GB1560880A - Diphenylmethane derivatives and pharmaceutical compositions containing them - Google Patents

Diphenylmethane derivatives and pharmaceutical compositions containing them Download PDF

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Publication number
GB1560880A
GB1560880A GB52999/75A GB5299975A GB1560880A GB 1560880 A GB1560880 A GB 1560880A GB 52999/75 A GB52999/75 A GB 52999/75A GB 5299975 A GB5299975 A GB 5299975A GB 1560880 A GB1560880 A GB 1560880A
Authority
GB
United Kingdom
Prior art keywords
radical
formula
hydrogen
compound
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52999/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB52999/75A priority Critical patent/GB1560880A/en
Priority to CY1147A priority patent/CY1147A/xx
Priority to IE2633/76A priority patent/IE43994B1/en
Priority to ZA767215A priority patent/ZA767215B/xx
Priority to IN2159/CAL/76A priority patent/IN145508B/en
Priority to CA267,212A priority patent/CA1086743A/en
Priority to US05/747,995 priority patent/US4113879A/en
Priority to NZ182807A priority patent/NZ182807A/xx
Priority to IL51065A priority patent/IL51065A/xx
Priority to MX765211U priority patent/MX4655E/es
Priority to PH19243A priority patent/PH13545A/en
Priority to AU20605/76A priority patent/AU512090B2/en
Priority to NL7614015A priority patent/NL7614015A/xx
Priority to SE7614304A priority patent/SE428468B/xx
Priority to HU76IE770A priority patent/HU176679B/hu
Priority to PL1976194591A priority patent/PL104291B1/pl
Priority to FR7638911A priority patent/FR2336921A1/fr
Priority to BE173648A priority patent/BE849872A/xx
Priority to DE19762658840 priority patent/DE2658840A1/de
Priority to DD7600196658A priority patent/DD128671A5/xx
Priority to AT971676A priority patent/AT346835B/de
Priority to JP16078376A priority patent/JPS5283356A/ja
Priority to LU76483A priority patent/LU76483A1/xx
Priority to NO764371A priority patent/NO146138C/no
Priority to DK586576A priority patent/DK147105C/da
Priority to FI763735A priority patent/FI763735A7/fi
Priority to ES454657A priority patent/ES454657A1/es
Priority to CS768759A priority patent/CS191326B2/cs
Priority to CH1643576A priority patent/CH624378A5/de
Priority to US05/907,861 priority patent/US4152341A/en
Publication of GB1560880A publication Critical patent/GB1560880A/en
Priority to US06/127,135 priority patent/USRE31467E/en
Priority to CH44281A priority patent/CH627156A5/de
Priority to KE3169A priority patent/KE3169A/xx
Priority to HK618/81A priority patent/HK61881A/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C205/60—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms in ortho-position to the carboxyl group, e.g. nitro-salicylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/61—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
GB52999/75A 1975-12-29 1975-12-29 Diphenylmethane derivatives and pharmaceutical compositions containing them Expired GB1560880A (en)

Priority Applications (34)

