SG108208A1 - Connective tissue growth factor - Google Patents

Connective tissue growth factor

Info

Publication number
SG108208A1
SG108208A1 SG9806251A SG1998006251A SG108208A1 SG 108208 A1 SG108208 A1 SG 108208A1 SG 9806251 A SG9806251 A SG 9806251A SG 1998006251 A SG1998006251 A SG 1998006251A SG 108208 A1 SG108208 A1 SG 108208A1
Authority
SG
Singapore
Prior art keywords
ctgf
growth factor
connective tissue
tissue growth
provides
Prior art date
Application number
SG9806251A
Other languages
English (en)
Inventor
R Grotendorst Gary
M Bradham Douglass Jr
Original Assignee
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida filed Critical Univ South Florida
Publication of SG108208A1 publication Critical patent/SG108208A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
SG9806251A 1995-06-02 1996-05-31 Connective tissue growth factor SG108208A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/459,717 US5770209A (en) 1991-08-30 1995-06-02 Acceleration of wound healing using connective tissue growth factor

Publications (1)

Publication Number Publication Date
SG108208A1 true SG108208A1 (en) 2005-01-28

Family

ID=23825885

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9806251A SG108208A1 (en) 1995-06-02 1996-05-31 Connective tissue growth factor

Country Status (11)

Country Link
US (4) US5770209A (de)
EP (2) EP0831885A4 (de)
JP (4) JPH11507332A (de)
CN (2) CN1191491A (de)
AT (1) ATE464067T1 (de)
AU (2) AU722919B2 (de)
BR (2) BR9608558A (de)
CA (2) CA2222509C (de)
DE (1) DE69638162D1 (de)
SG (1) SG108208A1 (de)
WO (2) WO1996038168A1 (de)

Families Citing this family (75)

