GR3027558T3 - Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate - Google Patents

Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Info

Publication number
GR3027558T3
GR3027558T3 GR980400355T GR980400355T GR3027558T3 GR 3027558 T3 GR3027558 T3 GR 3027558T3 GR 980400355 T GR980400355 T GR 980400355T GR 980400355 T GR980400355 T GR 980400355T GR 3027558 T3 GR3027558 T3 GR 3027558T3
Authority
GR
Greece
Prior art keywords
beta
butoxycarbonylamino
benzoyloxy
trihydroxy
tax
Prior art date
Application number
GR980400355T
Other languages
Greek (el)
English (en)
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3027558(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of GR3027558T3 publication Critical patent/GR3027558T3/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
GR980400355T 1994-07-08 1998-01-01 Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate GR3027558T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (1)

Publication Number Publication Date
GR3027558T3 true GR3027558T3 (en) 1998-11-30

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400355T GR3027558T3 (en) 1994-07-08 1998-01-01 Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Country Status (38)

Country Link
US (1) US6022985A (en:Method)
EP (1) EP0770070B1 (en:Method)
JP (1) JP3753155B2 (en:Method)
KR (1) KR100391753B1 (en:Method)
CN (1) CN1067996C (en:Method)
AT (1) ATE171702T1 (en:Method)
AU (1) AU706519B2 (en:Method)
BR (1) BR9508789A (en:Method)
CA (1) CA2193531C (en:Method)
CO (1) CO4410189A1 (en:Method)
CZ (1) CZ284695B6 (en:Method)
DE (1) DE69505128T2 (en:Method)
DK (1) DK0770070T3 (en:Method)
DZ (1) DZ1905A1 (en:Method)
ES (1) ES2121404T3 (en:Method)
FI (1) FI119246B (en:Method)
FR (1) FR2722191B1 (en:Method)
GR (1) GR3027558T3 (en:Method)
HU (1) HU220634B1 (en:Method)
IL (1) IL114274A (en:Method)
IN (1) IN183947B (en:Method)
IS (1) IS2032B (en:Method)
MA (1) MA23606A1 (en:Method)
MX (1) MX9700173A (en:Method)
MY (1) MY118481A (en:Method)
NO (1) NO314500B1 (en:Method)
NZ (1) NZ289455A (en:Method)
PE (1) PE8697A1 (en:Method)
PL (1) PL179876B1 (en:Method)
RU (1) RU2126397C1 (en:Method)
SI (1) SI0770070T1 (en:Method)
SK (1) SK280520B6 (en:Method)
TN (1) TNSN95071A1 (en:Method)
TW (1) TW419473B (en:Method)
UA (1) UA51624C2 (en:Method)
UY (1) UY23991A1 (en:Method)
WO (1) WO1996001815A1 (en:Method)
ZA (1) ZA955646B (en:Method)

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US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
PT1694660E (pt) 2003-12-12 2009-07-16 Quiral Quimica Do Brasil Processo de preparação de ingredientes farmacêuticos activos (api) anidros e hidratados; composições farmacêuticas estáveis preparadas a partir dos mesmos e utilizações das referidas composições
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
ES2784794T3 (es) 2005-08-31 2020-10-01 Abraxis Bioscience Llc Composiciones que comprenden agentes farmacéuticos poco solubles en agua y agentes antimicrobianos
AU2006284657B2 (en) * 2005-08-31 2012-07-19 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
US20070142457A1 (en) * 2005-10-12 2007-06-21 Alessandro Pontiroli Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
BRPI0706580A2 (pt) * 2006-01-20 2011-03-29 Landmark Graphics Corp gerenciamento dinámico de sistema de produção
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
WO2008051465A2 (en) * 2006-10-20 2008-05-02 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
EP2080764B1 (en) * 2008-01-18 2012-08-22 INDENA S.p.A. Solid forms of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
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US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
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JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2968406A4 (en) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
SI0770070T1 (en) 1998-12-31
FI970069L (fi) 1997-01-07
IL114274A0 (en) 1995-10-31
ZA955646B (en) 1996-02-21
KR970704721A (ko) 1997-09-06
FI119246B (fi) 2008-09-15
NO970007D0 (no) 1997-01-02
FI970069A0 (fi) 1997-01-07
HU220634B1 (hu) 2002-03-28
JPH10502627A (ja) 1998-03-10
UY23991A1 (es) 1995-09-20
IL114274A (en) 1999-04-11
HU9700041D0 (en) 1997-02-28
IS2032B (is) 2005-08-15
TW419473B (en) 2001-01-21
ES2121404T3 (es) 1998-11-16
CN1151741A (zh) 1997-06-11
EP0770070A1 (fr) 1997-05-02
DK0770070T3 (da) 1999-03-01
AU2930595A (en) 1996-02-09
NO970007L (no) 1997-01-02
CZ284695B6 (cs) 1999-02-17
FR2722191A1 (fr) 1996-01-12
HUT76833A (en) 1997-11-28
CA2193531C (fr) 2006-12-05
NZ289455A (en) 1997-12-19
ATE171702T1 (de) 1998-10-15
SK280520B6 (sk) 2000-03-13
BR9508789A (pt) 1997-10-21
RU2126397C1 (ru) 1999-02-20
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
DE69505128T2 (de) 1999-04-01
FR2722191B1 (fr) 1996-08-23
MX9700173A (es) 1997-04-30
UA51624C2 (uk) 2002-12-16
CA2193531A1 (fr) 1996-01-25
PL179876B1 (pl) 2000-11-30
IN183947B (en:Method) 2000-05-20
PL318195A1 (en) 1997-05-26
CO4410189A1 (es) 1997-01-09
CN1067996C (zh) 2001-07-04
SK697A3 (en) 1997-06-04
PE8697A1 (es) 1997-03-26
DZ1905A1 (fr) 2002-02-17
TNSN95071A1 (fr) 1996-02-06
IS4411A (is) 1997-01-07
EP0770070B1 (fr) 1998-09-30
DE69505128D1 (de) 1998-11-05
US6022985A (en) 2000-02-08
AU706519B2 (en) 1999-06-17
CZ3597A3 (en) 1997-04-16
KR100391753B1 (ko) 2004-02-11
JP3753155B2 (ja) 2006-03-08
MY118481A (en) 2004-11-30
WO1996001815A1 (fr) 1996-01-25

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