Application Number Priority Date Filing Date Title
GB52999/75A GB1560880A (en) 1975-12-29 1975-12-29 Diphenylmethane derivatives and pharmaceutical compositions containing them
CY1147A CY1147A (en) 1975-12-29 1976-11-29 Diphenylmethane derivatives and pharmaceutical compositions containing them
IE2633/76A IE43994B1 (en) 1975-12-29 1976-12-01 Pharmaceutical compositions
ZA767215A ZA767215B (en) 1975-12-29 1976-12-03 Pharmaceutical compositions
IN2159/CAL/76A IN145508B (enExample) 1975-12-29 1976-12-04
CA267,212A CA1086743A (en) 1975-12-29 1976-12-06 4,4'-dihydroxy-3,3'-thiphenylmethanedicarboxylic acid compounds
US05/747,995 US4113879A (en) 1975-12-29 1976-12-06 Pharmaceutical compositions and method of use
NZ182807A NZ182807A (en) 1975-12-29 1976-12-06 Pharmaceutical compsoitions containing benzoic acid derivatives
IL51065A IL51065A (en) 1975-12-29 1976-12-07 Pharmaceutical compositions containing triphenylmethanedi-carboxylic acid derivatives and analogs thereof,some novel compounds of this type and process for their preparation
MX765211U MX4655E (es) 1975-12-29 1976-12-10 Procedimiento para preparar derivados del acido 3,3,'-triarilmetanodicarboxilico
PH19243A PH13545A (en) 1975-12-29 1976-12-14 Topically antiinflammatory 4,4'-dihydroxy-3,3-triphenyl methane decarboxylic acid derivatives and related compounds and pharmaceutical compositions
AU20605/76A AU512090B2 (en) 1975-12-29 1976-12-16 Antiinflammatory pharmaceutical compositions
NL7614015A NL7614015A (nl) 1975-12-29 1976-12-17 Werkwijze voor het bereiden van een farmaceu- tisch preparaat.
SE7614304A SE428468B (sv) 1975-12-29 1976-12-20 Sett att framstella 3,3'-triarylmetandikarboxylsyraderivat
HU76IE770A HU176679B (en) 1975-12-29 1976-12-20 Process for producing triaryl-methane-dicarboxylic acid derivatives
PL1976194591A PL104291B1 (pl) 1975-12-29 1976-12-21 Sposob wytwarzania nowych pochodnych kwasu 3,3'-trojarylometanodwukarboksylowego
FR7638911A FR2336921A1 (fr) 1975-12-29 1976-12-23 Compositions pharmaceutiques anti-inflammatoires
BE173648A BE849872A (fr) 1975-12-29 1976-12-24 Compositions pharmaceutiques anti-inflammatoires
DE19762658840 DE2658840A1 (de) 1975-12-29 1976-12-24 Pharmazeutische zusammensetzung
DD7600196658A DD128671A5 (de) 1975-12-29 1976-12-28 Pharmazeutische mittel
AT971676A AT346835B (de) 1975-12-29 1976-12-28 Verfahren zur herstellung von neuen 3,3'- triarylmethan-dicarbonsaeuren
JP16078376A JPS5283356A (en) 1975-12-29 1976-12-28 Pharmaceutical composition novel compound containing therein and process for preparing same
LU76483A LU76483A1 (enExample) 1975-12-29 1976-12-28
NO764371A NO146138C (no) 1975-12-29 1976-12-28 Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoesyrederivater
ES454657A ES454657A1 (es) 1975-12-29 1976-12-29 Procedimiento para preparar derivados de acidos 3,3'-tria- rilmetanodicarboxilicos.
FI763735A FI763735A7 (enExample) 1975-12-29 1976-12-29
DK586576A DK147105C (da) 1975-12-29 1976-12-29 Analogifremgangsmaade til fremstilling af 4,4'-dihydroxy-3,3'-diphenylarylmethandicarboxylsyrer eller farmaceutisk acceptable salte heraf
CS768759A CS191326B2 (en) 1975-12-29 1976-12-29 Method of preparing derivatives of 3,3'-triarylmethan dicarboxylic acids
CH1643576A CH624378A5 (enExample) 1975-12-29 1976-12-29
US05/907,861 US4152341A (en) 1975-12-29 1978-05-19 Triaryl or diarylpyridyl methanes
US06/127,135 USRE31467E (en) 1975-12-29 1980-03-04 Triaryl or diarylpyridyl methanes
CH44281A CH627156A5 (enExample) 1975-12-29 1981-01-22
KE3169A KE3169A (en) 1975-12-29 1981-10-19 Diphenylmethane derivatives and pharmaceutical compositions containing them
HK618/81A HK61881A (en) 1975-12-29 1981-12-10 Diphenylmethane derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52999/75A GB1560880A (en) 1975-12-29 1975-12-29 Diphenylmethane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
GB1560880A true GB1560880A (en) 1980-02-13

