US4842868A
(en)
*
|
1986-09-26 |
1989-06-27 |
Helwing Robert F |
Covalently bonded active agents with carbonium ion base groups
|
US5214132A
(en)
*
|
1986-12-23 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
IE64284B1
(en)
*
|
1987-08-03 |
1995-07-26 |
Ddi Pharmaceuticals |
Conjugates of superoxide dismutase
|
AU611932B2
(en)
*
|
1987-08-21 |
1991-06-27 |
Wellcome Foundation Limited, The |
Novel complex
|
JPH079429B2
(ja)
*
|
1988-10-12 |
1995-02-01 |
財団法人化学及血清療法研究所 |
人工担体およびその製造方法
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
FI901810A7
(fi)
*
|
1989-04-13 |
1990-10-14 |
Vascular Laboratory Inc |
Puhtaan pro-urokinaasin plasminogeeniaktivaattorikompleksi, joka on sidottu ihmisen seerumialbumiiniin disulfidisillan välityksellä
|
WO1991001146A1
(en)
*
|
1989-07-14 |
1991-02-07 |
Praxis Biologics, Inc. |
Cytokine and hormone carriers for conjugate vaccines
|
US5767072A
(en)
*
|
1989-09-14 |
1998-06-16 |
Board Of Regents, The University Of Texas System |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
DK0676965T3
(da)
*
|
1992-11-16 |
2007-11-19 |
Centocor Inc |
Fremgangsmåde til at reducere immunogeniciteten af variable regioner på antistoffer
|
DE69331805T2
(de)
*
|
1992-12-10 |
2002-11-28 |
Enzon, Inc. |
Glycolipid enzym-polymer konjugate
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
DE69430251T2
(de)
*
|
1993-11-10 |
2002-11-07 |
Enzon, Inc. |
Verbesserte interferon-polymerkonjugate
|
US6458762B1
(en)
|
1994-03-28 |
2002-10-01 |
Baxter International, Inc. |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
|
WO1996004340A1
(en)
*
|
1994-08-04 |
1996-02-15 |
Gordon George Wallace |
Conducting electroactive biomaterials
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
US5770577A
(en)
*
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
MX9704137A
(es)
*
|
1994-12-07 |
1997-09-30 |
Novo Nordisk As |
Polipeptidos de alergenicidad reducida.
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
US6428790B1
(en)
*
|
1995-04-27 |
2002-08-06 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
EP2111876B1
(en)
*
|
1995-12-18 |
2011-09-07 |
AngioDevice International GmbH |
Crosslinked polymer compositions and methods for their use
|
US7883693B2
(en)
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
WO1997024421A2
(en)
*
|
1995-12-29 |
1997-07-10 |
The Procter & Gamble Company |
Detergent compositions comprising immobilized enzymes
|
US6106828A
(en)
*
|
1996-02-15 |
2000-08-22 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
CA2242488A1
(en)
*
|
1996-02-15 |
1997-08-21 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
WO1998016201A1
(en)
*
|
1996-10-11 |
1998-04-23 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
US6416756B1
(en)
|
1997-01-10 |
2002-07-09 |
Novozymes A/S |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
EP1075511A1
(en)
|
1998-05-08 |
2001-02-14 |
University Of Southern California |
Size enhanced fibrinolytic enzymes
|
HU228218B1
(en)
*
|
1998-06-08 |
2013-02-28 |
Hoffmann La Roche |
Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
|
US6461849B1
(en)
|
1998-10-13 |
2002-10-08 |
Novozymes, A/S |
Modified polypeptide
|
TWI242000B
(en)
|
1998-12-10 |
2005-10-21 |
Univ Southern California |
Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
EP1579874A3
(en)
*
|
1999-04-23 |
2006-01-25 |
ALZA Corporation |
Conjugate having a cleavable linkage for use in a liposome
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
EP1198565A1
(en)
*
|
1999-07-07 |
2002-04-24 |
Maxygen Aps |
A method for preparing modified polypeptides
|
US6423666B1
(en)
|
1999-10-05 |
2002-07-23 |
Bio-Rad Laboratories, Inc. |
Large-pore chromatographic beads prepared by suspension polymerization
|
US6413507B1
(en)
*
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
WO2001051510A2
(en)
|
2000-01-10 |
2001-07-19 |
Maxygen Holdings Ltd |
G-csf conjugates
|
CA2739933A1
(en)
|
2000-02-11 |
2001-08-16 |
Bayer Healthcare Llc |
Factor vii or viia-like molecules
|
US7829074B2
(en)
*
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
DE60232434D1
(de)
|
2001-02-27 |
2009-07-09 |
Maxygen Aps |
Neue interferon-beta-ähnliche moleküle
|
GB0123232D0
(en)
*
|
2001-09-26 |
2001-11-21 |
Smith & Nephew |
Polymers
|
IL161051A0
(en)
*
|
2001-10-02 |
2004-08-31 |
Genentech Inc |
Apo-2 ligand variants and uses thereof
|
CA2490360A1
(en)
|
2002-06-21 |
2003-12-31 |
Novo Nordisk Health Care Ag |
