EA200000325A1 - Способ доставки генов в антиген-презентирующие клетки кожи - Google Patents

Способ доставки генов в антиген-презентирующие клетки кожи

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Publication number
EA200000325A1
EA200000325A1 EA200000325A EA200000325A EA200000325A1 EA 200000325 A1 EA200000325 A1 EA 200000325A1 EA 200000325 A EA200000325 A EA 200000325A EA 200000325 A EA200000325 A EA 200000325A EA 200000325 A1 EA200000325 A1 EA 200000325A1
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EA
Eurasian Patent Office
Prior art keywords
antigen
delivery
presentating
genes
skin cells
Prior art date
Application number
EA200000325A
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English (en)
Other versions
EA003832B1 (ru
Inventor
Джулианна Лисцивич
Франко Лори
Original Assignee
Дженетик Иммьюнити, Ллс.
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Application filed by Дженетик Иммьюнити, Ллс. filed Critical Дженетик Иммьюнити, Ллс.
Publication of EA200000325A1 publication Critical patent/EA200000325A1/ru
Publication of EA003832B1 publication Critical patent/EA003832B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Молекулярный поставочный комплекс, специфичный в отношении антиген-презентирующих клеток, формируется на основе невирусной генной поставочной системы, к которой добавляется чужеродный генетический материал. Сформированный комплекс затем проникает в клетки-мишени опосредованно через специфический рецептор и преодолевает защитные механизмы, в результате чего проникновение чужеродного генетического материала или его трансдукция приводят к экспрессии гена. Также настоящее изобретение представляет способ генетической иммунизации без инъекций.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000325A 1997-09-15 1998-09-15 Ген-доставочный комплекс для чрескожной доставки чужеродного генетического материала в антиген-презентирующие клетки и способы его использования EA003832B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5893397P 1997-09-15 1997-09-15
PCT/US1998/019498 WO1999013915A1 (en) 1997-09-15 1998-09-15 Method of delivering genes to antigen presenting cells of the skin

Publications (2)

Publication Number Publication Date
EA200000325A1 true EA200000325A1 (ru) 2000-10-30
EA003832B1 EA003832B1 (ru) 2003-10-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000325A EA003832B1 (ru) 1997-09-15 1998-09-15 Ген-доставочный комплекс для чрескожной доставки чужеродного генетического материала в антиген-презентирующие клетки и способы его использования

Country Status (18)

Country Link
US (2) US6420176B1 (ru)
EP (1) EP1024836B1 (ru)
JP (1) JP2001516729A (ru)
KR (1) KR100615117B1 (ru)
CN (1) CN100391542C (ru)
AP (1) AP1427A (ru)
AT (1) ATE347911T1 (ru)
AU (1) AU754425B2 (ru)
BR (1) BR9813202B1 (ru)
CA (1) CA2302316A1 (ru)
DE (1) DE69836643T2 (ru)
EA (1) EA003832B1 (ru)
ES (1) ES2279580T3 (ru)
IL (2) IL134842A0 (ru)
NO (1) NO327491B1 (ru)
NZ (1) NZ503334A (ru)
OA (1) OA11612A (ru)
WO (1) WO1999013915A1 (ru)

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IL134842A0 (en) 2001-05-20
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CN100391542C (zh) 2008-06-04
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