Family

ID=10466224

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52999/75A Expired GB1560880A (en) 1975-12-29 1975-12-29 Diphenylmethane derivatives and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (2) US4113879A (enExample)
JP (1) JPS5283356A (enExample)
AU (1) AU512090B2 (enExample)
BE (1) BE849872A (enExample)
CA (1) CA1086743A (enExample)
CH (2) CH624378A5 (enExample)
CS (1) CS191326B2 (enExample)
CY (1) CY1147A (enExample)
DD (1) DD128671A5 (enExample)
DE (1) DE2658840A1 (enExample)
DK (1) DK147105C (enExample)
ES (1) ES454657A1 (enExample)
FI (1) FI763735A7 (enExample)
FR (1) FR2336921A1 (enExample)
GB (1) GB1560880A (enExample)
HK (1) HK61881A (enExample)
HU (1) HU176679B (enExample)
IE (1) IE43994B1 (enExample)
IL (1) IL51065A (enExample)
IN (1) IN145508B (enExample)
KE (1) KE3169A (enExample)
LU (1) LU76483A1 (enExample)
MX (1) MX4655E (enExample)
NL (1) NL7614015A (enExample)
NO (1) NO146138C (enExample)
NZ (1) NZ182807A (enExample)
PH (1) PH13545A (enExample)
PL (1) PL104291B1 (enExample)
SE (1) SE428468B (enExample)
ZA (1) ZA767215B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695408A (en) 1985-07-02 1987-09-22 The Dow Chemical Company Preparation of trisphenol methanes
US5434185A (en) * 1993-05-17 1995-07-18 The University Of Kentucky Research Foundation Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts
US5312988A (en) * 1993-05-28 1994-05-17 Hoechst Celanese Corporation Amines derived from THPE
US5756781A (en) * 1995-09-29 1998-05-26 General Electric Company Method for making tris(hydroxyphenyl) compounds using ion exchange
EP3071543B1 (en) 2013-11-18 2019-10-02 Aurin Biotech Inc. Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1004609A (en) * 1911-02-07 1911-10-03 Farbenfab Vorm Bayer F & Co Triphenylmethane dye.
US998139A (en) * 1911-04-11 1911-07-18 Farbenfab Vorm Bayer F & Co Greenish-blue triphenylmethane dye.
US1034173A (en) * 1911-09-07 1912-07-30 Farbenfab Vorm Bayer F & Co Red-violet triphenylmethane dye.
US2506486A (en) * 1948-04-21 1950-05-02 Union Carbide & Carbon Corp Thermosetting resin from a diphenol and a diglycidyl ether of a diphenol
US2764590A (en) * 1952-03-17 1956-09-25 Thomae Gmbh Dr K Certain 4, 4'-disubstituted-diphenylpyridyl methanes and process
US3558641A (en) * 1967-10-06 1971-01-26 Merck & Co Inc Certain pyridyl salicylic acid derivatives
US3549656A (en) * 1967-12-28 1970-12-22 Kefalas As Antidepressant 1 - aminoalkyl - thiophthalanes and acid addition salts thereof
US3579542A (en) * 1968-06-26 1971-05-18 Hoechst Co American 4,4',4''-trihydroxytriphenylmethyl-methane
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
US3794642A (en) * 1973-01-15 1974-02-26 Lilly Co Eli Oxidation of substituted methanes to the corresponding substituted methanols

Also Published As

Publication number Publication date
DK147105C (da) 1984-10-15
IE43994L (en) 1977-06-29
NL7614015A (nl) 1977-07-01
FR2336921B1 (enExample) 1980-03-07
CH627156A5 (enExample) 1981-12-31
AU2060576A (en) 1978-06-22
CS191326B2 (en) 1979-06-29
AU512090B2 (en) 1980-09-25
NO764371L (enExample) 1977-06-30
CA1086743A (en) 1980-09-30
DE2658840A1 (de) 1977-07-07
NZ182807A (en) 1978-04-03
IN145508B (enExample) 1978-10-28
HU176679B (en) 1981-04-28
US4113879A (en) 1978-09-12
IL51065A0 (en) 1977-02-28
NO146138C (no) 1982-08-04
IE43994B1 (en) 1981-07-15
CY1147A (en) 1982-09-10
MX4655E (es) 1982-07-19
SE7614304L (sv) 1977-06-30
LU76483A1 (enExample) 1978-01-18
HK61881A (en) 1981-12-18
IL51065A (en) 1980-12-31
FR2336921A1 (fr) 1977-07-29
USRE31467E (en) 1983-12-20
JPS5283356A (en) 1977-07-12
NO146138B (no) 1982-04-26
DD128671A5 (de) 1977-11-30
PL104291B1 (pl) 1979-08-31
FI763735A7 (enExample) 1977-06-30
DK586576A (da) 1977-06-30
DK147105B (da) 1984-04-09
PH13545A (en) 1980-06-26
ES454657A1 (es) 1978-03-16
ZA767215B (en) 1977-11-30
BE849872A (fr) 1977-06-24
SE428468B (sv) 1983-07-04
JPS6115061B2 (enExample) 1986-04-22
CH624378A5 (enExample) 1981-07-31
KE3169A (en) 1981-11-06

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
429A Application made for amendment of specification (sect. 29/1949)
429H Application (made) for amendment of specification now open to opposition (sect. 29/1949)
429D Case decided by the comptroller ** specification amended (sect. 29/1949)
SP Amendment (slips) printed
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921129