NL8105791A - Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. - Google Patents
Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. Download PDFInfo
- Publication number
- NL8105791A NL8105791A NL8105791A NL8105791A NL8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A NL 8105791 A NL8105791 A NL 8105791A
- Authority
- NL
- Netherlands
- Prior art keywords
- compounds
- preparation
- therapeutic use
- novel heterocyclic
- heterocyclic aminoalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8027252A FR2496653A1 (fr) | 1980-12-22 | 1980-12-22 | Nouveaux derives aminoalcoyl heterocycliques, leurs procedes de preparation et leur application en therapeutique |
FR8123304A FR2518087A2 (en) | 1981-12-14 | 1981-12-14 | Aminoalkyl di:hydro-naphthalene, isoquinoline and benzoxazepine cpds. - useful as analgesics and antidepressants |
Publications (1)
Publication Number | Publication Date |
---|---|
NL8105791A true NL8105791A (nl) | 1982-07-16 |
Family
ID=26222136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL8105791A NL8105791A (nl) | 1980-12-22 | 1981-12-22 | Nieuwe heterocyclische aminoalkylverbindingen, werkwijze voor hun bereiding alsmede de therapeutische toepassing van deze verbindingen. |
Country Status (11)
Country | Link |
---|---|
US (3) | US4386090A (nl) |
AU (1) | AU7875781A (nl) |
CA (1) | CA1181748A (nl) |
DE (1) | DE3150876A1 (nl) |
ES (3) | ES508670A0 (nl) |
GB (2) | GB2091250B (nl) |
GR (1) | GR78081B (nl) |
IT (1) | IT1168074B (nl) |
LU (1) | LU83850A1 (nl) |
NL (1) | NL8105791A (nl) |
SE (1) | SE8107537L (nl) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
FR2544718B1 (fr) * | 1983-04-21 | 1985-12-20 | Hexachimie | Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire |
US4745222A (en) * | 1983-05-25 | 1988-05-17 | Merrell Dow Pharmaceuticals Inc. | Novel aryloxycycloalkanolaminoalkylene aryl ketones |
DE3413897A1 (de) * | 1984-04-13 | 1985-10-17 | Bayer Ag, 5090 Leverkusen | (beta)-naphthylalkylamine |
DE3766335D1 (de) * | 1986-09-17 | 1991-01-03 | Zambeletti Spa L | N-1-acylierte-(1-(phenyl- oder benzyl-))-1,2-aethylendiamine. |
US5149714A (en) * | 1987-08-14 | 1992-09-22 | Merrell Dow Pharmaceuticals Inc. | Antidepressants |
CA1327795C (en) * | 1987-08-14 | 1994-03-15 | Jules Freedman | Antidepressants which are aryloxy inadanamines |
US5561152A (en) * | 1987-08-14 | 1996-10-01 | Merrell Pharmaceuticals Inc. | Antidepressants |
US5229414A (en) * | 1988-01-21 | 1993-07-20 | Imperial Chemical Industries Plc | Diamine compounds |
US5071845A (en) * | 1988-12-28 | 1991-12-10 | Suntory Limited | Benzoxazepine derivative |
US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
IT1303737B1 (it) * | 1998-11-11 | 2001-02-23 | Smithkline Beecham Spa | Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1. |
WO2002057215A2 (en) * | 2001-01-16 | 2002-07-25 | Theravance, Inc. | Sodium channel modulators |
WO2003000181A2 (en) * | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
WO2003000180A2 (en) * | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
CA2473461C (en) * | 2002-01-11 | 2011-11-01 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
WO2004007468A1 (en) * | 2002-07-15 | 2004-01-22 | Merck & Co., Inc. | Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes |
ES2291680T3 (es) * | 2002-10-07 | 2008-03-01 | MERCK & CO., INC. | Antidiabeticos beta-amino heterociclicos inhibidores de la dipeptidil peptidasa. |
CA2504735C (en) * | 2002-11-07 | 2009-06-23 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
AU2003297564A1 (en) * | 2002-12-04 | 2004-06-23 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
US20060052382A1 (en) * | 2002-12-20 | 2006-03-09 | Duffy Joseph L | 3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
AU2004206812A1 (en) * | 2003-01-17 | 2004-08-05 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
AU2004210149A1 (en) * | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
CN1787823A (zh) * | 2003-05-14 | 2006-06-14 | 麦克公司 | 作为二肽基肽酶抑制剂用于治疗或预防糖尿病的3-氨基-4-苯基丁酸衍生物 |
