ATE464067T1 - Bindegewebs wachstumsfaktor (ctgf) - Google Patents
Bindegewebs wachstumsfaktor (ctgf)Info
- Publication number
- ATE464067T1 ATE464067T1 AT96916841T AT96916841T ATE464067T1 AT E464067 T1 ATE464067 T1 AT E464067T1 AT 96916841 T AT96916841 T AT 96916841T AT 96916841 T AT96916841 T AT 96916841T AT E464067 T1 ATE464067 T1 AT E464067T1
- Authority
- AT
- Austria
- Prior art keywords
- ctgf
- growth factor
- connective tissue
- tissue growth
- provides
- Prior art date
Links
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 title abstract 10
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 title abstract 10
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 238000003556 assay Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 238000011144 upstream manufacturing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/459,717 US5770209A (en) | 1991-08-30 | 1995-06-02 | Acceleration of wound healing using connective tissue growth factor |
| PCT/US1996/008140 WO1996038172A1 (en) | 1995-06-02 | 1996-05-31 | Connective tissue growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE464067T1 true ATE464067T1 (de) | 2010-04-15 |
Family
ID=23825885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96916841T ATE464067T1 (de) | 1995-06-02 | 1996-05-31 | Bindegewebs wachstumsfaktor (ctgf) |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US5770209A (de) |
| EP (2) | EP0831903B1 (de) |
| JP (4) | JPH11507332A (de) |
| CN (2) | CN1195295A (de) |
| AT (1) | ATE464067T1 (de) |
| AU (2) | AU720268B2 (de) |
| BR (2) | BR9609521A (de) |
| CA (2) | CA2222609A1 (de) |
| DE (1) | DE69638162D1 (de) |
| SG (1) | SG108208A1 (de) |
| WO (2) | WO1996038168A1 (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5408040A (en) * | 1991-08-30 | 1995-04-18 | University Of South Florida | Connective tissue growth factor(CTGF) |
| US7384634B2 (en) | 1991-08-30 | 2008-06-10 | University Of South Florida | Connective tissue growth factor |
| US7026299B2 (en) | 1994-07-12 | 2006-04-11 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
| US6638912B2 (en) | 1995-05-01 | 2003-10-28 | The Regents Of The University Of California | Peptide compositions mimicking TGF-β activity |
| AU763649B2 (en) * | 1995-06-02 | 2003-07-31 | University Of South Florida | Connective tissue growth factor |
| US20090081228A1 (en) * | 1996-03-15 | 2009-03-26 | Munin Corporation | Cyr61 compositions and methods |
| CA2248549A1 (en) | 1996-03-15 | 1997-09-18 | Munin Corporation | Extracellular matrix signalling molecules |
| US7521540B2 (en) * | 1996-03-15 | 2009-04-21 | Munin Corporation | CYR61 compositions and methods |
| US6790606B1 (en) * | 1996-03-15 | 2004-09-14 | Munin Corporation | Extracellular matrix signaling molecules |
| US20040132987A1 (en) | 1996-11-08 | 2004-07-08 | Human Genome Sciences, Inc. | Connective tissue growth factor-3 |
| PT990000E (pt) * | 1996-11-08 | 2005-11-30 | Human Genome Sciences Inc | Factor 3 de crescimento do tecido conjuntivo |
| AU742638B2 (en) * | 1996-12-06 | 2002-01-10 | Mesoblast International Sarl | Improved chondrogenic differentiation of human mesenchymal stem cells |
| DE19719652A1 (de) * | 1997-05-09 | 1998-12-03 | Merckle Gmbh | Tissue-Faktor zur Förderung von Wundheilung |
| WO1998057976A1 (en) * | 1997-06-19 | 1998-12-23 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| EP0996724A1 (de) * | 1997-06-19 | 2000-05-03 | Incyte Pharmaceuticals, Inc. | Wachstumsfaktorähnliches portein-kodierendes polynukleotid |
| US5876730A (en) | 1997-08-07 | 1999-03-02 | Childrens Hospital Research Foundation | Heparin-binding growth factor (HBGF) polypeptides |
