GR3026129T3 - Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound. - Google Patents

Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound.

Info

Publication number
GR3026129T3
GR3026129T3 GR980400301T GR980400301T GR3026129T3 GR 3026129 T3 GR3026129 T3 GR 3026129T3 GR 980400301 T GR980400301 T GR 980400301T GR 980400301 T GR980400301 T GR 980400301T GR 3026129 T3 GR3026129 T3 GR 3026129T3
Authority
GR
Greece
Prior art keywords
methods
stress
diagnostic kits
toxic
compound
Prior art date
Application number
GR980400301T
Other languages
Greek (el)
English (en)
Inventor
Spencer B Farr
Marque D Todd
Original Assignee
Harvard College
Xenometrix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21734317&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3026129(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College, Xenometrix Inc filed Critical Harvard College
Publication of GR3026129T3 publication Critical patent/GR3026129T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/87—Mycoplasma

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GR980400301T 1993-01-21 1998-02-12 Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound. GR3026129T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US889693A 1993-01-21 1993-01-21
PCT/US1994/000583 WO1994017208A1 (en) 1993-01-21 1994-01-21 Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound

Publications (1)

Publication Number Publication Date
GR3026129T3 true GR3026129T3 (en) 1998-05-29

Family

ID=21734317

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400301T GR3026129T3 (en) 1993-01-21 1998-02-12 Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound.

Country Status (12)