DE602004026440D1 (de) * | 2003-06-06 | 2010-05-20 | Merck Sharp & Dohme | Kondensierte indole als dipeptidyl-peptidase-hemmer zur behandlung oder prävention von diabetes |
AU2004249163A1 (en) * | 2003-06-17 | 2004-12-29 | Merck & Co., Inc. | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
DE602004018503D1 (de) * | 2003-07-31 | 2009-01-29 | Merck & Co Inc | Hexahydrodiazepinone als inhibitoren des dipeptidylpeptidase-iv zur behandlung bzw. prävention von diabetes |
US7626034B2 (en) * | 2003-09-18 | 2009-12-01 | Takasago International Corporation | Asymmetric reductive amination of keto acid derivatives for producing amino acid derivatives |
CA2541212A1 (en) * | 2003-11-04 | 2005-05-19 | Wallace T. Ashton | Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
US7910617B2 (en) | 2004-02-24 | 2011-03-22 | Sankyo Company, Limited | Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound |
JP2007536234A (ja) * | 2004-05-04 | 2007-12-13 | メルク エンド カムパニー インコーポレーテッド | 糖尿病の治療又は予防のためのジペプチジルペプチダーゼ−iv阻害剤としての1,2,4−オキサジアゾール誘導体 |
US7795448B2 (en) * | 2004-05-06 | 2010-09-14 | Cytokinetics, Incorporated | Imidazoyl-benzamide anti-cancer agents |
US7618981B2 (en) * | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
US7504413B2 (en) * | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
EP1604662A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus |
US20070197640A1 (en) * | 2005-11-02 | 2007-08-23 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2168929A (en) * | 1936-12-12 | 1939-08-08 | Winthrop Chem Co Inc | Isoquinoline compounds and derivatives thereof |
US3663608A (en) * | 1969-12-10 | 1972-05-16 | Bristol Myers Co | 1-phenyl-3-aminoalkyl-1,2,3,4-tetrahydronaphthalenes and the salts thereof |
US3704328A (en) * | 1970-01-21 | 1972-11-28 | James S Kaltenbronn | 4- and 5-aryl-1-naphthaleneethanol compounds |
US3663627A (en) * | 1970-06-01 | 1972-05-16 | Bristol Myers Co | 1-indanmethanols |
GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
US4022791A (en) * | 1975-06-03 | 1977-05-10 | Pfizer Inc. | 2-Aminomethyl-3,4-dihydronaphthalenes |
-
1981
- 1981-12-16 US US06/331,484 patent/US4386090A/en not_active Expired - Fee Related
- 1981-12-16 SE SE8107537A patent/SE8107537L/xx not_active Application Discontinuation
- 1981-12-21 CA CA000392859A patent/CA1181748A/en not_active Expired
- 1981-12-21 IT IT25722/81A patent/IT1168074B/it active
- 1981-12-21 GB GB8138399A patent/GB2091250B/en not_active Expired
- 1981-12-21 ES ES508670A patent/ES508670A0/es active Granted
- 1981-12-22 LU LU83850A patent/LU83850A1/fr unknown
- 1981-12-22 DE DE19813150876 patent/DE3150876A1/de not_active Withdrawn
- 1981-12-22 AU AU78757/81A patent/AU7875781A/en not_active Abandoned
- 1981-12-22 NL NL8105791A patent/NL8105791A/nl not_active Application Discontinuation
-
1982
- 1982-12-16 ES ES518692A patent/ES518692A0/es active Granted
- 1982-12-16 ES ES518693A patent/ES518693A0/es active Granted
-
1983
- 1983-02-03 GR GR66782A patent/GR78081B/el unknown
- 1983-03-08 US US06/473,182 patent/US4431851A/en not_active Expired - Fee Related
- 1983-11-15 US US06/552,181 patent/US4504663A/en not_active Expired - Fee Related
-
1984
- 1984-04-09 GB GB08409163A patent/GB2137992B/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES8400093A1 (es) | 1983-11-01 |
CA1181748A (en) | 1985-01-29 |
ES8400388A1 (es) | 1983-11-01 |
ES8306093A1 (es) | 1983-06-01 |
LU83850A1 (fr) | 1983-09-02 |
IT8125722A0 (it) | 1981-12-21 |
IT1168074B (it) | 1987-05-20 |
US4386090A (en) | 1983-05-31 |
US4431851A (en) | 1984-02-14 |
GB2137992B (en) | 1985-05-09 |
DE3150876A1 (de) | 1982-07-29 |
ES518692A0 (es) | 1983-11-01 |
GB2137992A (en) | 1984-10-17 |
ES518693A0 (es) | 1983-11-01 |
SE8107537L (sv) | 1982-06-23 |
GB2091250A (en) | 1982-07-28 |
ES508670A0 (es) | 1983-06-01 |
AU7875781A (en) | 1982-07-01 |
GR78081B (nl) | 1984-09-26 |
US4504663A (en) | 1985-03-12 |
GB2091250B (en) | 1984-11-14 |
GB8409163D0 (en) | 1984-05-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A85 | Still pending on 85-01-01 | ||
BV | The patent application has lapsed |