GR1000576B - Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του. - Google Patents

Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του.

Info

Publication number
GR1000576B
GR1000576B GR890100771A GR890100771A GR1000576B GR 1000576 B GR1000576 B GR 1000576B GR 890100771 A GR890100771 A GR 890100771A GR 890100771 A GR890100771 A GR 890100771A GR 1000576 B GR1000576 B GR 1000576B
Authority
GR
Greece
Prior art keywords
piperazinyl
chlorophenyl
ethoxy
preparing
acetic acid
Prior art date
Application number
GR890100771A
Other languages
Greek (el)
English (en)
Other versions
GR890100771A (en
Inventor
Guy Bodson
Eric Cossement
Jean Gobert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of GR890100771A publication Critical patent/GR890100771A/el
Publication of GR1000576B publication Critical patent/GR1000576B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR890100771A 1988-11-23 1989-11-20 Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του. GR1000576B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827390A GB8827390D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride

Publications (2)

Publication Number Publication Date
GR890100771A GR890100771A (en) 1990-12-31
GR1000576B true GR1000576B (el) 1992-08-26

Family

ID=10647346

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100771A GR1000576B (el) 1988-11-23 1989-11-20 Μεθοδος παρασκευης του 2-(2-(4-((4-χλωροφενυλ)φενυλμεθυλ)-1-πιπεραζινυλ)εθοξυ)οξικου οξεος και του διυδροχλωρικου αλατιου του.

Country Status (17)

Country Link
KR (1) KR970009727B1 (ru)
AT (1) AT398970B (ru)
CA (1) CA1320732C (ru)
CY (1) CY1696A (ru)
DK (1) DK174289B1 (ru)
ES (1) ES2018967A6 (ru)
FI (1) FI91861C (ru)
GB (2) GB8827390D0 (ru)
GR (1) GR1000576B (ru)
HK (1) HK45493A (ru)
HU (1) HU208002B (ru)
NO (1) NO172287C (ru)
PH (1) PH26334A (ru)
PL (1) PL161374B1 (ru)
PT (1) PT92363B (ru)
RU (1) RU1838306C (ru)
SG (1) SG12793G (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994006430A1 (en) * 1992-09-24 1994-03-31 Sepracor, Inc. Methods and compositions for treating allergic disorders using optically pure (+) cetirizine
ATE170749T1 (de) * 1992-09-24 1998-09-15 Sepracor Inc Verwendung von (-) cetirizin zur behandlung allergischer rhinitis und und asthma
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
CA2180993A1 (en) * 1996-07-11 1998-01-12 Yong Tao Methods for the manufacture of cetirizine
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DK176706B1 (da) * 1999-03-04 2009-03-30 Sandoz As Fremgangsmåde til fremstilling af 2-{2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy}-eddikesyre-forbindelser eller salte deraf
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2003104212A1 (en) * 2002-06-05 2003-12-18 Dr.Reddy's Laboratories Ltd. A novel amorphous form of [2-[4-[(4-chlorophenyl)-phenyl methyl]-1- piperazinyl] ethoxy] acetic acid dihydrochloride (cetirizine dihydrochloride)
CN100378086C (zh) * 2003-01-23 2008-04-02 Ucb法奇姆股份有限公司 哌嗪衍生物和它们作为合成中间体的应用
WO2004103982A1 (en) * 2003-05-21 2004-12-02 Wockhardt Limited 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production
WO2010046908A2 (en) 2008-09-17 2010-04-29 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
KR101418404B1 (ko) 2012-01-06 2014-07-10 한미약품 주식회사 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
KR102226833B1 (ko) 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817231A (en) * 1956-01-27 1959-07-29 Henri Morren New derivatives of n-mono-benzhydryl-piperazine and process for the preparation thereof
US3090725A (en) * 1960-02-29 1963-05-21 Burroughs Wellcome Co Phosphorylated quaternary ammonium compounds of improved oral absorption
FI75816C (fi) * 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.

Also Published As

Publication number Publication date
PH26334A (en) 1992-04-29
DK174289B1 (da) 2002-11-18
PL161374B1 (pl) 1993-06-30
AT398970B (de) 1995-02-27
CY1696A (en) 1994-01-14
GB2225320B (en) 1992-09-02
GR890100771A (en) 1990-12-31
HU896130D0 (en) 1990-02-28
PT92363B (pt) 1995-07-18
NO894650D0 (no) 1989-11-22
FI91861B (fi) 1994-05-13
HK45493A (en) 1993-05-21
GB2225320A (en) 1990-05-30
DK586589A (da) 1990-05-24
SG12793G (en) 1993-04-16
NO172287B (no) 1993-03-22
HUT53626A (en) 1990-11-28
ATA266489A (de) 1994-07-15
FI91861C (fi) 1994-08-25
GB8827390D0 (en) 1988-12-29
HU208002B (en) 1993-07-28
RU1838306C (ru) 1993-08-30
KR900007824A (ko) 1990-06-02
ES2018967A6 (es) 1991-05-16
GB8926242D0 (en) 1990-01-10
NO894650L (no) 1990-05-25
DK586589D0 (da) 1989-11-22
KR970009727B1 (ko) 1997-06-17
CA1320732C (en) 1993-07-27
FI895563A0 (fi) 1989-11-22
PT92363A (pt) 1990-05-31
NO172287C (no) 1993-06-30

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