GB1461323A - Alpha-aminoacyl-3-halo-cephalosporins - Google Patents

Alpha-aminoacyl-3-halo-cephalosporins

Info

Publication number
GB1461323A
GB1461323A GB809774A GB809774A GB1461323A GB 1461323 A GB1461323 A GB 1461323A GB 809774 A GB809774 A GB 809774A GB 809774 A GB809774 A GB 809774A GB 1461323 A GB1461323 A GB 1461323A
Authority
GB
United Kingdom
Prior art keywords
group
mono
protecting
hydrogen
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB809774A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1461323A publication Critical patent/GB1461323A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB809774A 1973-02-23 1974-02-22 Alpha-aminoacyl-3-halo-cephalosporins Expired GB1461323A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33538173A 1973-02-23 1973-02-23

Publications (1)

Publication Number Publication Date
GB1461323A true GB1461323A (en) 1977-01-13

Family

ID=23311540

Family Applications (1)

Application Number Title Priority Date Filing Date
GB809774A Expired GB1461323A (en) 1973-02-23 1974-02-22 Alpha-aminoacyl-3-halo-cephalosporins

Country Status (37)

Country Link
JP (4) JPS6139313B2 (ja)
AR (1) AR199510A1 (ja)
AT (1) AT333953B (ja)
BE (1) BE811495A (ja)
BR (1) BR7401384D0 (ja)
CA (1) CA1016537A (ja)
CH (1) CH593988A5 (ja)
CS (1) CS187409B2 (ja)
CY (1) CY1043A (ja)
DD (1) DD110278A5 (ja)
DE (1) DE2408698C2 (ja)
DK (1) DK153157C (ja)
EG (1) EG11104A (ja)
ES (1) ES423531A1 (ja)
FI (1) FI63035C (ja)
FR (1) FR2218877B1 (ja)
GB (1) GB1461323A (ja)
GT (1) GT197432133A (ja)
HK (1) HK20080A (ja)
HU (1) HU166849B (ja)
IE (1) IE39046B1 (ja)
IL (1) IL44262A (ja)
IN (1) IN139620B (ja)
KE (1) KE3027A (ja)
MW (1) MW674A1 (ja)
MY (1) MY8100024A (ja)
NL (1) NL179057C (ja)
NO (2) NO148375C (ja)
OA (1) OA04809A (ja)
PH (1) PH9616A (ja)
PL (1) PL88702B1 (ja)
RO (1) RO64663A (ja)
SE (1) SE411212B (ja)
SU (1) SU676166A3 (ja)
YU (1) YU36970B (ja)
ZA (1) ZA741191B (ja)
ZM (1) ZM3574A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101805357A (zh) * 2010-04-28 2010-08-18 陶灵刚 一种头孢克洛化合物及其新制法
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法
CN106632400A (zh) * 2016-12-16 2017-05-10 石家庄柏奇化工有限公司 Pd‑C催化氢化脱除4‑硝基苄基制备7‑ACCA的方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
CH619233A5 (ja) * 1975-07-31 1980-09-15 Ciba Geigy Ag
CH622802A5 (ja) * 1975-08-20 1981-04-30 Ciba Geigy Ag
IE45158B1 (en) * 1976-08-16 1982-06-30 Lilly Co Eli 3-chloro-cephem synthesis
DE3508258A1 (de) * 1985-03-08 1986-09-18 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln
DE3509618A1 (de) 1985-03-16 1986-09-18 Bayer Ag, 5090 Leverkusen Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel
JPS6436445U (ja) * 1987-08-28 1989-03-06
DE3803169A1 (de) 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
ES2010075A6 (es) * 1989-01-10 1989-10-16 Antibioticos Sa Un procedimiento para la preparacion de compuestos de 3-cloro-cefem.
JP2539459Y2 (ja) * 1991-12-18 1997-06-25 三重ホーロー株式会社 組立式塵芥焼却器
IT1255458B (it) * 1992-05-11 1995-11-02 Col Marco Da Procedimento per la preparazione di derivati beta-lattamici alogenati
ES2079327B1 (es) 1994-12-13 1996-08-01 Lilly Sa Formulaciones farmaceuticas de cefaclor.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
DE2265798C2 (de) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka Verfahren zur Herstellung von Oxoazetidin-Derivaten
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101805357A (zh) * 2010-04-28 2010-08-18 陶灵刚 一种头孢克洛化合物及其新制法
CN101805357B (zh) * 2010-04-28 2012-01-11 陶灵刚 一种头孢克洛化合物及其制法
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法
CN106632400A (zh) * 2016-12-16 2017-05-10 石家庄柏奇化工有限公司 Pd‑C催化氢化脱除4‑硝基苄基制备7‑ACCA的方法

Also Published As

Publication number Publication date
NO148377B (no) 1983-06-20
JPS6140237B2 (ja) 1986-09-08
CA1016537A (en) 1977-08-30
AT333953B (de) 1976-12-27
PH9616A (en) 1976-01-20
FI63035B (fi) 1982-12-31
CS187409B2 (en) 1979-01-31
NO148377C (no) 1983-09-28
JPS6140235B2 (ja) 1986-09-08
YU36970B (en) 1984-08-31
IN139620B (ja) 1976-07-10
EG11104A (en) 1976-12-31
PL88702B1 (ja) 1976-09-30
SU676166A3 (ru) 1979-07-25
DE2408698A1 (de) 1974-09-05
IL44262A0 (en) 1974-05-16
JPS56138190A (en) 1981-10-28
CY1043A (en) 1980-08-01
CH593988A5 (ja) 1977-12-30
IE39046B1 (en) 1978-07-19
FR2218877B1 (ja) 1977-03-11
JPS56138192A (en) 1981-10-28
ATA142574A (de) 1976-04-15
JPS56138191A (en) 1981-10-28
JPS6139313B2 (ja) 1986-09-03
OA04809A (fr) 1980-08-31
IE39046L (en) 1974-08-23
JPS49110689A (ja) 1974-10-22
AU6591674A (en) 1975-08-28
NO148375C (no) 1983-09-28
AR199510A1 (es) 1974-09-09
MY8100024A (en) 1981-12-31
NL179057B (nl) 1986-02-03
NO740606L (no) 1974-08-26
RO64663A (fr) 1979-02-15
HU166849B (ja) 1975-06-28
DK153157C (da) 1988-10-31
FR2218877A1 (ja) 1974-09-20
ZA741191B (en) 1975-10-29
KE3027A (en) 1980-03-14
MW674A1 (en) 1975-04-09
DK153157B (da) 1988-06-20
ZM3574A1 (en) 1975-11-21
FI63035C (fi) 1983-04-11
DE2408698C2 (de) 1983-11-10
NO792681L (no) 1974-08-26
ES423531A1 (es) 1976-05-16
HK20080A (en) 1980-04-25
JPS6140236B2 (ja) 1986-09-08
GT197432133A (es) 1975-08-16
NL179057C (nl) 1986-07-01
NO148375B (no) 1983-06-20
SE411212B (sv) 1979-12-10
IL44262A (en) 1977-08-31
YU39974A (en) 1982-06-18
BE811495A (fr) 1974-08-22
NL7402489A (ja) 1974-08-27
BR7401384D0 (pt) 1974-11-05
DD110278A5 (ja) 1974-12-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
49R Reference inserted (sect. 9/1949)
SP Amendment (slips) printed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19940221