HK1005023A1 - Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors - Google Patents

Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors Download PDF

Info

Publication number
HK1005023A1
HK1005023A1 HK98102729A HK98102729A HK1005023A1 HK 1005023 A1 HK1005023 A1 HK 1005023A1 HK 98102729 A HK98102729 A HK 98102729A HK 98102729 A HK98102729 A HK 98102729A HK 1005023 A1 HK1005023 A1 HK 1005023A1
Authority
HK
Hong Kong
Prior art keywords
acid
formula
acids
acetyl
addition salt
Prior art date
Application number
HK98102729A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005023B (en
Inventor
Stanek Jaroslav
Frei Jorg
Caravatti Giorgio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1005023B publication Critical patent/HK1005023B/xx
Publication of HK1005023A1 publication Critical patent/HK1005023A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Cereal-Derived Products (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK98102729A 1991-10-16 1998-04-01 Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors HK1005023A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH304191 1991-10-16
CH304191 1991-10-16

Publications (2)

Publication Number Publication Date
HK1005023B HK1005023B (en) 1998-12-18
HK1005023A1 true HK1005023A1 (en) 1998-12-18

Family

ID=4247296

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102729A HK1005023A1 (en) 1991-10-16 1998-04-01 Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors

Country Status (24)

Country Link
EP (1) EP0538193B1 (cs)
JP (1) JP2788579B2 (cs)
KR (1) KR100265307B1 (cs)
AT (1) ATE145896T1 (cs)
AU (1) AU658931B2 (cs)
CA (1) CA2080545C (cs)
CY (1) CY2127B1 (cs)
CZ (1) CZ279601B6 (cs)
DE (1) DE59207617D1 (cs)
DK (1) DK0538193T3 (cs)
ES (1) ES2095444T3 (cs)
FI (1) FI112212B (cs)
GR (1) GR3021903T3 (cs)
HK (1) HK1005023A1 (cs)
HU (1) HU226954B1 (cs)
IL (1) IL103448A (cs)
MX (1) MX9205934A (cs)
NO (1) NO178108C (cs)
NZ (1) NZ244725A (cs)
RU (1) RU2081108C1 (cs)
SA (1) SA93130417B1 (cs)
SG (1) SG43185A1 (cs)
SK (1) SK279938B6 (cs)
ZA (1) ZA927957B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103166B1 (es) * 1992-08-26 1998-04-01 Ciba Geigy Ag Procedimiento para la obtencion de amidinohidrazonas biciclicas.
WO1996017930A1 (fr) * 1994-12-09 1996-06-13 Ajinomoto Co., Inc. Nouveau gene de decarboxylase de lysine et procede de production de lysine l
EP0808309B1 (en) * 1995-01-26 2004-10-06 Novartis AG Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors
JP2005519110A (ja) * 2002-03-04 2005-06-30 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規なケイ皮酸塩、その調製方法及び医薬品としての使用
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones

Also Published As

Publication number Publication date
FI924650A7 (fi) 1993-04-17
HU9203234D0 (en) 1992-12-28
IL103448A0 (en) 1993-03-15
SG43185A1 (en) 1997-10-17
CZ279601B6 (cs) 1995-05-17
CA2080545A1 (en) 1993-04-17
NO924001L (no) 1993-04-19
SA93130417B1 (ar) 2005-11-12
NO178108C (no) 1996-01-24
FI112212B (fi) 2003-11-14
ES2095444T3 (es) 1997-02-16
JP2788579B2 (ja) 1998-08-20
ATE145896T1 (de) 1996-12-15
JPH05239011A (ja) 1993-09-17
SK315292A3 (en) 1995-04-12
RU2081108C1 (ru) 1997-06-10
KR930007896A (ko) 1993-05-20
GR3021903T3 (en) 1997-03-31
EP0538193B1 (de) 1996-12-04
FI924650A0 (fi) 1992-10-14
NO178108B (no) 1995-10-16
CA2080545C (en) 2005-11-29
NO924001D0 (no) 1992-10-15
EP0538193A3 (en) 1993-06-16
AU2704092A (en) 1993-04-22
EP0538193A2 (de) 1993-04-21
CY2127B1 (en) 2002-06-21
DK0538193T3 (da) 1996-12-23
NZ244725A (en) 1995-05-26
IL103448A (en) 1998-01-04
SK279938B6 (sk) 1999-06-11
KR100265307B1 (ko) 2000-09-15
MX9205934A (es) 1993-04-01
ZA927957B (en) 1993-04-26
AU658931B2 (en) 1995-05-04
HU226954B1 (en) 2010-03-29
HUT63149A (en) 1993-07-28
DE59207617D1 (de) 1997-01-16
CZ315292A3 (en) 1993-05-12

Similar Documents

Publication Publication Date Title
US5639911A (en) Hydrazones
JPH0276843A (ja) ビアリール化合物及びその製造方法
CN107235923B (zh) 一类3-芳基喹喔啉酮衍生物的制备方法
TW406067B (en) Ortho-substituted benzoic acid derivatives
NO821768L (no) Fremgangsmaate for fremstilling av nye benzotiazin-dioksyd-salter
US4351770A (en) Preparation of N(2-pyrrolidinylmethyl)2-methoxy-5-benzenesulfonamidobenzamides
HK1005023A1 (en) Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors
HK1000919A1 (en) Hydrazones
HK1005023B (en) Condensed cycloaliphatir-amidino-hydrazon salts as s-adenosylmethionin decarboxylase inhibitors
HK1000919B (en) Hydrazones
UA58617C2 (uk) Похідні бензоїлгуанідину, спосіб їхнього одержання та фармацевтична композиція
DE3875820T2 (de) Aromatische heterozyklische karbonsaeureamidabkoemmlinge, verfahren zur herstellung und arzneimittel, die diese enthalten.
KR20030086312A (ko) 비사이클릭 구아니딘 유도체 및 이의 치료적 용도
WO2023061492A1 (zh) 2-氧代-3-氮杂双环[3.1.0]己烷衍生物
CN115260081B (zh) 一种磺酰胺类吲哚芳基砜衍生物及其制备方法与应用
Jones et al. Nucleophilic aromatic substitution with elimination in a dinitrosalicylic lactone or ester via Meisenheimer intermediates
CN119350311B (zh) 一种水飞蓟宾的衍生物，其制备方法及应用
CN108484584A (zh) 一种磺酰胺类衍生物及其在防治贫血药物中的用途
CN120554352A (zh) 一种丹皮酚咪唑并环类衍生物及其氯代制备方法与应用
CN103664716B (zh) 1-(1-芳砜基)苄基愈创兰烃薁类化合物及其制备方法
US2947743A (en) N4-aminoacetyl-, n4-lower alkylaminoacetyl- and n4-di-lower alkylamino-acetyl-6-sulfanilamido-2, 4-dimethoxypyrimidines
GB2104520A (en) Decarboxylase-inhibiting fluorinated alkane diamine derivatives
WO2023160541A1 (zh) 一种含氮杂环化合物的制备方法
JPS62103088A (ja) ４，５，６，７−テトラヒドロチエノ〔３，２−ｃ〕ピリジン又はその塩の製造方法
MXPA06014189A (es) Acidos 4-trifluorometoxifenoxibenceno-4'-sulfonicos, metodo para su produccion y su uso en medicamentos.

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101008