|
US4842868A
(en)
*
|
1986-09-26 |
1989-06-27 |
Helwing Robert F |
Covalently bonded active agents with carbonium ion base groups
|
|
US5214132A
(en)
*
|
1986-12-23 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
|
IE64284B1
(en)
*
|
1987-08-03 |
1995-07-26 |
Ddi Pharmaceuticals |
Conjugates of superoxide dismutase
|
|
DK468388A
(da)
*
|
1987-08-21 |
1989-02-22 |
Wellcome Found |
Kompleks af polyethylenglycol og vaevplasminogen-aktivator, fremgangsmaade til dets fremstilling og farmaceutiske kompositioner indeholdende komplekset
|
|
JPH079429B2
(ja)
*
|
1988-10-12 |
1995-02-01 |
財団法人化学及血清療法研究所 |
人工担体およびその製造方法
|
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
|
FI901810A7
(fi)
*
|
1989-04-13 |
1990-10-14 |
Vascular Laboratory Inc |
Puhtaan pro-urokinaasin plasminogeeniaktivaattorikompleksi, joka on sidottu ihmisen seerumialbumiiniin disulfidisillan välityksellä
|
|
FI920131A0
(fi)
*
|
1989-07-14 |
1992-01-13 |
Praxis Biolog Inc |
Cytokin- och hormonbaerare foer konjugatvaccin.
|
|
US5767072A
(en)
*
|
1989-09-14 |
1998-06-16 |
Board Of Regents, The University Of Texas System |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
|
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
US6652863B1
(en)
|
1992-11-16 |
2003-11-25 |
Centocor, Inc. |
Method of reducing the immunogenicity of compounds
|
|
DE69331805T2
(de)
*
|
1992-12-10 |
2002-11-28 |
Enzon, Inc. |
Glycolipid enzym-polymer konjugate
|
|
ATE214940T1
(de)
*
|
1993-11-10 |
2002-04-15 |
Enzon Inc |
Verbesserte interferon-polymerkonjugate
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US6458762B1
(en)
|
1994-03-28 |
2002-10-01 |
Baxter International, Inc. |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
|
|
EP0773975A4
(en)
*
|
1994-08-04 |
1998-06-10 |
Gordon George Wallace |
CONDUCTIVE ELECTROACTIVE BIOMATERIALS
|
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5770577A
(en)
*
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
|
FI972443L
(fi)
*
|
1994-12-07 |
1997-06-09 |
Novo Nordisk As |
Polypeptidi, jonka allergeenisuus on vähentynyt
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
US6428790B1
(en)
*
|
1995-04-27 |
2002-08-06 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
|
|
US7883693B2
(en)
*
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
|
JP4193917B2
(ja)
*
|
1995-12-18 |
2008-12-10 |
アンジオデバイス インターナショナル ゲーエムベーハー |
架橋ポリマー組成物およびその使用方法
|
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
JPH11502255A
(ja)
*
|
1995-12-29 |
1999-02-23 |
ザ、プロクター、エンド、ギャンブル、カンパニー |
固定化酵素を含有する洗剤組成物
|
|
AU725287B2
(en)
*
|
1996-02-15 |
2000-10-12 |
Novozymes A/S |
Conjugation of polypeptides
|
|
US6106828A
(en)
*
|
1996-02-15 |
2000-08-22 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
JP2001503396A
(ja)
|
1996-10-11 |
2001-03-13 |
アルザ コーポレイション |
治療用リポソーム組成物および方法
|
|
US6416756B1
(en)
|
1997-01-10 |
2002-07-09 |
Novozymes A/S |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
|
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
|
US6214594B1
(en)
|
1998-05-08 |
2001-04-10 |
University Of California |
Size enhanced fibrinolytic enzymes: limitations of plasma inactivation
|
|
KR20010052622A
(ko)
*
|
1998-06-08 |
2001-06-25 |
프리돌린 클라우스너, 롤란드 비. 보레르 |
만성 씨형 간염을 치료하기 위한 폴리에틸렌글리콜-인터페론-알파 및 리바비린의 용도
|
|
US6461849B1
(en)
|
1998-10-13 |
2002-10-08 |
Novozymes, A/S |
Modified polypeptide
|
|
TWI242000B
(en)
*
|
1998-12-10 |
2005-10-21 |
Univ Southern California |
Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
|
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
|
HUP0201425A3
(en)
|
1999-04-23 |
2006-07-28 |
Hadasit Med Res Service |
Conjugate having a cleavable linkage for use in a liposome
|
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
WO2001004287A1
(en)
*
|
1999-07-07 |
2001-01-18 |
Maxygen Aps |
A method for preparing modified polypeptides
|
|
US6423666B1
(en)
|
1999-10-05 |
2002-07-23 |
Bio-Rad Laboratories, Inc. |
Large-pore chromatographic beads prepared by suspension polymerization
