FR2435473A2 - Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique - Google Patents

Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2435473A2
FR2435473A2 FR7824024A FR7824024A FR2435473A2 FR 2435473 A2 FR2435473 A2 FR 2435473A2 FR 7824024 A FR7824024 A FR 7824024A FR 7824024 A FR7824024 A FR 7824024A FR 2435473 A2 FR2435473 A2 FR 2435473A2
Authority
FR
France
Prior art keywords
phenyl
cyclopentylmethoxy
cyclohexylmethoxy
och2ar
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7824024A
Other languages
English (en)
Other versions
FR2435473B2 (fr
Inventor
Jean-Francois Ancher
Guy Bourgery
Philippe Dostert
Patrick Guerret
Alain Lacour
Colette Douzon
Michel Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7824024A priority Critical patent/FR2435473A2/fr
Priority to US06/045,143 priority patent/US4348393A/en
Priority to LU81370A priority patent/LU81370A1/fr
Priority to CA329,220A priority patent/CA1129859A/fr
Priority to SE7904970A priority patent/SE446733B/sv
Priority to GR59290A priority patent/GR69969B/el
Priority to BE0/195621A priority patent/BE876831A/fr
Priority to AU47862/79A priority patent/AU525787B2/en
Priority to GB7920102A priority patent/GB2028306B/en
Priority to GB8021771A priority patent/GB2054575B/en
Priority to DE19792923295 priority patent/DE2923295A1/de
Priority to ES481909A priority patent/ES8100279A1/es
Priority to NL7904528A priority patent/NL7904528A/xx
Priority to IT7923395A priority patent/IT1206305B/it
Priority to CH540079A priority patent/CH642069A5/fr
Priority to US06/119,073 priority patent/US4287351A/en
Priority to SE8001674A priority patent/SE447381B/sv
Priority to NL8001539A priority patent/NL8001539A/nl
Priority to CH216180A priority patent/CH639962A5/fr
Priority to ES490112A priority patent/ES490112A0/es
Priority to ES490114A priority patent/ES8101060A1/es
Priority to ES490110A priority patent/ES8106509A1/es
Priority to ES490113A priority patent/ES490113A0/es
Publication of FR2435473A2 publication Critical patent/FR2435473A2/fr
Priority to IT8022284A priority patent/IT1206307B/it
Application granted granted Critical
Publication of FR2435473B2 publication Critical patent/FR2435473B2/fr
Priority to US06/389,136 priority patent/US4435415A/en
Priority to US06/388,867 priority patent/US4413001A/en
Priority to US06/388,866 priority patent/US4526786A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Abstract

a. Nouvelles N-aryle oxazolidinones et oxazolidinethiones. b. Elle répondent à la formule :
FR7824024A 1978-06-09 1978-08-17 Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique Granted FR2435473A2 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR7824024A FR2435473A2 (fr) 1978-08-17 1978-08-17 Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
US06/045,143 US4348393A (en) 1978-06-09 1979-06-04 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
LU81370A LU81370A1 (fr) 1978-06-09 1979-06-06 Nouvelles n-aryle oxazolidinones,oxazolidinethiones,pyrrolidinones,pyrrolidines et thiazolidinones,leur procede de preparation et leur application en therapeutique
CA329,220A CA1129859A (fr) 1978-06-09 1979-06-06 Procede d'obtention et applications therapeutiques de n-aryloxazolidinones, d'oxazolidinethiones et de pyrrolidinones
GR59290A GR69969B (fr) 1978-06-09 1979-06-07
BE0/195621A BE876831A (fr) 1978-06-09 1979-06-07 Nouvelles n-aryle oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines et thiazolidinones, leur procede de preparation et leur application en therapeutique
AU47862/79A AU525787B2 (en) 1978-06-09 1979-06-07 N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
SE7904970A SE446733B (sv) 1978-06-09 1979-06-07 Nya n-aryloxazolidinoner, oxazolidintioner, pyrrolidinoner, pyrrolidiner och tiazolidinoner och sett att framstella desamma samt kompositioner derav
CH540079A CH642069A5 (fr) 1978-06-09 1979-06-08 N-aryle oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines et thiazolidinones, leurs procedes de preparation, et medicaments les contenant.
GB8021771A GB2054575B (en) 1978-06-09 1979-06-08 N-aryl oxazolidinones and pyrrolidinones and their processes
DE19792923295 DE2923295A1 (de) 1978-06-09 1979-06-08 Neue n-aryl-oxazolidinone, -oxazolidinthione, -pyrrolidinone, -pyrrolidine und -thiazolidinone, verfahren zu ihrer herstellung und solche verbindungen enthaltende arzneimittel
ES481909A ES8100279A1 (es) 1978-06-09 1979-06-08 Procedimiento para la preparacion de nuevas aril-3 eter-5 o-xazolidinonas-2
NL7904528A NL7904528A (nl) 1978-06-09 1979-06-08 Nieuwe n-aryloxazolidinonen, oxazolidinethionen, pyrro- lidinonen, pyrrolidinen en thiazolidinonen.
IT7923395A IT1206305B (it) 1978-06-09 1979-06-08 N-aril-ossazolidinoni, -ossazolidintioni, -pirrolidinoni, -pirrolidine e -tiazolidinoni, loro procedimento di preparazione eloro applicazione in terapia.
GB7920102A GB2028306B (en) 1978-06-09 1979-06-08 Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application
US06/119,073 US4287351A (en) 1978-06-09 1980-02-06 3-Parahydroxyphenyl-5-methylether-2-oxazolidinone compounds
SE8001674A SE447381B (sv) 1978-06-09 1980-03-04 Nya n-aryloxazolidinoner och pyrrolidinoner
NL8001539A NL8001539A (nl) 1978-06-09 1980-03-14 Nieuwe n-aryl-oxazolidinonen en n-arylpyrrolidinonen.
CH216180A CH639962A5 (fr) 1978-06-09 1980-03-19 N-aryle oxazolidinones et pyrrolidinones.
ES490112A ES490112A0 (es) 1978-06-09 1980-03-31 Procedimiento de preparar oxazolidinationas
ES490114A ES8101060A1 (es) 1978-06-09 1980-03-31 Metodo de preparar nuevas aril-3 eter-5 oxazolidinonas-2
ES490110A ES8106509A1 (es) 1978-06-09 1980-03-31 Procedimiento de preparar aril-3 ester-5 oxazolidinonas-2 y oxazolidinationas-2 nuevas
ES490113A ES490113A0 (es) 1978-06-09 1980-03-31 Metodo de preparacion de aril-3 aminometil-5 oxazolidinonas-2 nuevas
IT8022284A IT1206307B (it) 1978-06-09 1980-05-23 N-aril-ossazolidinoni e -pirrolidinoni, e procedimenti per la loro preparazione.
US06/389,136 US4435415A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US06/388,867 US4413001A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US06/388,866 US4526786A (en) 1978-06-09 1982-06-16 N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7824024A FR2435473A2 (fr) 1978-08-17 1978-08-17 Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2435473A2 true FR2435473A2 (fr) 1980-04-04
FR2435473B2 FR2435473B2 (fr) 1982-01-22

