ES8401929A1 - Procedimiento de preparar derivados de p-acilaminofenol. - Google Patents

Procedimiento de preparar derivados de p-acilaminofenol.

Info

Publication number
ES8401929A1
ES8401929A1 ES516880A ES516880A ES8401929A1 ES 8401929 A1 ES8401929 A1 ES 8401929A1 ES 516880 A ES516880 A ES 516880A ES 516880 A ES516880 A ES 516880A ES 8401929 A1 ES8401929 A1 ES 8401929A1
Authority
ES
Spain
Prior art keywords
derivatives
therapeutical effect
preparation
active ingredients
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516880A
Other languages
English (en)
Other versions
ES516880A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cermol SA
Original Assignee
Cermol SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cermol SA filed Critical Cermol SA
Publication of ES8401929A1 publication Critical patent/ES8401929A1/es
Publication of ES516880A0 publication Critical patent/ES516880A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL P-ACILAMINOFENOL Y DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE N VALE 0-3; R ES HIDROGENO; R1 ES HIDROGENO O METILO; Y R2 Y R3 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DEL COMPUESTO DE FORMULA (II), CON UNA AMINA SECUNDARIA DE FORMULA R2NHR3, EN LAS QUE X ES UN ATOMO DE HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, TAL COMO DIMETILFORMAMIDA O METILETILCETONA, EN PRESENCIA DE UN ACEPTORDE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANALGESICO Y/O ANTIINFLAMATORIO.
ES516880A 1981-11-02 1982-10-27 Procedimiento de preparar derivados de p-acilaminofenol. Granted ES516880A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH700081 1981-11-02
CH250782 1982-04-26

Publications (2)

Publication Number Publication Date
ES8401929A1 true ES8401929A1 (es) 1984-01-16
ES516880A0 ES516880A0 (es) 1984-01-16

Family

ID=25690624

Family Applications (2)

Application Number Title Priority Date Filing Date
ES516880A Granted ES516880A0 (es) 1981-11-02 1982-10-27 Procedimiento de preparar derivados de p-acilaminofenol.
ES526647A Granted ES526647A0 (es) 1981-11-02 1983-10-21 Metodo de preparar derivados de p-acilaminofenol

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526647A Granted ES526647A0 (es) 1981-11-02 1983-10-21 Metodo de preparar derivados de p-acilaminofenol

Country Status (7)

Country Link
US (1) US4532249A (es)
EP (1) EP0078765B1 (es)
CA (1) CA1211105A (es)
DE (1) DE3269449D1 (es)
ES (2) ES516880A0 (es)
GR (1) GR77703B (es)
PT (1) PT75767B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849737A (en) * 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US6166085A (en) * 1995-04-14 2000-12-26 The Regents Of The University Of California Method of producing analgesia
JP2001516335A (ja) * 1996-03-15 2001-09-25 エラン ファーマシューティカルズ，インコーポレイテッド 鎮痛を生じるための方法および組成物
US7718692B2 (en) 2004-02-13 2010-05-18 Carson John R Hetero-substituted acetanilide derivatives as analgesic agents
BRPI0404222A (pt) * 2004-06-07 2006-02-07 Fundacao Oswaldo Cruz Compostos derivados da lidocaìna, composições farmacêuticas contendo os mesmos, uso das respectivas composições farmacêuticas no tratamento, prevenção ou inibição de doenças bem como o método de tratamento, prevenção ou inibição de doenças com as ditas composições farmacêuticas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE940828C (de) * 1953-08-20 1956-03-29 Leo Pharm Prod Ltd Verfahren zur Herstellung von Estern des Penicillins mit Phenolen und Thiophenolen
GB888664A (en) * 1959-02-18 1962-01-31 May & Baker Improvements in or relating to acylamidophenol derivatives
FR2043489B1 (es) * 1969-05-29 1973-07-13 Orsymonde
DE2625195A1 (de) * 1976-06-04 1977-12-22 Hoechst Ag 1-methyl-2-(4-aminophenyl-substit.- methyl)-5-nitro-imidazole und verfahren zu ihrer herstellung
GB1587070A (en) * 1977-06-02 1981-03-25 Sterwin Ag Pharmacologically-active 4-acetamidophenyl a-(2-methyl-ind(en/ol)-3-yl)-acetates processes for their preparation and pharmaceutical composition incorporating them

Also Published As

Publication number Publication date
CA1211105A (fr) 1986-09-09
DE3269449D1 (en) 1986-04-03
EP0078765B1 (fr) 1986-02-26
GR77703B (es) 1984-09-25
EP0078765A1 (fr) 1983-05-11
PT75767A (fr) 1982-11-01
US4532249A (en) 1985-07-30
PT75767B (fr) 1985-07-26
ES8504665A1 (es) 1985-05-16
ES526647A0 (es) 1985-05-16
ES516880A0 (es) 1984-01-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010301