ES490113A0 - Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas - Google Patents

Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas

Info

Publication number
ES490113A0
ES490113A0 ES490113A ES490113A ES490113A0 ES 490113 A0 ES490113 A0 ES 490113A0 ES 490113 A ES490113 A ES 490113A ES 490113 A ES490113 A ES 490113A ES 490113 A0 ES490113 A0 ES 490113A0
Authority
ES
Spain
Prior art keywords
aminometil
aril
oxazolidinones
preparation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES490113A
Other languages
English (en)
Other versions
ES8101059A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7817388A external-priority patent/FR2428032A1/fr
Priority claimed from FR7824024A external-priority patent/FR2435473A2/fr
Application filed by Delalande SA filed Critical Delalande SA
Publication of ES8101059A1 publication Critical patent/ES8101059A1/es
Publication of ES490113A0 publication Critical patent/ES490113A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
ES490113A 1978-06-09 1980-03-31 Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas Granted ES490113A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7817388A FR2428032A1 (fr) 1978-06-09 1978-06-09 Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FR7824024A FR2435473A2 (fr) 1978-08-17 1978-08-17 Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES8101059A1 ES8101059A1 (es) 1980-12-16
ES490113A0 true ES490113A0 (es) 1980-12-16

Family

ID=26220626

Family Applications (5)

Application Number Title Priority Date Filing Date
ES481909A Granted ES481909A0 (es) 1978-06-09 1979-06-08 Procedimiento para la preparacion de nuevas aril-3 eter-5 o-xazolidinonas-2
ES490112A Expired ES8102105A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar oxazolidinationas
ES490113A Granted ES490113A0 (es) 1978-06-09 1980-03-31 Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas
ES490114A Expired ES8101060A1 (es) 1978-06-09 1980-03-31 Metodo de preparar nuevas aril-3 eter-5 oxazolidinonas-2
ES490110A Expired ES8106509A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar aril-3 ester-5 oxazolidinonas-2 y oxazolidinationas-2 nuevas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES481909A Granted ES481909A0 (es) 1978-06-09 1979-06-08 Procedimiento para la preparacion de nuevas aril-3 eter-5 o-xazolidinonas-2
ES490112A Expired ES8102105A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar oxazolidinationas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES490114A Expired ES8101060A1 (es) 1978-06-09 1980-03-31 Metodo de preparar nuevas aril-3 eter-5 oxazolidinonas-2
ES490110A Expired ES8106509A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar aril-3 ester-5 oxazolidinonas-2 y oxazolidinationas-2 nuevas

Country Status (13)