| JP4537507B2 (ja) * | 1997-12-25 | 2010-09-01 | アムジェン インコーポレイテッド | 結合組織増殖因子に対するモノクローナル抗体及びその医薬用途 |
| EP1043335A4 (de) * | 1997-12-25 | 2005-08-31 | Japan Tobacco Inc | Monoklonaler antikörper gegen den bindegewebewachstumsfaktor sowie dessen medizinische verwendungen |
| US6797289B2 (en) * | 1998-02-13 | 2004-09-28 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
| US6451771B1 (en) | 1999-02-12 | 2002-09-17 | Nutramax Laboratories, Inc. | Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals |
| US20070141181A1 (en) * | 1998-02-13 | 2007-06-21 | Nutramax Laboratories, Inc. | Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals |
| ES2302373T3 (es) * | 1998-02-13 | 2008-07-01 | Nutramax Laboratories, Inc. | Agentes y metodos para la proteccion, tratamiento y reparacion de tejidos conectivos. |
| EP1112088B1 (de) * | 1998-09-08 | 2010-10-27 | Henry Ford Health System | Verfahren zum Nachweis von Bindegewebswachstumsfaktor zur Diagnose von Nierkrankheiten |
| US6348329B1 (en) | 1998-11-06 | 2002-02-19 | Fibrogen, Inc. | Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use |
| US6350472B1 (en) * | 1998-12-14 | 2002-02-26 | Steinbach, Pylant, And Hermann, L.L.C. | Method of treating HIV infection with transdermal gel containing mammalian liver extract |
| KR100664625B1 (ko) | 1998-12-14 | 2007-01-04 | 유니버시티 오브 마이애미 | 결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도 |
| US7115390B1 (en) | 1998-12-14 | 2006-10-03 | Fibrogen, Inc. | Connective tissue growth factor fragments and methods and uses thereof |
| CN100435859C (zh) * | 1999-02-01 | 2008-11-26 | 遗传研究所公司 | 用于关节软骨愈合和修复的骨软骨移植物的制备方法和组合物 |
| AU4033500A (en) * | 1999-03-25 | 2000-10-09 | Hyseq, Inc. | Solution-based methods and materials for sequence analysis by hybridization |
| US6555322B1 (en) | 1999-08-27 | 2003-04-29 | Fibrogen, Inc. | α2-macroglobulin receptor as a receptor for CTGF |
| CA2412124A1 (en) * | 2000-07-11 | 2002-01-17 | Haodong Li | Connective tissue growth factor-2 |
| US20060052328A1 (en) * | 2000-07-11 | 2006-03-09 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
| US6939540B1 (en) | 2000-07-31 | 2005-09-06 | Cornell Research Foundation, Inc. | Method of enhancing bone density |
| US6599526B2 (en) * | 2000-08-18 | 2003-07-29 | The University Of North Texas Health Science Center At Fort Worth | Pericardial anti-adhesion patch |
| AU2002224056A1 (en) * | 2000-11-22 | 2002-06-03 | Yamanouchi Pharmaceutical Co..Ltd. | Novel polypeptide |
| AU2002326939A1 (en) * | 2001-09-18 | 2003-04-01 | Fibrogen, Inc. | Methods of assaying connective tissue growth factor |
| CN1592635A (zh) * | 2001-09-24 | 2005-03-09 | 维里根股份公司 | 自体生长因子鸡尾酒组合物,生产方法以及应用 |
| JP4456796B2 (ja) * | 2001-09-27 | 2010-04-28 | 株式会社林原生物化学研究所 | コラーゲン産生増強剤の製造方法とその用途 |
| US6965025B2 (en) | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
| WO2003054541A2 (en) * | 2001-12-12 | 2003-07-03 | Merck Patent Gmbh | Inhibition of tristetraproline for protection of the heart from cardiac injuries |
| BR0309623A (pt) * | 2002-04-30 | 2005-02-09 | Alcon Inc | Agentes que regulam. inibem ou modulam a atividade e/ou a expressão do fator de crescimento de tecido conjuntivo (ctgf) como um único meio de diminuir a pressão intraocular e tratar retinopatias glaucomatosas/neuropatias ópticas |
| EP1616568A3 (de) | 2002-04-30 | 2006-06-21 | Alcon, Inc | GSK-3- und CDK-Inhibitoren als Antiglaukomamittel |
| US7462602B2 (en) * | 2003-05-01 | 2008-12-09 | University Of Florida Research Foundation, Inc. | Anti-scarring ribozymes and methods |
| US7405274B2 (en) * | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
