FR2528046B1 - Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation - Google Patents

Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation

Info

Publication number
FR2528046B1
FR2528046B1 FR8209972A FR8209972A FR2528046B1 FR 2528046 B1 FR2528046 B1 FR 2528046B1 FR 8209972 A FR8209972 A FR 8209972A FR 8209972 A FR8209972 A FR 8209972A FR 2528046 B1 FR2528046 B1 FR 2528046B1
Authority
FR
France
Prior art keywords
preparation
specific
type
optically active
reversible inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8209972A
Other languages
English (en)
Other versions
FR2528046A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR8209972A priority Critical patent/FR2528046B1/fr
Priority to CH633/86A priority patent/CH661500A5/fr
Priority to CH632/86A priority patent/CH661507A5/fr
Priority to CH2900/83A priority patent/CH657362A5/fr
Priority to SE8303136A priority patent/SE8303136L/xx
Priority to US06/500,682 priority patent/US4598084A/en
Priority to GB08315433A priority patent/GB2121413B/en
Priority to NL8302013A priority patent/NL8302013A/nl
Priority to BE0/210943A priority patent/BE896972A/fr
Priority to DE3320394A priority patent/DE3320394A1/de
Priority to ZA834119A priority patent/ZA834119B/xx
Priority to LU84851A priority patent/LU84851A1/fr
Priority to IT21497/83A priority patent/IT1164269B/it
Priority to AU15462/83A priority patent/AU1546283A/en
Priority to JP58102526A priority patent/JPS5980668A/ja
Publication of FR2528046A1 publication Critical patent/FR2528046A1/fr
Priority to GB08512020A priority patent/GB2157693B/en
Priority to GB08512019A priority patent/GB2157692B/en
Application granted granted Critical
Publication of FR2528046B1 publication Critical patent/FR2528046B1/fr
Priority to SE8802281A priority patent/SE8802281L/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
FR8209972A 1982-06-08 1982-06-08 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation Expired FR2528046B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR8209972A FR2528046B1 (fr) 1982-06-08 1982-06-08 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
CH633/86A CH661500A5 (fr) 1982-06-08 1983-05-27 Derives de la para-benzyloxy aniline et leur procede de preparation.
CH632/86A CH661507A5 (fr) 1982-06-08 1983-05-27 Derives de l'hydroxymethyl-5 oxazolidinone-2 n-arylee et leur procede de preparation.
CH2900/83A CH657362A5 (fr) 1982-06-08 1983-05-27 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation.
US06/500,682 US4598084A (en) 1982-06-08 1983-06-03 Optically active derivatives of N-arylated oxazolidine-2-one, the process for preparing same and their application in therapeutics
SE8303136A SE8303136L (sv) 1982-06-08 1983-06-03 Optiskt aktiva derivat av n-arylerat oxazolidinon-2, specifika och reversibla inhibitorer av monoaminoxydas av typ b, och deras framstellningssett
DE3320394A DE3320394A1 (de) 1982-06-08 1983-06-06 Optisch aktive n-arylierte oxazolidinon-(2)-derivate, deren verwendung als spezifische und reversible inhibitoren von monoaminooxydase des b-typs sowie verfahren zu deren herstellung
BE0/210943A BE896972A (fr) 1982-06-08 1983-06-06 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques t reversibles de la nonoamine oxydase de type b et leur procede de preparation
GB08315433A GB2121413B (en) 1982-06-08 1983-06-06 Oxazolidines
NL8302013A NL8302013A (nl) 1982-06-08 1983-06-06 Optisch actieve n-aryloxazolidinon-2 verbindingen, die specifiek en omkeerbare remmende stoffen van mono-amino-oxydase van het type b zijn en werkwijze ter bereiding van deze verbindingen.
LU84851A LU84851A1 (fr) 1982-06-08 1983-06-07 Derives de l'oxazolidinone-2 n-arylee optiquement actifs,inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
IT21497/83A IT1164269B (it) 1982-06-08 1983-06-07 Derivati dell'ossazolidinone-2n-arilato otticamente attivi, inibitori specifici e reversibili della monoammino ossidasi di tipo b e loro procedimento di preparazione
ZA834119A ZA834119B (en) 1982-06-08 1983-06-07 Optically active derivatives of n-arylated oxazolidine-2-one,the process for preparing same and their application in therapeutics
AU15462/83A AU1546283A (en) 1982-06-08 1983-06-07 Optically-active derivatives of n-arylated oxazolidine-2- ones
JP58102526A JPS5980668A (ja) 1982-06-08 1983-06-08 Ｎ−アリル化オキサゾリジン−２−オンの光学活性な誘導体、該誘導体の製法及び該誘導体による薬剤
GB08512020A GB2157693B (en) 1982-06-08 1985-05-13 (s) 5-hydroxymethyl 3-para-hydroxy phenyl oxazolidine-2-one, and a process for its preparation
GB08512019A GB2157692B (en) 1982-06-08 1985-05-13 (s(-)) 3-para-(benzyloxy) anilino 1,2-propanediol and a process for its preparation
SE8802281A SE8802281L (sv) 1982-06-08 1988-06-17 Mellanprodukt foer framstaellning av derivat av n-arylerad oxazolidin-2-on

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8209972A FR2528046B1 (fr) 1982-06-08 1982-06-08 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation

Publications (2)

Publication Number Publication Date
FR2528046A1 FR2528046A1 (fr) 1983-12-09
FR2528046B1 true FR2528046B1 (fr) 1985-06-21

Family

ID=9274766

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8209972A Expired FR2528046B1 (fr) 1982-06-08 1982-06-08 Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation

Country Status (13)

Country Link
US (1) US4598084A (fr)
JP (1) JPS5980668A (fr)
AU (1) AU1546283A (fr)
BE (1) BE896972A (fr)
CH (3) CH657362A5 (fr)
DE (1) DE3320394A1 (fr)
FR (1) FR2528046B1 (fr)
GB (3) GB2121413B (fr)
IT (1) IT1164269B (fr)
LU (1) LU84851A1 (fr)
NL (1) NL8302013A (fr)
SE (2) SE8303136L (fr)
ZA (1) ZA834119B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60241893A (ja) * 1984-05-15 1985-11-30 Kanegafuchi Chem Ind Co Ltd 光学活性（ｓ）―オキサゾリジノン誘導体の製造方法
DE3525648A1 (de) * 1985-07-18 1987-01-29 Bokel Heinz Hermann Dr 1-oxa-2-oxo-2-r-3-aza-5-z-cyclopentanderivate
FR2609029B1 (fr) * 1986-12-30 1989-12-08 Delalande Sa Derives 5-aminoethyles de l'oxazolidinone-2, leur procede de preparation et leur application en therapeutique
AU7778087A (en) * 1986-09-03 1988-04-14 Delalande S.A. 5-aminoethyloxazolidin-2-one derivatives
FR2603279B1 (fr) * 1986-09-03 1988-12-16 Rech Ind Benzyloxy-phenyl-oxazolidinones, procede de preparation et utilisation en therapeutique
FR2626877B1 (fr) * 1988-02-05 1991-04-05 Delalande Sa Ethers alkyliques ou benzyliques du phenol, leurs procedes de preparation et leur application en therapeutique
US5196543A (en) * 1989-10-17 1993-03-23 Delalande S.A. 3-aryloxazolidinone derivatives, process for their preparation and their use in therapy
US5235063A (en) * 1989-10-17 1993-08-10 Delalande S.A. Process of preparing by condensation certain
JPH06508836A (ja) * 1991-06-26 1994-10-06 セプラコア，インコーポレーテッド 光学的に純粋なｒ（＋）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物
AU3147593A (en) * 1991-11-26 1993-06-28 Sepracor, Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
CA2371822A1 (fr) 1999-03-01 2000-09-08 Sepracor Inc. Procedes de traitement de l'apnee et de troubles de l'apnee a l'aide de r(+) ondansetron optiquement pur

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
FR2380780A2 (fr) * 1977-02-22 1978-09-15 Delalande Sa Application en therapeutique des hydroxymethyl-5 oxazolidinones-2, notamment comme antidepresseurs
LU80081A1 (fr) * 1977-08-26 1979-05-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique
FR2428032A1 (fr) * 1978-06-09 1980-01-04 Delalande Sa Nouvelles oxazolidimones, oxazolidinethiones et pyrrolidinones, leur procede de preparation et leur application en therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones

Also Published As

Publication number Publication date
BE896972A (fr) 1983-12-06
US4598084A (en) 1986-07-01
GB2157693A (en) 1985-10-30
GB8512020D0 (en) 1985-06-19
FR2528046A1 (fr) 1983-12-09
GB8315433D0 (en) 1983-07-13
SE8802281D0 (sv) 1988-06-17
CH661500A5 (fr) 1987-07-31
NL8302013A (nl) 1984-01-02
GB8512019D0 (en) 1985-06-19
GB2157692A (en) 1985-10-30
GB2121413A (en) 1983-12-21
IT1164269B (it) 1987-04-08
LU84851A1 (fr) 1985-03-29
SE8303136L (sv) 1983-12-09
CH661507A5 (fr) 1987-07-31
JPS5980668A (ja) 1984-05-10
IT8321497A0 (it) 1983-06-07
GB2157693B (en) 1986-05-08
GB2121413B (en) 1986-05-08
ZA834119B (en) 1984-03-28
SE8802281L (sv) 1988-06-17
AU1546283A (en) 1983-12-15
GB2157692B (en) 1986-05-08
SE8303136D0 (sv) 1983-06-03
DE3320394A1 (de) 1983-12-08
CH657362A5 (fr) 1986-08-29

Similar Documents

Publication Publication Date Title
FR2487353B1 (fr) Derives d'hydantoine, leur procede de preparation et leur application therapeutique
MA20281A1 (fr) Nouvelles N-(heterocyclyl) - 4 - piperidinamines et leur procede de preparation.
MC1389A1 (fr) Derives d'imidazole et procede pour leur preparation
FR2515645B1 (fr) Derives de la proline optiquement actifs, procede pour leur preparation et leur application
FR2528046B1 (fr) Derives de l'oxazolidinone-2 n-arylee optiquement actifs, inhibiteurs specifiques et reversibles de la monoamine oxydase de type b et leur procede de preparation
BE891092A (fr) Derives de benzofuranne-2 substitues utiles comme medicaments et procede de leur preparation
BE882133A (fr) Derives d'acides 1-omega-mercaptoacyl)-4,5-dihydropyrazole-5-carboxyliques et leur procede de preparation
FR2571052B1 (fr) Derives de 1,3-oxazolidine-2-one et leur procede de preparation
FR2552433B1 (fr) Nouveaux derives de 1,3,4-thiadiazole, procede pour leur preparation et leur utilisation comme agents anti-ulcere
FR2491928B1 (fr) Cristaux de b-nicotinamide adenine dinucleotide et procede de leur preparation
BE888598A (fr) Composition dentaire de stabilite amelioree et procede d'utilisation de celle-ci,
MC1692A1 (fr) Procede de preparation de derives de phenyltetraenyle derives de phenyltetraenyle et leur application
FR2559771B1 (fr) Derives de la 3-pyrrolidinopropiophenone et procede pour leur preparation
BE880477A (fr) Derives d'acides 1,3,4-thi adiazole-2-carboxylique, leur procede de preparation et leur utilisation
FR2604174B1 (fr) Nouveaux derives de la 5-pyrazolone, leur procede de preparation et leur utilisation comme herbicides
MA20088A1 (fr) Nouvelles formes galeniques du sulpiride utilisables par voie orale et leur procede de preparation.
ES502121A0 (es) Metodo para la preparacion de n-(2-(((5-dialquilamino)-me- til-2-metil-2-furanil)-metil)-etil)-n'alquil-2-nitro-1,1- etendiamina
BE856044A (fr) Derives optiquement actifs d'acide benzoxazolylpropionique, leur procede de preparation et leur utilisation
BE889339A (fr) 6-hydrazono-pyrido(2,1-b)quinazoline-11-ones et procede pour leur preparation
BE893117A (fr) Procede d'halogenation de n-(0,0'-dialkyl phenyl) alaniates et homologues)
FR2541277B1 (fr) Derives d'azetidinone et procede pour leur preparation
RO88035A (fr) Procede d'obtention des derives de 28-methylbrasinolide
FR2510574B1 (fr) Kanamycines modifiees en 2', leur procede d'obtention et leur utilisation comme agents antibacteriens
BE877695A (fr) Derives de 2,4,6-triiodo-benzene, leur procede de preparation et leur utilisation
BE883087A (fr) Nouveaux derives 5-(2-(2,3-dihydro-1,4-benzodioxanne-2-ylmethyl)-amino) -1-hydroxyethyl) -2-hydroxybenzoiques, utiles notamment comme agents bloquants des recepteurs adrenergiques alpha et beta, et leur procede de preparation

Legal Events

Date Code Title Description
ST Notification of lapse