Country Link
US (3) US5811231A (es)
EP (1) EP0680517B2 (es)
JP (1) JP3509100B2 (es)
AT (1) ATE160178T1 (es)
AU (1) AU692434B2 (es)
CA (1) CA2154265C (es)
DE (1) DE69406772T3 (es)
DK (1) DK0680517T4 (es)
ES (1) ES2111289T5 (es)
GR (1) GR3026129T3 (es)
HK (1) HK1004920A1 (es)
WO (1) WO1994017208A1 (es)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2111289T5 (es) * 1993-01-21 2005-07-16 President And Fellows Of Harvard College Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.
EP0759170B1 (en) * 1993-09-10 2008-07-09 The Trustees Of Columbia University In The City Of New York Uses of green fluorescent protein
GB9420735D0 (en) * 1994-10-14 1994-11-30 Karobio Ab Reporter cell line
GB9424497D0 (en) * 1994-12-05 1995-01-25 Karobio Ab Reporter cell line
US6387651B1 (en) 1995-04-12 2002-05-14 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
US6326140B1 (en) 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
GB9526509D0 (en) * 1995-12-23 1996-02-28 Univ Dundee Gene control
US6110671A (en) * 1996-04-04 2000-08-29 The United States Of America As Represented By The Secretary Of The Army Method of measuring tumor suppressor gene p53
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
WO1998038336A1 (en) * 1997-02-28 1998-09-03 E.I. Du Pont De Nemours And Company A method for identifying the site of action of xenobiotic chemicals
US6165709A (en) 1997-02-28 2000-12-26 Fred Hutchinson Cancer Research Center Methods for drug target screening
GB9706414D0 (en) 1997-03-27 1997-05-14 Univ Manchester Detection of DNA damage
US7031843B1 (en) * 1997-09-23 2006-04-18 Gene Logic Inc. Computer methods and systems for displaying information relating to gene expression data
CA2273081A1 (en) * 1997-09-29 1999-04-08 Tetsuya Mori Method for screening heat shock protein expression induction regulators
WO1999027090A1 (en) * 1997-11-20 1999-06-03 Smithkline Beecham Corporation Methods for identifying the toxic/pathologic effect of environmental stimuli on gene transcription
EP1060268A2 (en) * 1998-03-06 2000-12-20 E.I. Du Pont De Nemours And Company Methods for identifying polycationic, peptide-like compounds with antibacterial activity
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
CN1309722A (zh) * 1998-05-12 2001-08-22 罗斯塔英法美蒂克斯公司 定量分析基因表达的方法、系统及设备
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
US6501003B1 (en) * 1998-07-08 2002-12-31 Wisconsin Alumni Research Foundation Transgentic mouse expressing green fluorescent protein in glial cells
US20030105044A1 (en) * 2001-10-17 2003-06-05 Isis Pharmaceuticals Inc. Antisense modulation of matrix metalloproteinase 1 expression
US6593084B2 (en) 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
US6468476B1 (en) 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
US6950752B1 (en) 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
US6203987B1 (en) 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
US6453241B1 (en) 1998-12-23 2002-09-17 Rosetta Inpharmatics, Inc. Method and system for analyzing biological response signal data
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6370478B1 (en) 1998-12-28 2002-04-09 Rosetta Inpharmatics, Inc. Methods for drug interaction prediction using biological response profiles
WO2000058457A2 (en) * 1999-03-31 2000-10-05 Rosetta Inpharmatics, Inc. Essential genes of yeast as targets for antifungal agents, herbicides, insecticides and anti-proliferation drugs
DE60030796T2 (de) 1999-04-14 2007-09-13 Sumitomo Chemical Co., Ltd. Zelle zur Bestimmung der Fähigkeit die Aktivität eines Liganden-abhängigen Transkriptionskontrollfaktors zu kontrollieren
CA2370749A1 (en) 1999-04-20 2000-10-26 Target Discovery, Inc. Polypeptide fingerprinting methods, metabolic profiling, and bioinformatics database
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US20050060101A1 (en) * 1999-06-28 2005-03-17 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US7049132B1 (en) * 1999-06-28 2006-05-23 University Of Southern California Stress-responsive induction of a therapeutic agent and methods of use
US20040225449A1 (en) * 1999-06-28 2004-11-11 Bevilacqua Michael P. Systems and methods for characterizing a biological condition or agent using selected gene expression profiles
CA2377434A1 (en) * 1999-06-28 2001-01-04 University Of Southern California Stress-responsive induction of a therapeutic agent and methods of use
US20080183395A1 (en) * 1999-06-28 2008-07-31 Michael Bevilacqua Gene expression profiling for identification, monitoring and treatment of multiple sclerosis
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US20060115826A1 (en) * 1999-06-28 2006-06-01 Michael Bevilacqua Gene expression profiling for identification monitoring and treatment of multiple sclerosis
