GB2210875B - Aromatase inhibiting 4(5)-imidazoles - Google Patents

Aromatase inhibiting 4(5)-imidazoles

Info

Publication number
GB2210875B
GB2210875B GB8723715A GB8723715A GB2210875B GB 2210875 B GB2210875 B GB 2210875B GB 8723715 A GB8723715 A GB 8723715A GB 8723715 A GB8723715 A GB 8723715A GB 2210875 B GB2210875 B GB 2210875B
Authority
GB
United Kingdom
Prior art keywords
imidazoles
aromatase inhibiting
aromatase
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
GB8723715A
Other languages
English (en)
Other versions
GB2210875A (en
GB8723715D0 (en
Inventor
Arto Johannes Karjalainen
Lauri Veikko Matti Kangas
Kauko Oiva Antero Kurkela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmos Yhtyma Oy
Original Assignee
Farmos Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Yhtyma Oy filed Critical Farmos Yhtyma Oy
Priority to GB8723715A priority Critical patent/GB2210875B/en
Publication of GB8723715D0 publication Critical patent/GB8723715D0/en
Priority to CA000578192A priority patent/CA1329616C/en
Priority to FI884497A priority patent/FI93105C/fi
Priority to DK550988A priority patent/DK550988A/da
Priority to DD88320542A priority patent/DD282912A5/de
Priority to NZ226483A priority patent/NZ226483A/xx
Priority to AU23490/88A priority patent/AU615482B2/en
Priority to DE8888309413T priority patent/DE3874073T2/de
Priority to IE305588A priority patent/IE61180B1/en
Priority to IL87969A priority patent/IL87969A/xx
Priority to HU885213A priority patent/HU201024B/hu
Priority to UA4356681A priority patent/UA13218A/uk
Priority to ES88309413T priority patent/ES2043839T3/es
Priority to AT88309413T priority patent/ATE79872T1/de
Priority to ZA887545A priority patent/ZA887545B/xx
Priority to NO884473A priority patent/NO172048C/no
Priority to PT88717A priority patent/PT88717B/pt
Priority to EP88309413A priority patent/EP0311447B1/en
Priority to SU884356681A priority patent/RU1819263C/ru
Priority to JP63254665A priority patent/JPH01132568A/ja
Priority to KR1019880013196A priority patent/KR890006593A/ko
Priority to CN88108425A priority patent/CN1036993C/zh
Publication of GB2210875A publication Critical patent/GB2210875A/en
Priority to US07/588,873 priority patent/US5098923A/en
Application granted granted Critical
Publication of GB2210875B publication Critical patent/GB2210875B/en
Priority to SU925010700A priority patent/RU2045519C1/ru
Priority to GR920402701T priority patent/GR3006343T3/el
Priority to LVP-93-639A priority patent/LV10438B/en
Priority to LTIP916A priority patent/LT3658B/lt
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8723715A 1987-10-09 1987-10-09 Aromatase inhibiting 4(5)-imidazoles Revoked GB2210875B (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GB8723715A GB2210875B (en) 1987-10-09 1987-10-09 Aromatase inhibiting 4(5)-imidazoles
