GR880100868A - Μέ?οδος παρασκευής νέων παραγώγων 17βητα-ΟΗ 19-NOR στεροειδών υποκαταστημένων στήν 17αλφα. - Google Patents

Μέ?οδος παρασκευής νέων παραγώγων 17βητα-ΟΗ 19-NOR στεροειδών υποκαταστημένων στήν 17αλφα.

Info

Publication number
GR880100868A
GR880100868A GR880100868A GR880100868A GR880100868A GR 880100868 A GR880100868 A GR 880100868A GR 880100868 A GR880100868 A GR 880100868A GR 880100868 A GR880100868 A GR 880100868A GR 880100868 A GR880100868 A GR 880100868A
Authority
GR
Greece
Prior art keywords
products
product
19nor
17alpha
substituted
Prior art date
Application number
GR880100868A
Other languages
Greek (el)
English (en)
Inventor
Martine Moguilewsky
Lucien Nedelec
Francois Nique
Daniel Philibert
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8718376A external-priority patent/FR2625505B2/fr
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of GR880100868A publication Critical patent/GR880100868A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR880100868A 1987-12-30 1988-12-29 Μέ?οδος παρασκευής νέων παραγώγων 17βητα-ΟΗ 19-NOR στεροειδών υποκαταστημένων στήν 17αλφα. GR880100868A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8718376A FR2625505B2 (fr) 1981-01-09 1987-12-30 Nouveaux derives steroides substitues en 11beta leur procede de preparation et leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
GR880100868A true GR880100868A (el) 1994-03-31

Family

ID=9358447

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100868A GR880100868A (el) 1987-12-30 1988-12-29 Μέ?οδος παρασκευής νέων παραγώγων 17βητα-ΟΗ 19-NOR στεροειδών υποκαταστημένων στήν 17αλφα.

Country Status (14)

Country Link
US (1) US5006518A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2785023B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT396787B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE1004905A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1303025C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH676852A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3844408C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2012197A6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2213484B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR880100868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1235358B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU87417A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8803196A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE503267C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4042004A1 (de) * 1990-12-22 1992-06-25 Schering Ag 14(beta)-h-, 14- u. 15-en-11(beta)-aryl-4-estrene
EP0496520A1 (en) * 1991-01-22 1992-07-29 Merck & Co. Inc. Novel bone acting agents
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
JP3862295B2 (ja) * 1993-09-30 2006-12-27 独立行政法人理化学研究所 抗肥満剤
EP0683172B1 (en) * 1994-05-19 1997-08-13 Akzo Nobel N.V. 11,21-Bisphenyl-19-norpregnane derivatives
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
JP2001301596A (ja) 2000-04-19 2001-10-31 Sumitomo Denko Brake Systems Kk 車両用液圧ブレーキシステムの制御方法
US20090023914A1 (en) * 2007-05-01 2009-01-22 Alessandro Pontiroli Process for preparing drospirenone and intermediate thereof
PL2576582T3 (pl) 2010-05-26 2020-06-29 Corcept Therapeutics, Inc. Leczenie dystrofii mięśniowej
JP6821582B2 (ja) 2015-03-02 2021-01-27 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用
ES2906778T3 (es) 2015-03-30 2022-04-20 Corcept Therapeutics Inc Uso de antagonistas del receptor de glucocorticoides en combinación con glucocorticoides para tratar la insuficiencia suprarrenal
CA2994422A1 (en) 2015-08-13 2017-02-16 Corcept Therapeutics, Inc. Method for differentially diagnosing acth-dependent cushing's syndrome
US11208432B2 (en) 2015-12-23 2021-12-28 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
WO2017112902A1 (en) 2015-12-23 2017-06-29 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
US11110103B2 (en) 2015-12-23 2021-09-07 Oric Pharmaceuticals, Inc. Inhibitors of glucocorticoid receptor
AU2017210156B2 (en) 2016-01-19 2021-10-28 Corcept Therapeutics, Inc. Differential diagnosis of Ectopic Cushing's Syndrome
CN110099915A (zh) 2016-10-07 2019-08-06 欧瑞克制药公司 糖皮质激素受体抑制剂
RU2019129299A (ru) 2017-03-31 2021-04-30 Корсепт Терапьютикс, Инк. Модуляторы глюкокортикоидного рецептора для лечения рака шейки матки
AU2018289307B2 (en) 2017-06-20 2024-02-01 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
JP2024500748A (ja) 2020-12-18 2024-01-10 インスティル バイオ （ユーケイ） リミテッド 腫瘍浸潤リンパ球の処理

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
EP0057115A2 (fr) * 1981-01-09 1982-08-04 Roussel-Uclaf Nouveaux dérivés stéroides substitués en 11beta, procédé de préparation, leur application comme médicament et les compositions les renfermant