| WO2005033136A1 (en) * | 2003-09-29 | 2005-04-14 | Children's Hospital, Inc. | Unique integrin binding site in connective tissue growth factor (ctgf) |
| WO2005038013A1 (en) * | 2003-10-07 | 2005-04-28 | Isis Pharmaceuticals, Inc. | Artisense oligonucleotides optimized for kidney targeting |
| US20050191653A1 (en) * | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
| CN101884789A (zh) | 2004-02-11 | 2010-11-17 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
| AU2005244154C1 (en) | 2004-04-28 | 2010-07-01 | Fibrogen, Inc. | Treatments for pancreatic cancer |
| WO2005120231A1 (en) * | 2004-06-08 | 2005-12-22 | Fibrogen, Inc. | Connective tissue growth factor regulates intracellular signaling pathways |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| WO2006102333A2 (en) * | 2005-03-21 | 2006-09-28 | Alcon Manufacturing, Ltd. | Ophthalmic use of agents which inhibit connective tissue growth factor binding and signalling via the trka/p75ntr receptor complex |
| JP2008540456A (ja) | 2005-05-05 | 2008-11-20 | ファイブローゲン、インコーポレーテッド | 血管疾患の治療 |
| WO2009070698A1 (en) * | 2007-11-29 | 2009-06-04 | The Trustees Of Columbia University In The City Of New York | Microsphere skin treatment |
| US20100331249A1 (en) * | 2008-07-23 | 2010-12-30 | National Taiwan University | Pharmaceutical composition for inhibiting peritoneal dissemination |
| MX2011002143A (es) | 2008-08-25 | 2011-07-20 | Excaliard Pharmaceuticals Inc | Oligonucleotidos antisentido dirigidos contra el factor de crecimiento del tejido conectivo y usos de los mismos. |
| US8946172B2 (en) | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
| US8796443B2 (en) * | 2008-09-22 | 2014-08-05 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
| EP2221387A1 (de) * | 2009-02-19 | 2010-08-25 | Université de la Méditerranée | Fibroseanfälligkeitsgen und Verwendungen davon |
| JP5166360B2 (ja) * | 2009-06-23 | 2013-03-21 | 株式会社島津製作所 | マイクロ反応装置を用いた細胞運動評価方法 |
| US8771692B2 (en) | 2009-07-02 | 2014-07-08 | Fibrogen, Inc. | Methods for treatment of muscular dystrophy |
| WO2011056234A1 (en) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Treatment for radiation-induced disorders |
| KR20180044433A (ko) | 2010-03-24 | 2018-05-02 | 알엑스아이 파마슈티칼스 코포레이션 | 진피 및 섬유증성 적응증에서의 ｒｎａ 간섭 |
| CA2794187C (en) | 2010-03-24 | 2020-07-14 | Rxi Pharmaceuticals Corporation | Rna interference in ocular indications |
| KR101249041B1 (ko) | 2010-04-28 | 2013-03-29 | 포항공과대학교 산학협력단 | 결합조직 성장인자를 이용한 약학적 조성물 |
| WO2012061811A2 (en) | 2010-11-05 | 2012-05-10 | Fibrogen, Inc. | Treatment method for lung remodeling diseases |
| WO2012100262A1 (en) | 2011-01-21 | 2012-07-26 | Fibrogen, Inc. | Therapeutic method using anti - ctgf antibody |
| PT2670411T (pt) | 2011-02-02 | 2019-06-18 | Excaliard Pharmaceuticals Inc | Compostos anti sentido visando um fator de crescimento do tecido conetivo (ctfg) para utilização num método de tratamento de queloides ou cicatrizes hipertróficas |
| KR102003835B1 (ko) | 2011-08-05 | 2019-07-25 | 엑스-마르세이유 위니베르시테 | 섬유증 감수성 il22ra2 유전자 및 이의 용도 |
| ES2718472T3 (es) | 2012-05-03 | 2019-07-02 | Fibrogen Inc | Métodos para tratar fibrosis pulmonar idiopática |
| US9631013B2 (en) | 2014-01-28 | 2017-04-25 | Fibrogen, Inc. | Therapeutic method for pancreatic cancer |
| KR20250162599A (ko) * | 2018-11-08 | 2025-11-18 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | 부착 비의존성 세포 및 그 용도 |
| BR112021023669A2 (pt) | 2019-06-04 | 2022-03-29 | Jiangsu Hengrui Medicine Co | Anticorpo do fator de crescimento de tecido anti-conjuntivo e aplicação do mesmo |
| JP2022551086A (ja) * | 2019-10-03 | 2022-12-07 | ヴィトルヴィア ホールディングス インコーポレイテッド | 結合組織修復の方法 |
| US12472234B2 (en) | 2021-09-10 | 2025-11-18 | Bjorn Eek | Treatment of connective tissue injuries |