Family

ID=9211888

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7824024A Granted FR2435473A2 (fr) 1978-06-09 1978-08-17 Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique

Country Status (1)

Country Link
FR (1) FR2435473A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458547A2 (fr) * 1978-06-09 1981-01-02 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2021204A1 (fr) * 1968-10-22 1970-07-17 Delalande Sa
FR1602544A (en) * 1968-10-29 1970-12-21 Acetylenic 2-oxazolidinones
FR2121442A1 (en) * 1971-01-14 1972-08-25 Delalande Sa 5-hydroxymethyl-3-phenyl-oxazolidone-2-esters - - antidepressants, anticonvulsants, tranquillisers and analgesics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2021204A1 (fr) * 1968-10-22 1970-07-17 Delalande Sa
FR1602544A (en) * 1968-10-29 1970-12-21 Acetylenic 2-oxazolidinones
FR2121442A1 (en) * 1971-01-14 1972-08-25 Delalande Sa 5-hydroxymethyl-3-phenyl-oxazolidone-2-esters - - antidepressants, anticonvulsants, tranquillisers and analgesics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458547A2 (fr) * 1978-06-09 1981-01-02 Delalande Sa Nouvelles n-aryle azolones, leur procede de preparation et leur application en therapeutique
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2435473B2 (fr) 1982-01-22

Similar Documents

Publication Publication Date Title
FR2428032A1 (fr) Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
FI913704A0 (fi) Foerfarande foer framstaellning av benzofuran-, benzotiofen- indol- eller indolizinderivat.
DE3783415D1 (de) Aryloxycarbonsaeurederivate, ihre herstellung und verwendung.
ATE210634T1 (de) Neue amiderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonistischer wirkung
DE69219089D1 (de) 5,6-Disubstituierte-3-Pyridylmethylammoniumhalogenid-Verbindungen, verwendbar für die Herstellung von 5-(substituierte Methyl)-2,3-Pyridindicarbonsäuren
FR2435473A2 (fr) Nouvelles n-aryle oxazolidinones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
GB1178627A (en) Herbicides
ES2043982T3 (es) Derivado de difenil-metano, compuesto farmaceutico y utilizacion del mismo.
DE3575140D1 (de) Dreizyklische oxindole als antientzuendungsmittel.
MY129935A (en) Dihydropyridine derivatives useful in antitumor therapy
AP9701048A0 (en) Parasiticidal pyrazoles.
TW325477B (en) Thermochromic compounds, their preparation and the use thereof
DE69311402T2 (de) Zusammensetzungen und wässrige Lösungen reaktiver Azofarbstoffe
ES8602773A1 (es) Procedimiento para la fabricacion de derivados del dioxolano de tipo azolico
ES8601987A1 (es) Un procedimiento para preparar derivados de acido 4,7-dihidropirazolo (3,4-b)piridin-5-carboxilico
FI834410A0 (fi) Foerfarande foer framstaellning av pyrimidinonderivat
ATE117982T1 (de) Nichtionische oberflächenaktivverbindungen.
ATA501280A (de) Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salze
ES8604591A1 (es) Procedimiento para preparar nuevas 11-piperazinil-5h-imidazo(2,1-c)(1,4)-benzodiazepinas
KR940011464A (ko) 천식치료/항알러지, 소염, 근변력작용 양성 및 혈압 강하 효과가 있는 헤테로사이클릭 화합물
NZ292108A (en) [1,2,4]triazolo[4,3-a]quinoxaline derivatives and medicaments
DE59409756D1 (de) 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als herzfrequenzsenkendes Mittel
GB1526451A (en) Alpha,alpha,1-trimethyl-2-nitroimidazole-5-methanol derivatives
EP0133162A3 (fr) Dérivés d'oxydes de phosphine et leur utilisation comme agents herbicides et régulateurs de la croissance des plantes
DE69407056T2 (de) 5-(1-fluorovinyl)-1h-pyrimidin-2,4-dion-derivate als antineoplastische mittel