HK1005592A1 - Benzimidazole derivatives, process for their preparation and therapeutic application - Google Patents

Benzimidazole derivatives, process for their preparation and therapeutic application Download PDF

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Publication number
HK1005592A1
HK1005592A1 HK98104746A HK98104746A HK1005592A1 HK 1005592 A1 HK1005592 A1 HK 1005592A1 HK 98104746 A HK98104746 A HK 98104746A HK 98104746 A HK98104746 A HK 98104746A HK 1005592 A1 HK1005592 A1 HK 1005592A1
Authority
HK
Hong Kong
Prior art keywords
radical
methyl
hydrogen atom
alkyl
compound
Prior art date
Application number
HK98104746A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005592B (en
Inventor
Manoury Philippe
Binet Jean
Defosse Gerard
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HK1005592B publication Critical patent/HK1005592B/xx
Publication of HK1005592A1 publication Critical patent/HK1005592A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK98104746A 1985-09-11 1998-06-02 Benzimidazole derivatives, process for their preparation and therapeutic application HK1005592A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8513453A FR2587029B1 (fr) 1985-09-11 1985-09-11 Derives de benzimidazole, leur preparation et leur application en therapeutique
FR8513453 1985-09-11

Publications (2)

Publication Number Publication Date
HK1005592B HK1005592B (en) 1999-01-15
HK1005592A1 true HK1005592A1 (en) 1999-01-15

Family

ID=9322797

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104746A HK1005592A1 (en) 1985-09-11 1998-06-02 Benzimidazole derivatives, process for their preparation and therapeutic application

Country Status (25)

Country Link
US (2) US4820710A (cs)
EP (1) EP0217700B1 (cs)
JP (1) JPS6261979A (cs)
KR (1) KR930001411B1 (cs)
AR (1) AR243187A1 (cs)
AT (1) ATE103603T1 (cs)
AU (1) AU582894B2 (cs)
CA (1) CA1272486A (cs)
CS (1) CS357991A3 (cs)
DE (2) DE3689748T2 (cs)
DK (1) DK170594B1 (cs)
ES (1) ES2001782A6 (cs)
FI (1) FI87210C (cs)
FR (1) FR2587029B1 (cs)
GR (1) GR862318B (cs)
HK (1) HK1005592A1 (cs)
HU (1) HU196597B (cs)
IE (1) IE61607B1 (cs)
IL (1) IL79992A (cs)
LU (1) LU90085I2 (cs)
NL (1) NL970029I2 (cs)
NO (2) NO167026C (cs)
NZ (1) NZ217537A (cs)
PT (1) PT83355B (cs)
ZA (1) ZA866901B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
FR2637595B1 (fr) * 1988-10-11 1990-11-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
JPH02294758A (ja) * 1989-05-09 1990-12-05 Nec Corp 計算機使用時間管理方式
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
FR2666582B1 (fr) * 1990-09-07 1994-09-02 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique.
FR2693194B1 (fr) * 1992-07-03 1994-09-23 Synthelabo Dérivés d'alcanecarboxamide, leur préparation et leur application thérapeutique.
FR2745500B1 (fr) * 1996-03-04 1998-04-03 Synthelabo Formulations pharmaceutiques a liberation prolongee contenant de la mizolastine
JPH10101564A (ja) * 1996-09-27 1998-04-21 Mitsubishi Chem Corp 鼻炎予防及び／又は治療剤
ATE238998T1 (de) 1997-02-25 2003-05-15 Us Gov Health & Human Serv Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore
FR2762214B1 (fr) * 1997-04-17 2000-10-06 Synthelabo Utilisation de la mizolastine pour la preparation d'un medicament destine au traitement de l'inflammation
EP0958820A1 (en) * 1998-05-19 1999-11-24 Sanofi-Synthelabo Use of an imidazol derivative for the manufacture of a medicament for treating auto-immunodiseases
ES2208098B1 (es) * 2002-10-02 2005-10-16 Ragactives, S.L. Procedimiento e intermedios para la obtencion de derivados de 1-(1h-bencimidazol-2-il)-4-(2-aminopirimidin) piperidina.
DE602004020364D1 (de) * 2003-09-30 2009-05-14 Janssen Pharmaceutica Nv Benzoimidazolverbindungen
ES2245227B1 (es) * 2004-04-06 2007-03-01 Ragactives, S.L. Formas cristalinas de mizolastina, procedimientos para su obtencion y composiciones farmaceuticas que las contienen.
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
WO2010151711A1 (en) * 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
CN102140076A (zh) * 2010-02-03 2011-08-03 辽宁本源制药有限公司 咪唑斯汀中间体的制备
EP2790734B1 (en) 2011-12-15 2019-02-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
US20220204477A1 (en) * 2019-04-11 2022-06-30 Teijin Pharma Limited Benzimidazole derivatives and their uses
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
CN116655596A (zh) * 2022-02-17 2023-08-29 济南同路医药科技发展有限公司 一种大粒径咪唑斯汀原料药制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
DE19775081I2 (de) 2002-08-29
FI87210C (fi) 1992-12-10
ES2001782A6 (es) 1988-06-16
IL79992A0 (en) 1986-12-31
JPH0460596B2 (cs) 1992-09-28
ZA866901B (en) 1987-04-29
FI863661A0 (fi) 1986-09-10
NL970029I2 (nl) 1998-04-01
FR2587029B1 (fr) 1987-10-30
EP0217700A1 (fr) 1987-04-08
HU196597B (en) 1988-12-28
NL970029I1 (nl) 1997-10-01
DK170594B1 (da) 1995-11-06
IL79992A (en) 1990-07-12
PT83355B (pt) 1989-05-12
DK431586D0 (da) 1986-09-10
AU582894B2 (en) 1989-04-13
FI863661L (fi) 1987-03-12
NO863608D0 (no) 1986-09-10
DK431586A (da) 1987-03-12
NO167026C (no) 1991-09-25
JPS6261979A (ja) 1987-03-18
NO2001017I1 (no) 2001-11-05
FI87210B (fi) 1992-08-31
AU6255286A (en) 1987-03-12
LU90085I2 (fr) 1997-09-25
NO863608L (no) 1987-03-12
DE3689748T2 (de) 1994-08-11
KR930001411B1 (ko) 1993-02-27
NZ217537A (en) 1988-11-29
EP0217700B1 (fr) 1994-03-30
HUT41771A (en) 1987-05-28
KR870003100A (ko) 1987-04-15
US4820710A (en) 1989-04-11
US4912219A (en) 1990-03-27
PT83355A (fr) 1986-10-01
ATE103603T1 (de) 1994-04-15
DE3689748D1 (de) 1994-05-05
CA1272486A (en) 1990-08-07
NO167026B (no) 1991-06-17
IE862416L (en) 1987-03-11
CS357991A3 (en) 1992-06-17
IE61607B1 (en) 1994-11-16
AR243187A1 (es) 1993-07-30
GR862318B (en) 1987-01-19
FR2587029A1 (fr) 1987-03-13

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Legal Events

Date Code Title Description
PF Patent in force
CHPA Change of a particular in the register (except of change of ownership)
PE Patent expired

Effective date: 20060901