ES2112421T3 - Nuevos farmacos a base de fosfolipidos acilados. - Google Patents
Nuevos farmacos a base de fosfolipidos acilados.Info
- Publication number
- ES2112421T3 ES2112421T3 ES93912305T ES93912305T ES2112421T3 ES 2112421 T3 ES2112421 T3 ES 2112421T3 ES 93912305 T ES93912305 T ES 93912305T ES 93912305 T ES93912305 T ES 93912305T ES 2112421 T3 ES2112421 T3 ES 2112421T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- hydrogen
- hydrocarbyl
- chain
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003904 phospholipids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002327 glycerophospholipids Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA INVENCION DESCRIBE UN COMPONENTE QUE TIENE LA FORMULA (A) O SALES DE ELLO ACEPTABLES FARMACEUTICAMENTE, EN DONDE UNO DE R1 Y R2 ES UN GRUPO ACILO DE ACIDO GRASO HETEROATOMO QUE TIENE 13-14 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 18 ATOMOS DE CARBONOS, MIENTRAS EL OTRO ES HIDROGENO, UN HETEROATOMO DE GRUPO ACILO DE ACIDO GRASO QUE CONTIENE DE 13-14 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 18 ATOMOS DE CARBONO O UN GRUPO ACIL DE UN ACIDO GRASO QUE CONTIENE 4-26 ATOMOS DE CARBONO EN LA CADENA PRINCIPAL Y HASTA UN TOTAL DE 30 ATOMOS DE CARBONO Y R ES UN CARACTERISTICO GRUPO POLAR QUE SE ORIGINA NATURALMENTE DE UN GLICEROLFOSFOLIPIDO AISLADO DE ORIGEN ENDOGENO. ESTA INVENCION TAMBIEN DESCRIBE LA APLICACION DE LOS COMPONENTES DE LA PRESENTE INVENCION PARA EVITAR LAS INFECCIONES DE RETROVIRUS Y PARA EL TRATAMIENTO DE AIDS O ENFERMEDADES RELACIONADAS A AIDS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/869,697 US6602861B1 (en) | 1992-04-16 | 1992-04-16 | Acylated phospholipid drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2112421T3 true ES2112421T3 (es) | 1998-04-01 |
Family
ID=25354097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93912305T Expired - Lifetime ES2112421T3 (es) | 1992-04-16 | 1993-04-16 | Nuevos farmacos a base de fosfolipidos acilados. |
Country Status (7)
Country | Link |
---|---|
US (2) | US6602861B1 (es) |
EP (1) | EP0636134B1 (es) |
AT (1) | ATE161261T1 (es) |
CA (1) | CA2133444A1 (es) |
DE (1) | DE69315827T2 (es) |
ES (1) | ES2112421T3 (es) |
WO (1) | WO1993021191A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5599947A (en) * | 1993-01-14 | 1997-02-04 | G. D. Searle & Co. | Fatty acid analogs and prodrugs |
US5859052A (en) * | 1993-01-14 | 1999-01-12 | G. D. Searle & Co. | Fatty acid analogs and prodrugs |
US5962437A (en) | 1994-08-29 | 1999-10-05 | Wake Forest University | Lipid analogs for treating viral infections |
US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
US6350472B1 (en) * | 1998-12-14 | 2002-02-26 | Steinbach, Pylant, And Hermann, L.L.C. | Method of treating HIV infection with transdermal gel containing mammalian liver extract |
AU2503900A (en) | 1999-01-15 | 2000-08-01 | Board Of Trustees Of The University Of Illinois, The | Sulfated phosphatidylinositols, their preparation and use |
US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
NO328803B1 (no) | 2000-03-03 | 2010-05-18 | Thia Medica | Nye fettsyreanaloger |
US7659240B2 (en) * | 2002-01-14 | 2010-02-09 | Vertex Pharmaceuticals Incorporated | Mucin immobilized chromatography |
CN100351259C (zh) | 2002-06-20 | 2007-11-28 | Icvec有限公司 | 含硫的磷脂衍生物 |
CA2514126A1 (en) * | 2003-01-22 | 2004-08-05 | Encore Pharmaceuticals, Inc. | Fat substitutes |
EP2242495A2 (en) * | 2008-01-16 | 2010-10-27 | Technion Research and Development Foundation, Ltd. | Use of antimicrobial polymers for re-sensitization of microorganisms upon emergence of resistance to anti-microbial agents |
