ES8604591A1 - Procedimiento para preparar nuevas 11-piperazinil-5h-imidazo(2,1-c)(1,4)-benzodiazepinas - Google Patents
Procedimiento para preparar nuevas 11-piperazinil-5h-imidazo(2,1-c)(1,4)-benzodiazepinasInfo
- Publication number
- ES8604591A1 ES8604591A1 ES544670A ES544670A ES8604591A1 ES 8604591 A1 ES8604591 A1 ES 8604591A1 ES 544670 A ES544670 A ES 544670A ES 544670 A ES544670 A ES 544670A ES 8604591 A1 ES8604591 A1 ES 8604591A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- intermediates
- imidazoû2
- piperazinyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVAS 11-PIPERAZINIL-5H-IMIDAZO2,1-C1,4BENZODIAZEPINAS. COMPRENDE: A) ALQUILAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN DIMETILFORMAMIDA, EN PRESENCIA DE CARBONATO POTASICO ANHIDRO Y ENTRE 80 Y 120JC, PARA OBTENER UN COMPUESTO DE FORMULA (IV); B) HIDROGENAR CATALITICAMENTE A (IV) CON CLORURO DE ESTAÑO Y ACIDO CLORHIDRICO EN ALCOHOL ACUOSO Y CON NI RANEY COMO CATALIZADOR, PARA REALIZAR UN COMPUESTO DE FORMULA (V); Y C) HACER REACIONAR A (V) CON UNA PIPERAZINA DE FORMULA (VI), EN PRESENCIA DE TICL4 Y EN ANISOL, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. SIENDO: R1 Y R2, H, HAL, NITRO Y OTROS; R3, H, HAL Y OTROS; R4, H, ALQUILO DE C 1 A 4 Y OTROS; R, ALQUILO DE C 1 A 4; Y N, 1 O 2. SE UTILIZAN COMO ANTIALERGICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833331858 DE3331858A1 (de) | 1983-09-03 | 1983-09-03 | Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8604591A1 true ES8604591A1 (es) | 1986-02-01 |
ES544670A0 ES544670A0 (es) | 1986-02-01 |
Family
ID=6208184
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535569A Granted ES535569A0 (es) | 1983-09-03 | 1984-08-31 | Procedimiento para preparar 11-piperazinil-5h-imidazo(2, 1-c) (1, 4) benzodiazepinas |
ES544670A Expired ES8604591A1 (es) | 1983-09-03 | 1985-06-28 | Procedimiento para preparar nuevas 11-piperazinil-5h-imidazo(2,1-c)(1,4)-benzodiazepinas |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535569A Granted ES535569A0 (es) | 1983-09-03 | 1984-08-31 | Procedimiento para preparar 11-piperazinil-5h-imidazo(2, 1-c) (1, 4) benzodiazepinas |
Country Status (7)
Country | Link |
---|---|
US (1) | US4686219A (es) |
EP (1) | EP0137993B1 (es) |
JP (1) | JPS60155178A (es) |
AT (1) | ATE49601T1 (es) |
CA (1) | CA1225396A (es) |
DE (2) | DE3331858A1 (es) |
ES (2) | ES535569A0 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3331858A1 (de) * | 1983-09-03 | 1985-03-21 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel |
DE4041465A1 (de) * | 1990-12-22 | 1992-06-25 | Basf Ag | 10-cyanmethylen-4-(piperazin-1-yl)-pyrrolo (4,3-e)benzoazepinen zur bekaempfung der migraene |
JP5460435B2 (ja) | 2010-04-09 | 2014-04-02 | 日立コンシューマエレクトロニクス株式会社 | 画像表示装置および画像表示装置の制御方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4431589A (en) * | 1980-12-11 | 1984-02-14 | Lilly House | Benzodiazepine compounds and their use as pharmaceuticals |
US4460508A (en) * | 1981-12-07 | 1984-07-17 | Ciba-Geigy Corporation | 5-Diazacycloalkylimidazo[1,2-c][1,3]benzodiazepines |
US4495101A (en) * | 1983-04-28 | 1985-01-22 | American Home Products Corporation | Antiinflammatory 5H-tetrazolo (5,1-c)(1,4)benzodiazepine derivatives |
DE3331858A1 (de) * | 1983-09-03 | 1985-03-21 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel |
-
1983
- 1983-09-03 DE DE19833331858 patent/DE3331858A1/de not_active Withdrawn
-
1984
- 1984-08-28 EP EP84110215A patent/EP0137993B1/de not_active Expired - Lifetime
- 1984-08-28 AT AT84110215T patent/ATE49601T1/de not_active IP Right Cessation
- 1984-08-28 DE DE8484110215T patent/DE3481059D1/de not_active Expired - Lifetime
- 1984-08-31 JP JP59182551A patent/JPS60155178A/ja active Granted
- 1984-08-31 CA CA000462220A patent/CA1225396A/en not_active Expired
- 1984-08-31 ES ES535569A patent/ES535569A0/es active Granted
-
1985
- 1985-06-28 ES ES544670A patent/ES8604591A1/es not_active Expired
-
1986
- 1986-02-07 US US06/827,849 patent/US4686219A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0137993A2 (de) | 1985-04-24 |
JPS60155178A (ja) | 1985-08-15 |
JPH0473435B2 (es) | 1992-11-20 |
EP0137993A3 (en) | 1986-02-19 |
ATE49601T1 (de) | 1990-02-15 |
US4686219A (en) | 1987-08-11 |
ES8602797A1 (es) | 1985-12-01 |
DE3481059D1 (de) | 1990-02-22 |
DE3331858A1 (de) | 1985-03-21 |
EP0137993B1 (de) | 1990-01-17 |
ES535569A0 (es) | 1985-12-01 |
ES544670A0 (es) | 1986-02-01 |
CA1225396A (en) | 1987-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |