ES2095444T3 - Sales condensadas cicloalifaticas de amidinohidrazona como inhibidores de la s-adenosilmeltionina de carboxilasa. - Google Patents

Sales condensadas cicloalifaticas de amidinohidrazona como inhibidores de la s-adenosilmeltionina de carboxilasa.

Info

Publication number
ES2095444T3
ES2095444T3 ES92810767T ES92810767T ES2095444T3 ES 2095444 T3 ES2095444 T3 ES 2095444T3 ES 92810767 T ES92810767 T ES 92810767T ES 92810767 T ES92810767 T ES 92810767T ES 2095444 T3 ES2095444 T3 ES 2095444T3
Authority
ES
Spain
Prior art keywords
acids
acid
unsubstituted
substituted
apart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92810767T
Other languages
English (en)
Inventor
Jaroslav Dr Stanek
Jorg Dr Frei
Giorgio Dr Caravatti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2095444T3 publication Critical patent/ES2095444T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Cereal-Derived Products (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION CONCIERNE A SALES DE ADICION DE ACIDOS DE BASES DE LA FORMULA I, DONDE A, R1, R2, R3, R4, R5, X Y Z TIENEN EL SIGNIFICADO DADO EN LA DESCRIPCION, CON UN ACIDO [PA], EL CUAL EQUIVALE A UN ACIDO DE UNO O MAS PROTONES, ESCOGIDO ENTRE ACIDO CARBONICO, ACIDOS ALCANICOS, QUE ESTAN INSUSTITUIDOS O SUSTITUIDOS UNA O MAS VECES, EXCEPTO EL ACIDO FORMICO, ACIDO ACETICO INSUSTITUIDO, LISINA Y ARGININA; ACIDOS ALCANICOS QUE ESTAN INSUSTITUIDOS O SUSTITUIDOS, EXCEPTO EL ACIDO FUMARICO INSUSTITUIDO, ACIDOS CICLOALQUILOCABOXILICOS, ACIDOS ARILCARBOXILICOS, ACIDOS ARILALQUILO-BAJO-CARBOXILICO, DONDE EL ALQUILO BAJO ESTA INSUSTITUIDO O SUSTITUIDO, ACIDOS ARILALQUENIL-BAJO-CARBOXILICOS, ACIDOS HETEROCICLOCARBOXILICOS, ACIDOS ALCANSULFONICOS, QUE ESTAN INSUSTITUIDOS O SUSTITUIDOS, EXCEPTO ACIDO METANOSULFONICO INSUSTITUIDO, ACIDOS SULFONICOS AROMATICOS, ACIDOS ALQUILSULFURICOS, ACIDOS SULFAMINICOS N SUSTITUIDOS, ACIDOS ORGANICOS SIN GRUPOS CARBOXI, SULFO, SULFATO O FOSFATO, Y ADEMAS DE ACIDO PIROFOSFORICO Y YODHIDRICO; Y LOS TAUTOMEROS DE ELLOS. LAS SALES ACIDAS DE ADICION, SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES QUE REACCIONAN ANTE LA INHIBICION DE LA S ADENOSILMETIONINADECARBOXILASA.
ES92810767T 1991-10-16 1992-10-08 Sales condensadas cicloalifaticas de amidinohidrazona como inhibidores de la s-adenosilmeltionina de carboxilasa. Expired - Lifetime ES2095444T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH304191 1991-10-16

Publications (1)

Publication Number Publication Date
ES2095444T3 true ES2095444T3 (es) 1997-02-16

Family

ID=4247296

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92810767T Expired - Lifetime ES2095444T3 (es) 1991-10-16 1992-10-08 Sales condensadas cicloalifaticas de amidinohidrazona como inhibidores de la s-adenosilmeltionina de carboxilasa.

Country Status (24)

Country Link
EP (1) EP0538193B1 (es)
JP (1) JP2788579B2 (es)
KR (1) KR100265307B1 (es)
AT (1) ATE145896T1 (es)
AU (1) AU658931B2 (es)
CA (1) CA2080545C (es)
CY (1) CY2127B1 (es)
CZ (1) CZ279601B6 (es)
DE (1) DE59207617D1 (es)
DK (1) DK0538193T3 (es)
ES (1) ES2095444T3 (es)
FI (1) FI112212B (es)
GR (1) GR3021903T3 (es)
HK (1) HK1005023A1 (es)
HU (1) HU226954B1 (es)
IL (1) IL103448A (es)
MX (1) MX9205934A (es)
NO (1) NO178108C (es)
NZ (1) NZ244725A (es)
RU (1) RU2081108C1 (es)
SA (1) SA93130417B1 (es)
SG (1) SG43185A1 (es)
SK (1) SK279938B6 (es)
ZA (1) ZA927957B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103166B1 (es) * 1992-08-26 1998-04-01 Ciba Geigy Ag Procedimiento para la obtencion de amidinohidrazonas biciclicas.
JP3989543B2 (ja) * 1995-01-26 2007-10-10 ノバルティス・アクチエンゲゼルシャフト イミダゾール誘導体、その製造およびｓ−アデノシルメチオニンデカルボキシラーゼ（＝ｓａｍｄｃ）阻害剤としてのその使用
WO2003074469A1 (de) * 2002-03-04 2003-09-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue zimtsäuresalze, verfahren zu deren herstellung und deren verwendung als arzneimittel
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones

Also Published As

Publication number Publication date
HUT63149A (en) 1993-07-28
AU658931B2 (en) 1995-05-04
CA2080545A1 (en) 1993-04-17
HK1005023A1 (en) 1998-12-18
ZA927957B (en) 1993-04-26
MX9205934A (es) 1993-04-01
DE59207617D1 (de) 1997-01-16
HU9203234D0 (en) 1992-12-28
IL103448A0 (en) 1993-03-15
DK0538193T3 (da) 1996-12-23
CZ315292A3 (en) 1993-05-12
AU2704092A (en) 1993-04-22
ATE145896T1 (de) 1996-12-15
HU226954B1 (en) 2010-03-29
FI924650A0 (fi) 1992-10-14
EP0538193A3 (en) 1993-06-16
JPH05239011A (ja) 1993-09-17
SA93130417B1 (ar) 2005-11-12
KR100265307B1 (ko) 2000-09-15
EP0538193B1 (de) 1996-12-04
SK279938B6 (sk) 1999-06-11
FI924650A (fi) 1993-04-17
CA2080545C (en) 2005-11-29
JP2788579B2 (ja) 1998-08-20
KR930007896A (ko) 1993-05-20
FI112212B (fi) 2003-11-14
IL103448A (en) 1998-01-04
SK315292A3 (en) 1995-04-12
NZ244725A (en) 1995-05-26
SG43185A1 (en) 1997-10-17
RU2081108C1 (ru) 1997-06-10
CZ279601B6 (cs) 1995-05-17
NO178108B (no) 1995-10-16
GR3021903T3 (en) 1997-03-31
CY2127B1 (en) 2002-06-21
NO924001D0 (no) 1992-10-15
NO924001L (no) 1993-04-19
NO178108C (no) 1996-01-24
EP0538193A2 (de) 1993-04-21

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