ES8106906A1 - Un procedimiento para la preparacion de un derivado penam - Google Patents

Un procedimiento para la preparacion de un derivado penam

Info

Publication number
ES8106906A1
ES8106906A1 ES495750A ES495750A ES8106906A1 ES 8106906 A1 ES8106906 A1 ES 8106906A1 ES 495750 A ES495750 A ES 495750A ES 495750 A ES495750 A ES 495750A ES 8106906 A1 ES8106906 A1 ES 8106906A1
Authority
ES
Spain
Prior art keywords
pharmaceutically acceptable
acceptable salt
ester
preparation
forming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495750A
Other languages
English (en)
Other versions
ES495750A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES495750A0 publication Critical patent/ES495750A0/es
Publication of ES8106906A1 publication Critical patent/ES8106906A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/50—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical
    • C07D499/56—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE UN DERIVADO "PENAM" DE FORMULA (I), SIENDO R FENILO, P-HIDROXIFENILO, P-ALQUILO CARBONILOXIFENILO O 2- O 3-TIENILO; R1 HIDROGENO O UN GRUPO SUSCEPTIBLE DE FORMAR UNA SAL O UN ESTER FARMACEUTICAMENTE ACEPTABLE, Y R2 HIDROGENO, O UN GRUPO SUSCEPTIBLE DE FORMAR UNA SAL O UN ESTER HIDROLIZABLE "IN VIVO", FARMACOLOGICAMENTE ACEPTABLE. SE HACE REACCIONAR A TEMPERATURA DE -20G A 20GC UN COMPUESTO DE FORMULA (II), DONDE R ELEVADO A X ES UN RADICAL QUE FORMA UN ESTER, R ELEVADO A Y ES HIDROGENO O RADICAL QUE FORMA UNA SAL O UN GRUPO BLOQUEANTE DE CARBOXILO, Y R3 ES UN GRUPO ARILO; CON METANOL, EN PRESENCIA DE IONES PLATA, TALIO O MERCURICOS, O DE CLORO Y UNA BASE. OPCIONALMENTE SE ELIMINAN LOS GRUPOS BLOQUEANTES DE CARBOXILO Y SE TRATA EL PRODUCTO PARA OBTENERLO EN FORMA DE SAL O ESTER. DE APLICACION COMO AGENTE BACTERIANO. *FORMULA*
ES495750A 1979-10-09 1980-10-08 Un procedimiento para la preparacion de un derivado penam Expired ES8106906A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934994 1979-10-09

Publications (2)

Publication Number Publication Date
ES495750A0 ES495750A0 (es) 1981-09-16
ES8106906A1 true ES8106906A1 (es) 1981-09-16

Family

ID=10508387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495750A Expired ES8106906A1 (es) 1979-10-09 1980-10-08 Un procedimiento para la preparacion de un derivado penam

Country Status (13)

Country Link
EP (1) EP0027010B1 (es)
JP (1) JPS5661387A (es)
KR (1) KR830004310A (es)
AU (1) AU6301980A (es)
CA (1) CA1147325A (es)
DK (1) DK425980A (es)
ES (1) ES8106906A1 (es)
GR (1) GR70774B (es)
IL (1) IL61184A0 (es)
MX (1) MX6642E (es)
NZ (1) NZ195030A (es)
PL (1) PL227154A1 (es)
ZA (1) ZA806009B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO1395B1 (en) * 1981-07-10 1986-11-30 بيتشام جروب بي ال سي Method for preparing active and antibacterial sleeper derivatives
JO1228B1 (en) * 1982-01-22 1985-04-20 بيتشام جروب بي ال سي Method for preparing the derivative of sleep

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU36181B (en) * 1971-11-29 1982-02-25 Merck & Co Inc Process for obtaining 7-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylates
US3954731A (en) * 1972-07-03 1976-05-04 Eli Lilly And Company Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids

Also Published As

Publication number Publication date
DK425980A (da) 1981-04-10
NZ195030A (en) 1983-06-17
GR70774B (es) 1983-03-22
EP0027010B1 (en) 1983-10-05
PL227154A1 (es) 1981-06-19
IL61184A0 (en) 1980-11-30
ZA806009B (en) 1981-09-30
AU6301980A (en) 1981-04-16
JPS5661387A (en) 1981-05-26
EP0027010A1 (en) 1981-04-15
ES495750A0 (es) 1981-09-16
KR830004310A (ko) 1983-07-09
CA1147325A (en) 1983-05-31
MX6642E (es) 1985-09-17

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