SK280836B6 - Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze - Google Patents

Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze Download PDF

Info

Publication number
SK280836B6
SK280836B6 SK881-94A SK88194A SK280836B6 SK 280836 B6 SK280836 B6 SK 280836B6 SK 88194 A SK88194 A SK 88194A SK 280836 B6 SK280836 B6 SK 280836B6
Authority
SK
Slovakia
Prior art keywords
carbon atoms
group
lower alkyl
alkyl
straight
Prior art date
Application number
SK881-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK88194A3 (en
Inventor
Jay D. Albright
Marvin F. Reich
Fuk-Wah Sum
Santos Efren Guillermo Delos
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of SK88194A3 publication Critical patent/SK88194A3/sk
Publication of SK280836B6 publication Critical patent/SK280836B6/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK881-94A 1993-07-29 1994-07-20 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze SK280836B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10000493A 1993-07-29 1993-07-29

Publications (2)

Publication Number Publication Date
SK88194A3 SK88194A3 (en) 1995-04-12
SK280836B6 true SK280836B6 (sk) 2000-08-14

Family

ID=22277643

Family Applications (1)

Application Number Title Priority Date Filing Date
SK881-94A SK280836B6 (sk) 1993-07-29 1994-07-20 Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze

Country Status (29)

Country Link
US (2) US5516774A (ja)
EP (1) EP0636625B1 (ja)
JP (1) JP3782475B2 (ja)
KR (1) KR100347479B1 (ja)
CN (2) CN1039908C (ja)
AT (1) ATE176234T1 (ja)
AU (1) AU683660B2 (ja)
BR (1) BR1100563A (ja)
CA (1) CA2128956C (ja)
CZ (1) CZ291322B6 (ja)
DE (1) DE69416211T2 (ja)
DK (1) DK0636625T3 (ja)
EC (1) ECSP941137A (ja)
ES (1) ES2129090T3 (ja)
FI (3) FI110944B (ja)
GR (1) GR3030069T3 (ja)
HK (1) HK1011363A1 (ja)
HU (1) HU220707B1 (ja)
IL (1) IL110435A (ja)
LV (1) LV12497B (ja)
NO (1) NO301827B1 (ja)
NZ (1) NZ264115A (ja)
PE (1) PE17895A1 (ja)
PH (1) PH31469A (ja)
PL (1) PL178563B1 (ja)
RU (1) RU2126006C1 (ja)
SG (1) SG47522A1 (ja)
SK (1) SK280836B6 (ja)
ZA (1) ZA945603B (ja)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889001A (en) * 1993-07-29 1999-03-30 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5733905A (en) * 1993-07-29 1998-03-31 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5968930A (en) * 1993-07-29 1999-10-19 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
AR002459A1 (es) * 1995-01-17 1998-03-25 American Cyanamid Co Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion.
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
US5536718A (en) * 1995-01-17 1996-07-16 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5756497A (en) * 1996-03-01 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
JP2001503759A (ja) * 1996-11-01 2001-03-21 アメリカン・ホーム・プロダクツ・コーポレイション 5H―ピロロ[2,1―c][1,4]ベンゾジアゼピンの3―カルボキサミド誘導体
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
AUPO395396A0 (en) * 1996-12-02 1997-01-02 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
CN1183134C (zh) * 1997-07-30 2005-01-05 惠氏公司 三环后叶加压素激动剂
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
AR018818A1 (es) * 1998-04-03 2001-12-12 Yamano Masaki Una composicion farmaceutica para la terapia de un edema.
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
DE69911259T4 (de) * 1999-01-19 2009-07-09 Ortho-Mcneil Pharmaceutical, Inc. Tricyclische benzodiazepine als vasopressin antagonisten
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6620807B1 (en) 1999-02-04 2003-09-16 Wyeth Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
US6344451B1 (en) 1999-02-04 2002-02-05 American Home Products Pyrrolobenzodiazepine carboxyamide vasopressin agonists
WO2000046228A2 (en) * 1999-02-04 2000-08-10 American Home Products Corporation Pyrrolobenzodiazepine carboxyamide vasopressin agonists
