ITTO20020729A1 - Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'. - Google Patents

Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'.

Info

Publication number
ITTO20020729A1
ITTO20020729A1 IT000729A ITTO20020729A ITTO20020729A1 IT TO20020729 A1 ITTO20020729 A1 IT TO20020729A1 IT 000729 A IT000729 A IT 000729A IT TO20020729 A ITTO20020729 A IT TO20020729A IT TO20020729 A1 ITTO20020729 A1 IT TO20020729A1
Authority
IT
Italy
Prior art keywords
procedure
production
genetically modified
human mammal
modified non
Prior art date
Application number
IT000729A
Other languages
English (en)
Inventor
Laura Amicone
Maria Grazia Sacco
Marco Tripodi
Paolo Maria Vezzoni
Original Assignee
Consorzio Interuniversitario Per Le Biotecnologie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consorzio Interuniversitario Per Le Biotecnologie filed Critical Consorzio Interuniversitario Per Le Biotecnologie
Priority to IT000729A priority Critical patent/ITTO20020729A1/it
Publication of ITTO20020729A0 publication Critical patent/ITTO20020729A0/it
Priority to EP03788002A priority patent/EP1529111A2/en
Priority to PCT/IT2003/000506 priority patent/WO2004016777A2/en
Publication of ITTO20020729A1 publication Critical patent/ITTO20020729A1/it
Priority to US11/056,941 priority patent/US20050255595A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT000729A 2002-08-14 2002-08-14 Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'. ITTO20020729A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT000729A ITTO20020729A1 (it) 2002-08-14 2002-08-14 Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'.
EP03788002A EP1529111A2 (en) 2002-08-14 2003-08-11 Genetically modified non-human mammal cells, procedure for their production and use in toxicity tests
PCT/IT2003/000506 WO2004016777A2 (en) 2002-08-14 2003-08-11 Genetically modified non-human mammal cells, procedure for their production and use in toxicity tests
US11/056,941 US20050255595A1 (en) 2002-08-14 2005-02-11 Genetically modified non-human mammal cells, procedure for their production and use in toxicity tests

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000729A ITTO20020729A1 (it) 2002-08-14 2002-08-14 Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'.

Publications (2)

Publication Number Publication Date
ITTO20020729A0 ITTO20020729A0 (it) 2002-08-14
ITTO20020729A1 true ITTO20020729A1 (it) 2004-02-15

Family

ID=11459581

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000729A ITTO20020729A1 (it) 2002-08-14 2002-08-14 Cellule di mammifero non umano geneticamente modificate, procedimento per la loro produzione e utilizzo in test di tossicita'.

Country Status (4)

Country Link
US (1) US20050255595A1 (it)
EP (1) EP1529111A2 (it)
IT (1) ITTO20020729A1 (it)
WO (1) WO2004016777A2 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030395A1 (it) 2003-08-12 2005-02-13 Istituto Naz Per Le Malattie Infettive Lazz Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero.
GB0610792D0 (en) * 2006-06-02 2006-07-12 Remynd Nv Methods and tools for the screening of factors affecting protein misfolding

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0680517B2 (en) * 1993-01-21 2005-01-19 President And Fellows Of Harvard College Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
IT1294450B1 (it) * 1997-08-28 1999-03-25 Consiglio Nazionale Ricerche Animali transgenici per lo studio di agenti tossici chimici fisici o biologici

Also Published As

Publication number Publication date
ITTO20020729A0 (it) 2002-08-14
EP1529111A2 (en) 2005-05-11
WO2004016777A3 (en) 2004-03-25
WO2004016777A8 (en) 2005-02-03
WO2004016777A2 (en) 2004-02-26
US20050255595A1 (en) 2005-11-17

Similar Documents

Publication Publication Date Title
DK1597382T3 (da) Genetisk modificerede ikke-humane pattedyr og celler
WO2004086091A3 (en) Gravity techniques for drilling and logging
GB2417806B (en) Memory with bit swapping on the fly and testing
NO20044141D0 (no) Elektrokjemiske brenselceller
DE60308850D1 (de) Pyridinoylpiperidine als 5-ht1f agonisten
WO2004029219A3 (en) Cell-based rna interference and related methods and compositions
GB2423588B (en) Probe testing structure
GT200000002AA (es) Ureas difenilicias x-carboxiaril sustituidas como inhibidores de raf quinasa
DE60326145D1 (de) Spielermittlungsverfahren
IS7829A (is) Nýjar 1,4-díazabísýklóalkan-afleiður, framleiðslaþeirra og notkun
DE60303193D1 (de) Antiverschmutzungsreinigungsmittel für harte oberflächen
AU2003265258A8 (en) Cell buffer with built-in test
FI20031677A0 (fi) Elektrodirakenne sähköisten vasteiden mittaamiseksi ihmiskehosta
WO2006089268A3 (en) Gene and cognate protein profiles and methods to determine connective tissue markers in normal and pathologic conditions
IS8179A (is) Díarýlmetýlídenpíparídínafleiður og notkun þeirrasem deltaópíóíðviðtakagerandefna
ITTO20020729A0 (it) Cellule di mammifero non umano geneticamente modificate,procedimento per la loro produzione e utilizzo in test di tossicita'.
FI20021500A0 (fi) Paristosovitelma sondeja varten sekä sondi
ATA2792002A (de) Temperaturfühler
DE50302580D1 (de) Kugelzapfen
GB0210486D0 (en) Improvements in or relating to transducer testing
ITMI20020872A0 (it) Derivati dell'iperforina loro uso e formulazioni che li contengono
AU2003252164A8 (en) Insulin-producing cell compositions and related methods
ITTO20030218A1 (it) Sonda, in particolare per cavita' tubolari.
DE04252651T1 (de) Eine Einfassung für einen Geldautomaten
WO2003052380A3 (en) Recruitment of mst1 or mst2 protein kinase to induce apoptosis in eukaryotic cells