CY1108860T1 - Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους - Google Patents

Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους

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Publication number
CY1108860T1
CY1108860T1 CY20071101018T CY071101018T CY1108860T1 CY 1108860 T1 CY1108860 T1 CY 1108860T1 CY 20071101018 T CY20071101018 T CY 20071101018T CY 071101018 T CY071101018 T CY 071101018T CY 1108860 T1 CY1108860 T1 CY 1108860T1
Authority
CY
Cyprus
Prior art keywords
methods
ctgf
brushes
growth
fragments
Prior art date
Application number
CY20071101018T
Other languages
English (en)
Inventor
Gary R Grotendorst
Original Assignee
University Of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Miami filed Critical University Of Miami
Publication of CY1108860T1 publication Critical patent/CY1108860T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)

Abstract

Η παρούσα εφεύρεση απευθύνεται στα θραύσματα του CTGF τα οποία περιλαμβάνουν τουλάχιστον το εξόνιο 2 ή το εξόνιο 3 του CTGF και έχουν την δυνατότητα να προκαλούν την σύνθεση εξωκυττάριας μήτρας, ειδικότερα, τη σύνθεση κολλαγόνου και τη διαφοροποίηση μυοϊνοβλάστη. Η παρούσα εφεύρεση περαιτέρω απευθύνεται σε μεθόδους που χρησιμοποιούν τα εν λόγω θραύσματα του CTGF για αναγνώριση συνθέσεων που διαμορφώνουν τη δραστηριότητα των εν λόγω θραυσμάτων του CTGF και στις συνθέσεις έτσι αναγνωρισμένες. Η εφεύρεση αναφέρεται επίσης σε μεθόδους θεραπείας των συνδεδεμένων με CTGF διαταραχών και των ασθενειών που συνδέονται με την υπερπαραγωγή της εξωκυττάριας μήτρας.
CY20071101018T 1998-12-14 2007-07-31 Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους CY1108860T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11224198P 1998-12-14 1998-12-14
US11224098P 1998-12-14 1998-12-14
EP99965256A EP1140969B1 (en) 1998-12-14 1999-12-14 Connective tissue growth factor fragments and methods and uses thereof

Publications (1)

Publication Number Publication Date
CY1108860T1 true CY1108860T1 (el) 2014-07-02

Family

ID=26809725

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101018T CY1108860T1 (el) 1998-12-14 2007-07-31 Θραυσματα αυξητικου παραγοντα συνδετικου ιστου και μεθοδοι και χρησεις τους

Country Status (16)

Country Link
US (3) US6492129B1 (el)
EP (2) EP1140964B1 (el)
JP (2) JP4722290B2 (el)
KR (2) KR100664626B1 (el)
CN (3) CN1660911A (el)
AT (2) ATE364617T1 (el)
AU (3) AU773278B2 (el)
CA (2) CA2354456A1 (el)
CY (1) CY1108860T1 (el)
DE (2) DE69936315T2 (el)
DK (1) DK1140969T3 (el)
ES (2) ES2288321T3 (el)
HK (2) HK1041268B (el)
MX (1) MXPA01005949A (el)
PT (1) PT1140969E (el)
WO (2) WO2000035936A1 (el)

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HK1041268A1 (en) 2002-07-05
DK1140969T3 (da) 2007-09-17
CN1170849C (zh) 2004-10-13
WO2000035936A1 (en) 2000-06-22
EP1140964B1 (en) 2008-04-09
AU3121100A (en) 2000-07-03
DE69938507T2 (de) 2009-06-10
HK1041268B (zh) 2009-02-27
EP1140969A1 (en) 2001-10-10
KR20010101207A (ko) 2001-11-14
JP2002532082A (ja) 2002-10-02
US6492129B1 (en) 2002-12-10
ATE364617T1 (de) 2007-07-15
AU2181900A (en) 2000-07-03
EP1140969B1 (en) 2007-06-13
HK1041005B (zh) 2007-11-09
JP4722290B2 (ja) 2011-07-13
DE69936315D1 (de) 2007-07-26
HK1041005A1 (en) 2002-06-28
PT1140969E (pt) 2007-08-30
EP1140964A4 (en) 2003-06-18
CN1334819A (zh) 2002-02-06
EP1140964A2 (en) 2001-10-10
KR100664626B1 (ko) 2007-01-04
CN1334820A (zh) 2002-02-06
CA2354422A1 (en) 2000-06-22
US20030180300A1 (en) 2003-09-25
JP2002532084A (ja) 2002-10-02
MXPA01005949A (es) 2002-09-18
JP4634614B2 (ja) 2011-02-16
ES2288321T3 (es) 2008-01-01
WO2000035939A3 (en) 2000-10-12
EP1140969A4 (en) 2003-07-23
AU773278B2 (en) 2004-05-20
CN1187370C (zh) 2005-02-02
US7718177B2 (en) 2010-05-18
ATE391724T1 (de) 2008-04-15
DE69936315T2 (de) 2008-02-14
US20100190838A1 (en) 2010-07-29
CA2354456A1 (en) 2000-06-22
WO2000035939A2 (en) 2000-06-22
KR100664625B1 (ko) 2007-01-04
DE69938507D1 (en) 2008-05-21
KR20010101194A (ko) 2001-11-14
AU2004205171B2 (en) 2007-08-09
CN1660911A (zh) 2005-08-31
AU775391B2 (en) 2004-07-29
AU2004205171A1 (en) 2004-09-16
ES2304811T3 (es) 2008-10-16

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