IE33537B1 - Delta2 - cephem-4-carboxylic acid esters - Google Patents

Delta2 - cephem-4-carboxylic acid esters

Info

Publication number
IE33537B1
IE33537B1 IE906/69A IE90669A IE33537B1 IE 33537 B1 IE33537 B1 IE 33537B1 IE 906/69 A IE906/69 A IE 906/69A IE 90669 A IE90669 A IE 90669A IE 33537 B1 IE33537 B1 IE 33537B1
Authority
IE
Ireland
Prior art keywords
cephem
carboxylic acid
acid esters
formula
delta2
Prior art date
Application number
IE906/69A
Other versions
IE33537L (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE33537L publication Critical patent/IE33537L/en
Publication of IE33537B1 publication Critical patent/IE33537B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/60—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 3 and 4
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B17/00—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
    • F26B17/12—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed solely by gravity, i.e. the material moving through a substantially vertical drying enclosure, e.g. shaft
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1,263,343. Cephem-4-carboxylic acid esters. ELI LILLY & CO. 5 Aug., 1969 [12 Sept., 1968], No. 39210/69. Heading C2A. #<SP>2</SP>-Cephem-4-carboxylic acid esters having the formula are prepared by (a) converting a #<SP>3</SP>-cephem-4- carboxylic acid having the formula to the corresponding acid chloride; and (b) treating the acid chloride with 1-2 moles of a tertiary amine base having a pKa within the range of 7-11 and at least 1 mole of an esterforming aliphatic alcohol (as defined) having the formula R<SP>1</SP>OH at a temperature within the range of -100‹ to +50‹ C.; wherein X is hydrogen or acetoxy, R is an amino protecting group, and R<SP>1</SP> is the residue of the ester-forming alcohol. The compounds having the following formulae are stated to be novel and are claimed per se: [GB1263343A]
IE906/69A 1968-09-12 1969-07-02 Delta2 - cephem-4-carboxylic acid esters IE33537B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75949068A 1968-09-12 1968-09-12

Publications (2)

Publication Number Publication Date
IE33537L IE33537L (en) 1970-03-19
IE33537B1 true IE33537B1 (en) 1974-08-07

Family

ID=25055841

Family Applications (1)

Application Number Title Priority Date Filing Date
IE906/69A IE33537B1 (en) 1968-09-12 1969-07-02 Delta2 - cephem-4-carboxylic acid esters

Country Status (10)

Country Link
JP (1) JPS5013276B1 (en)
BE (1) BE737123A (en)
CH (1) CH519517A (en)
DE (1) DE1940081C3 (en)
DK (1) DK139725B (en)
FR (1) FR2017860A1 (en)
GB (1) GB1263343A (en)
IE (1) IE33537B1 (en)
IL (1) IL32545A (en)
NL (1) NL165750C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3849408A (en) * 1971-05-03 1974-11-19 Squibb & Sons Inc 4-substituted-delta2-cephalosporin derivatives
JPS5254972U (en) * 1975-10-18 1977-04-20

Also Published As

Publication number Publication date
IL32545A (en) 1974-05-16
IL32545A0 (en) 1969-11-12
JPS5013276B1 (en) 1975-05-19
GB1263343A (en) 1972-02-09
DE1940081A1 (en) 1970-05-06
BE737123A (en) 1970-02-06
DE1940081B2 (en) 1973-09-27
CH519517A (en) 1972-02-29
NL165750B (en) 1980-12-15
NL165750C (en) 1981-05-15
IE33537L (en) 1970-03-19
NL6911731A (en) 1970-03-16
DK139725B (en) 1979-04-02
FR2017860A1 (en) 1970-05-22
DK139725C (en) 1979-09-17
DE1940081C3 (en) 1974-05-02

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