GB2028306B - Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application - Google Patents
Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic applicationInfo
- Publication number
- GB2028306B GB2028306B GB7920102A GB7920102A GB2028306B GB 2028306 B GB2028306 B GB 2028306B GB 7920102 A GB7920102 A GB 7920102A GB 7920102 A GB7920102 A GB 7920102A GB 2028306 B GB2028306 B GB 2028306B
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxazolidinethiones
- thiazolidinones
- pyrrolidinones
- pyrrolidines
- proparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- UMURLIQHQSKULR-UHFFFAOYSA-N 1,3-oxazolidine-2-thione Chemical class S=C1NCCO1 UMURLIQHQSKULR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000003235 pyrrolidines Chemical class 0.000 abstract 1
- 150000004040 pyrrolidinones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7817388A FR2428032A1 (fr) | 1978-06-09 | 1978-06-09 | Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique |
| FR7824024A FR2435473A2 (fr) | 1978-08-17 | 1978-08-17 | Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2028306A GB2028306A (en) | 1980-03-05 |
| GB2028306B true GB2028306B (en) | 1983-01-12 |
Family
ID=26220626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7920102A Expired GB2028306B (en) | 1978-06-09 | 1979-06-08 | Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application |
| GB8021771A Expired GB2054575B (en) | 1978-06-09 | 1979-06-08 | N-aryl oxazolidinones and pyrrolidinones and their processes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8021771A Expired GB2054575B (en) | 1978-06-09 | 1979-06-08 | N-aryl oxazolidinones and pyrrolidinones and their processes |
Country Status (13)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
| CA1171865A (en) * | 1980-06-04 | 1984-07-31 | Alain Lacour | N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics |
| US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
| FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| FR2528046B1 (fr) * | 1982-06-08 | 1985-06-21 | Delalande Sa | Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| ES533097A0 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
| HU191408B (en) * | 1984-04-25 | 1987-02-27 | Egis Gyogyszergyar,Hu | Process for preparing new imino-thiazolidine derivatives |
| GB8610432D0 (en) * | 1986-04-29 | 1986-06-04 | Akzo Nv | Amino-thiazole & oxazole derivatives |
| USRE34242E (en) * | 1986-04-29 | 1993-05-04 | Akzo N.V. | Amino-oxazole compounds having dopaminergic activity |
| CA1302422C (en) * | 1986-09-03 | 1992-06-02 | Margherita Strolin-Benedetti | 5-aminoethyloxazolidin-2-one derivatives, process for the preparation thereofand their therapeutic use |
| SE8801518D0 (sv) * | 1988-04-22 | 1988-04-22 | Astra Pharma Prod | A novel process |
| US4876352A (en) * | 1988-09-14 | 1989-10-24 | Schering Corporation | Pressurized fluorination of hydroxy alkyl groups |
| US4933463A (en) * | 1989-05-08 | 1990-06-12 | Gaf Chemicals Corporation | Polymerizable pyrrolidonyl oxazoline monomers, homopolymers and copolymers |
| FR2653017B1 (fr) * | 1989-10-17 | 1995-05-05 | Delalande Sa | Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique. |
| US5235063A (en) * | 1989-10-17 | 1993-08-10 | Delalande S.A. | Process of preparing by condensation certain |
| US5196543A (en) * | 1989-10-17 | 1993-03-23 | Delalande S.A. | 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| ES2104708T3 (es) * | 1990-06-07 | 1997-10-16 | Zeneca Ltd | Compuestos heterociclicos terapeuticos. |
| FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
| JPH0559022A (ja) * | 1991-09-05 | 1993-03-09 | Nippon Paint Co Ltd | ５位に置換基を有する２−オキサゾリジノン化合物 |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| TW286317B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
| EP0710657B1 (de) * | 1994-11-02 | 1998-08-26 | MERCK PATENT GmbH | Adhäsionsrezeptor-Antagonisten |
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| SK18362000A3 (sk) | 1998-06-05 | 2001-06-11 | Astrazeneca Ab | Oxazolidinónové deriváty, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6498170B2 (en) | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
| US6465501B2 (en) | 2000-07-17 | 2002-10-15 | Wyeth | Azolidines as β3 adrenergic receptor agonists |
| US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
| US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| US6410734B1 (en) | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
| WO2002018354A1 (en) * | 2000-08-31 | 2002-03-07 | Abbott Laboratories | Oxazolidinones and their use as antibacterial agents |
| PE20050077A1 (es) * | 2002-09-20 | 2005-03-01 | Hoffmann La Roche | Derivados de 4-pirrolidino-fenil-bencil-eter |
| AU2004267007C1 (en) * | 2003-06-03 | 2010-04-29 | Melinta Subsidiary Corp. | Biaryl heterocyclic compounds and methods of making and using the same |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| US7148362B2 (en) * | 2003-09-18 | 2006-12-12 | Hoffmann-La Roche Inc. | Process for the preparation of enantiopure pyrrolidin-2-one derivatives |
| CN100441188C (zh) * | 2003-10-23 | 2008-12-10 | 弗·哈夫曼-拉罗切有限公司 | 作为mao－b抑制剂的苯并氮杂衍生物 |
| JP2007514782A (ja) * | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
| US7501528B2 (en) * | 2005-03-15 | 2009-03-10 | Hoffmann-La Roche Inc. | Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives |