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US5408040A (en) * 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US7384634B2 (en) 1991-08-30 2008-06-10 University Of South Florida Connective tissue growth factor
US7026299B2 (en) 1994-07-12 2006-04-11 Human Genome Sciences, Inc. Connective tissue growth factor-2
US6638912B2 (en) 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
AU763649B2 (en) * 1995-06-02 2003-07-31 University Of South Florida Connective tissue growth factor
US20090081228A1 (en) * 1996-03-15 2009-03-26 Munin Corporation Cyr61 compositions and methods
US6790606B1 (en) * 1996-03-15 2004-09-14 Munin Corporation Extracellular matrix signaling molecules
CA2248549A1 (en) 1996-03-15 1997-09-18 Munin Corporation Extracellular matrix signalling molecules
US7521540B2 (en) * 1996-03-15 2009-04-21 Munin Corporation CYR61 compositions and methods
US20040132987A1 (en) 1996-11-08 2004-07-08 Human Genome Sciences, Inc. Connective tissue growth factor-3
DE69634994T2 (de) * 1996-11-08 2006-03-23 Human Genome Sciences, Inc. Bindegewebs-Wachstumsfaktor 3
AU742638B2 (en) * 1996-12-06 2002-01-10 Mesoblast International Sarl Improved chondrogenic differentiation of human mesenchymal stem cells
DE19719652A1 (de) * 1997-05-09 1998-12-03 Merckle Gmbh Tissue-Faktor zur Förderung von Wundheilung
CA2294569A1 (en) * 1997-06-19 1998-12-23 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
CA2294564A1 (en) * 1997-06-19 1998-12-23 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a growth factor-like protein
US5876730A (en) * 1997-08-07 1999-03-02 Childrens Hospital Research Foundation Heparin-binding growth factor (HBGF) polypeptides
AU1682699A (en) * 1997-12-25 1999-07-19 Japan Tobacco Inc. Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
JP4537507B2 (ja) * 1997-12-25 2010-09-01 アムジェン インコーポレイテッド 結合組織増殖因子に対するモノクローナル抗体及びその医薬用途
US20070141181A1 (en) 1998-02-13 2007-06-21 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6797289B2 (en) 1998-02-13 2004-09-28 Nutramax Laboratories, Inc. Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals
US6451771B1 (en) 1999-02-12 2002-09-17 Nutramax Laboratories, Inc. Use of anabolic agents anti-catabolic agents and antioxidant agents for protection treatment and repair of connective tissues in humans and animals
DE69941966D1 (de) * 1998-02-13 2010-03-11 Nutramax Lab Inc Mittel und Verfahren zum Schutz, zur Behandlung und Reparatur von Bindegewebe
CN1326361A (zh) * 1998-09-08 2001-12-12 亨利福特保健系统公司 通过修饰、调节及抑制结缔组织生长因子来检查、预防和治疗肾脏疾病的方法
US6348329B1 (en) 1998-11-06 2002-02-19 Fibrogen, Inc. Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use
US7115390B1 (en) 1998-12-14 2006-10-03 Fibrogen, Inc. Connective tissue growth factor fragments and methods and uses thereof
US6350472B1 (en) * 1998-12-14 2002-02-26 Steinbach, Pylant, And Hermann, L.L.C. Method of treating HIV infection with transdermal gel containing mammalian liver extract
KR100664625B1 (ko) * 1998-12-14 2007-01-04 유니버시티 오브 마이애미 결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도
CN101385851A (zh) * 1999-02-01 2009-03-18 遗传研究所公司 用于关节软骨愈合和修复的方法和组合物
US6537755B1 (en) * 1999-03-25 2003-03-25 Radoje T. Drmanac Solution-based methods and materials for sequence analysis by hybridization
US6555322B1 (en) 1999-08-27 2003-04-29 Fibrogen, Inc. α2-macroglobulin receptor as a receptor for CTGF
EP1373299A4 (de) * 2000-07-11 2005-01-19 Human Genome Sciences Inc Bindegewebs-wachstumsfaktor-2
US20060052328A1 (en) * 2000-07-11 2006-03-09 Human Genome Sciences, Inc. Connective tissue growth factor-2
US6939540B1 (en) 2000-07-31 2005-09-06 Cornell Research Foundation, Inc. Method of enhancing bone density
US6599526B2 (en) * 2000-08-18 2003-07-29 The University Of North Texas Health Science Center At Fort Worth Pericardial anti-adhesion patch
AU2002224056A1 (en) 2000-11-22 2002-06-03 Yamanouchi Pharmaceutical Co..Ltd. Novel polypeptide
AU2002326939A1 (en) * 2001-09-18 2003-04-01 Fibrogen, Inc. Methods of assaying connective tissue growth factor
RU2004112543A (ru) * 2001-09-24 2005-03-27 Вериген Аг (De) Композиция-коктейль аутологичных факторов роста, способ получения и применение
JP4456796B2 (ja) * 2001-09-27 2010-04-28 株式会社林原生物化学研究所 コラーゲン産生増強剤の製造方法とその用途
US6965025B2 (en) * 2001-12-10 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of connective tissue growth factor expression
AU2002352201B2 (en) * 2001-12-12 2009-01-29 Merck Patent Gmbh Inhibition of tristetraproline for protection of the heart from cardiac injuries
JP2005523928A (ja) * 2002-04-30 2005-08-11 アルコン，インコーポレイテッド 眼内圧の低下および緑内障性網膜症／眼神経障害の処置の両方のための独特の手段としての、結合組織増殖因子（ｃｔｇｆ）の活性および／または発現を調節するか、阻害するか、または調整する薬剤
EP1925306A3 (de) 2002-04-30 2008-09-17 Alcon, Inc. Agentien welche die Aktivität und/oder Expression des Connective Tissue Growth Factor (CTGF) regulieren, unterdrücken oder modulieren zur Verringerung des Augeninnendruckes
WO2004099372A2 (en) * 2003-05-01 2004-11-18 University Of Florida Anti-scarring ribozymes and methods
US7405274B2 (en) 2003-06-04 2008-07-29 Fibrogen, Inc. Connective tissue growth factor antibodies
WO2005033136A1 (en) * 2003-09-29 2005-04-14 Children's Hospital, Inc. Unique integrin binding site in connective tissue growth factor (ctgf)
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US20050191653A1 (en) * 2003-11-03 2005-09-01 Freier Susan M. Modulation of SGLT2 expression
AU2005212371B2 (en) 2004-02-11 2010-05-13 Fibrogen, Inc. CTGF as target for the therapy of diabetic nephropathy
MXPA06012576A (es) 2004-04-28 2007-01-31 Fibrogen Inc Tratamientos para cancer pancreatico.
WO2005120231A1 (en) * 2004-06-08 2005-12-22 Fibrogen, Inc. Connective tissue growth factor regulates intracellular signaling pathways
TWI386225B (zh) * 2004-12-23 2013-02-21 Alcon Inc 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術
US20060275797A1 (en) * 2005-03-21 2006-12-07 Alcon Manufacturing, Ltd. Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders
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US20110244006A1 (en) * 2007-11-29 2011-10-06 The Trustees Of Columbia University In The City Of New York Microsphere skin treatment
US20100331249A1 (en) * 2008-07-23 2010-12-30 National Taiwan University Pharmaceutical composition for inhibiting peritoneal dissemination
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US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
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JP5166360B2 (ja) * 2009-06-23 2013-03-21 株式会社島津製作所 マイクロ反応装置を用いた細胞運動評価方法
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WO2011056234A1 (en) 2009-11-06 2011-05-12 Fibrogen, Inc. Treatment for radiation-induced disorders
JP6060071B2 (ja) 2010-03-24 2017-01-11 アールエックスアイ ファーマシューティカルズ コーポレーション 皮膚および線維症適用におけるｒｎａ干渉
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CN104302780B (zh) 2011-08-05 2017-04-12 艾克斯-马赛大学 纤维变性易感性il22ra2基因及其用途
WO2013165590A1 (en) 2012-05-03 2013-11-07 Fibrogen, Inc. Methods for treating idiopathic pulmonary fibrosis
US9631013B2 (en) 2014-01-28 2017-04-25 Fibrogen, Inc. Therapeutic method for pancreatic cancer
KR20240004541A (ko) * 2018-11-08 2024-01-11 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. 부착 비의존성 세포 및 그 용도
MX2021014803A (es) 2019-06-04 2022-01-18 Jiangsu Hengrui Medicine Co Anticuerpo anti-factor de crecimiento de tejido conectivo y aplicacion del mismo.
US20210100608A1 (en) * 2019-10-03 2021-04-08 CyPhi LLC Method of connective tissue restoration
EP4238558A1 (de) * 2022-03-02 2023-09-06 Bjorn Eek Behandlung von bindegewebsverletzungen