US6352718B1 (en) 1999-09-27 2002-03-05 American Cyanamid Company Vasopressin antagonist formulation and process
US6420358B1 (en) 1999-09-27 2002-07-16 American Cyanamid Company Vasopressin antagonist and diuretic combination
US6437006B1 (en) 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
MXPA02003189A (es) * 1999-09-27 2002-09-30 American Cyanamid Co Formulacion antagonista de vasopresina y proceso para elaborar la misma.
GB0000079D0 (en) 2000-01-05 2000-02-23 Ferring Bv Novel antidiuretic agents
IL152451A0 (en) * 2000-04-28 2003-05-29 Sankyo Co 2-chloro-2-nitrophenylcarboxamide derivatives and pharmaceutical compositions containing the same
GB0015601D0 (en) 2000-06-26 2000-08-16 Ferring Bv Novel antidiuretic agents
JP2004530668A (ja) 2001-04-12 2004-10-07 ワイス バソプレッシンアゴニストとしてのn−ビフェニルカルボニル−およびn−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
CA2443870A1 (en) * 2001-04-12 2002-10-24 Wyeth Cyclohexylphenyl vasopressin agonists
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
WO2003035602A1 (fr) * 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
US7414052B2 (en) * 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en) * 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
GB0412874D0 (en) * 2004-06-09 2004-07-14 Pfizer Ltd Novel pharmaceuticals
EP1632494A1 (en) * 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
EP2113178A1 (en) 2008-04-30 2009-11-04 Philip Morris Products S.A. An electrically heated smoking system having a liquid storage portion
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
AU2011272738B2 (en) * 2010-07-01 2015-08-20 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
WO2012075456A1 (en) 2010-12-02 2012-06-07 Constellation Pharmaceuticals Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP3178510B1 (en) 2011-03-09 2018-08-01 Chong Corporation Medicant delivery system
US9399110B2 (en) 2011-03-09 2016-07-26 Chong Corporation Medicant delivery system
US8903228B2 (en) 2011-03-09 2014-12-02 Chong Corporation Vapor delivery devices and methods
EP2705039B1 (en) * 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
PL3811800T3 (pl) 2011-09-06 2023-06-26 Nicoventures Trading Limited Ogrzewanie materiału do palenia
JP5808490B2 (ja) 2011-09-06 2015-11-10 ブリティッシュ アメリカン タバコ (インヴェストメンツ) リミテッドBritish Americantobacco (Investments) Limited 喫煙材の加熱
CN103288829A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓-5-酮的方法
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
CN104379561B (zh) * 2012-06-22 2016-12-21 住友化学株式会社 酰胺化合物及其有害生物防除用途
EP2765128A1 (en) * 2013-02-07 2014-08-13 Almirall, S.A. Substituted benzamides with activity towards EP4 receptors
CN104059070B (zh) * 2013-09-17 2016-02-10 天津药物研究院有限公司 利希普坦晶型ⅰ及其制备方法和用途
CN103755707B (zh) * 2013-09-17 2015-11-18 天津药物研究院 利希普坦晶型ⅱ及其制备方法和用途
CN103694240B (zh) * 2013-09-18 2015-11-18 天津药物研究院 利希普坦的溶剂合物及其制备方法和用途
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide
CN104140429B (zh) * 2014-07-25 2015-11-18 天津药物研究院 利希普坦晶型ⅴ及其制备方法和用途
CN104710429B (zh) * 2015-02-04 2017-02-22 浙江大学 手性螺环磷酸催化合成光学活性喹喔啉衍生物的方法
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
MX2019014475A (es) * 2017-06-09 2020-08-17 Palladio Biosciences Inc Formulaciones de lixivaptan para el tratamiento de enfermedades poliquisticas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860600A (en) * 1972-07-10 1975-01-14 Sterling Drug Inc Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
DK0382185T3 (da) * 1989-02-10 1994-07-04 Otsuka Pharma Co Ltd Carbostyrilderivater
DE122009000062I2 (de) * 1989-10-20 2011-01-13 Otsuka Pharma Co Ltd Benzoheterozyklische verbindungen
TW199153B (ja) * 1990-08-07 1993-02-01 Dtsuka Seiyaku Kk
CA2066104C (en) * 1991-04-19 2003-05-27 Hidenori Ogawa Benzazepine derivatives as vasopressin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists

