AU2704092A - Salts of hydrazones - Google Patents
Salts of hydrazonesInfo
- Publication number
- AU2704092A AU2704092A AU27040/92A AU2704092A AU2704092A AU 2704092 A AU2704092 A AU 2704092A AU 27040/92 A AU27040/92 A AU 27040/92A AU 2704092 A AU2704092 A AU 2704092A AU 2704092 A AU2704092 A AU 2704092A
- Authority
- AU
- Australia
- Prior art keywords
- acids
- acid
- unsubstituted
- substituted
- apart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Photoreceptors In Electrophotography (AREA)
- Detergent Compositions (AREA)
- Cereal-Derived Products (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention relates to acid addition salts of bases of the formula I <IMAGE> in which A, R1, R2, R3, R4, R5, X and Z have the meanings given in the description, with an acid [PA], which denotes a mono- or polybasic acid selected from carbonic acid, alkanoic acids which are unsubstituted or monosubstituted to polysubstituted, apart from formic acid, unsubstituted acetic acid, lysine and arginine; alkenoic acids which are unsubstituted or substituted, apart from unsubstituted fumaric acid, cycloalkylcarboxylic acids, arylcarboxylic acids, aryl-lower alkylcarboxylic acids in which lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkanesulphonic acids which are unsubstituted or substituted, apart from unsubstituted methanesulphonic acid, aromatic sulphonic acids, alkylsulphuric acids, N-substituted sulphamic acids, organic acids without carboxyl, sulpho, sulphate or phospho groups, and further from pyrophosphoric acid and hydrogen iodide; and tautomers thereof. The acid addition salts are employed for the treatment of disorders which respond to inhibition of S-adenosylmethionine decarboxylase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3041/91 | 1991-10-16 | ||
| CH304191 | 1991-10-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2704092A true AU2704092A (en) | 1993-04-22 |
| AU658931B2 AU658931B2 (en) | 1995-05-04 |
Family
ID=4247296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27040/92A Ceased AU658931B2 (en) | 1991-10-16 | 1992-10-14 | Salts of hydrazones |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0538193B1 (en) |
| JP (1) | JP2788579B2 (en) |
| KR (1) | KR100265307B1 (en) |
| AT (1) | ATE145896T1 (en) |
| AU (1) | AU658931B2 (en) |
| CA (1) | CA2080545C (en) |
| CY (1) | CY2127B1 (en) |
| CZ (1) | CZ279601B6 (en) |
| DE (1) | DE59207617D1 (en) |
| DK (1) | DK0538193T3 (en) |
| ES (1) | ES2095444T3 (en) |
| FI (1) | FI112212B (en) |
| GR (1) | GR3021903T3 (en) |
| HK (1) | HK1005023A1 (en) |
| HU (1) | HU226954B1 (en) |
| IL (1) | IL103448A (en) |
| MX (1) | MX9205934A (en) |
| NO (1) | NO178108C (en) |
| NZ (1) | NZ244725A (en) |
| RU (1) | RU2081108C1 (en) |
| SA (1) | SA93130417B1 (en) |
| SG (1) | SG43185A1 (en) |
| SK (1) | SK279938B6 (en) |
| ZA (1) | ZA927957B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2103166B1 (en) * | 1992-08-26 | 1998-04-01 | Ciba Geigy Ag | PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES. |
| DE69633557T2 (en) * | 1995-01-26 | 2005-10-13 | Novartis Ag | IMDAZOL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONES DECARBOXYLASE (= SAMDC) INHIBITORS |
| CA2477714C (en) * | 2002-03-04 | 2011-01-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New cinnamic acid salts, processes for the preparation thereof and use thereof as medicament |
| GT200600316A (en) * | 2005-07-20 | 2007-04-02 | SALTS OF 4-METHYL-N- (3- (4-METHYL-IMIDAZOL-1-ILO) -5-TRIFLUOROMETILO-PHENYL) -3- (4-PIRIDINA-3-ILO-PIRIMIDINA-2-ILOAMINO) - BENZAMIDA. | |
| EP1884515A1 (en) | 2006-07-31 | 2008-02-06 | Laboratorios del Dr. Esteve S.A. | Substituted indanyl sulfonamide compounds, their preparation and use as medicaments |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU645799B2 (en) * | 1990-05-07 | 1994-01-27 | Novartis Ag | Hydrazones |
-
1992
- 1992-09-03 RU SU925052359A patent/RU2081108C1/en active
- 1992-10-07 JP JP4268353A patent/JP2788579B2/en not_active Expired - Fee Related
- 1992-10-08 DE DE59207617T patent/DE59207617D1/en not_active Expired - Lifetime
- 1992-10-08 AT AT92810767T patent/ATE145896T1/en not_active IP Right Cessation
- 1992-10-08 SG SG1996005083A patent/SG43185A1/en unknown
- 1992-10-08 DK DK92810767.1T patent/DK0538193T3/en active
- 1992-10-08 ES ES92810767T patent/ES2095444T3/en not_active Expired - Lifetime
- 1992-10-08 EP EP92810767A patent/EP0538193B1/en not_active Expired - Lifetime
- 1992-10-14 NZ NZ244725A patent/NZ244725A/en not_active IP Right Cessation
- 1992-10-14 CA CA002080545A patent/CA2080545C/en not_active Expired - Fee Related
- 1992-10-14 AU AU27040/92A patent/AU658931B2/en not_active Ceased
- 1992-10-14 FI FI924650A patent/FI112212B/en active
- 1992-10-14 HU HU9203234A patent/HU226954B1/en unknown
- 1992-10-15 IL IL103448A patent/IL103448A/en not_active IP Right Cessation
- 1992-10-15 NO NO924001A patent/NO178108C/en not_active IP Right Cessation
- 1992-10-15 MX MX9205934A patent/MX9205934A/en not_active IP Right Cessation
- 1992-10-15 KR KR1019920018941A patent/KR100265307B1/en not_active IP Right Cessation
- 1992-10-15 ZA ZA927957A patent/ZA927957B/en unknown
- 1992-10-16 CZ CS923152A patent/CZ279601B6/en not_active IP Right Cessation
- 1992-10-16 SK SK3152-92A patent/SK279938B6/en not_active IP Right Cessation
-
1993
- 1993-03-10 SA SA93130417A patent/SA93130417B1/en unknown
-
1996
- 1996-12-05 GR GR960402936T patent/GR3021903T3/en unknown
-
1998
- 1998-04-01 HK HK98102729A patent/HK1005023A1/en not_active IP Right Cessation
-
1999
- 1999-02-03 CY CY9900005A patent/CY2127B1/en unknown
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