Pegylated factor vii glycoforms
|
EP1556076A4
(en)
|
2002-06-24 |
2009-07-08 |
Genentech Inc |
APO-2 LIGAND / TRAIL VARIANTS AND ITS USES
|
AU2003285200A1
(en)
*
|
2002-11-09 |
2004-06-03 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
AU2003300076C1
(en)
|
2002-12-30 |
2010-03-04 |
Angiotech International Ag |
Drug delivery from rapid gelling polymer composition
|
AU2003303513A1
(en)
*
|
2002-12-30 |
2004-07-29 |
Angiotech International Ag |
Tissue reactive compounds and compositions and uses thereof
|
US20040151766A1
(en)
*
|
2003-01-30 |
2004-08-05 |
Monahan Sean D. |
Protein and peptide delivery to mammalian cells in vitro
|
GB0305989D0
(en)
*
|
2003-03-15 |
2003-04-23 |
Delta Biotechnology Ltd |
Agent
|
CN102516386A
(zh)
|
2003-10-10 |
2012-06-27 |
诺沃挪第克公司 |
Il-21衍生物
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
MXPA06008507A
(es)
|
2004-02-02 |
2008-02-13 |
Ambrx Inc |
Cuatro polipeptidos en haz helicoidal humanos modificados y sus usos.
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
WO2005105154A1
(en)
*
|
2004-04-21 |
2005-11-10 |
Alza Corporation |
Polymer conjugate releasable under mild thiolytic conditions
|
CN104174071A
(zh)
|
2004-04-28 |
2014-12-03 |
安希奥设备国际有限责任公司 |
用于形成交联生物材料的组合物和系统及关联的制备方法与用途
|
NZ582684A
(en)
|
2004-06-18 |
2011-05-27 |
Ambrx Inc |
Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
|
WO2009100255A2
(en)
|
2008-02-08 |
2009-08-13 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
EP1771573A4
(en)
|
2004-07-21 |
2009-02-18 |
Ambrx Inc |
BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS
|
US8303973B2
(en)
|
2004-09-17 |
2012-11-06 |
Angiotech Pharmaceuticals (Us), Inc. |
Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
|
CN103690936A
(zh)
|
2004-12-22 |
2014-04-02 |
Ambrx公司 |
经修饰的人类生长激素
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
US8633300B2
(en)
|
2005-06-17 |
2014-01-21 |
Novo Nordisk Healthcare Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
MX2008014685A
(es)
|
2006-05-24 |
2008-11-27 |
Novo Nordisk Healthcare Ag |
Analogos de factor ix con semivida prolongada in vivo.
|
EP2615108B1
(en)
|
2006-09-08 |
2016-10-26 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and thier uses
|
KR20090091145A
(ko)
|
2006-10-27 |
2009-08-26 |
웨이-치앙 션 |
지질화된 인터페론 및 이의 용도
|
ES2385114T3
(es)
|
2007-03-30 |
2012-07-18 |
Ambrx, Inc. |
Polipéptidos de FGF-21 modificados y sus usos
|
WO2009036349A1
(en)
*
|
2007-09-12 |
2009-03-19 |
Anaphore, Inc. |
Hsp70-based treatment for autoimmune diseases
|
EP2214716B1
(en)
|
2007-10-23 |
2021-11-17 |
Nektar Therapeutics |
Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
|
JP2011502520A
(ja)
*
|
2007-11-09 |
2011-01-27 |
アナフォア インコーポレイテッド |
疾患治療のためのマンノース結合レクチンの融合タンパク質
|
US8946148B2
(en)
|
2007-11-20 |
2015-02-03 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
UA118536C2
(uk)
|
2008-07-23 |
2019-02-11 |
Амбркс, Інк. |
Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
|
CA2737026C
(en)
|
2008-09-26 |
2019-12-24 |
Ambrx, Inc. |
Modified animal erythropoietin polypeptides and their uses
|
PT2337846T
(pt)
|
2008-09-26 |
2018-04-05 |
Ambrx Inc |
Vacinas e microrganismos dependentes da replicação de aminoácidos não naturais
|
EP2379585A2
(en)
|
2008-10-10 |
2011-10-26 |
Anaphore, Inc. |
Polypeptides that bind trail-ri and trail-r2
|
WO2010080720A2
(en)
*
|
2009-01-12 |
2010-07-15 |
Nektar Therapeutics |
Conjugates of a lysosomal enzyme moiety and a water soluble polymer
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
CA2777162A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that bind il-23r
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
NZ600363A
(en)
|
2009-12-21 |
2014-07-25 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
CA2791841C
(en)
|
2010-03-05 |
2023-01-03 |
Rigshospitalet |
Chimeric inhibitor molecules of complement activation
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
MY162837A
(en)
|
2010-08-17 |
2017-07-31 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
CA2834776A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
|
CN103930440A
(zh)
|
2011-07-01 |
2014-07-16 |
拜耳知识产权有限责任公司 |
松弛素融合多肽及其用途
|
GB201117428D0
(en)
*
|
2011-10-07 |
2011-11-23 |
Bicycle Therapeutics Ltd |
Structured polypeptides with sarcosine linkers
|
EP2606884A1
(en)
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
BR112014030278A2
(pt)
|
2012-06-08 |
2017-06-27 |
Sutro Biopharma Inc |
anticorpo, e, composição.