US6931396B1 (en) 1999-06-29 2005-08-16 Gene Logic Inc. Biological data processing
US20020087511A1 (en) * 1999-09-02 2002-07-04 Johnson Peter C. Methods for profiling and manufacturing tissue using a database that includes indices representative of a tissue population
US6727100B1 (en) * 1999-10-21 2004-04-27 4Sc Ag Method of identifying candidate molecules
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
EP1130086A1 (en) * 2000-02-18 2001-09-05 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Genetically engineered keratinocytes and toxicity assay using said keratinocytes
US20040115627A1 (en) * 2000-04-12 2004-06-17 Judy Raucy Compositions and methods for induction of proteins involved in xenobiotic metabolism
US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US6828097B1 (en) * 2000-05-16 2004-12-07 The Childrens Mercy Hospital Single copy genomic hybridization probes and method of generating same
WO2001088089A2 (en) * 2000-05-16 2001-11-22 Children's Mercy Hospital Single copy genomic hybridization probes and method of generating same
US7020561B1 (en) 2000-05-23 2006-03-28 Gene Logic, Inc. Methods and systems for efficient comparison, identification, processing, and importing of gene expression data
US6902882B2 (en) 2000-05-23 2005-06-07 Kerong Gu Methods of monitoring production of gene products and uses thereof
US20030171876A1 (en) * 2002-03-05 2003-09-11 Victor Markowitz System and method for managing gene expression data
KR100865664B1 (ko) 2000-06-14 2008-10-29 비스타겐 인코포레이티드 간 줄기 세포를 사용하는 독성 타이핑
JP2004504607A (ja) * 2000-07-19 2004-02-12 ポインティリスト・インコーポレイテッド ネスト化ソーティングおよびハイスループットスクリーニングのための結合タンパク質およびタグのコレクションならびにそれら使用
WO2002008453A2 (en) * 2000-07-21 2002-01-31 Phase-1 Molecular Toxicology Canine toxicity genes
US7613571B2 (en) * 2000-07-28 2009-11-03 Doyle Michael D Method and system for the multidimensional morphological reconstruction of genome expression activity
JP2004522411A (ja) * 2000-07-31 2004-07-29 ジーン ロジック インコーポレイテッド 分子毒性学モデリング
US7590493B2 (en) * 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
CA2327581A1 (en) * 2000-12-27 2002-06-27 Yves Blais Methods and compositions for the establishment of genetically altered cell-based library designed for monitoring transcriptional activity of compounds and molecules
AU2002237879A1 (en) * 2001-01-23 2002-08-06 Gene Logic, Inc. A method and system for predicting the biological activity, including toxicology and toxicity, of substances
AU2002230372B2 (en) * 2001-02-05 2008-03-13 Shen Quan Pan Methods and kits for identifying scavengers of reactive oxygen species (ROS)
EP1434988A4 (en) * 2001-02-23 2005-12-14 Elan Pharm Inc TRANSGENIC ANIMALS KNOCKOUT WITH GENE BACE-1 INACTIVE
WO2002073504A1 (en) * 2001-03-14 2002-09-19 Gene Logic, Inc. A system and method for retrieving and using gene expression data from multiple sources
US20020159625A1 (en) * 2001-04-02 2002-10-31 Cytoprint, Inc. Method and apparatus for discovering, identifying and comparing biological activity mechanisms
US20070015146A1 (en) * 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
AU2002339829A1 (en) * 2001-05-22 2002-12-03 Gene Logic, Inc. Molecular toxicology modeling
US20040014040A1 (en) * 2001-07-10 2004-01-22 Donna Mendrick Cardiotoxin molecular toxicology modeling
US20070054269A1 (en) * 2001-07-10 2007-03-08 Mendrick Donna L Molecular cardiotoxicology modeling
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US20030143612A1 (en) * 2001-07-18 2003-07-31 Pointilliste, Inc. Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening
US7251642B1 (en) 2001-08-06 2007-07-31 Gene Logic Inc. Analysis engine and work space manager for use with gene expression data
AU2002323286A1 (en) * 2001-08-16 2003-03-03 Phase-1 Molecular Toxicology, Inc. Human toxicologically relevant genes and arrays
WO2003018839A1 (en) * 2001-08-23 2003-03-06 University College Dublin, National University Of Ireland, Dublin Identification of a common promoter module in disease associated genes
JP2003079365A (ja) 2001-09-07 2003-03-18 Kanegafuchi Chem Ind Co Ltd 環境有害化学物質の高感度検出法
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
WO2003040404A1 (en) * 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
WO2003062402A2 (en) * 2002-01-24 2003-07-31 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
US7704272B2 (en) 2002-01-31 2010-04-27 University Of Rochester Method for introducing an ultraviolet light activated viral vector into the spinal column
CA2474485A1 (en) 2002-01-31 2003-08-07 University Of Rochester Light activated gene transduction using ultraviolet light for cell targeted gene delivery
CA2471661A1 (en) * 2002-01-31 2003-08-07 Gene Logic, Inc. Molecular hepatotoxicology modeling