| KR101394307B1 (ko) | 2005-06-08 | 2014-05-13 | 멜린타 테라퓨틱스, 인크. | 트리아졸의 합성 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1180089A (en) * | 1967-10-20 | 1970-02-04 | Delalande Sa | Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation |
| GB1222708A (en) * | 1968-10-22 | 1971-02-17 | Delalande Sa | Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation |
| GB1252101A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-03-18 | 1971-11-03 | ||
| US4062862A (en) * | 1975-07-04 | 1977-12-13 | Nippon Chemiphar Co., Ltd. | 5-Benzyl-2-oxazolidone derivatives and a process for producing the same |
| FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| SU888821A3 (ru) * | 1976-12-03 | 1981-12-07 | Шеринг Аг (Инофирма) | Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов |
| FR2380780A2 (fr) | 1977-02-22 | 1978-09-15 | Delalande Sa | Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs |
| LU80081A1 (fr) | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| US4348393A (en) * | 1978-06-09 | 1982-09-07 | Delalande S.A. | N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones |
| CA1171865A (en) | 1980-06-04 | 1984-07-31 | Alain Lacour | N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics |
-
1979
- 1979-06-04 US US06/045,143 patent/US4348393A/en not_active Expired - Lifetime
- 1979-06-06 CA CA329,220A patent/CA1129859A/en not_active Expired
- 1979-06-06 LU LU81370A patent/LU81370A1/fr unknown
- 1979-06-07 GR GR59290A patent/GR69969B/el unknown
- 1979-06-07 BE BE0/195621A patent/BE876831A/xx not_active IP Right Cessation
- 1979-06-07 SE SE7904970A patent/SE446733B/sv not_active IP Right Cessation
- 1979-06-07 AU AU47862/79A patent/AU525787B2/en not_active Ceased
- 1979-06-08 NL NL7904528A patent/NL7904528A/xx not_active Application Discontinuation
- 1979-06-08 CH CH540079A patent/CH642069A5/fr not_active IP Right Cessation
- 1979-06-08 DE DE19792923295 patent/DE2923295A1/de active Granted
- 1979-06-08 IT IT7923395A patent/IT1206305B/it active
- 1979-06-08 GB GB7920102A patent/GB2028306B/en not_active Expired
- 1979-06-08 GB GB8021771A patent/GB2054575B/en not_active Expired
- 1979-06-08 ES ES481909A patent/ES481909A0/es active Granted
-
1980
- 1980-02-06 US US06/119,073 patent/US4287351A/en not_active Expired - Lifetime
- 1980-03-04 SE SE8001674A patent/SE447381B/sv not_active IP Right Cessation
- 1980-03-19 CH CH216180A patent/CH639962A5/fr not_active IP Right Cessation
- 1980-03-31 ES ES490113A patent/ES490113A0/es active Granted
- 1980-03-31 ES ES490114A patent/ES8101060A1/es not_active Expired
- 1980-03-31 ES ES490112A patent/ES490112A0/es active Granted
- 1980-03-31 ES ES490110A patent/ES490110A0/es active Granted
- 1980-05-23 IT IT8022284A patent/IT1206307B/it active
-
1982
- 1982-06-16 US US06/388,866 patent/US4526786A/en not_active Expired - Fee Related
- 1982-06-16 US US06/388,867 patent/US4413001A/en not_active Expired - Fee Related
- 1982-06-16 US US06/389,136 patent/US4435415A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2028306B (en) | Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application | |
| NO154764C (no) | Gel for behandling av underjordiske formasjoner. | |
| NL7900871A (nl) | Werkwijze voor de therapeutische behandeling van hyperlipidemie en hyperlipiproteinemie. | |
| NL8105791A (nl) | Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. | |
| GB2029218B (en) | Pharmaceutical composition for treatment of cardiovascular disease | |
| DE3587741D1 (de) | Behandlung von Hautkrankheiten. | |
| DK148435C (da) | Behandlingsplads for tandlaeger | |
| BE889091R (fr) | Nouvelles n-aryle oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines et thiazolidinones, leur procede de preparation et leur application en therapeutique | |
| AU526697B2 (en) | Novel heterocyclic compounds, process fur preparing them and medical compositions containing them | |
| AU538641B2 (en) | Treatment of cattle | |
| TR20880A (tr) | Akrilonitrilin aritilmasi | |
| AU3657478A (en) | Treatment of wood | |
| GB1555830A (en) | Haet treatment of titanium all/ys | |
| NO803403L (no) | Anordning for behandling av virke. | |
| JPS5551064A (en) | Novel aryloxazolidinone*oxazolidinethione* pyrrolidinone*pyrrolidine and thiazolidinone* their manufacture and their therapeutic application | |
| GB2015601B (en) | Treatment of timber | |
| SE7610167L (sv) | Biocidalt aktiva foreningar | |
| NO147601C (no) | Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse l-pyroglutamyl-l-histidyl-glycin | |
| GB2003206B (en) | Treatment of timber | |
| SE7804556L (sv) | Preparat for behandling av djur | |
| SE7908379L (sv) | Forfarande for virkesbehandling | |
| BE885851A (fr) | Composition therapeutique pour le traitement de la dustrophie musculaire, de la myopathie et de la myotonie | |
| SE7808862L (sv) | Forfarande for behandling av avloppsvetskor | |
| JPS5680404A (en) | Manufacture of antiseptically treated plywood | |
| JPS5470404A (en) | Treatment of wood |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 817A | Application for correction of clerical errors now open to opposition (sect. 117/1977) | ||
| 711A | Proceeding under section 117(1) patents act 1977 | ||
| PCNP | Patent ceased through non-payment of renewal fee |