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
US9682934B2
(en)
|
2012-08-31 |
2017-06-20 |
Sutro Biopharma, Inc. |
Modified amino acids
|
ES2658039T3
(es)
|
2013-07-10 |
2018-03-08 |
Sutro Biopharma, Inc. |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
CN107318267B
(zh)
|
2013-08-12 |
2021-08-17 |
豪夫迈·罗氏有限公司 |
用于治疗补体相关的病症的组合物和方法
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
MA39934A
(fr)
|
2014-05-01 |
2017-03-08 |
Hoffmann La Roche |
Variants d'anticorps anti-facteur d et leurs utilisations
|
SI3412302T1
(sl)
|
2014-10-24 |
2021-09-30 |
Bristol-Myers Squibb Company |
Modificirani FGF-21 polipeptidi in njihova uporaba
|
CA2989400A1
(en)
|
2015-06-15 |
2016-12-22 |
Angiochem Inc. |
Ang1005 for the treatment of leptomeningeal carcinomatosis
|
JP2018534930A
(ja)
|
2015-10-30 |
2018-11-29 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体及びコンジュゲート
|
HK1257422A1
(zh)
|
2015-10-30 |
2019-10-18 |
豪夫迈‧罗氏有限公司 |
抗-因子d抗体变体缀合物及其用途
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
US11472771B2
(en)
|
2018-06-21 |
2022-10-18 |
Cellestia Biotech Ag |
Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
US20220009986A1
(en)
|
2018-10-19 |
2022-01-13 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
EP3923991A1
(en)
|
2019-02-12 |
2021-12-22 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
KR20220021462A
(ko)
|
2019-04-10 |
2022-02-22 |
셀레스티아 바이오테크 아게 |
Notch 신호 전달 경로의 억제제 및 암의 치료에서 이의 용도
|
EP4117732A1
(en)
|
2020-03-11 |
2023-01-18 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
PE20230414A1
(es)
|
2020-03-24 |
2023-03-07 |
Genentech Inc |
Agentes de fijacion a tie2 y metodos de uso
|
TW202227449A
(zh)
|
2020-08-20 |
2022-07-16 |
美商Ambrx 公司 |
抗體-tlr促效劑偶聯物、其方法及用途
|
EP4008324A1
(en)
|
2020-12-07 |
2022-06-08 |
Cellestia Biotech AG |
Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
|
WO2022122667A1
(en)
|
2020-12-07 |
2022-06-16 |
Cellestia Biotech Ag |
Pharmaceutical combinations for treating cancer
|
CN112451681B
(zh)
*
|
2020-12-09 |
2023-08-25 |
苏州大学 |
酸敏感型聚合物-药物偶联物及其制备和应用
|
IL307282A
(en)
|
2021-04-03 |
2023-11-01 |
Ambrx Inc |
Antidote conjugates against HER2 and their applications
|
TW202313020A
(zh)
|
2021-06-02 |
2023-04-01 |
瑞士商西萊絲蒂亞生物科技股份有限公司 |
自體免疫及發炎性疾病的治療方法
|
WO2023079132A1
(en)
|
2021-11-08 |
2023-05-11 |
Cellestia Biotech Ag |
Pharmaceutical combinations for treating cancer
|
EP4223292A1
(en)
|
2022-02-07 |
2023-08-09 |
Cellestia Biotech AG |
Pharmaceutical combinations for treating cancer
|