US7469185B2 (en) * 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
MXPA04011424A (es) * 2002-05-17 2005-02-17 Baylor College Medicine Patrones diferenciales de expresion genetica que predicen la quimioresistencia y quimiosensibilidad a docetaxel.
ITTO20020729A1 (it) * 2002-08-14 2004-02-15 Consorzio Interuniversitario Per Le Biotecnologie Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'.
EP1576126A3 (en) * 2002-10-30 2005-10-26 Pointilliste, Inc. Systems for capture and analysis of biological particles and methods using the systems
EP1597577A4 (en) * 2003-02-10 2007-02-21 Pointilliste Inc SELF-ARRANGING ARRAYS AND ITS APPLICATION
US7853406B2 (en) 2003-06-13 2010-12-14 Entelos, Inc. Predictive toxicology for biological systems
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
WO2005014793A2 (en) * 2003-08-07 2005-02-17 Gene Logic, Inc. Primary rat hepatocyte toxicity modeling
WO2005045426A2 (en) * 2003-11-10 2005-05-19 Aic Gene expression profiling of hazardous compounds and corresponding database clustering algorithm
US20080281526A1 (en) * 2004-03-22 2008-11-13 Diggans James C Methods For Molecular Toxicology Modeling
EP1751303A2 (en) * 2004-04-07 2007-02-14 Gene Logic, Inc. Hepatotoxicity molecular models
GB0410105D0 (en) * 2004-05-06 2004-06-09 Amersham Biosciences Uk Ltd Method for characterising compounds
WO2006017559A1 (en) * 2004-08-02 2006-02-16 University Of Iowa Research Foundation Methods of inhibiting manganese-containing superoxide dismutase 2 (mnsod)
US7646450B2 (en) * 2005-12-29 2010-01-12 Lg Display Co., Ltd. Light emitting diode array, method of manufacturing the same, backlight assembly having the same, and LCD having the same
WO2007092938A2 (en) * 2006-02-08 2007-08-16 Invitrogen Corporation Cellular assays for signaling receptors
US20100015128A1 (en) * 2006-10-03 2010-01-21 University Of Southern California GRP78 as a Predictor of Responsiveness to Therapeutic Agents
AU2008307643B9 (en) 2007-09-28 2014-04-17 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
KR101629071B1 (ko) 2008-10-08 2016-06-09 인트렉손 코포레이션 다수의 면역조절자를 발현하는 조작된 세포 및 그 용도
EP2199794A1 (en) 2008-12-17 2010-06-23 Universiteit Maastricht Method for the identification of carcinogenic compounds
CN103582704A (zh) * 2011-04-08 2014-02-12 安瑟生物科技私人有限公司 用于高通量筛选真核细胞中基因毒性剂的体外方法
CN103930566B (zh) * 2011-09-08 2018-01-26 埃塔格尼公司 用于测定水中生物污染物的系统和方法
US20200299686A1 (en) * 2017-10-02 2020-09-24 Georgia Tech Research Corporation Methods and Compositions for Engineering Synthetic Bioswitches for Remote Control of Biological Activity
EP3749176A1 (en) 2018-02-09 2020-12-16 W.L. Gore & Associates, Inc. Implantable access chamber and associated methods of use
KR102382748B1 (ko) * 2020-07-28 2022-04-05 가톨릭대학교 산학협력단 Egr1 프로모터 영역을 포함하는 재조합 벡터 및 이의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533584B1 (fr) * 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US4997757A (en) * 1987-12-23 1991-03-05 Genebiomed, Inc. Process for detecting potential carcinogens
NL8801826A (nl) * 1988-07-19 1990-02-16 Tno Werkwijze voor het detecteren van mutaties in markergenen.
US5232833A (en) * 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
GB8905394D0 (en) * 1989-03-09 1989-04-19 Delta Biotechnology Ltd Detection of certain molecules
US5149634A (en) * 1989-04-14 1992-09-22 The University Of Maryland Bioassay for environmental quality
ATE238431T1 (de) † 1989-07-18 2003-05-15 Osi Pharm Inc Methode der veränderung der expression von genen bei der transkription und zum nachweis von chemischen substanzen, die wie modulatoren der genexpression wirken
US5665543A (en) * 1989-07-18 1997-09-09 Oncogene Science, Inc. Method of discovering chemicals capable of functioning as gene expression modulators
KR920703785A (ko) † 1989-07-18 1992-12-18 존 알. 스텝헨손 자동화 실험장치
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
JPH06503713A (ja) * 1990-09-24 1994-04-28 ブレント，ロジャー スクリーニング・アッセイ
ATE190354T1 (de) * 1990-12-20 2000-03-15 Arch Dev Corp The University O Kontrolle der genexpression durch ionisierende strahlung
NL9100567A (nl) * 1991-04-02 1992-11-02 Ingeny Bv Werkwijze voor het detecteren van mutaties, transgeen zoogdier, transgene zoogdiercel, en werkwijze voor het onderzoeken van stoffen of omstandigheden op mutagene eigenschappen.
CA2070058A1 (en) * 1991-05-31 1992-12-01 Robert A. Gadski Vectors and methods for assaying the regulation of apolipoprotein ai synthesis
CA2139667C (en) * 1992-07-06 2005-03-29 Spencer B. Farr Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes
ES2111289T5 (es) * 1993-01-21 2005-07-16 President And Fellows Of Harvard College Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.

