19 | 1993-01-21 | Dtsuka Seiyaku Kk | |
US5204349A (en) * | 1991-09-16 | 1993-04-20 | Merck & Co., Inc. | Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists |
EP0533242A3 (en) * | 1991-09-16 | 1993-09-15 | Merck & Co. Inc. | Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
EP0533243B1 (en) * | 1991-09-16 | 1997-12-17 | Merck & Co. Inc. | Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives |
EP0533240A3 (en) * | 1991-09-16 | 1993-09-29 | Merck & Co. Inc. | Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists |
-
1994
- 1994-06-13 US US08/254,822 patent/US5516774A/en not_active Expired - Lifetime
- 1994-07-15 DK DK94111039T patent/DK0636625T3/da active
- 1994-07-15 AT AT94111039T patent/ATE176234T1/de active
- 1994-07-15 EP EP94111039A patent/EP0636625B1/en not_active Expired - Lifetime
- 1994-07-15 DE DE69416211T patent/DE69416211T2/de not_active Expired - Lifetime
- 1994-07-15 ES ES94111039T patent/ES2129090T3/es not_active Expired - Lifetime
- 1994-07-15 SG SG1996002643A patent/SG47522A1/en unknown
- 1994-07-20 SK SK881-94A patent/SK280836B6/sk not_active IP Right Cessation
- 1994-07-25 IL IL11043594A patent/IL110435A/xx not_active IP Right Cessation
- 1994-07-26 PE PE1994247526A patent/PE17895A1/es not_active Application Discontinuation
- 1994-07-26 CZ CZ19941799A patent/CZ291322B6/cs not_active IP Right Cessation
- 1994-07-27 PH PH48700A patent/PH31469A/en unknown
- 1994-07-27 CA CA002128956A patent/CA2128956C/en not_active Expired - Fee Related
- 1994-07-28 RU RU94027583A patent/RU2126006C1/ru not_active IP Right Cessation
- 1994-07-28 JP JP19585794A patent/JP3782475B2/ja not_active Expired - Lifetime
- 1994-07-28 EC EC1994001137A patent/ECSP941137A/es unknown
- 1994-07-28 NO NO942816A patent/NO301827B1/no not_active IP Right Cessation
- 1994-07-28 NZ NZ264115A patent/NZ264115A/en not_active IP Right Cessation
- 1994-07-28 KR KR1019940018496A patent/KR100347479B1/ko not_active IP Right Cessation
- 1994-07-28 AU AU68777/94A patent/AU683660B2/en not_active Ceased
- 1994-07-28 HU HU9402219A patent/HU220707B1/hu not_active IP Right Cessation
- 1994-07-28 FI FI943543A patent/FI110944B/fi not_active IP Right Cessation
- 1994-07-28 ZA ZA945603A patent/ZA945603B/xx unknown
- 1994-07-29 CN CN94108769A patent/CN1039908C/zh not_active Expired - Fee Related
- 1994-07-29 PL PL94304498A patent/PL178563B1/pl not_active IP Right Cessation
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1995
- 1995-06-06 US US08/468,737 patent/US5624923A/en not_active Expired - Lifetime
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1997
- 1997-05-13 BR BR1100563-7A patent/BR1100563A/pt active IP Right Grant
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1998
- 1998-02-10 CN CN98103834A patent/CN1056374C/zh not_active Expired - Fee Related
- 1998-11-27 HK HK98112375A patent/HK1011363A1/xx not_active IP Right Cessation
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1999
- 1999-04-26 GR GR990401154T patent/GR3030069T3/el unknown
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2000
- 2000-01-27 LV LVP-00-13A patent/LV12497B/lv unknown
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2001
- 2001-06-07 FI FI20011206A patent/FI113867B/fi not_active IP Right Cessation
- 2001-06-07 FI FI20011207A patent/FI113868B/fi not_active IP Right Cessation
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20120715 |