FI112212B - Menetelmä aminoindanonien lääkeaineina käyttökelpoisten happoadditiosuolojen valmistamiseksi - Google Patents

Menetelmä aminoindanonien lääkeaineina käyttökelpoisten happoadditiosuolojen valmistamiseksi Download PDF

Info

Publication number
FI112212B
FI112212B FI924650A FI924650A FI112212B FI 112212 B FI112212 B FI 112212B FI 924650 A FI924650 A FI 924650A FI 924650 A FI924650 A FI 924650A FI 112212 B FI112212 B FI 112212B
Authority
FI
Finland
Prior art keywords
acid
formula
acids
acid addition
indanone
Prior art date
Application number
FI924650A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924650A0 (fi
FI924650A (fi
Inventor
Jaroslav Stanek
Joerg Frei
Giorgio Caravatti
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI924650A0 publication Critical patent/FI924650A0/fi
Publication of FI924650A publication Critical patent/FI924650A/fi
Application granted granted Critical
Publication of FI112212B publication Critical patent/FI112212B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Detergent Compositions (AREA)
  • Cereal-Derived Products (AREA)
  • Cosmetics (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
FI924650A 1991-10-16 1992-10-14 Menetelmä aminoindanonien lääkeaineina käyttökelpoisten happoadditiosuolojen valmistamiseksi FI112212B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH304191 1991-10-16
CH304191 1991-10-16

Publications (3)

Publication Number Publication Date
FI924650A0 FI924650A0 (fi) 1992-10-14
FI924650A FI924650A (fi) 1993-04-17
FI112212B true FI112212B (fi) 2003-11-14

Family

ID=4247296

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924650A FI112212B (fi) 1991-10-16 1992-10-14 Menetelmä aminoindanonien lääkeaineina käyttökelpoisten happoadditiosuolojen valmistamiseksi

Country Status (24)

Country Link
EP (1) EP0538193B1 (es)
JP (1) JP2788579B2 (es)
KR (1) KR100265307B1 (es)
AT (1) ATE145896T1 (es)
AU (1) AU658931B2 (es)
CA (1) CA2080545C (es)
CY (1) CY2127B1 (es)
CZ (1) CZ279601B6 (es)
DE (1) DE59207617D1 (es)
DK (1) DK0538193T3 (es)
ES (1) ES2095444T3 (es)
FI (1) FI112212B (es)
GR (1) GR3021903T3 (es)
HK (1) HK1005023A1 (es)
HU (1) HU226954B1 (es)
IL (1) IL103448A (es)
MX (1) MX9205934A (es)
NO (1) NO178108C (es)
NZ (1) NZ244725A (es)
RU (1) RU2081108C1 (es)
SA (1) SA93130417B1 (es)
SG (1) SG43185A1 (es)
SK (1) SK279938B6 (es)
ZA (1) ZA927957B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2103166B1 (es) * 1992-08-26 1998-04-01 Ciba Geigy Ag Procedimiento para la obtencion de amidinohidrazonas biciclicas.
CA2210533C (en) * 1995-01-26 2007-12-04 Novartis Ag Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors
AU2003221482A1 (en) * 2002-03-04 2003-09-16 Boehringer Ingelheim Pharma Gmbh And Co. Kg Novel cinnamate salts, method for production and use thereof as medicaments
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1884515A1 (en) 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones

Also Published As

Publication number Publication date
FI924650A0 (fi) 1992-10-14
IL103448A (en) 1998-01-04
EP0538193A2 (de) 1993-04-21
IL103448A0 (en) 1993-03-15
RU2081108C1 (ru) 1997-06-10
HUT63149A (en) 1993-07-28
EP0538193B1 (de) 1996-12-04
NO178108C (no) 1996-01-24
DK0538193T3 (da) 1996-12-23
CA2080545A1 (en) 1993-04-17
NO924001D0 (no) 1992-10-15
KR930007896A (ko) 1993-05-20
MX9205934A (es) 1993-04-01
ES2095444T3 (es) 1997-02-16
NO924001L (no) 1993-04-19
ZA927957B (en) 1993-04-26
ATE145896T1 (de) 1996-12-15
SK315292A3 (en) 1995-04-12
HU226954B1 (en) 2010-03-29
GR3021903T3 (en) 1997-03-31
DE59207617D1 (de) 1997-01-16
SA93130417B1 (ar) 2005-11-12
NO178108B (no) 1995-10-16
HU9203234D0 (en) 1992-12-28
AU658931B2 (en) 1995-05-04
NZ244725A (en) 1995-05-26
CA2080545C (en) 2005-11-29
FI924650A (fi) 1993-04-17
AU2704092A (en) 1993-04-22
SK279938B6 (sk) 1999-06-11
KR100265307B1 (ko) 2000-09-15
CY2127B1 (en) 2002-06-21
SG43185A1 (en) 1997-10-17
EP0538193A3 (en) 1993-06-16
CZ279601B6 (cs) 1995-05-17
HK1005023A1 (en) 1998-12-18
JPH05239011A (ja) 1993-09-17
JP2788579B2 (ja) 1998-08-20
CZ315292A3 (en) 1993-05-12

Similar Documents

Publication Publication Date Title
US5461076A (en) Hydrazones
US4971986A (en) Arylhydrazones useful as SAMDC inhibitors
HU208811B (en) Process for producton of biaryl-compounds and pharmaceutical compositions comprising them as medical agent
CA2202578A1 (en) Hydroxypyridine derivatives, their production and use
FI107916B (fi) Menetelmä hydratsonijohdannaisten valmistamiseksi
FI112212B (fi) Menetelmä aminoindanonien lääkeaineina käyttökelpoisten happoadditiosuolojen valmistamiseksi
EP2543661B1 (en) Guanylhydrazone compounds, compositions, methods of making and using
US5238941A (en) Arylhydrazones and pharmaceutical compositions thereof
AU2002254911B2 (en) Bicyclic guanidine derivatives and therapeutics uses thereof
US4794122A (en) Novel benzimidazolyl-thiomethyl-benzothiazoles
US8742120B2 (en) Methods of preparing factor xa inhibitors and salts thereof
JPS6016975A (ja) 双環性化合物のn−イミダゾリル誘導体およびそれらの製造法
FI113168B (fi) Menetelmä bisyklisten amidinohydratsonien valmistamiseksi ja menetelmässä käyttökelpoinen välituote
JP2002509134A (ja) トリアゼピノン、その製造方法および治療への利用
PL165358B1 (pl) Sposób wytwarzania nowego 5-[4-(2-metyloimidazo[4,3-c]pirydylo-1)fenylo]-1,8-dwumetylo-3-(pirydylo-3)-1, 6 , 7, 8 -tetrahydropirazolo[3,4-b][1,4]-diazepinonu-7 PL

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: NOVARTIS AG