HK1003623A1 - Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine - Google Patents

Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine

Info

Publication number
HK1003623A1
HK1003623A1 HK98103016A HK98103016A HK1003623A1 HK 1003623 A1 HK1003623 A1 HK 1003623A1 HK 98103016 A HK98103016 A HK 98103016A HK 98103016 A HK98103016 A HK 98103016A HK 1003623 A1 HK1003623 A1 HK 1003623A1
Authority
HK
Hong Kong
Prior art keywords
cytokine
tri
certain
compounds useful
imidazole compounds
Prior art date
Application number
HK98103016A
Other languages
English (en)
Inventor
Jerry Leroy Adams
Timothy F Gallagher
Jeffrey Charles Boehm
Ravi Shanker Garigipati
Joseph Sisko
Zhi-Qiang Peng
John Cheung-Lun Lee
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of HK1003623A1 publication Critical patent/HK1003623A1/xx

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • General Health & Medical Sciences (AREA)
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  • Diabetes (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
HK98103016A 1995-01-09 1998-04-09 Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine HK1003623A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36996495A 1995-01-09 1995-01-09
US08/472,366 US5593992A (en) 1993-07-16 1995-06-07 Compounds
PCT/US1996/000546 WO1996021452A1 (en) 1995-01-09 1996-01-11 Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine

Publications (1)

Publication Number Publication Date
HK1003623A1 true HK1003623A1 (en) 1999-02-12

Family

ID=27004764

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98103016A HK1003623A1 (en) 1995-01-09 1998-04-09 Certain 1,4,5-tri-substituted imidazole compounds useful as cytokine

Country Status (34)

Country Link
US (5) US5593992A (de)
EP (2) EP0809499B1 (de)
JP (2) JP3330952B2 (de)
CN (1) CN1138546C (de)
AP (1) AP1270A (de)
AR (1) AR002267A1 (de)
AT (1) ATE254613T1 (de)
AU (1) AU705207C (de)
BG (1) BG63769B1 (de)
BR (1) BR9606904A (de)
CA (1) CA2209938A1 (de)
CZ (1) CZ215897A3 (de)
DE (1) DE69630777T2 (de)
DK (1) DK0809499T3 (de)
DZ (1) DZ1961A1 (de)
ES (1) ES2210348T3 (de)
FI (1) FI972901A (de)
HK (1) HK1003623A1 (de)
HU (1) HUP9702409A3 (de)
ID (3) ID23599A (de)
IL (7) IL134323A (de)
IN (3) IN184957B (de)
MA (1) MA23770A1 (de)
MX (1) MX9705142A (de)
NO (3) NO973167L (de)
NZ (1) NZ301204A (de)
OA (1) OA10738A (de)
PL (1) PL322249A1 (de)
PT (1) PT809499E (de)
RU (2) RU2196139C2 (de)
SI (1) SI0809499T1 (de)
SK (1) SK90297A3 (de)
TW (1) TW523511B (de)
WO (1) WO1996021452A1 (de)

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