CY1108860T1 - Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους - Google Patents
Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τουςInfo
- Publication number
- CY1108860T1 CY1108860T1 CY20071101018T CY071101018T CY1108860T1 CY 1108860 T1 CY1108860 T1 CY 1108860T1 CY 20071101018 T CY20071101018 T CY 20071101018T CY 071101018 T CY071101018 T CY 071101018T CY 1108860 T1 CY1108860 T1 CY 1108860T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- ctgf
- brushes
- growth
- fragments
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Abstract
Η παρούσα εφεύρεση απευθύνεται στα θραύσματα του CTGF τα οποία περιλαμβάνουν τουλάχιστον το εξόνιο 2 ή το εξόνιο 3 του CTGF και έχουν την δυνατότητα να προκαλούν την σύνθεση εξωκυττάριας μήτρας, ειδικότερα, τη σύνθεση κολλαγόνου και τη διαφοροποίηση μυοϊνοβλάστη. Η παρούσα εφεύρεση περαιτέρω απευθύνεται σε μεθόδους που χρησιμοποιούν τα εν λόγω θραύσματα του CTGF για αναγνώριση συνθέσεων που διαμορφώνουν τη δραστηριότητα των εν λόγω θραυσμάτων του CTGF και στις συνθέσεις έτσι αναγνωρισμένες. Η εφεύρεση αναφέρεται επίσης σε μεθόδους θεραπείας των συνδεδεμένων με CTGF διαταραχών και των ασθενειών που συνδέονται με την υπερπαραγωγή της εξωκυττάριας μήτρας.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11224198P | 1998-12-14 | 1998-12-14 | |
US11224098P | 1998-12-14 | 1998-12-14 | |
EP99965256A EP1140969B1 (en) | 1998-12-14 | 1999-12-14 | Connective tissue growth factor fragments and methods and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108860T1 true CY1108860T1 (el) | 2014-07-02 |
Family
ID=26809725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101018T CY1108860T1 (el) | 1998-12-14 | 2007-07-31 | Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους |
Country Status (16)
Country | Link |
---|---|
US (3) | US6492129B1 (el) |
EP (2) | EP1140964B1 (el) |
JP (2) | JP4722290B2 (el) |
KR (2) | KR100664626B1 (el) |
CN (3) | CN1660911A (el) |
AT (2) | ATE364617T1 (el) |
AU (3) | AU773278B2 (el) |
CA (2) | CA2354456A1 (el) |
CY (1) | CY1108860T1 (el) |
DE (2) | DE69936315T2 (el) |
DK (1) | DK1140969T3 (el) |
ES (2) | ES2288321T3 (el) |
HK (2) | HK1041268B (el) |
MX (1) | MXPA01005949A (el) |
PT (1) | PT1140969E (el) |
WO (2) | WO2000035936A1 (el) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10502534A (ja) | 1994-07-12 | 1998-03-10 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | 結合組織増殖因子−2 |
US7026299B2 (en) | 1994-07-12 | 2006-04-11 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
ATE364617T1 (de) * | 1998-12-14 | 2007-07-15 | Univ Miami | Fragmente des wachstumsfaktors für bindegewebe (ctgf) und verfahren und anwendungen davon |
US7115390B1 (en) * | 1998-12-14 | 2006-10-03 | Fibrogen, Inc. | Connective tissue growth factor fragments and methods and uses thereof |
AU2001276868A1 (en) * | 2000-07-11 | 2002-01-21 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
JP4226471B2 (ja) * | 2001-09-18 | 2009-02-18 | ファイブローゲン、インコーポレーテッド | 結合組織増殖因子の分析方法 |
WO2003035868A1 (de) * | 2001-10-26 | 2003-05-01 | Ribopharma Ag | Medikament zur erhöhung der wirksamkeit eines rezeptor-vermittelt apoptose in tumorzellen auslösenden arzeimittels |
US6965025B2 (en) | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
AU2002366641A1 (en) * | 2001-12-11 | 2003-06-23 | Fibrogen, Inc. | Methods for inhibiting ocular processes |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7405274B2 (en) | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
WO2005033136A1 (en) * | 2003-09-29 | 2005-04-14 | Children's Hospital, Inc. | Unique integrin binding site in connective tissue growth factor (ctgf) |
EP1687410A4 (en) | 2003-10-07 | 2008-04-09 | Isis Pharmaceuticals Inc | ANTISENSE OLIGONUCLEOTIDES OPTIMIZED TO TARGET THE KIDNEY |
US20050191653A1 (en) | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
GB0326778D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
CN1929861B (zh) * | 2004-02-11 | 2010-12-29 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
CN101884789A (zh) | 2004-02-11 | 2010-11-17 | 法布罗根股份有限公司 | Ctgf作为糖尿病肾病的治疗靶点 |
MXPA06012576A (es) * | 2004-04-28 | 2007-01-31 | Fibrogen Inc | Tratamientos para cancer pancreatico. |