Country Link
US (5) US4348393A (es)
AU (1) AU525787B2 (es)
BE (1) BE876831A (es)
CA (1) CA1129859A (es)
CH (2) CH642069A5 (es)
DE (1) DE2923295A1 (es)
ES (5) ES481909A0 (es)
GB (2) GB2054575B (es)
GR (1) GR69969B (es)
IT (2) IT1206305B (es)
LU (1) LU81370A1 (es)
NL (1) NL7904528A (es)
SE (2) SE446733B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
CA1171865A (en) * 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics
US4340606A (en) * 1980-10-23 1982-07-20 E. I. Du Pont De Nemours And Company 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
FR2528046B1 (fr) * 1982-06-08 1985-06-21 Delalande Sa Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
ES533097A0 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
HU191408B (en) * 1984-04-25 1987-02-27 Egis Gyogyszergyar,Hu Process for preparing new imino-thiazolidine derivatives
USRE34242E (en) * 1986-04-29 1993-05-04 Akzo N.V. Amino-oxazole compounds having dopaminergic activity
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
US4897409A (en) * 1986-09-03 1990-01-30 Delalande S.A. 5-aminoethyloxazolidin-2-one derivatives
SE8801518D0 (sv) * 1988-04-22 1988-04-22 Astra Pharma Prod A novel process
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US4933463A (en) * 1989-05-08 1990-06-12 Gaf Chemicals Corporation Polymerizable pyrrolidonyl oxazoline monomers, homopolymers and copolymers
US5235063A (en) * 1989-10-17 1993-08-10 Delalande S.A. Process of preparing by condensation certain
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
US5196543A (en) * 1989-10-17 1993-03-23 Delalande S.A. 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy
US5182296A (en) * 1989-10-26 1993-01-26 Tanabe Seiyaky Co., Ltd. Naphthyloxazolidone derivatives
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
FR2675504B1 (fr) * 1991-04-16 1995-01-27 Delalande Sa Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique.
JPH0559022A (ja) * 1991-09-05 1993-03-09 Nippon Paint Co Ltd ５位に置換基を有する２−オキサゾリジノン化合物
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
TW286317B (es) * 1993-12-13 1996-09-21 Hoffmann La Roche
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999064417A2 (en) * 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6525202B2 (en) * 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6498170B2 (en) 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US6465501B2 (en) 2000-07-17 2002-10-15 Wyeth Azolidines as β3 adrenergic receptor agonists
US6537994B2 (en) 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
US6410734B1 (en) * 2000-07-17 2002-06-25 Wyeth 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
WO2002018354A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Oxazolidinones and their use as antibacterial agents
PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
SG2009082793A (en) 2003-06-03 2015-03-30 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7148362B2 (en) * 2003-09-18 2006-12-12 Hoffmann-La Roche Inc. Process for the preparation of enantiopure pyrrolidin-2-one derivatives
CN100441188C (zh) * 2003-10-23 2008-12-10 弗·哈夫曼-拉罗切有限公司 作为mao－b抑制剂的苯并氮杂衍生物
WO2005061468A1 (en) * 2003-12-17 2005-07-07 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
JP5534497B2 (ja) 2005-06-08 2014-07-02 メリンタ セラピューティクス，インコーポレイテッド トリアゾール類の合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
GB1252101A (es) 1969-03-18 1971-11-03
US4062862A (en) * 1975-07-04 1977-12-13 Nippon Chemiphar Co., Ltd. 5-Benzyl-2-oxazolidone derivatives and a process for producing the same
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
SU888821A3 (ru) * 1976-12-03 1981-12-07 Шеринг Аг (Инофирма) Способ получени 5-(замещенный фенил)-оксазолидинонов или их серусодержащих аналогов
FR2380780A2 (fr) 1977-02-22 1978-09-15 Delalande Sa Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs
LU80081A1 (fr) 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
CA1171865A (en) 1980-06-04 1984-07-31 Alain Lacour N-aryl azolone derivatives, the process for preparing the same and their application in therapeutics

Also Published As

Publication number Publication date
GB2028306A (en) 1980-03-05
CA1129859A (en) 1982-08-17
ES8101059A1 (es) 1980-12-16
US4526786A (en) 1985-07-02
AU4786279A (en) 1979-12-13
ES490112A0 (es) 1981-01-16
GB2028306B (en) 1983-01-12
CH639962A5 (fr) 1983-12-15
SE8001674L (sv) 1980-03-04
DE2923295C2 (es) 1987-12-23
CH642069A5 (fr) 1984-03-30
US4348393A (en) 1982-09-07
US4287351A (en) 1981-09-01
ES490110A0 (es) 1981-09-01
IT1206305B (it) 1989-04-14
ES490114A0 (es) 1980-12-16
LU81370A1 (fr) 1981-02-03
SE447381B (sv) 1986-11-10
IT8022284A0 (it) 1980-05-23
GR69969B (es) 1982-07-22
IT7923395A0 (it) 1979-06-08
DE2923295A1 (de) 1979-12-13
ES8101060A1 (es) 1980-12-16
BE876831A (fr) 1979-12-07
GB2054575A (en) 1981-02-18
SE7904970L (sv) 1979-12-10
ES8102105A1 (es) 1981-01-16
ES8100279A1 (es) 1980-11-01
NL7904528A (nl) 1979-12-11
AU525787B2 (en) 1982-12-02
ES481909A0 (es) 1980-11-01
GB2054575B (en) 1982-11-10
US4413001A (en) 1983-11-01
US4435415A (en) 1984-03-06
ES8106509A1 (es) 1981-09-01
IT1206307B (it) 1989-04-14
SE446733B (sv) 1986-10-06

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