GB2209671B - Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients - Google Patents

Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients

Info

Publication number
GB2209671B
GB2209671B GB8821443A GB8821443A GB2209671B GB 2209671 B GB2209671 B GB 2209671B GB 8821443 A GB8821443 A GB 8821443A GB 8821443 A GB8821443 A GB 8821443A GB 2209671 B GB2209671 B GB 2209671B
Authority
GB
United Kingdom
Prior art keywords
solubilisers
water soluble
active compounds
pharmacologically active
pharmaceutical excipients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8821443A
Other languages
English (en)
Other versions
GB8821443D0 (en
GB2209671A (en
Inventor
Lorenz Hahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB8821443D0 publication Critical patent/GB8821443D0/en
Publication of GB2209671A publication Critical patent/GB2209671A/en
Application granted granted Critical
Publication of GB2209671B publication Critical patent/GB2209671B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB8821443A 1987-09-15 1988-09-13 Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients Expired - Lifetime GB2209671B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3730909 1987-09-15
DE3802355 1988-01-27

Publications (3)

Publication Number Publication Date
GB8821443D0 GB8821443D0 (en) 1988-10-12
GB2209671A GB2209671A (en) 1989-05-24
GB2209671B true GB2209671B (en) 1991-11-13

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8821443A Expired - Lifetime GB2209671B (en) 1987-09-15 1988-09-13 Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients

Country Status (24)

Country Link
JP (1) JP3090666B2 (it)
KR (1) KR0131084B1 (it)
AT (1) AT395819B (it)
AU (1) AU628787B2 (it)
BE (1) BE1001204A5 (it)
CA (1) CA1338775C (it)
CH (1) CH683672A5 (it)
DK (1) DK175132B1 (it)
ES (1) ES2012118A6 (it)
FI (1) FI94837C (it)
FR (1) FR2620336B1 (it)
GB (1) GB2209671B (it)
GR (1) GR1002243B (it)
HU (1) HU205010B (it)
IE (1) IE61195B1 (it)
IL (1) IL87746A (it)
IT (1) IT1224886B (it)
LU (1) LU87335A1 (it)
MY (1) MY103769A (it)
NL (1) NL195094C (it)
NO (1) NO179434C (it)
NZ (1) NZ226163A (it)
PT (1) PT88492B (it)
SE (1) SE503279C2 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
FR2642650B1 (fr) * 1989-02-09 1994-12-09 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
DE69307505T2 (de) 1992-05-13 1997-07-24 Sandoz-Patent-Gmbh, 79539 Loerrach Opthalmische zusammensetzungen enthaltend ein cyclosporin
PT589843E (pt) 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
DE69435104D1 (de) * 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
EP0789580B1 (de) 1994-11-03 2002-06-05 Novartis AG Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
TW414696B (en) * 1996-07-01 2000-12-11 Mitsubishi Kagaku Foods Kk Anti-bacteria agent
BR9807528A (pt) 1997-01-30 2000-03-14 Novartis Ag Composições farmacêuticas isentas de óleo contendo ciclosporina a
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
AU2003267747A1 (en) * 2003-10-14 2005-05-05 Ramesh Varada Bapat Sterile gelling agents
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284933A (it) * 1961-10-31
FR5986M (it) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pharm. Res. 3(1), 48-51 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Also Published As

Publication number Publication date
SE8803221L (sv) 1989-03-16
PT88492B (pt) 1993-03-31
GB8821443D0 (en) 1988-10-12
MY103769A (en) 1993-09-30
IT1224886B (it) 1990-10-24
ATA224988A (de) 1992-08-15
NO884052L (no) 1989-03-16
FR2620336B1 (fr) 1991-10-25
ES2012118A6 (es) 1990-03-01
NO179434C (no) 1996-10-09
SE503279C2 (sv) 1996-05-13
BE1001204A5 (fr) 1989-08-16
AT395819B (de) 1993-03-25
FI94837C (fi) 1995-11-10
JP3090666B2 (ja) 2000-09-25
DK175132B1 (da) 2004-06-14
NO179434B (no) 1996-07-01
AU628787B2 (en) 1992-09-24
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
LU87335A1 (fr) 1989-04-06
FI884192A0 (fi) 1988-09-13
KR0131084B1 (ko) 1998-04-17
FI94837B (fi) 1995-07-31
GR880100602A (el) 1989-06-22
NL8802275A (nl) 1989-04-03
IT8848349A0 (it) 1988-09-14
DK511188D0 (da) 1988-09-14
JPH01151526A (ja) 1989-06-14
IE882772L (en) 1989-03-15
DK511188A (da) 1989-03-16
FI884192A (fi) 1989-03-16
KR890004694A (ko) 1989-05-09
NZ226163A (en) 1991-08-27
FR2620336A1 (fr) 1989-03-17
NO884052D0 (no) 1988-09-13
GB2209671A (en) 1989-05-24
AU2217288A (en) 1989-04-27
IL87746A (en) 1992-07-15
CH683672A5 (de) 1994-04-29
IE61195B1 (en) 1994-10-19
PT88492A (pt) 1988-10-01
HUT49494A (en) 1989-10-30
CA1338775C (en) 1996-12-10
HU205010B (en) 1992-03-30
IL87746A0 (en) 1989-02-28
GR1002243B (en) 1996-04-22

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Expiry date: 20080912