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
KR100773323B1
(ko)
|
2000-01-10 |
2007-11-05 |
맥시겐 홀딩스 리미티드 |
지-씨에스에프 접합체
|
|
US6806063B2
(en)
|
2000-02-11 |
2004-10-19 |
Maxygen Aps |
Factor VII or VIIa-like molecules
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
US7829074B2
(en)
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
|
WO2002074806A2
(en)
|
2001-02-27 |
2002-09-26 |
Maxygen Aps |
New interferon beta-like molecules
|
|
GB0123232D0
(en)
*
|
2001-09-26 |
2001-11-21 |
Smith & Nephew |
Polymers
|
|
JP2005508162A
(ja)
*
|
2001-10-02 |
2005-03-31 |
ジェネンテック・インコーポレーテッド |
Apo−2リガンド変異体とその使用法
|
|
CA2490360A1
(en)
|
2002-06-21 |
2003-12-31 |
Novo Nordisk Health Care Ag |
Pegylated factor vii glycoforms
|
|
WO2004001009A2
(en)
|
2002-06-24 |
2003-12-31 |
Genentech, Inc. |
Apo-2 ligand/trail variants and uses thereof
|
|
WO2004043396A2
(en)
*
|
2002-11-09 |
2004-05-27 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
|
DE60331367D1
(de)
*
|
2002-12-30 |
2010-04-01 |
Angiotech Int Ag |
Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
|
|
AU2003303513A1
(en)
*
|
2002-12-30 |
2004-07-29 |
Angiotech International Ag |
Tissue reactive compounds and compositions and uses thereof
|
|
US20040151766A1
(en)
*
|
2003-01-30 |
2004-08-05 |
Monahan Sean D. |
Protein and peptide delivery to mammalian cells in vitro
|
|
GB0305989D0
(en)
*
|
2003-03-15 |
2003-04-23 |
Delta Biotechnology Ltd |
Agent
|
|
JP2007533298A
(ja)
|
2003-10-10 |
2007-11-22 |
ノボ ノルディスク アクティーゼルスカブ |
Il−21の誘導体
|
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
US8906676B2
(en)
|
2004-02-02 |
2014-12-09 |
Ambrx, Inc. |
Modified human four helical bundle polypeptides and their uses
|
|
WO2006069220A2
(en)
|
2004-12-22 |
2006-06-29 |
Ambrx, Inc. |
Modified human growth hormone
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
MXPA06012144A
(es)
*
|
2004-04-21 |
2007-01-31 |
Alza Corp |
Conjugado polimerico liberable bajo condiciones tioliticas suaves.
|
|
CN101080246A
(zh)
|
2004-04-28 |
2007-11-28 |
安希奥设备国际有限责任公司 |
用于形成交联生物材料的组合物和系统及关联的制备方法与用途
|
|
AU2005265163B2
(en)
|
2004-06-18 |
2009-10-01 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
|
WO2006091231A2
(en)
|
2004-07-21 |
2006-08-31 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
EP1796602A4
(en)
|
2004-09-17 |
2016-10-19 |
Angiotech Pharm Inc |
MULTIFUNCTIONAL COMPOUNDS FOR PRODUCING NETWORKED BIOMATERIALS AND MANUFACTURING AND USE METHOD THEREFOR
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
JP5335422B2
(ja)
|
2005-06-17 |
2013-11-06 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化
|
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
|
CA2653154A1
(en)
|
2006-05-24 |
2007-11-29 |
Novo Nordisk Health Care Ag |
Prolonged fix analogues and derivatives
|
|
EP2069396B1
(en)
|
2006-09-08 |
2015-10-21 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
KR20090091145A
(ko)
|
2006-10-27 |
2009-08-26 |
웨이-치앙 션 |
지질화된 인터페론 및 이의 용도
|
|
US8012931B2
(en)
|
2007-03-30 |
2011-09-06 |
Ambrx, Inc. |
Modified FGF-21 polypeptides and their uses
|
|
EP2195333A1
(en)
*
|
2007-09-12 |
2010-06-16 |
Anaphore, Inc. |
Hsp70-based treatment for autoimmune diseases
|
|
KR101644658B1
(ko)
|
2007-10-23 |
2016-08-01 |
넥타르 테라퓨틱스 |
하이드록시아파타이트-표적 다중팔 중합체 및 그로부터 제조된 컨쥬게이트
|
|
AU2008323678A1
(en)
*
|
2007-11-09 |
2009-05-14 |
Anaphore, Inc. |
Fusion proteins of mannose binding lectins for treatment of disease
|
|
MX338336B
(es)
|
2007-11-20 |
2016-04-07 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
EP2247743B1
(en)
|
2008-02-08 |
2016-04-06 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
ES2963062T3
(es)
|
2008-07-23 |
2024-03-25 |
Ambrx Inc |
Polipéptidos G-CSF bovinos modificados y sus usos
|
|
EA019653B1
(ru)
|
2008-09-26 |
2014-05-30 |
Амбркс Инк. |
Модифицированные полипептиды эритропоэтина животных и их применение
|
|
TR201802361T4
(tr)
|
2008-09-26 |
2018-03-21 |
Ambrx Inc |
Doğal olmayan amino asit replikasyonuna bağımlı mikroorganizmalar ve aşılar.