| EP4238558A1 (de) * | 2022-03-02 | 2023-09-06 | Bjorn Eek | Behandlung von bindegewebsverletzungen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1989A (en) | 1841-02-20 | Stump-extractor | ||
| US5356630A (en) * | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
| US5149691A (en) * | 1991-03-12 | 1992-09-22 | Creative Biomolecules, Inc. | Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone |
| FR2678283A1 (fr) * | 1991-06-25 | 1992-12-31 | Centre Nat Rech Scient | Sequences de nucleotides, sequences d'acides amines correspondantes, et leurs applications biologiques. |
| US5408040A (en) * | 1991-08-30 | 1995-04-18 | University Of South Florida | Connective tissue growth factor(CTGF) |
| IL105529A0 (en) * | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
-
1995
- 1995-06-02 US US08/459,717 patent/US5770209A/en not_active Expired - Lifetime
-
1996
- 1996-05-31 EP EP96916841A patent/EP0831903B1/de not_active Expired - Lifetime
- 1996-05-31 SG SG9806251A patent/SG108208A1/en unknown
- 1996-05-31 BR BR9609521A patent/BR9609521A/pt not_active Application Discontinuation
- 1996-05-31 BR BR9608558-4A patent/BR9608558A/pt not_active Application Discontinuation
- 1996-05-31 CA CA002222609A patent/CA2222609A1/en not_active Abandoned
- 1996-05-31 WO PCT/US1996/008210 patent/WO1996038168A1/en not_active Ceased
- 1996-05-31 AT AT96916841T patent/ATE464067T1/de not_active IP Right Cessation
- 1996-05-31 WO PCT/US1996/008140 patent/WO1996038172A1/en not_active Ceased
- 1996-05-31 CN CN96195711A patent/CN1195295A/zh active Pending
- 1996-05-31 CN CN96195767A patent/CN1191491A/zh active Pending
- 1996-05-31 JP JP8536688A patent/JPH11507332A/ja not_active Withdrawn
- 1996-05-31 JP JP8536723A patent/JPH11506449A/ja active Pending
- 1996-05-31 AU AU59582/96A patent/AU720268B2/en not_active Expired
- 1996-05-31 DE DE69638162T patent/DE69638162D1/de not_active Expired - Lifetime
- 1996-05-31 AU AU58855/96A patent/AU722919B2/en not_active Ceased
- 1996-05-31 CA CA2222509A patent/CA2222509C/en not_active Expired - Lifetime
- 1996-05-31 EP EP96920597A patent/EP0831885A4/de not_active Withdrawn
-
1998
- 1998-03-30 US US09/056,704 patent/US6232064B1/en not_active Expired - Fee Related
- 1998-04-02 US US09/054,368 patent/US6069006A/en not_active Expired - Fee Related
- 1998-04-02 US US09/054,274 patent/US6150101A/en not_active Expired - Fee Related
-
2003
- 2003-09-11 JP JP2003320335A patent/JP2004132974A/ja active Pending
-
2006
- 2006-10-04 JP JP2006273122A patent/JP2007051150A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996038172A1 (en) | 1996-12-05 |
| EP0831903B1 (de) | 2010-04-14 |
| US5770209A (en) | 1998-06-23 |
| AU5958296A (en) | 1996-12-18 |
| US6232064B1 (en) | 2001-05-15 |
| JPH11506449A (ja) | 1999-06-08 |
| MX9709294A (es) | 1998-08-30 |
| US6069006A (en) | 2000-05-30 |
| JPH11507332A (ja) | 1999-06-29 |
| BR9609521A (pt) | 1999-06-15 |
| CA2222609A1 (en) | 1996-12-05 |
| EP0831903A1 (de) | 1998-04-01 |
| AU720268B2 (en) | 2000-05-25 |
| CN1195295A (zh) | 1998-10-07 |
| DE69638162D1 (de) | 2010-05-27 |
| SG108208A1 (en) | 2005-01-28 |
| JP2007051150A (ja) | 2007-03-01 |
| EP0831885A4 (de) | 2000-11-29 |
| BR9608558A (pt) | 1999-11-30 |
| AU722919B2 (en) | 2000-08-17 |
| EP0831885A1 (de) | 1998-04-01 |
| JP2004132974A (ja) | 2004-04-30 |
| EP0831903A4 (de) | 2001-02-28 |
| CN1191491A (zh) | 1998-08-26 |
| US6150101A (en) | 2000-11-21 |
| CA2222509C (en) | 2012-12-04 |
| WO1996038168A1 (en) | 1996-12-05 |
| CA2222509A1 (en) | 1996-12-05 |
| AU5885596A (en) | 1996-12-18 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |