KR830004310A - 항균력이 있는 페남(penam) 유도체 제조방법 - Google Patents
항균력이 있는 페남(penam) 유도체 제조방법 Download PDFInfo
- Publication number
- KR830004310A KR830004310A KR1019800003848A KR800003848A KR830004310A KR 830004310 A KR830004310 A KR 830004310A KR 1019800003848 A KR1019800003848 A KR 1019800003848A KR 800003848 A KR800003848 A KR 800003848A KR 830004310 A KR830004310 A KR 830004310A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- hydrogen
- formula
- generating
- producing
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002959 penams Chemical class 0.000 title 1
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- -1 hydrogen ions Chemical class 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 claims 1
- 229910052716 thallium Inorganic materials 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/50—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical
- C07D499/56—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 화학식(I)을 가지는 페남유도체를 제조함에 있어서(단, 위의 식에서 R는 페닐기, P-히드록시페닐기, P-(C1-6)-알킬카르보닐옥시페닐기, 또는 2-또는 3-티엔일기, R1은 수소 또는 약학적으로 섭취가 가능한 염 생성 이온 또는 에스테르 생성라디칼, R2는 수소 또는 약학적으로 섭취가 가능한 염 생성이온 또는 생체내에서 가수 분해가 되는 에스테르생성라디칼), (가)은, 탈륨 또는 수소 이온이나 (나) 염소와 염기존재하에 화학식(Ⅱ)을 가지는 화합물과 메탄올을 반응시킨후 필요에 따라서 다음의 단계중 한가지 이상을 거치도록 하여 제조함을 특징으로 하는 방법.(단, 위의 식에서 R은 화학식(I)에서 정의된 바와 같고 Rx는 에스테르 생성 라디칼, Ry는 수소, 염생성 라디칼 또는 카르복시-차단기,R3는 아릴기.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34994 | 1979-10-09 | ||
| GB7934994 | 1979-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830004310A true KR830004310A (ko) | 1983-07-09 |
Family
ID=10508387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800003848A KR830004310A (ko) | 1979-10-09 | 1980-10-07 | 항균력이 있는 페남(penam) 유도체 제조방법 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0027010B1 (ko) |
| JP (1) | JPS5661387A (ko) |
| KR (1) | KR830004310A (ko) |
| AU (1) | AU6301980A (ko) |
| CA (1) | CA1147325A (ko) |
| DK (1) | DK425980A (ko) |
| ES (1) | ES495750A0 (ko) |
| GR (1) | GR70774B (ko) |
| IL (1) | IL61184A0 (ko) |
| MX (1) | MX6642E (ko) |
| NZ (1) | NZ195030A (ko) |
| PL (1) | PL227154A1 (ko) |
| ZA (1) | ZA806009B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO1395B1 (en) * | 1981-07-10 | 1986-11-30 | بيتشام جروب بي ال سي | Method for preparing active and antibacterial sleeper derivatives |
| JO1228B1 (en) * | 1982-01-22 | 1985-04-20 | بيتشام جروب بي ال سي | Method for preparing the derivative of sleep |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU36181B (en) * | 1971-11-29 | 1982-02-25 | Merck & Co Inc | Process for obtaining 7-(2-thienylacetamido)-7-methoxy-3-carbamoyloxymethyl-3-cephem-4-carboxylates |
| US3954731A (en) * | 1972-07-03 | 1976-05-04 | Eli Lilly And Company | Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids |
-
1980
- 1980-09-23 NZ NZ195030A patent/NZ195030A/xx unknown
- 1980-09-26 EP EP80303379A patent/EP0027010B1/en not_active Expired
- 1980-09-29 ZA ZA00806009A patent/ZA806009B/xx unknown
- 1980-09-30 IL IL61184A patent/IL61184A0/xx unknown
- 1980-10-06 GR GR63058A patent/GR70774B/el unknown
- 1980-10-06 MX MX809078U patent/MX6642E/es unknown
- 1980-10-07 KR KR1019800003848A patent/KR830004310A/ko unknown
- 1980-10-07 AU AU63019/80A patent/AU6301980A/en not_active Abandoned
- 1980-10-08 CA CA000361783A patent/CA1147325A/en not_active Expired
- 1980-10-08 PL PL22715480A patent/PL227154A1/xx unknown
- 1980-10-08 DK DK425980A patent/DK425980A/da unknown
- 1980-10-08 ES ES495750A patent/ES495750A0/es active Granted
- 1980-10-09 JP JP14183880A patent/JPS5661387A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ195030A (en) | 1983-06-17 |
| EP0027010A1 (en) | 1981-04-15 |
| IL61184A0 (en) | 1980-11-30 |
| MX6642E (es) | 1985-09-17 |
| ES8106906A1 (es) | 1981-09-16 |
| JPS5661387A (en) | 1981-05-26 |
| CA1147325A (en) | 1983-05-31 |
| AU6301980A (en) | 1981-04-16 |
| ZA806009B (en) | 1981-09-30 |
| DK425980A (da) | 1981-04-10 |
| PL227154A1 (ko) | 1981-06-19 |
| GR70774B (ko) | 1983-03-22 |
| ES495750A0 (es) | 1981-09-16 |
| EP0027010B1 (en) | 1983-10-05 |
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