|
|
WO2010042890A2
(en)
|
2008-10-10 |
2010-04-15 |
Anaphore, Inc. |
Polypeptides that bind trail-ri and trail-r2
|
|
US20110318322A1
(en)
*
|
2009-01-12 |
2011-12-29 |
Nektar Therapeutics |
Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
CA2777162A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that bind il-23r
|
|
CA2784793A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
|
US20120283172A1
(en)
|
2009-12-21 |
2012-11-08 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
AU2011222883B2
(en)
|
2010-03-05 |
2016-05-26 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
|
MX346786B
(es)
|
2010-08-17 |
2017-03-31 |
Ambrx Inc |
Polipeptidos de relaxina modificados y sus usos.
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
WO2012151317A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Vascular disruption agents and uses thereof
|
|
CN103930440A
(zh)
|
2011-07-01 |
2014-07-16 |
拜耳知识产权有限责任公司 |
松弛素融合多肽及其用途
|
|
GB201117428D0
(en)
*
|
2011-10-07 |
2011-11-23 |
Bicycle Therapeutics Ltd |
Structured polypeptides with sarcosine linkers
|
|
EP2606884A1
(en)
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
|
BR112014030278A2
(pt)
|
2012-06-08 |
2017-06-27 |
Sutro Biopharma Inc |
anticorpo, e, composição.
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
DK2890402T3
(da)
|
2012-08-31 |
2019-07-15 |
Sutro Biopharma Inc |
Modificerede aminosyrer omfattende en azidogruppe
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
PE20160192A1
(es)
|
2013-08-12 |
2016-04-27 |
Genentech Inc |
Composiciones y metodo para tratar condiciones asociadas con el complemento
|
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
JP2017515811A
(ja)
|
2014-05-01 |
2017-06-15 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体変異体及びその使用法
|
|
EP3909596A1
(en)
|
2014-10-24 |
2021-11-17 |
Bristol-Myers Squibb Company |
Modified fgf-21 polypeptides and uses thereof
|
|
DK3307326T3
(da)
|
2015-06-15 |
2020-10-19 |
Angiochem Inc |
Fremgangsmåder til behandling af leptomeningeal karcinomatose
|
|
CN108289951A
(zh)
|
2015-10-30 |
2018-07-17 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体和缀合物
|
|
US10654932B2
(en)
|
2015-10-30 |
2020-05-19 |
Genentech, Inc. |
Anti-factor D antibody variant conjugates and uses thereof
|
|
EP3474901B1
(en)
|
2016-06-27 |
2025-08-06 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
MY193457A
(en)
|
2017-02-08 |
2022-10-14 |
Bristol Myers Squibb Co |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
MA52954A
(fr)
|
2018-06-21 |
2021-04-28 |
Cellestia Biotech Ag |
Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle
|
|
PL3849614T3
(pl)
|
2018-09-11 |
2024-04-22 |
Ambrx, Inc. |
Koniugaty polipeptydu interleukiny-2 i ich zastosowania
|
|
US20220009986A1
(en)
|
2018-10-19 |
2022-01-13 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
NZ778565A
(en)
|
2019-02-12 |
2025-10-31 |
Ambrx Inc |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
|
AU2020271268B2
(en)
|
2019-04-10 |
2025-11-20 |
Cellestia Biotech Ag |
Inhibitors of Notch signalling pathway and use thereof in treatment of cancers
|
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