CA000578192A CA1329616C (en) 1987-10-09 1988-09-22 Aromatase inhibiting 4(5)-imidazoles
FI884497A FI93105C (fi) 1987-10-09 1988-09-30 Menetelmä uusien, aromataasia inhiboivien 4(5)-imidatsolien valmistamiseksi
DK550988A DK550988A (da) 1987-10-09 1988-10-03 Aromataseinhiberende 4(5)-imidazoler og farmaceutisk praeparat indeholdende saadanne forbindelser
DD88320542A DD282912A5 (de) 1987-10-09 1988-10-06 Verfahren zur herstellung eines substituierten imidazols
NZ226483A NZ226483A (en) 1987-10-09 1988-10-06 Substituted imidazole derivatives and pharmaceutical compositions
AU23490/88A AU615482B2 (en) 1987-10-09 1988-10-06 Aromatase inhibiting 4(5)-imidazoles
ZA887545A ZA887545B (en) 1987-10-09 1988-10-07 Aromatase inhibiting 4(5)-imidazoles
IE305588A IE61180B1 (en) 1987-10-09 1988-10-07 Aromatase inhibiting 4(5)-imidazoles
IL87969A IL87969A (en) 1987-10-09 1988-10-07 Aromatase inhibiting 4(5)-imidazoles and pharmaceutical compositions containing them
HU885213A HU201024B (en) 1987-10-09 1988-10-07 Process for producing 4(5)-imidazole derivatives having aromatase inhibiting activity
UA4356681A UA13218A (uk) 1987-10-09 1988-10-07 Спосіб одержаhhя заміщеhих імідазолів або їх hетоксичhих фармацевтичhо прийhятhих адитивhих солей
ES88309413T ES2043839T3 (es) 1987-10-09 1988-10-07 Un procedimiento para preparar un imidazol sustituido.
AT88309413T ATE79872T1 (de) 1987-10-09 1988-10-07 Aromatasehemmende 4(5)-imidazole.
DE8888309413T DE3874073T2 (de) 1987-10-09 1988-10-07 Aromatasehemmende 4(5)-imidazole.
NO884473A NO172048C (no) 1987-10-09 1988-10-07 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazoler
PT88717A PT88717B (pt) 1987-10-09 1988-10-07 Processo para a preparacao de derivados imidazolicos substituidos e de composicoes farmaceuticas que os contem
EP88309413A EP0311447B1 (en) 1987-10-09 1988-10-07 Aromatase inhibiting 4(5)-imidazoles
SU884356681A RU1819263C (ru) 1987-10-09 1988-10-07 Способ получени замещенных имидазолов или их нетоксичных фармацевтически приемлемых аддитивных солей
KR1019880013196A KR890006593A (ko) 1987-10-09 1988-10-08 아르마타제 억제4(5)- 이미다졸
JP63254665A JPH01132568A (ja) 1987-10-09 1988-10-08 アロマターゼ阻害置換４（５）‐イミダゾール
CN88108425A CN1036993C (zh) 1987-10-09 1988-10-08 制备抑制芳香酶的4(5)－咪唑的方法
US07/588,873 US5098923A (en) 1987-10-09 1990-09-27 Aromatase inhibiting 4(5)-imidazoles
SU925010700A RU2045519C1 (ru) 1987-10-09 1992-01-23 Способ получения замещенного имидазола
GR920402701T GR3006343T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-10-09 1992-11-26
LVP-93-639A LV10438B (en) 1987-10-09 1993-06-22 Aromatase inhibiting 4(5)-imidazoles
LTIP916A LT3658B (en) 1987-10-09 1993-08-31 Method for preparing aromatase inhibiting 4(5)-imidazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8723715A GB2210875B (en) 1987-10-09 1987-10-09 Aromatase inhibiting 4(5)-imidazoles