WO2005116194A1 (ja) * | 2004-05-25 | 2005-12-08 | Riken | 試験管内筋繊維形成のための筋芽細胞又は筋芽細胞様細胞培養法 |
EP1692935A1 (en) * | 2005-02-22 | 2006-08-23 | Boehringer Ingelheim International GmbH | Transgenic animal as a model for human pulmonary disease |
MX2007013819A (es) | 2005-05-05 | 2008-02-05 | Fibrogen Inc | Terapias de enfermedades cardiovasculares. |
PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
CN102898519B (zh) | 2005-11-30 | 2015-10-28 | Abbvie公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
US20100034892A1 (en) * | 2006-08-30 | 2010-02-11 | The Trustees Of Columbia University In The City Of New York | Treatment for bone formation disorders by growth factor delivery |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8617877B2 (en) * | 2007-11-02 | 2013-12-31 | The Johns Hopkins University | Cardiac stem cell and myocyte secreted paracrine factors |
US8946172B2 (en) | 2008-08-25 | 2015-02-03 | Excaliard Pharmaceuticals, Inc. | Method for reducing scarring during wound healing using antisense compounds directed to CTGF |
WO2010027830A2 (en) * | 2008-08-25 | 2010-03-11 | Excaliard Pharmaceuticals, Inc. | Methods for modulation of connective tissue growth factor expression by administering antisense oligonucleotides through a delivery system so as to reduce scarring from wound healing and threat fibrotic diseases |
EP3081648A1 (en) * | 2008-08-25 | 2016-10-19 | Excaliard Pharmaceuticals, Inc. | Antisense oligonucleotides directed against connective tissue growth factor and uses thereof |
US10138485B2 (en) | 2008-09-22 | 2018-11-27 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
WO2011002525A1 (en) | 2009-07-02 | 2011-01-06 | Fibrogen, Inc. | Methods for treatment of muscular dystrophy |
US20120244169A1 (en) | 2009-11-06 | 2012-09-27 | Fibrogen, Inc. | Treatment for Radiation-Induced Disorders |
US9095504B2 (en) | 2010-03-24 | 2015-08-04 | Rxi Pharmaceuticals Corporation | RNA interference in ocular indications |
AU2011232365A1 (en) | 2010-03-24 | 2012-10-25 | Rxi Pharmaceuticals Corporation | RNA interference in dermal and fibrotic indications |
EP2558494B1 (en) | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Amyloid-beta binding proteins |
KR101249041B1 (ko) | 2010-04-28 | 2013-03-29 | 포항공과대학교 산학협력단 | 결합조직 성장인자를 이용한 약학적 조성물 |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
WO2012061811A2 (en) | 2010-11-05 | 2012-05-10 | Fibrogen, Inc. | Treatment method for lung remodeling diseases |
US9102721B2 (en) | 2011-01-21 | 2015-08-11 | Fibrogen, Inc. | Therapeutic method |
EP2670411B1 (en) * | 2011-02-02 | 2019-04-10 | Excaliard Pharmaceuticals, Inc. | Antisense compounds targeting connective tissue growth factor (ctgf) for use in a method of treating keloids or hypertrophic scars |
AR089425A1 (es) | 2011-12-22 | 2014-08-20 | Astellas Pharma Inc | Anticuerpo ctgf (factor de crecimiento de tejido conectivo) antihumano |
ES2718472T3 (es) | 2012-05-03 | 2019-07-02 | Fibrogen Inc | Métodos para tratar fibrosis pulmonar idiopática |
US9132171B2 (en) | 2012-05-23 | 2015-09-15 | Wisconsin Alumni Research Foundation | Test of insulin as a drug to reduce restenosis of vessels |
US9631013B2 (en) | 2014-01-28 | 2017-04-25 | Fibrogen, Inc. | Therapeutic method for pancreatic cancer |
WO2016205226A1 (en) | 2015-06-15 | 2016-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and treating affective disorders |
CN109402127B (zh) * | 2018-09-29 | 2021-12-10 | 复旦大学附属眼耳鼻喉科医院 | 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用 |
CN111424035A (zh) * | 2020-04-13 | 2020-07-17 | 西南大学 | 基于家蚕丝腺表达具有生物学活性的人结缔组织生长因子的方法及其产品和应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US392024A (en) * | 1888-10-30 | Jjett | ||
US4906742A (en) * | 1986-07-31 | 1990-03-06 | Whitehead Institute For Biomedical Research | Encoding antigens of M. Leprae |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
FR2678283A1 (fr) * | 1991-06-25 | 1992-12-31 | Centre Nat Rech Scient | Sequences de nucleotides, sequences d'acides amines correspondantes, et leurs applications biologiques. |
US5770209A (en) * | 1991-08-30 | 1998-06-23 | University Of South Florida | Acceleration of wound healing using connective tissue growth factor |