Also Published As

Publication number Publication date
PL178563B1 (pl) 2000-05-31
AU683660B2 (en) 1997-11-20
ES2129090T3 (es) 1999-06-01
FI943543A0 (fi) 1994-07-28
RU2126006C1 (ru) 1999-02-10
NO942816D0 (no) 1994-07-28
CN1205335A (zh) 1999-01-20
CA2128956C (en) 2004-10-05
PE17895A1 (es) 1995-07-18
AU6877794A (en) 1995-02-09
ATE176234T1 (de) 1999-02-15
US5516774A (en) 1996-05-14
GR3030069T3 (en) 1999-07-30
NO301827B1 (no) 1997-12-15
KR100347479B1 (ko) 2002-12-06
NO942816L (no) 1995-01-30
SK88194A3 (en) 1995-04-12
IL110435A0 (en) 1994-10-21
JPH07157486A (ja) 1995-06-20
KR950003295A (ko) 1995-02-16
DE69416211D1 (de) 1999-03-11
EP0636625A3 (en) 1995-05-17
FI113867B (fi) 2004-06-30
HUT71495A (en) 1995-11-28
CZ291322B6 (cs) 2003-02-12
CA2128956A1 (en) 1995-01-30
HU9402219D0 (en) 1994-09-28
RU94027583A (ru) 1996-07-20
HU220707B1 (hu) 2002-04-29
CN1056374C (zh) 2000-09-13
PH31469A (en) 1998-11-03
CZ179994A3 (en) 1995-02-15
HK1011363A1 (en) 1999-07-09
BR1100563A (pt) 2000-02-08
CN1039908C (zh) 1998-09-23
DE69416211T2 (de) 1999-09-02
FI20011207A (fi) 2001-06-07
FI20011206A (fi) 2001-06-07
IL110435A (en) 2003-11-23
ZA945603B (en) 1995-03-09
NZ264115A (en) 1997-10-24
ECSP941137A (es) 1995-02-27
LV12497B (lv) 2000-09-20
EP0636625A2 (en) 1995-02-01
PL304498A1 (en) 1995-02-06
EP0636625B1 (en) 1999-01-27
US5624923A (en) 1997-04-29
FI110944B (fi) 2003-04-30
LV12497A (en) 2000-06-20
CN1106812A (zh) 1995-08-16
DK0636625T3 (da) 1999-09-13
SG47522A1 (en) 1998-04-17
JP3782475B2 (ja) 2006-06-07
FI113868B (fi) 2004-06-30
FI943543A (fi) 1995-01-30

Similar Documents

Publication Publication Date Title
SK280836B6 (sk) Tricyklické diazepíny, spôsob ich výroby, ich použitie a farmaceutický prípravok na ich báze
US5843944A (en) Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
JP4163252B2 (ja) 三環式ベンゾアゼピンバソプレッシンアンタゴニスト類
RU2149160C1 (ru) Трициклические производные, способ получения, фармацевтическая композиция, способ ингибирования вазопрессина
EA000056B1 (ru) Трициклические диазепины в качестве антагонистов вазопрессина, способ их получения и способ лечения с использованием трициклических диазепинов
US5968937A (en) Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5747487A (en) Tricyclic benzazepine vasopressin antagonists
US5854236A (en) Tricyclic benzazepine vasopressin antagonists
US5889001A (en) Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5736538A (en) Tricyclic Benzazepine vasopressin antagonists
WO1997047624A1 (en) Tricyclic benzazepine vasopressin antagonists
US5843952A (en) Tricyclic benzazepine vasopressin antagonists

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120720