ES8600243A1 - Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina - Google Patents

Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina

Info

Publication number
ES8600243A1
ES8600243A1 ES527894A ES527894A ES8600243A1 ES 8600243 A1 ES8600243 A1 ES 8600243A1 ES 527894 A ES527894 A ES 527894A ES 527894 A ES527894 A ES 527894A ES 8600243 A1 ES8600243 A1 ES 8600243A1
Authority
ES
Spain
Prior art keywords
radical
lower alkyl
compounds
denotes
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527894A
Other languages
English (en)
Other versions
ES527894A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES527894A0 publication Critical patent/ES527894A0/es
Publication of ES8600243A1 publication Critical patent/ES8600243A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE 2-HIDROXIMETIL-3-CARBAMOIL-1,4-DIHIDROPIRIDINA.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA H-AM, PARA OBTENER UN COMPUESTO DE 2-HIDROXIMETIL-3-CARBAMOIL-1,4-DIHIDROPIRIDINA DE FORMULA (I), DONDE R SIGNIFICA UN RESTO ARILO CARBOCICLICO O HETEROCICLICO; R1 SIGNIFICA H O ALQUILO INFERIOR INSUSTITUIDO O SUSTITUIDO; R2 SIGNIFICA H, ALQUILO INFERIOR O ALQUILO INFERIOR CONTENIENDO HIDROXI LIBRE; AC REPRESENTA EL RESTO ACILO DE UN ACIDO; Y AM SIGNIFICA UN GRUPO AMINO INSUSTITUIDO O MONOSUSTITUIDO.TIENEN APLICACIONES FARMACEUTICAS EN EL TERRENO CARDIOVASCULAR POR ACTUAR COMO DILATADORES DE LA CORONARIA.
ES527894A 1982-12-10 1983-12-07 Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina Expired ES8600243A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH721282 1982-12-10
CH164383 1983-03-25

Publications (2)

Publication Number Publication Date
ES527894A0 ES527894A0 (es) 1985-10-01
ES8600243A1 true ES8600243A1 (es) 1985-10-01

Family

ID=25688250

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527894A Expired ES8600243A1 (es) 1982-12-10 1983-12-07 Procedimiento para la obtencion de compuestos de 2-hidroximetil-3-carbamoil-1,4-dihidropiridina

Country Status (5)

Country Link
EP (1) EP0111453A1 (es)
AU (1) AU2227483A (es)
DK (1) DK567983A (es)
ES (1) ES8600243A1 (es)
FI (1) FI834473A (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145956A1 (de) * 1983-11-16 1985-06-26 Ciba-Geigy Ag Neue Amid-Verbindungen
DE3412947A1 (de) * 1984-04-06 1985-10-17 Bayer Ag, 5090 Leverkusen Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS61293972A (ja) * 1985-06-24 1986-12-24 Nisshin Flour Milling Co Ltd １，４−ジヒドロピリジンスルホン誘導体およびその製法
JPS62174050A (ja) * 1985-10-21 1987-07-30 Nippon Shoji Kk ３−アミノカルボニル−１，４−ジヒドロピリジン−５−カルボン酸誘導体、その製法および医薬組成物
DE3544693A1 (de) * 1985-12-18 1987-06-19 Bayer Ag 4-thienyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3545347A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 1-aryl-pyrazole
US5162338A (en) * 1986-01-11 1992-11-10 Bayer Aktiengesellschaft Circulation active 4-aminoaryldihydropryidine lactones
DE3600596A1 (de) * 1986-01-11 1987-07-16 Bayer Ag 4-aminoaryldihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3601397A1 (de) * 1986-01-18 1987-07-23 Bayer Ag Substituierte 1,4-dihydropyridin-3-carbonsaeurepiperazide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
GB8620880D0 (en) * 1986-08-29 1986-10-08 Pfizer Ltd Therapeutic agents
DE3711991A1 (de) * 1987-04-09 1988-10-20 Bayer Ag Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
EP1307453A2 (en) * 2000-08-02 2003-05-07 Abbott Laboratories Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
US20090012103A1 (en) 2007-07-05 2009-01-08 Matthew Abelman Substituted heterocyclic compounds
WO2009006580A1 (en) * 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2228377A1 (de) * 1972-06-10 1974-01-03 Bayer Ag Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
FR2508446B1 (fr) * 1981-06-25 1986-05-02 Rhone Poulenc Agrochimie Herbicides a fonctions amide et ester derives de la pyridine ainsi que leur procede de preparation et leur application
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
US4497808A (en) * 1981-12-30 1985-02-05 Ciba-Geigy Corporation N-Oxide compounds useful in the treatment of cardiovascular ailments

Also Published As

Publication number Publication date
DK567983D0 (da) 1983-12-09
EP0111453A1 (de) 1984-06-20
DK567983A (da) 1984-06-11
ES527894A0 (es) 1985-10-01
FI834473A0 (fi) 1983-12-07
AU2227483A (en) 1984-06-14
FI834473A (fi) 1984-06-11

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