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408040A (en) * 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)

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US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
FR2678283A1 (fr) * 1991-06-25 1992-12-31 Centre Nat Rech Scient Sequences de nucleotides, sequences d'acides amines correspondantes, et leurs applications biologiques.
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins

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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
DE69638162D1 (de) 2010-05-27
CA2222609A1 (en) 1996-12-05
AU5885596A (en) 1996-12-18
BR9608558A (pt) 1999-11-30
US6069006A (en) 2000-05-30
CN1195295A (zh) 1998-10-07
JPH11506449A (ja) 1999-06-08
AU722919B2 (en) 2000-08-17
MX9709294A (es) 1998-08-30
EP0831903B1 (de) 2010-04-14
BR9609521A (pt) 1999-06-15
EP0831885A4 (de) 2000-11-29
US6150101A (en) 2000-11-21
WO1996038168A1 (en) 1996-12-05
JPH11507332A (ja) 1999-06-29
EP0831903A1 (de) 1998-04-01
EP0831885A1 (de) 1998-04-01
CA2222509A1 (en) 1996-12-05
CN1191491A (zh) 1998-08-26
EP0831903A4 (de) 2001-02-28
JP2004132974A (ja) 2004-04-30
US5770209A (en) 1998-06-23
ATE464067T1 (de) 2010-04-15
CA2222509C (en) 2012-12-04
JP2007051150A (ja) 2007-03-01
AU720268B2 (en) 2000-05-25
US6232064B1 (en) 2001-05-15
WO1996038172A1 (en) 1996-12-05
AU5958296A (en) 1996-12-18

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