KR100664625B1 - 결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도 - Google Patents
결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도 Download PDFInfo
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- KR100664625B1 KR100664625B1 KR1020017007367A KR20017007367A KR100664625B1 KR 100664625 B1 KR100664625 B1 KR 100664625B1 KR 1020017007367 A KR1020017007367 A KR 1020017007367A KR 20017007367 A KR20017007367 A KR 20017007367A KR 100664625 B1 KR100664625 B1 KR 100664625B1
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Abstract
Description
Claims (14)
- (a) 서열 4에 기재된 잔기 4 내지 잔기 74;(b) 서열 4에 기재된 잔기 75 내지 잔기 172; 또는(c) 서열 4에 기재된 잔기 4 내지 잔기 172의 아미노산 서열을 가지며 유사분열 촉진 활성이 있는 결합 조직 성장인자 (CTGF) 폴리펩티드 단편.
- 삭제
- 삭제
- 삭제
- 제1항의 CTGF 단편을 코딩하는 폴리뉴클레오티드.
- 제1항의 CTGF 단편에 특이적으로 결합하는 항체.
- 제1항의 CTGF 단편을 코딩하는 핵산 서열에 특이적으로 혼성화하는 안티센스 분자.
- 제6항의 항체인, CTGF 관련 질병 또는 장애의 치료용 제약 조성물.
- 제8항에 있어서, 상기 질병 또는 장애가 섬유증식성 질병인 제약 조성물.
- 제8항에 있어서, 상기 질병 또는 장애가 신장 섬유증, 경피증, 폐 섬유증, 간 섬유증, 관절염, 고혈압, 신장 장애, 혈관형성 관련 장애, 피부 섬유증 장애, 및 심혈관계 장애로 이루어진 군에서 선택된 것인 제약 조성물.
- 제7항의 안티센스 분자인, CTGF 관련 질병 또는 장애의 치료용 제약 조성물.
- 세포를 시험 작용제 및 유사분열 촉진 CTGF 폴리펩티드 단편과 이들 성분들이 상호작용할 수 있는 조건하에서 접촉시키고, 시험 작용제의 존재하에서의 세포의 증식능을 그 작용제의 부재하에서의 세포의 증식능과 비교하는 것을 포함하며, 이때 세포의 증식능 차이가 CTGF 폴리펩티드 단편의 유사분열 촉진 활성을 조정하는 작용제 또는 화합물임을 지시하는 것인, CTGF 폴리펩티드 단편의 유사분열 촉진 활성을 조정하는 작용제 또는 화합물의 확인 방법.
- 제12항에 있어서, 조정이 활성의 억제인 방법.
- 제12항에 있어서, 조정이 활성의 촉진인 방법.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11224198P | 1998-12-14 | 1998-12-14 | |
US11224098P | 1998-12-14 | 1998-12-14 | |
US60/112,241 | 1998-12-14 | ||
US60/112,240 | 1998-12-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010101194A KR20010101194A (ko) | 2001-11-14 |
KR100664625B1 true KR100664625B1 (ko) | 2007-01-04 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020017007367A KR100664625B1 (ko) | 1998-12-14 | 1999-12-14 | 결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도 |
KR1020017007410A KR100664626B1 (ko) | 1998-12-14 | 1999-12-14 | 결합조직 성장인자 단편, 그의 제조 방법 및 그의 용도 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020017007410A KR100664626B1 (ko) | 1998-12-14 | 1999-12-14 | 결합조직 성장인자 단편, 그의 제조 방법 및 그의 용도 |
Country Status (16)
Country | Link |
---|---|
US (3) | US6492129B1 (ko) |
EP (2) | EP1140964B1 (ko) |
JP (2) | JP4722290B2 (ko) |
KR (2) | KR100664625B1 (ko) |
CN (3) | CN1187370C (ko) |
AT (2) | ATE391724T1 (ko) |
AU (3) | AU773278B2 (ko) |
CA (2) | CA2354422A1 (ko) |
CY (1) | CY1108860T1 (ko) |
DE (2) | DE69936315T2 (ko) |
DK (1) | DK1140969T3 (ko) |
ES (2) | ES2304811T3 (ko) |
HK (2) | HK1041268B (ko) |
MX (1) | MXPA01005949A (ko) |
PT (1) | PT1140969E (ko) |
WO (2) | WO2000035939A2 (ko) |
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