WO2011016043A2 (en) | 2009-08-06 | 2011-02-10 | Technion Research & Development Foundation Ltd. | Antibiotic drug delivery and potentiation |
BR112018077350A2 (pt) * | 2016-06-29 | 2019-04-09 | Machavert Pharmaceuticals Llc | composições de fosfolipídio |
WO2019208392A1 (ja) * | 2018-04-27 | 2019-10-31 | 株式会社レオロジー機能食品研究所 | 新規プラズマローゲン誘導体 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4471113A (en) | 1982-02-03 | 1984-09-11 | The United States Of America As Represented By The Department Of Energy | Prodrugs based on phospholipid-nucleoside conjugates |
US5059591B1 (en) | 1983-05-26 | 2000-04-25 | Liposome Co Inc | Drug preparations of reduced toxicity |
JPS608948A (ja) * | 1983-06-29 | 1985-01-17 | Fujitsu Ltd | 動作モ−ド検査方式 |
US4594193A (en) * | 1984-09-26 | 1986-06-10 | Research Corporation | Thiol based lipids and membranes made therefrom |
US4569794A (en) | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
US4772475A (en) * | 1985-03-08 | 1988-09-20 | Yamanouchi Pharmaceutical Co., Ltd. | Controlled-release multiple units pharmaceutical formulation |
JPH068302B2 (ja) | 1986-03-04 | 1994-02-02 | 財団法人生産開発科学研究所 | 重合性リン脂質化合物 |
DE3638687A1 (de) * | 1986-11-13 | 1988-05-19 | Lentia Gmbh | Einstufiges verfahren zur herstellung von gemischt substituierten 1,2-di-acyl-sn-glycero-3-phosphocholinen |
IL84387A0 (en) | 1987-11-06 | 1990-02-09 | Rapaport Erich | Pharmaceutical compositions containing a substituted phosphatide |
US5151445A (en) | 1988-02-03 | 1992-09-29 | Washington University | Method of inhibiting parasitic activity |
US4931498A (en) | 1988-02-25 | 1990-06-05 | Purdue Research Foundation | Immobilized artificial membranes |
US4927879A (en) | 1988-02-25 | 1990-05-22 | Purdue Research Foundation | Method for solid phase membrane mimetics |
US5073571A (en) | 1988-06-16 | 1991-12-17 | Washington University | Method of inhibiting virus |
US5082967A (en) | 1988-06-16 | 1992-01-21 | Washington University | Novel fatty acid analog enzyme substrates |
DE3929217A1 (de) | 1989-09-02 | 1991-03-07 | Boehringer Mannheim Gmbh | Verwendung von phospholipid-derivaten als antivirale arzneimittel und neue phospholipide |
SE463789B (sv) | 1990-03-27 | 1991-01-21 | Henrik Gerhard Renvall | Saett att registrera, oeverfoera och lagra information med hjaelp av streckkoder |
US5149527A (en) * | 1990-09-18 | 1992-09-22 | Oncotech, Inc. | Immunopotentiating protocol for chemotherapy-responsive tumors |
-
1992
- 1992-04-16 US US07/869,697 patent/US6602861B1/en not_active Expired - Fee Related
-
1993
- 1993-04-16 WO PCT/US1993/003650 patent/WO1993021191A1/en active IP Right Grant
- 1993-04-16 DE DE69315827T patent/DE69315827T2/de not_active Expired - Fee Related
- 1993-04-16 EP EP93912305A patent/EP0636134B1/en not_active Expired - Lifetime
- 1993-04-16 ES ES93912305T patent/ES2112421T3/es not_active Expired - Lifetime
- 1993-04-16 AT AT93912305T patent/ATE161261T1/de not_active IP Right Cessation
- 1993-04-16 CA CA002133444A patent/CA2133444A1/en not_active Abandoned
-
1995
- 1995-06-06 US US08/469,312 patent/US5846955A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69315827T2 (de) | 1998-07-16 |
US5846955A (en) | 1998-12-08 |
WO1993021191A1 (en) | 1993-10-28 |
ATE161261T1 (de) | 1998-01-15 |
DE69315827D1 (de) | 1998-01-29 |
EP0636134B1 (en) | 1997-12-17 |
EP0636134A1 (en) | 1995-02-01 |
US6602861B1 (en) | 2003-08-05 |
CA2133444A1 (en) | 1993-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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