ES8106906A1 - Un procedimiento para la preparacion de un derivado penam - Google Patents
Un procedimiento para la preparacion de un derivado penamInfo
- Publication number
- ES8106906A1 ES8106906A1 ES495750A ES495750A ES8106906A1 ES 8106906 A1 ES8106906 A1 ES 8106906A1 ES 495750 A ES495750 A ES 495750A ES 495750 A ES495750 A ES 495750A ES 8106906 A1 ES8106906 A1 ES 8106906A1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- ester
- preparation
- forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000002959 penams Chemical class 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 150000002500 ions Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- -1 p-hydroxyphenyl Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
- 229910052716 thallium Inorganic materials 0.000 abstract 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/50—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical
- C07D499/56—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE UN DERIVADO "PENAM" DE FORMULA (I), SIENDO R FENILO, P-HIDROXIFENILO, P-ALQUILO CARBONILOXIFENILO O 2- O 3-TIENILO; R1 HIDROGENO O UN GRUPO SUSCEPTIBLE DE FORMAR UNA SAL O UN ESTER FARMACEUTICAMENTE ACEPTABLE, Y R2 HIDROGENO, O UN GRUPO SUSCEPTIBLE DE FORMAR UNA SAL O UN ESTER HIDROLIZABLE "IN VIVO", FARMACOLOGICAMENTE ACEPTABLE. SE HACE REACCIONAR A TEMPERATURA DE -20G A 20GC UN COMPUESTO DE FORMULA (II), DONDE R ELEVADO A X ES UN RADICAL QUE FORMA UN ESTER, R ELEVADO A Y ES HIDROGENO O RADICAL QUE FORMA UNA SAL O UN GRUPO BLOQUEANTE DE CARBOXILO, Y R3 ES UN GRUPO ARILO; CON METANOL, EN PRESENCIA DE IONES PLATA, TALIO O MERCURICOS, O DE CLORO Y UNA BASE. OPCIONALMENTE SE ELIMINAN LOS GRUPOS BLOQUEANTES DE CARBOXILO Y SE TRATA EL PRODUCTO PARA OBTENERLO EN FORMA DE SAL O ESTER. DE APLICACION COMO AGENTE BACTERIANO. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7934994 | 1979-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8106906A1 true ES8106906A1 (es) | 1981-09-16 |
| ES495750A0 ES495750A0 (es) | 1981-09-16 |
Family
ID=10508387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495750A Granted ES495750A0 (es) | 1979-10-09 | 1980-10-08 | Un procedimiento para la preparacion de un derivado penam |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0027010B1 (es) |
| JP (1) | JPS5661387A (es) |
| KR (1) | KR830004310A (es) |
| AU (1) | AU6301980A (es) |
| CA (1) | CA1147325A (es) |
| DK (1) | DK425980A (es) |
| ES (1) | ES495750A0 (es) |
| GR (1) | GR70774B (es) |
| IL (1) | IL61184A0 (es) |
| MX (1) | MX6642E (es) |
| NZ (1) | NZ195030A (es) |
| PL (1) | PL227154A1 (es) |
| ZA (1) | ZA806009B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO1395B1 (en) * | 1981-07-10 | 1986-11-30 | بيتشام جروب بي ال سي | Method for preparing active and antibacterial sleeper derivatives |
| JO1228B1 (en) * | 1982-01-22 | 1985-04-20 | بيتشام جروب بي ال سي | Method for preparing the derivative of sleep |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU36181B (en) * | 1971-11-29 | 1982-02-25 | Merck & Co Inc | Process for obtaining 7-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylates |
| US3954731A (en) * | 1972-07-03 | 1976-05-04 | Eli Lilly And Company | Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids |
-
1980
- 1980-09-23 NZ NZ195030A patent/NZ195030A/xx unknown
- 1980-09-26 EP EP80303379A patent/EP0027010B1/en not_active Expired
- 1980-09-29 ZA ZA00806009A patent/ZA806009B/xx unknown
- 1980-09-30 IL IL61184A patent/IL61184A0/xx unknown
- 1980-10-06 GR GR63058A patent/GR70774B/el unknown
- 1980-10-06 MX MX809078U patent/MX6642E/es unknown
- 1980-10-07 KR KR1019800003848A patent/KR830004310A/ko not_active Ceased
- 1980-10-07 AU AU63019/80A patent/AU6301980A/en not_active Abandoned
- 1980-10-08 PL PL22715480A patent/PL227154A1/xx unknown
- 1980-10-08 CA CA000361783A patent/CA1147325A/en not_active Expired
- 1980-10-08 DK DK425980A patent/DK425980A/da unknown
- 1980-10-08 ES ES495750A patent/ES495750A0/es active Granted
- 1980-10-09 JP JP14183880A patent/JPS5661387A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1147325A (en) | 1983-05-31 |
| AU6301980A (en) | 1981-04-16 |
| PL227154A1 (es) | 1981-06-19 |
| IL61184A0 (en) | 1980-11-30 |
| JPS5661387A (en) | 1981-05-26 |
| EP0027010B1 (en) | 1983-10-05 |
| NZ195030A (en) | 1983-06-17 |
| DK425980A (da) | 1981-04-10 |
| ES495750A0 (es) | 1981-09-16 |
| EP0027010A1 (en) | 1981-04-15 |
| GR70774B (es) | 1983-03-22 |
| ZA806009B (en) | 1981-09-30 |
| KR830004310A (ko) | 1983-07-09 |
| MX6642E (es) | 1985-09-17 |
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