GB201115841D0 - Protein and method - Google Patents

Protein and method

Info

Publication number
GB201115841D0
GB201115841D0 GB201115841A GB201115841A GB201115841D0 GB 201115841 D0 GB201115841 D0 GB 201115841D0 GB 201115841 A GB201115841 A GB 201115841A GB 201115841 A GB201115841 A GB 201115841A GB 201115841 D0 GB201115841 D0 GB 201115841D0
Authority
GB
United Kingdom
Prior art keywords
endos49
igg
mutant
endos
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201115841A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genovis AB
Original Assignee
Genovis AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genovis AB filed Critical Genovis AB
Priority to GB201115841A priority Critical patent/GB201115841D0/en
Publication of GB201115841D0 publication Critical patent/GB201115841D0/en
Priority to CA2848230A priority patent/CA2848230C/en
Priority to EA201490447A priority patent/EA028490B8/ru
Priority to BR112014005816-4A priority patent/BR112014005816A2/pt
Priority to PL12756523T priority patent/PL2756077T3/pl
Priority to EP12756523.2A priority patent/EP2756077B1/en
Priority to NZ622172A priority patent/NZ622172B2/en
Priority to US14/343,938 priority patent/US9493752B2/en
Priority to DK12756523.2T priority patent/DK2756077T3/en
Priority to KR1020147009205A priority patent/KR102001427B1/ko
Priority to JP2014530196A priority patent/JP6076349B2/ja
Priority to PT127565232T priority patent/PT2756077T/pt
Priority to CN201280044106.0A priority patent/CN103946377B/zh
Priority to ES12756523.2T priority patent/ES2627334T3/es
Priority to IN2163CHN2014 priority patent/IN2014CN02163A/en
Priority to PCT/EP2012/067841 priority patent/WO2013037824A1/en
Priority to GB1406321.8A priority patent/GB2509284A/en
Priority to AU2012307461A priority patent/AU2012307461B2/en
Priority to MX2014002906A priority patent/MX347727B/es
Priority to SG11201400505YA priority patent/SG11201400505YA/en
Priority to IL231410A priority patent/IL231410A0/en
Priority to ZA2014/01840A priority patent/ZA201401840B/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01096—Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (3.2.1.96)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56944—Streptococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB201115841A 2011-09-13 2011-09-13 Protein and method Ceased GB201115841D0 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB201115841A GB201115841D0 (en) 2011-09-13 2011-09-13 Protein and method
SG11201400505YA SG11201400505YA (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
JP2014530196A JP6076349B2 (ja) 2011-09-13 2012-09-12 ストレプトコッカス・ピオゲネス由来のエンドグリコシダーゼ及びその使用方法
CN201280044106.0A CN103946377B (zh) 2011-09-13 2012-09-12 来自化脓性链球菌的内切糖苷酶及其使用方法
BR112014005816-4A BR112014005816A2 (pt) 2011-09-13 2012-09-12 endoglicosidase de streptococcus pyogenes e métodos de uso
PL12756523T PL2756077T3 (pl) 2011-09-13 2012-09-12 Endoglikozydaza ze streptococcus pyogenes i sposoby jej stosowania
EP12756523.2A EP2756077B1 (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
NZ622172A NZ622172B2 (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
US14/343,938 US9493752B2 (en) 2011-09-13 2012-09-12 Endoglycosidase from Streptococcus pyogenes and methods using it
DK12756523.2T DK2756077T3 (en) 2011-09-13 2012-09-12 ENDOGLYCOSIDASE FROM THE STREPTOCOCCUS PYOGENES AND METHODS OF USING IT
KR1020147009205A KR102001427B1 (ko) 2011-09-13 2012-09-12 스트렙토코쿠스 피오게네스 유래의 엔도글리코시다아제 및 그의 이용방법
CA2848230A CA2848230C (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
PT127565232T PT2756077T (pt) 2011-09-13 2012-09-12 Endoglicosidase de streptococcus pyogenes e métodos que a utilizam
EA201490447A EA028490B8 (ru) 2011-09-13 2012-09-12 Способ дегликозилирования иммуноглобулина
ES12756523.2T ES2627334T3 (es) 2011-09-13 2012-09-12 Endoglucosidasa de streptococcus pyogenes y métodos para usarla
IN2163CHN2014 IN2014CN02163A (https=) 2011-09-13 2012-09-12
PCT/EP2012/067841 WO2013037824A1 (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
GB1406321.8A GB2509284A (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it
AU2012307461A AU2012307461B2 (en) 2011-09-13 2012-09-12 Endoglycosidase from Streptococcus pyogenes and methods using it
MX2014002906A MX347727B (es) 2011-09-13 2012-09-12 Endoglicosidasa del streptococcus pyogenes y metodos para usarla.
IL231410A IL231410A0 (en) 2011-09-13 2014-03-09 Endoglycosidase from Streptococcus pyogenes and methods of using it
ZA2014/01840A ZA201401840B (en) 2011-09-13 2014-03-12 Endoglycosidase from streptococcus pyogenes and methods using it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201115841A GB201115841D0 (en) 2011-09-13 2011-09-13 Protein and method