US5408040A (en) * | 1991-08-30 | 1995-04-18 | University Of South Florida | Connective tissue growth factor(CTGF) |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
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JPH10502534A (ja) | 1994-07-12 | 1998-03-10 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | 結合組織増殖因子−2 |
US5789389A (en) * | 1995-03-17 | 1998-08-04 | Board Of Trustees Of University Of Illinois | BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs |
US5688915A (en) | 1995-06-01 | 1997-11-18 | The University Of Medicine And Dentistry Of New Jersey | Long term maintenance of lymphocytes in vitro |
EP0871705A4 (en) * | 1995-06-05 | 2000-01-26 | Human Genome Sciences Inc | CCN TYPE HUMAN GROWTH FACTOR |
EP0827742A1 (en) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Use of histone deacetylase inhibitors for treating fribosis or cirrhosis |
US5876730A (en) * | 1997-08-07 | 1999-03-02 | Childrens Hospital Research Foundation | Heparin-binding growth factor (HBGF) polypeptides |
AU1682699A (en) * | 1997-12-25 | 1999-07-19 | Japan Tobacco Inc. | Monoclonal antibody against connective tissue growth factor and medicinal uses thereof |
JP2002504332A (ja) * | 1998-02-20 | 2002-02-12 | ザイモジェネティクス,インコーポレイティド | 結合組織成長因子ホモローグ |
US6238921B1 (en) * | 1998-03-26 | 2001-05-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human mdm2 expression |
US6348329B1 (en) * | 1998-11-06 | 2002-02-19 | Fibrogen, Inc. | Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use |
ATE364617T1 (de) * | 1998-12-14 | 2007-07-15 | Univ Miami | Fragmente des wachstumsfaktors für bindegewebe (ctgf) und verfahren und anwendungen davon |
US7405274B2 (en) * | 2003-06-04 | 2008-07-29 | Fibrogen, Inc. | Connective tissue growth factor antibodies |
-
1999
- 1999-12-14 AT AT99965256T patent/ATE364617T1/de active
- 1999-12-14 EP EP99966224A patent/EP1140964B1/en not_active Expired - Lifetime
- 1999-12-14 US US09/461,688 patent/US6492129B1/en not_active Expired - Lifetime
- 1999-12-14 KR KR1020017007410A patent/KR100664626B1/ko active IP Right Grant
- 1999-12-14 JP JP2000588194A patent/JP4722290B2/ja not_active Expired - Lifetime
- 1999-12-14 CN CN2004101024245A patent/CN1660911A/zh active Pending
- 1999-12-14 DK DK99965256T patent/DK1140969T3/da active
- 1999-12-14 CA CA002354456A patent/CA2354456A1/en not_active Abandoned
- 1999-12-14 CN CNB99815850XA patent/CN1170849C/zh not_active Expired - Lifetime
- 1999-12-14 CA CA002354422A patent/CA2354422A1/en not_active Abandoned
- 1999-12-14 ES ES99965256T patent/ES2288321T3/es not_active Expired - Lifetime
- 1999-12-14 MX MXPA01005949A patent/MXPA01005949A/es unknown
- 1999-12-14 PT PT99965256T patent/PT1140969E/pt unknown
- 1999-12-14 JP JP2000588197A patent/JP4634614B2/ja not_active Expired - Fee Related
- 1999-12-14 DE DE69936315T patent/DE69936315T2/de not_active Expired - Lifetime
- 1999-12-14 AU AU31211/00A patent/AU773278B2/en not_active Expired
- 1999-12-14 EP EP99965256A patent/EP1140969B1/en not_active Expired - Lifetime
- 1999-12-14 ES ES99966224T patent/ES2304811T3/es not_active Expired - Lifetime
- 1999-12-14 KR KR1020017007367A patent/KR100664625B1/ko active IP Right Grant
- 1999-12-14 AT AT99966224T patent/ATE391724T1/de not_active IP Right Cessation
- 1999-12-14 WO PCT/US1999/029652 patent/WO2000035936A1/en active IP Right Grant
- 1999-12-14 AU AU21819/00A patent/AU775391B2/en not_active Expired
- 1999-12-14 WO PCT/US1999/029654 patent/WO2000035939A2/en active IP Right Grant
- 1999-12-14 DE DE69938507T patent/DE69938507T2/de not_active Expired - Lifetime
- 1999-12-14 CN CNB998158747A patent/CN1187370C/zh not_active Expired - Lifetime
-
2002
- 2002-04-09 HK HK02102627.5A patent/HK1041268B/zh not_active IP Right Cessation
- 2002-04-10 HK HK02102721.0A patent/HK1041005B/zh not_active IP Right Cessation
- 2002-12-09 US US10/315,568 patent/US7718177B2/en not_active Expired - Lifetime
-
2004
- 2004-08-20 AU AU2004205171A patent/AU2004205171B2/en not_active Expired
-
2007
- 2007-07-31 CY CY20071101018T patent/CY1108860T1/el unknown
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2010
- 2010-04-06 US US12/755,367 patent/US20100190838A1/en not_active Abandoned
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