GB1263343A - Delta<2>-CEPHEM-4-CARBOXYLIC ACID ESTERS - Google Patents

Delta<2>-CEPHEM-4-CARBOXYLIC ACID ESTERS

Info

Publication number
GB1263343A
GB1263343A GB39210/69A GB3921069A GB1263343A GB 1263343 A GB1263343 A GB 1263343A GB 39210/69 A GB39210/69 A GB 39210/69A GB 3921069 A GB3921069 A GB 3921069A GB 1263343 A GB1263343 A GB 1263343A
Authority
GB
United Kingdom
Prior art keywords
cephem
carboxylic acid
acid esters
formula
delta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39210/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1263343A publication Critical patent/GB1263343A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B17/00—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
    • F26B17/12—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed solely by gravity, i.e. the material moving through a substantially vertical drying enclosure, e.g. shaft
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1,263,343. Cephem-4-carboxylic acid esters. ELI LILLY & CO. 5 Aug., 1969 [12 Sept., 1968], No. 39210/69. Heading C2A. #<SP>2</SP>-Cephem-4-carboxylic acid esters having the formula are prepared by (a) converting a #<SP>3</SP>-cephem-4- carboxylic acid having the formula to the corresponding acid chloride; and (b) treating the acid chloride with 1-2 moles of a tertiary amine base having a pKa within the range of 7-11 and at least 1 mole of an esterforming aliphatic alcohol (as defined) having the formula R<SP>1</SP>OH at a temperature within the range of -100‹ to +50‹ C.; wherein X is hydrogen or acetoxy, R is an amino protecting group, and R<SP>1</SP> is the residue of the ester-forming alcohol. The compounds having the following formulae are stated to be novel and are claimed per se:
GB39210/69A 1968-09-12 1969-08-05 Delta<2>-CEPHEM-4-CARBOXYLIC ACID ESTERS Expired GB1263343A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75949068A 1968-09-12 1968-09-12

Publications (1)

Publication Number Publication Date
GB1263343A true GB1263343A (en) 1972-02-09

Family

ID=25055841

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39210/69A Expired GB1263343A (en) 1968-09-12 1969-08-05 Delta<2>-CEPHEM-4-CARBOXYLIC ACID ESTERS

Country Status (10)

Country Link
JP (1) JPS5013276B1 (en)
BE (1) BE737123A (en)
CH (1) CH519517A (en)
DE (1) DE1940081C3 (en)
DK (1) DK139725B (en)
FR (1) FR2017860A1 (en)
GB (1) GB1263343A (en)
IE (1) IE33537B1 (en)
IL (1) IL32545A (en)
NL (1) NL165750C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849408A (en) * 1971-05-03 1974-11-19 Squibb & Sons Inc 4-substituted-delta2-cephalosporin derivatives
JPS5254972U (en) * 1975-10-18 1977-04-20

Also Published As

Publication number Publication date
IE33537L (en) 1970-03-19
JPS5013276B1 (en) 1975-05-19
DE1940081B2 (en) 1973-09-27
IL32545A (en) 1974-05-16
IL32545A0 (en) 1969-11-12
NL165750B (en) 1980-12-15
NL165750C (en) 1981-05-15
DK139725B (en) 1979-04-02
DK139725C (en) 1979-09-17
CH519517A (en) 1972-02-29
DE1940081A1 (en) 1970-05-06
IE33537B1 (en) 1974-08-07
BE737123A (en) 1970-02-06
FR2017860A1 (en) 1970-05-22
NL6911731A (en) 1970-03-16
DE1940081C3 (en) 1974-05-02

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