Publications (1)

Publication Number Publication Date
GB201115841D0 true GB201115841D0 (en) 2011-10-26

Family

ID=44908522

Family Applications (2)

Application Number Title Priority Date Filing Date
GB201115841A Ceased GB201115841D0 (en) 2011-09-13 2011-09-13 Protein and method
GB1406321.8A Withdrawn GB2509284A (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1406321.8A Withdrawn GB2509284A (en) 2011-09-13 2012-09-12 Endoglycosidase from streptococcus pyogenes and methods using it

Country Status (20)

Country Link
US (1) US9493752B2 (https=)
EP (1) EP2756077B1 (https=)
JP (1) JP6076349B2 (https=)
KR (1) KR102001427B1 (https=)
CN (1) CN103946377B (https=)
AU (1) AU2012307461B2 (https=)
BR (1) BR112014005816A2 (https=)
CA (1) CA2848230C (https=)
DK (1) DK2756077T3 (https=)
EA (1) EA028490B8 (https=)
ES (1) ES2627334T3 (https=)
GB (2) GB201115841D0 (https=)
IL (1) IL231410A0 (https=)
IN (1) IN2014CN02163A (https=)
MX (1) MX347727B (https=)
PL (1) PL2756077T3 (https=)
PT (1) PT2756077T (https=)
SG (1) SG11201400505YA (https=)
WO (1) WO2013037824A1 (https=)
ZA (1) ZA201401840B (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002216863B8 (en) * 2000-12-21 2008-03-20 Id Biomedical Corporation Streptococcus pyogenes antigens and corresponding DNA fragments
CN105142672B (zh) 2012-10-23 2019-04-05 西纳福克斯股份有限公司 经修饰的抗体、抗体-缀合物及其制备方法
PL2991683T3 (pl) * 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
US9987373B2 (en) 2013-10-14 2018-06-05 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
WO2015057063A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
WO2015057066A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
US20160235861A1 (en) 2013-10-14 2016-08-18 SynAffix. B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
GB201318490D0 (en) * 2013-10-18 2013-12-04 Genovis Ab Method
US11168085B2 (en) 2014-01-24 2021-11-09 Synaffix B.V. Process for the cycloaddition of a hetero(aryl) 1,3-dipole compound with a (hetero)cycloalkyne
EP3160513B1 (en) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
GB201413240D0 (en) * 2014-07-25 2014-09-10 Hansa Medical Ab Method
EP4148138A1 (en) 2014-08-04 2023-03-15 SynAffix B.V. Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
GB201502306D0 (en) * 2015-02-12 2015-04-01 Hansa Medical Ab Protein
GB201502305D0 (en) * 2015-02-12 2015-04-01 Hansa Medical Ab Protein
WO2016170186A1 (en) 2015-04-23 2016-10-27 Synaffix B.V. PROCESS FOR THE MODIFICATION OF A GLYCOPROTEIN USING A GLYCOSYLTRANSFERASE THAT IS OR IS DERIVED FROM A β(1,4)-N-ACETYLGALACTOSAMINYLTRANSFERASE
WO2017124084A1 (en) * 2016-01-15 2017-07-20 University Of Maryland, College Park Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
AU2017214441B2 (en) 2016-02-04 2021-08-19 Genovis Ab New Streptococcal proteases
WO2018039373A1 (en) * 2016-08-24 2018-03-01 Cho Pharma Inc Endoglycosidase mutants for glycoprotein remodeling and methods of using it
CN111183220B (zh) 2017-05-26 2024-03-22 杰诺维斯公司 用于聚糖分析的工具
US20210228738A1 (en) 2017-07-17 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
CN112672764A (zh) 2018-06-19 2021-04-16 格莱科斯生物医药公司 结合物
US20210138080A1 (en) 2018-06-29 2021-05-13 Glykos Biomedical Oy Conjugates
WO2021123506A1 (en) 2019-12-18 2021-06-24 Glykos Biomedical Oy Stabile conjugate
CN111044731B (zh) * 2019-12-19 2021-05-07 北京科技大学 脉冲温育免疫反应分离富集多肽药物中肽类杂质的方法
BR112022013255A2 (pt) 2020-01-09 2022-09-06 Mersana Therapeutics Inc Conjugados anticorpo-fármaco específicos de sítio com ligantes contendo peptídeo
GB202002072D0 (en) * 2020-02-14 2020-04-01 Hansa Biopharma AB immunoglobulin detection and associated therapies
CN120078887A (zh) * 2020-09-21 2025-06-03 上海宝济药业股份有限公司 一种药物组合及其应用
MX2023008000A (es) 2021-01-04 2023-07-13 Mersana Therapeutics Inc Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos.
EP4079848A1 (en) 2021-04-22 2022-10-26 Genovis Ab Immunoglobulin cleaving enzyme
CN115873833B (zh) * 2022-11-08 2024-08-16 上海泰昶生物技术有限公司 生产免疫球蛋白g降解酶的工程菌株和工艺
CN117165643B (zh) * 2023-08-17 2025-10-28 山东大学 一种糖苷内切酶在水解高甘露糖型n-糖蛋白中的应用
WO2025098484A1 (zh) * 2023-11-10 2025-05-15 上海齐鲁制药研究中心有限公司 新型Endo S2突变体酶
WO2025180451A1 (zh) * 2024-03-01 2025-09-04 上海齐鲁制药研究中心有限公司 新型Endo S2突变体酶
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3
GB202413764D0 (en) 2024-09-18 2024-10-30 Genovis Ab Immunoglobulin proteases and their uses