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
EP0110434B1 (fr) * 1981-01-09 1986-10-29 Roussel-Uclaf Nouveaux produits intermédiaires stéroides substitués en 11-beta et procédé de préparation de ces produits
DE3461090D1 (en) * 1983-02-18 1986-12-04 Schering Ag 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
FR2549067B1 (fr) * 1983-06-14 1985-12-27 Roussel Uclaf Derives estradieniques radioactifs marques au tritium, leur procede de preparation et leur application pour l'etude et le dosage radio-immunologique de steroides dans les fluides biologiques
ES533260A0 (es) * 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2566779B2 (fr) * 1984-06-29 1987-03-06 Roussel Uclaf Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
DE3506785A1 (de) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3619413C2 (de) * 1986-06-10 2000-04-06 Schering Ag 9alpha, 10alpha-Methylen-Estrene, deren Herstellung und diese enthaltende pharmazeutische Präparate
DE3625315A1 (de) * 1986-07-25 1988-01-28 Schering Ag 11ss-(4-isopropenylphenyl)-estra-4,9-diene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4774236A (en) * 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
EP0057115A2 (fr) * 1981-01-09 1982-08-04 Roussel-Uclaf Nouveaux dérivés stéroides substitués en 11beta, procédé de préparation, leur application comme médicament et les compositions les renfermant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
ATA318788A (de) 1993-04-15
AT396787B (de) 1993-11-25
CA1303025C (fr) 1992-06-09
GB8830380D0 (en) 1989-03-01
JPH01213296A (ja) 1989-08-28
GB2213484A (en) 1989-08-16
GB2213484B (en) 1991-10-09
ES2012197A6 (es) 1990-03-01
SE8804692D0 (sv) 1988-12-29
LU87417A1 (fr) 1989-06-14
IT1235358B (it) 1992-06-30
BE1004905A4 (fr) 1993-02-23
JP2785023B2 (ja) 1998-08-13
SE8804692L (sv) 1989-07-01
SE503267C2 (sv) 1996-04-29
NL8803196A (nl) 1989-07-17
DE3844408A1 (de) 1989-07-13
CH676852A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1991-03-15
US5006518A (en) 1991-04-09
DE3844408C2 (de) 2001-07-26
IT8848730A0 (it) 1988-12-29

Similar Documents

Publication Publication Date Title
GR880100868A (el) Μέ?οδος παρασκευής νέων παραγώγων 17βητα-ΟΗ 19-NOR στεροειδών υποκαταστημένων στήν 17αλφα.
EP0136011A3 (en) A method of hormonal treatment of peri-menopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor
HUT53359A (en) Process for producing pharmaceutical compositions comprising oxooxazolinidyl cyclopentano benzene derivatives as active ingredient
DE3068412D1 (en) Derivatives of 2,5-disubstituted-cyclohexane-1,3-diones, process for preparation thereof and pharmaceutical composition containing them
DE3380410D1 (en) Derivatives of 9-(2-hydroxyethoxymethyl)guanine
GR3005035T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA19756A1 (uk) Спосіб одержаhhя піперазиhілалкіл-3(2h)піридазиhоhів або їх фармацевтичhо прийhятих солей
IL51586A (en) 3-oxo-17 beta-hydroxy-17 alpha-hydroxypropyl androstane and estrane derivatives,process for their preparation and pharmaceutical preparations containing them
AU634266B2 (en) Cycloalkylene azoles, processes for their production and use,and pharmaceutical preparations obtained therefrom
FI883392A7 (fi) Silybiinin liukoiset johdannaiset, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset.
ES8502076A1 (es) Procedimiento para la preparacion de acido 3b-(3-carboxipropioniloxi)-ursa-9(11),12-dien-28-oico
GB1483650A (en) Pharmaceutical preparations based on mesterolone
NO960425L (no) 15,15-dialkyl-substituerte derivater av östradiol
US3658990A (en) Diuretic compositions
MD776C2 (ro) Complecşi de incluziune a 3-morfolino-sidnoniminei sau a sărurilor ei, sau a izomerului ei tautomeric cu ciclordeătrină, sau cu derivaţii ei, procedeu de obţinere a lor, compoziţii farmaceutice care îi conţin, procedeu de obţinere a lor şi de tratarea a stenocardiei, sau a bolii ischemice
IT8722276A0 (it) Solubili atti alla terapia marziale derivati polipeptidici a elevato procedimenti di preparazione e tenore di ferro e altamente loro forme farmaceutiche.
ES8302735A1 (es) "procedimiento para la preparacion de nuevos compuestos de salificacion de acidos colicos con trimebutina".
ES8503511A1 (es) Medicamento que contiene muzolimina
IL51057A0 (en) Thiadiazolyl derivatives of 7-acylamido-3-cephem-4-carboxylic acid and process for their preparation
ZA796194B (en) New 2,2-dimethyl 19-nor steroid derivatives,process for their preparation,their application as medicaments and pharmaceutical compositions containing them
ES8401929A1 (es) Procedimiento de preparar derivados de p-acilaminofenol.
UA5590A1 (uk) Спосіб одержання пропіленглікового ефіру заміщеної 1,4-дігідропіріділ-5-фосфорної кислоти, або його фармацевтично прийнятной солі або сольвата
ZA784569B (en) Derivatives of 2,6-bisamino-benzo (1,2-d5,4d)bisthiazole,pocesses for their preparation and pharmaceutical compositiions thereof
IL49208A (en) 13,14-dehydro-16-fluoro prostanoic acid derivatives of the f2,a2 and e2 series,process for their preparation and pharmaceutical compositions containing same
GB1459485A (en) Medicament pack for the oral treatment with oestrogen