HK1006967A1 - Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation - Google Patents
Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparationInfo
- Publication number
- HK1006967A1 HK1006967A1 HK98106190A HK98106190A HK1006967A1 HK 1006967 A1 HK1006967 A1 HK 1006967A1 HK 98106190 A HK98106190 A HK 98106190A HK 98106190 A HK98106190 A HK 98106190A HK 1006967 A1 HK1006967 A1 HK 1006967A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pct
- halophenylamino
- derivatives
- preparation
- phenylacetic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI922006A IT1256345B (it) | 1992-08-20 | 1992-08-20 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione |
PCT/EP1993/001906 WO1994004484A1 (en) | 1992-08-20 | 1993-07-20 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1006967A1 true HK1006967A1 (en) | 1999-03-26 |
Family
ID=11363881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98106190A HK1006967A1 (en) | 1992-08-20 | 1998-06-23 | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation |
Country Status (15)
Country | Link |
---|---|
US (1) | US5597847A (ja) |
EP (1) | EP0609415B1 (ja) |
JP (1) | JP3231042B2 (ja) |
KR (1) | KR100269727B1 (ja) |
AT (1) | ATE143941T1 (ja) |
CA (1) | CA2120942C (ja) |
DE (1) | DE69305322T2 (ja) |
DK (1) | DK0609415T3 (ja) |
ES (1) | ES2093979T3 (ja) |
GR (1) | GR3021404T3 (ja) |
HK (1) | HK1006967A1 (ja) |
IT (1) | IT1256345B (ja) |
RU (1) | RU2109009C1 (ja) |
UA (1) | UA39172C2 (ja) |
WO (1) | WO1994004484A1 (ja) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0722434B1 (en) * | 1993-10-06 | 1998-07-29 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
KR100387359B1 (ko) * | 1994-05-10 | 2003-08-27 | 니콕스 에스. 에이. | 항-염증성,비알러지성및항-혈전성을가지는니트로화합물들과그들의조성물들 |
US5703073A (en) | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
ES2092962B1 (es) * | 1995-04-19 | 1997-07-16 | Prodes Sa | Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. |
US5792758A (en) * | 1995-12-08 | 1998-08-11 | G. D. Searle & Co. | Steroid nitrite ester derivatives useful as anti-inflammatory drugs |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
US6355680B1 (en) * | 1996-02-20 | 2002-03-12 | Exocell, Inc. | Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies |
IT1282686B1 (it) | 1996-02-26 | 1998-03-31 | Nicox Sa | Composti in grado di ridurre la tossicita' da farmaci |
WO1998007701A1 (en) * | 1996-08-16 | 1998-02-26 | Handforth Investments Ltd. | Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative |
IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
IT1285770B1 (it) | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
FR2757159B1 (fr) * | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
CO4960662A1 (es) | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
EP1126838A4 (en) | 1998-10-30 | 2005-02-16 | Nitromed Inc | NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE |
IT1308633B1 (it) * | 1999-03-02 | 2002-01-09 | Nicox Sa | Nitrossiderivati. |
IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IT1311923B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
TWI243672B (en) * | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
IT1312115B1 (it) * | 1999-06-24 | 2002-04-04 | Nicox Sa | Composti amorfi e relative composizioni farmaceutiche |
IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
US6552078B2 (en) | 1999-10-27 | 2003-04-22 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6436990B1 (en) | 1999-10-27 | 2002-08-20 | Nobex Corporation | 6-methoxy-2-naphthylacetic acid prodrugs |
TWI262791B (en) | 1999-10-27 | 2006-10-01 | Nobex Corp | 6-methoxy-2-naphthylacetic acid prodrugs |
US6649629B2 (en) | 1999-12-23 | 2003-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
CA2432642A1 (en) | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
SE0102993D0 (sv) * | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
JP2006501161A (ja) | 2002-06-11 | 2006-01-12 | ニトロメッド インク. | ニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物ならびに使用方法 |
WO2004002420A2 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
JP2005539089A (ja) | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
SE0203093D0 (en) * | 2002-10-18 | 2002-10-18 | Astrazeneca Uk Ltd | New use |
PE20040844A1 (es) | 2002-11-26 | 2004-12-30 | Novartis Ag | Acidos fenilaceticos y derivados como inhibidores de la cox-2 |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
