DK0538193T3 - Condensed cycloaliphatic amidinohydrazone salts as inhibitors of S-adenosylmethionine decarboxylase - Google Patents

Condensed cycloaliphatic amidinohydrazone salts as inhibitors of S-adenosylmethionine decarboxylase

Info

Publication number
DK0538193T3
DK0538193T3 DK92810767.1T DK92810767T DK0538193T3 DK 0538193 T3 DK0538193 T3 DK 0538193T3 DK 92810767 T DK92810767 T DK 92810767T DK 0538193 T3 DK0538193 T3 DK 0538193T3
Authority
DK
Denmark
Prior art keywords
acids
acid
unsubstituted
substituted
apart
Prior art date
Application number
DK92810767.1T
Other languages
Danish (da)
Inventor
Joerg Dr Frei
Jaroslav Dr Stanek
Giorgio Dr Caravatti
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Application granted granted Critical
Publication of DK0538193T3 publication Critical patent/DK0538193T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cereal-Derived Products (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to acid addition salts of bases of the formula I <IMAGE> in which A, R1, R2, R3, R4, R5, X and Z have the meanings given in the description, with an acid [PA], which denotes a mono- or polybasic acid selected from carbonic acid, alkanoic acids which are unsubstituted or monosubstituted to polysubstituted, apart from formic acid, unsubstituted acetic acid, lysine and arginine; alkenoic acids which are unsubstituted or substituted, apart from unsubstituted fumaric acid, cycloalkylcarboxylic acids, arylcarboxylic acids, aryl-lower alkylcarboxylic acids in which lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkanesulphonic acids which are unsubstituted or substituted, apart from unsubstituted methanesulphonic acid, aromatic sulphonic acids, alkylsulphuric acids, N-substituted sulphamic acids, organic acids without carboxyl, sulpho, sulphate or phospho groups, and further from pyrophosphoric acid and hydrogen iodide; and tautomers thereof. The acid addition salts are employed for the treatment of disorders which respond to inhibition of S-adenosylmethionine decarboxylase.
DK92810767.1T 1991-10-16 1992-10-08 Condensed cycloaliphatic amidinohydrazone salts as inhibitors of S-adenosylmethionine decarboxylase DK0538193T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH304191 1991-10-16

Publications (1)

Publication Number Publication Date
DK0538193T3 true DK0538193T3 (en) 1996-12-23

Family

ID=4247296

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92810767.1T DK0538193T3 (en) 1991-10-16 1992-10-08 Condensed cycloaliphatic amidinohydrazone salts as inhibitors of S-adenosylmethionine decarboxylase

Country Status (24)

Country Link
EP (1) EP0538193B1 (en)
JP (1) JP2788579B2 (en)
KR (1) KR100265307B1 (en)
AT (1) ATE145896T1 (en)
AU (1) AU658931B2 (en)
CA (1) CA2080545C (en)
CY (1) CY2127B1 (en)
CZ (1) CZ279601B6 (en)
DE (1) DE59207617D1 (en)
DK (1) DK0538193T3 (en)
ES (1) ES2095444T3 (en)
FI (1) FI112212B (en)
GR (1) GR3021903T3 (en)
HK (1) HK1005023A1 (en)
HU (1) HU226954B1 (en)
IL (1) IL103448A (en)
MX (1) MX9205934A (en)
NO (1) NO178108C (en)
NZ (1) NZ244725A (en)
RU (1) RU2081108C1 (en)
SA (1) SA93130417B1 (en)
SG (1) SG43185A1 (en)
SK (1) SK279938B6 (en)
ZA (1) ZA927957B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103166B1 (en) * 1992-08-26 1998-04-01 Ciba Geigy Ag PROCEDURE FOR OBTAINING BICYCLE AMIDINOHYDRAZONES.
ATE278676T1 (en) * 1995-01-26 2004-10-15 Novartis Pharma Gmbh IMDAZOLE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS
EP1483231A1 (en) * 2002-03-04 2004-12-08 Boehringer Ingelheim Pharma GmbH & Co.KG Novel cinnamate salts, method for production and use thereof as medicaments
GT200600316A (en) * 2005-07-20 2007-04-02 SALTS OF 4-METHYL-N- (3- (4-METHYL-IMIDAZOL-1-ILO) -5-TRIFLUOROMETILO-PHENYL) -3- (4-PIRIDINA-3-ILO-PIRIMIDINA-2-ILOAMINO) - BENZAMIDA.
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones

Also Published As

Publication number Publication date
NO924001L (en) 1993-04-19
SG43185A1 (en) 1997-10-17
EP0538193B1 (en) 1996-12-04
SA93130417B1 (en) 2005-11-12
ZA927957B (en) 1993-04-26
AU658931B2 (en) 1995-05-04
NO178108C (en) 1996-01-24
FI112212B (en) 2003-11-14
CY2127B1 (en) 2002-06-21
FI924650A (en) 1993-04-17
AU2704092A (en) 1993-04-22
KR100265307B1 (en) 2000-09-15
RU2081108C1 (en) 1997-06-10
NO924001D0 (en) 1992-10-15
HU9203234D0 (en) 1992-12-28
FI924650A0 (en) 1992-10-14
HUT63149A (en) 1993-07-28
JPH05239011A (en) 1993-09-17
EP0538193A2 (en) 1993-04-21
NZ244725A (en) 1995-05-26
MX9205934A (en) 1993-04-01
CA2080545A1 (en) 1993-04-17
ATE145896T1 (en) 1996-12-15
GR3021903T3 (en) 1997-03-31
HK1005023A1 (en) 1998-12-18
ES2095444T3 (en) 1997-02-16
EP0538193A3 (en) 1993-06-16
SK315292A3 (en) 1995-04-12
IL103448A0 (en) 1993-03-15
IL103448A (en) 1998-01-04
JP2788579B2 (en) 1998-08-20
CA2080545C (en) 2005-11-29
KR930007896A (en) 1993-05-20
CZ315292A3 (en) 1993-05-12
HU226954B1 (en) 2010-03-29
CZ279601B6 (en) 1995-05-17
NO178108B (en) 1995-10-16
DE59207617D1 (en) 1997-01-16
SK279938B6 (en) 1999-06-11

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