Also Published As

Publication number Publication date
EP0680517B1 (en) 1997-11-12
DE69406772T3 (de) 2005-11-17
JPH09503121A (ja) 1997-03-31
CA2154265A1 (en) 1994-08-04
ES2111289T3 (es) 1998-03-01
DK0680517T4 (da) 2005-05-02
EP0680517A1 (en) 1995-11-08
JP3509100B2 (ja) 2004-03-22
AU692434B2 (en) 1998-06-11
WO1994017208A1 (en) 1994-08-04
CA2154265C (en) 2011-01-04
DE69406772T2 (de) 1998-03-12
ATE160178T1 (de) 1997-11-15
US5811231A (en) 1998-09-22
US20030219714A1 (en) 2003-11-27
EP0680517B2 (en) 2005-01-19
DE69406772D1 (de) 1997-12-18
AU6124394A (en) 1994-08-15
DK0680517T3 (da) 1998-07-27
HK1004920A1 (en) 1998-12-11
ES2111289T5 (es) 2005-07-16
US20030027127A1 (en) 2003-02-06

Similar Documents

Publication Publication Date Title
GR3026129T3 (en) Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound.
EA199800566A1 (ru) Аденовирусный вектор (варианты), способ его получения, применение, репликационно-компетентное не содержащее аденовирус потомство, способ повышения размножения в комплементирующей клеточной линии аденовирусного вектора, способ генетической модификации клетки, композиция, клетка-хозяин, способ тестирования токсичности аденовирусного вектора, способ тестирования экспрессии чужеродного гена или гена-пассажира аденовирусного вектора
ATE464067T1 (de) Bindegewebs wachstumsfaktor (ctgf)
EA200000325A1 (ru) Способ доставки генов в антиген-презентирующие клетки кожи
CA2139667A1 (en) Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes
DK1005540T3 (da) IKK-beta-proteiner, nukleinsyrer og fremgangsmåder
BR0303011A (pt) Painel de diagnóstico de câncer
ATE266723T1 (de) Lösung die chaotropische mittel enthält und verwendung dieser lösung in verfahren zur isolierung von dna, rna und proteinen
FI925986A0 (fi) Slumpartat bio-oligomer bibliotek, ett foerfarande foer syntetisering avdet samt ett foerfarande foer anvaendning av det
FI950409A (fi) Yhdistelmä soluja, DNA-rakenteita, vektoreita ja menetelmiä fytaattia hajoittavien entsyymien ilmentämiseksi toivotuissa suhteissa
BR9812540A (pt) Expressão de genes endógenos por recombinaçãonão homóloga de uma construção de vetor comdna celular
CA2298681A1 (en) Methods and compositions for overcoming resistance to biologic and chemotherapy
DE69322166D1 (de) Prüfung auf ein vielfache resistenz gegen antibiotika verursachendes operon
EA199900507A1 (ru) Способы профилактики отторжения трансплантата при трансплантации и продуцирования универсальной клетки-хозяина для генной терапии
EP0716591A4 (en) METHODS AND COMPOSITIONS FOR FIXING TAU AND MAP2c PROTEINS
ATE347606T1 (de) Gentherapie für kongestives herzversagen
DE69428278D1 (de) Leukozytadhaesiontest
DK0782630T3 (da) Polycystisk nyresygdomsgen
DE69837808D1 (de) pRb2/p130 PEPTIDINHIBITOREN DER cdk2 KINASEAKTIVITÄT
UA27771C2 (uk) Електролітична комірка (варіанти) та спосіб мічення протеїнів, пептидів і інших органічних молекул
WO2000018907A3 (de) Antisense-sequenzen für die hemmung der expression des adhäsionsmoleküls icam-1
IT1283899B1 (it) Peptidi e loro usi nella terapia della malattia celiaca
AU6363486A (en) Promoter arrangement for streptomycetes vectors