AR061623A1 (es) | 2006-06-26 | 2008-09-10 | Novartis Ag | Derivados de acido fenilacetico |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
DE3407507A1 (de) * | 1984-03-01 | 1985-09-05 | A. Nattermann & Cie GmbH, 5000 Köln | Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US5021576A (en) * | 1989-10-27 | 1991-06-04 | American Home Products Corporation | 2-Anilino phenylacetic acid derivatives |
-
1992
- 1992-08-20 IT ITMI922006A patent/IT1256345B/it active IP Right Grant
-
1993
- 1993-07-20 EP EP93917596A patent/EP0609415B1/en not_active Expired - Lifetime
- 1993-07-20 AT AT93917596T patent/ATE143941T1/de not_active IP Right Cessation
- 1993-07-20 DK DK93917596.4T patent/DK0609415T3/da active
- 1993-07-20 UA UA94005348A patent/UA39172C2/uk unknown
- 1993-07-20 RU RU94046148A patent/RU2109009C1/ru not_active IP Right Cessation
- 1993-07-20 KR KR1019940701286A patent/KR100269727B1/ko not_active IP Right Cessation
- 1993-07-20 JP JP50582694A patent/JP3231042B2/ja not_active Expired - Fee Related
- 1993-07-20 WO PCT/EP1993/001906 patent/WO1994004484A1/en active IP Right Grant
- 1993-07-20 DE DE69305322T patent/DE69305322T2/de not_active Expired - Lifetime
- 1993-07-20 ES ES93917596T patent/ES2093979T3/es not_active Expired - Lifetime
- 1993-07-20 CA CA002120942A patent/CA2120942C/en not_active Expired - Fee Related
- 1993-07-20 US US08/211,447 patent/US5597847A/en not_active Expired - Lifetime
-
1996
- 1996-10-21 GR GR960402711T patent/GR3021404T3/el unknown
-
1998
- 1998-06-23 HK HK98106190A patent/HK1006967A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT1256345B (it) | 1995-12-01 |
US5597847A (en) | 1997-01-28 |
RU2109009C1 (ru) | 1998-04-20 |
CA2120942C (en) | 2005-09-27 |
GR3021404T3 (en) | 1997-01-31 |
UA39172C2 (uk) | 2001-06-15 |
JP3231042B2 (ja) | 2001-11-19 |
DE69305322D1 (de) | 1996-11-14 |
ITMI922006A1 (it) | 1994-02-20 |
ATE143941T1 (de) | 1996-10-15 |
DK0609415T3 (da) | 1996-11-18 |
DE69305322T2 (de) | 1997-02-20 |
WO1994004484A1 (en) | 1994-03-03 |
EP0609415B1 (en) | 1996-10-09 |
KR100269727B1 (ko) | 2000-10-16 |
EP0609415A1 (en) | 1994-08-10 |
ES2093979T3 (es) | 1997-01-01 |
JPH07500355A (ja) | 1995-01-12 |
CA2120942A1 (en) | 1994-03-03 |
ITMI922006A0 (it) | 1992-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1006967A1 (en) | Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation | |
GB9308957D0 (en) | Novel produgs | |
DK0810209T3 (da) | Alpha - and beta-aminosyre-hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser | |
DE69310204D1 (de) | Salpetersäureester mit pharmazeutischer wirkung und verfahren zu deren herstellung | |
IL124537A0 (en) | Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same | |
NO950849L (no) | Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter | |
FI933424A0 (fi) | Peptidyl-4-amino-2,2-difluor-3-oxo-1,6-hexandisyraderivat som antiinflammatoriska medel | |
ATE83773T1 (de) | 3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a. | |
AU1321697A (en) | Dispersing agent | |
PL310398A1 (en) | Novel compounds | |
BG104569A (en) | Substituted 2-benzylamino-2-phenyl-acetamide compounds | |
HUT43943A (en) | Herbicide compositions comprising urea derivatives as active substance and process for preparing such compounds | |
GR3023934T3 (en) | New naphthalene amides and sulfonamides, process for their preparation and pharmaceutical compositions containing them | |
HU9402466D0 (en) | Indole derivatives as steroid-5-alpha-reductase inhibitors | |
YU69699A (sh) | Derivati aril karbonske kiseline i tetrazola | |
DK0689534T3 (da) | Amidderivater som 5-HT1A-ligander | |
IL105669A0 (en) | Dithiolanylglycine-containing hiv protease inhibitors of the hydroxyethylene isostere type,their preparation and pharmaceutical compositions containing them | |
ITMI922742A1 (it) | Composti ad attivita' terapeutica utili per il trattamento di malattie connesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono. | |
IL107520A0 (en) | Substituted ortho-ethenylphenylacetic acid derivatives and pharmaceutical compositions containing them | |
ZA957449B (en) | Bicyclic carboxamides | |
GB9523637D0 (en) | Synthesis of carboxylic acid derivatives | |
GR3024366T3 (en) | INDOLE DERIVATIVES AS STEROID 5-g(a)-REDUCTASE INHIBITORS | |
ES2164665T3 (es) | Inhibidores de proteasas retrovirales. | |
JO1648B1 (en) | Nitrogen compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20110720 |