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130228D0 (en) 2001-12-18 2002-02-06 Hansa Medica Ab Protein
GB0624874D0 (en) * 2006-12-13 2007-01-24 Hansa Medical Ab Treatment
DK2190984T3 (da) * 2007-09-14 2013-12-02 Genovis Ab Fremgangsmåder og kits til oprensning og påvisning af glycosyleret IgG
GB0821100D0 (en) 2008-11-18 2008-12-24 Hansa Medical Ab Antibodies
US20120196310A1 (en) * 2009-10-02 2012-08-02 Christiane Jaeger A-fucosylation detection in antibodies

Also Published As

Publication number Publication date
AU2012307461A1 (en) 2014-03-27
PL2756077T3 (pl) 2017-09-29
NZ622172A (en) 2016-04-29
ZA201401840B (en) 2018-05-30
IN2014CN02163A (https=) 2015-05-29
WO2013037824A1 (en) 2013-03-21
KR20140081813A (ko) 2014-07-01
CA2848230C (en) 2020-03-24
MX2014002906A (es) 2014-10-17
IL231410A0 (en) 2014-04-30
EA201490447A1 (ru) 2014-09-30
DK2756077T3 (en) 2017-07-03
SG11201400505YA (en) 2014-04-28
EA028490B8 (ru) 2018-01-31
PT2756077T (pt) 2017-06-21
MX347727B (es) 2017-05-10
CN103946377A (zh) 2014-07-23
ES2627334T3 (es) 2017-07-27
JP6076349B2 (ja) 2017-02-08
US9493752B2 (en) 2016-11-15
CN103946377B (zh) 2016-10-05
CA2848230A1 (en) 2013-03-21
KR102001427B1 (ko) 2019-07-18
EA028490B1 (ru) 2017-11-30
GB201406321D0 (en) 2014-05-21
US20140302519A1 (en) 2014-10-09
JP2014531205A (ja) 2014-11-27
GB2509284A (en) 2014-06-25
EP2756077A1 (en) 2014-07-23
EP2756077B1 (en) 2017-03-29
AU2012307461B2 (en) 2016-08-18
BR112014005816A2 (pt) 2020-12-29

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