Publications (3)

Publication Number Publication Date
GB8723715D0 GB8723715D0 (en) 1987-11-11
GB2210875A GB2210875A (en) 1989-06-21
GB2210875B true GB2210875B (en) 1991-05-29

Family

ID=10625036

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8723715A Revoked GB2210875B (en) 1987-10-09 1987-10-09 Aromatase inhibiting 4(5)-imidazoles

Country Status (24)

Country Link
US (1) US5098923A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0311447B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH01132568A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR890006593A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1036993C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU615482B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1329616C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD282912A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3874073T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK550988A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2043839T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI93105C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2210875B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006343T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU201024B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE61180B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL87969A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LT (1) LT3658B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO172048C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ226483A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT88717B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (2) RU1819263C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (1) UA13218A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA887545B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2210875B (en) 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
AU627559B2 (en) * 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles
US5439928A (en) * 1989-03-30 1995-08-08 Orion-Yhtyma Oy Aromatase inhibiting 4(5)-imidazoles
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
GB2248058B (en) 1990-09-21 1994-09-14 Orion Yhtymae Oy Aromatase inhibiting 4(5)-imidazoles
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
ZA962879B (en) * 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
WO1997026246A1 (en) * 1996-01-16 1997-07-24 Warner-Lambert Company Substituted histidine inhibitors of protein farnesyltransferase
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
CZ300929B6 (cs) * 1997-08-15 2009-09-16 Duke University Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6515074B2 (en) * 2001-01-22 2003-02-04 Delphi Technologies, Inc. Thermoplastic polymer alloy compositions and process for manufacture thereof
RS51097B (sr) 2002-03-26 2010-10-31 Boehringer Ingelheim Pharmaceuticals Inc. Glukokortikoidni mimetici,postupci za njihovo dobijanje, farmaceutski preparati i njihova primena
JP2005521717A (ja) * 2002-03-26 2005-07-21 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
MXPA05006872A (es) 2003-01-03 2005-08-16 Boehringer Ingelheim Pharma Derivados de 1-propanol y 1-propilamina y su uso como ligandos glucocorticoides.
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
US7635711B2 (en) 2004-12-27 2009-12-22 Boehringer-Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
BRPI0720131A2 (pt) 2006-12-06 2014-02-04 Boehringer Ingelheim Int Glicocorticoides miméticos, métodos para fazê-los, composições farmacêuticas e usos dos mesmos.
EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
BRPI0915680A2 (pt) 2008-06-06 2019-09-24 Boehringer Ingelheim Int miméticos de glicocorticoide, métodos de prepará-los, composições farmacêuticas, e usos dos mesmos

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2096987B (en) * 1981-04-22 1984-04-04 Farmos Oy Substituted imidazole and imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB2210875B (en) 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
AU627559B2 (en) 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles

Also Published As

Publication number Publication date
RU2045519C1 (ru) 1995-10-10
AU2349088A (en) 1989-04-13
FI884497A7 (fi) 1989-04-10
IL87969A (en) 1993-04-04
EP0311447B1 (en) 1992-08-26
CA1329616C (en) 1994-05-17
CN1036993C (zh) 1998-01-14
DE3874073D1 (de) 1992-10-01
NO172048B (no) 1993-02-22
HU201024B (en) 1990-09-28
UA13218A (uk) 1997-02-28
FI884497A0 (fi) 1988-09-30
GR3006343T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
IE61180B1 (en) 1994-10-05
AU615482B2 (en) 1991-10-03
ES2043839T3 (es) 1994-01-01
DK550988A (da) 1989-04-10
US5098923A (en) 1992-03-24
JPH01132568A (ja) 1989-05-25
NO884473L (no) 1989-04-10
LT3658B (en) 1996-01-25
NO172048C (no) 1993-06-02
NZ226483A (en) 1991-02-26
HUT49582A (en) 1989-10-30
KR890006593A (ko) 1989-06-14
DE3874073T2 (de) 1993-01-21
GB2210875A (en) 1989-06-21
CN1033995A (zh) 1989-07-19
NO884473D0 (no) 1988-10-07
PT88717B (pt) 1992-12-31
FI93105C (fi) 1995-02-27
LTIP916A (en) 1995-03-27
GB8723715D0 (en) 1987-11-11
ZA887545B (en) 1989-06-28
RU1819263C (ru) 1993-05-30
EP0311447A1 (en) 1989-04-12
DK550988D0 (da) 1988-10-03
IE883055L (en) 1989-04-09
DD282912A5 (de) 1990-09-26
IL87969A0 (en) 1989-03-31
FI93105B (fi) 1994-11-15

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Legal Events

Date Code Title Description
773K Patent revoked under sect. 73(2)/1977